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Protein

Rab-3A-interacting protein

Gene

Rab3ip

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity).By similarity1 Publication

GO - Molecular functioni

  • Rab guanyl-nucleotide exchange factor activity Source: RGD

GO - Biological processi

  • negative regulation of filopodium assembly Source: RGD
  • protein transport Source: UniProtKB-KW

Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Rab-3A-interacting protein
Short name:
Rab3A-interacting protein
Alternative name(s):
Rabin-3
SSX2-interacting protein
Gene namesi
Name:Rab3ipBy similarity
Synonyms:Rabin3, Rabin8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620650 Rab3ip

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000971461 – 460Rab-3A-interacting proteinAdd BLAST460

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei147PhosphoserineBy similarity1
Modified residuei247PhosphoserineBy similarity1
Modified residuei250PhosphoserineBy similarity1
Modified residuei272PhosphoserineBy similarity1
Modified residuei280PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ62739
PRIDEiQ62739

Expressioni

Tissue specificityi

Ubiquitously expressed. Expressed at highest level in testis.1 Publication

Interactioni

Subunit structurei

Interacts with the N-terminal region of SSX2. Interacts with the GDP-bound forms of RAB8A and RAB8B (By similarity). Interacts with the GDP-bound forms of RAB3A and RAB3D (PubMed:7532276). Interacts with DCDC5 (By similarity).By similarity1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • Rab guanyl-nucleotide exchange factor activity Source: RGD

Protein-protein interaction databases

IntActiQ62739, 4 interactors
MINTiQ62739
STRINGi10116.ENSRNOP00000007258

Structurei

3D structure databases

ProteinModelPortaliQ62739
SMRiQ62739
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili149 – 244Sequence analysisAdd BLAST96

Sequence similaritiesi

Belongs to the SEC2 family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4324 Eukaryota
ENOG410XPSY LUCA
HOGENOMiHOG000220814
HOVERGENiHBG057034
InParanoidiQ62739
PhylomeDBiQ62739

Family and domain databases

InterProiView protein in InterPro
IPR009449 Sec2_N
PfamiView protein in Pfam
PF06428 Sec2p, 1 hit

Sequencei

Sequence statusi: Complete.

Q62739-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANDPLEGFH EVNLASPTSP DLLGVCDPGT QEQTTSPSVI YRPHPSTLCS
60 70 80 90 100
ATIQANALNL SDLPTQPVYS SPRHLNCAEI SNISIHVPEP ASSVASEVAA
110 120 130 140 150
GLTRFTSRKD SCNAEREFLQ GATVTEASAG NDDIFGLSTD SLSRLRSPSV
160 170 180 190 200
LEVREKGYER LKEELAKAQR ELKLKDEECE RLSKVRDQLG QELEELTASL
210 220 230 240 250
FEEAHKMVRE ANVKQATAEK QLKEAQGKID VLQAEVAALK TLVLSSSPTS
260 270 280 290 300
PTQEPLADGK TPFKGGHTRN KSTSSAMSGS HQDFSAIQAI VKDCREADLS
310 320 330 340 350
LYNEFRSWKD EPTMDRTCPF LDKIYQEDIF PCLTFAKSEL ASAVLEAVEN
360 370 380 390 400
NTLSIEPVGL QPIRFVKASA VECGGPKKCA LTGQSKPCKH RIKLGDSSSY
410 420 430 440 450
YYISPVCRYR ITSVCNFFTY IRYIQQGLVK QQDVDQMFWE VMQLRKEMSL
460
AKLGYFKEEL
Length:460
Mass (Da):50,951
Last modified:November 1, 1996 - v1
Checksum:iD590A8BDE2AEBB4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19181 mRNA Translation: AAA67890.1
PIRiI57546
UniGeneiRn.31889

Genome annotation databases

UCSCiRGD:620650 rat

Similar proteinsi

Entry informationi

Entry nameiRAB3I_RAT
AccessioniPrimary (citable) accession number: Q62739
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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