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Protein

Secreted phosphoprotein 24

Gene

Spp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Could coordinate an aspect of bone turnover.By similarity

GO - Biological processi

  • bone remodeling Source: InterPro
  • protein complex assembly Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Secreted phosphoprotein 24
Short name:
Spp-24
Alternative name(s):
Secreted phosphoprotein 2
Gene namesi
Name:Spp2
Synonyms:Spp24
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi708488. Spp2.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB-SubCell
  • protein complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 203180Secreted phosphoprotein 24PRO_0000072146Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi86 ↔ 96By similarity
Modified residuei90 – 901PhosphoserineBy similarity
Disulfide bondi109 ↔ 127By similarity
Modified residuei137 – 1371PhosphoserineCombined sources
Modified residuei138 – 1381PhosphoserineCombined sources
Modified residuei174 – 1741PhosphoserineCombined sources

Post-translational modificationi

Multiply phosphorylated at serine residues.By similarity
Phosphorylation sites are present in the extracellular medium.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ62740.
PRIDEiQ62740.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026108.

Structurei

3D structure databases

ProteinModelPortaliQ62740.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SPP2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWPI. Eukaryota.
ENOG410Z1VS. LUCA.
HOGENOMiHOG000264228.
HOVERGENiHBG065800.
InParanoidiQ62740.
OMAiCAGFPVY.
OrthoDBiEOG754HQN.
PhylomeDBiQ62740.
TreeFamiTF335972.

Family and domain databases

InterProiIPR010892. Spp-24.
[Graphical view]
PfamiPF07448. Spp-24. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62740-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELATMKTLV MLVLGMHYWC ASGFPVYDYD PSSLQEALSA SVAKVNSQSL
60 70 80 90 100
SPYLFRATRS SLKRVNVLDE DTLVMNLEFT VQETTCLRES GDPSTCAFQR
110 120 130 140 150
GYSVPTAACR STVQMSKGQV KDVWAHCRWA STSESNSSEE MIFGDMARSH
160 170 180 190 200
RRRNDYLLGF LYDEPKGEQF YDRSIEITRR GHPPAHRRFL NLQRRARVNS

GFE
Length:203
Mass (Da):23,170
Last modified:March 21, 2006 - v2
Checksum:i5B9BCA590DC7F63E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti130 – 1301A → R in AAA87903 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088193 mRNA. Translation: AAH88193.1.
U19485 mRNA. Translation: AAA87903.1.
RefSeqiNP_446029.1. NM_053577.1.
UniGeneiRn.106183.

Genome annotation databases

GeneIDi94168.
KEGGirno:94168.
UCSCiRGD:708488. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC088193 mRNA. Translation: AAH88193.1.
U19485 mRNA. Translation: AAA87903.1.
RefSeqiNP_446029.1. NM_053577.1.
UniGeneiRn.106183.

3D structure databases

ProteinModelPortaliQ62740.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026108.

Proteomic databases

PaxDbiQ62740.
PRIDEiQ62740.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi94168.
KEGGirno:94168.
UCSCiRGD:708488. rat.

Organism-specific databases

CTDi6694.
RGDi708488. Spp2.

Phylogenomic databases

eggNOGiENOG410IWPI. Eukaryota.
ENOG410Z1VS. LUCA.
HOGENOMiHOG000264228.
HOVERGENiHBG065800.
InParanoidiQ62740.
OMAiCAGFPVY.
OrthoDBiEOG754HQN.
PhylomeDBiQ62740.
TreeFamiTF335972.

Miscellaneous databases

NextBioi617812.
PROiQ62740.

Family and domain databases

InterProiIPR010892. Spp-24.
[Graphical view]
PfamiPF07448. Spp-24. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  2. Hu B., Price P.A.
    Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 24-203.
    Strain: Sprague-Dawley.
    Tissue: Liver.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-137; SER-138 AND SER-174, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSPP24_RAT
AccessioniPrimary (citable) accession number: Q62740
Secondary accession number(s): Q5M874
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 21, 2006
Last modified: May 11, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.