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Q62739

- RAB3I_RAT

UniProt

Q62739 - RAB3I_RAT

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Protein
Rab-3A-interacting protein
Gene
Rab3ip, Rabin3, Rabin8
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis By similarity.1 Publication

GO - Molecular functioni

  1. GTPase binding Source: RGD
  2. Rab guanyl-nucleotide exchange factor activity Source: UniProtKB
  3. protein binding Source: UniProtKB

GO - Biological processi

  1. protein transport Source: UniProtKB-KW
  2. regulation of Rab GTPase activity Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Rab-3A-interacting protein
Short name:
Rab3A-interacting protein
Alternative name(s):
Rabin-3
SSX2-interacting protein
Gene namesi
Name:Rab3ip
Synonyms:Rabin3, Rabin8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620650. Rab3ip.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity. Cytoplasmcytoskeleton By similarity. Cell projectionlamellipodium By similarity
Note: Predominantly cytoplasmic but a small proportion colocalizes with SSX2 in the nucleus. Activation of protein kinase C results in redistribution to the periphery of lamellipodia. In the cytoskeleton, localizes to cortical actin By similarity.1 Publication

GO - Cellular componenti

  1. cytoskeleton Source: UniProtKB-SubCell
  2. cytosol Source: UniProtKB
  3. lamellipodium Source: UniProtKB-SubCell
  4. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 460460Rab-3A-interacting protein
PRO_0000097146Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei147 – 1471Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ62739.

Expressioni

Tissue specificityi

Ubiquitously expressed. Expressed at highest level in testis.1 Publication

Gene expression databases

GenevestigatoriQ62739.

Interactioni

Subunit structurei

Interacts with the N-terminal region of SSX2 By similarity. Interacts with the GDP-bound forms of RAB3A, RAB3D, RAB8A and RAB8B.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Exoc6Q8R3132EBI-2028671,EBI-9202179From a different organism.
Rab11aP624924EBI-2028671,EBI-770256From a different organism.

Protein-protein interaction databases

IntActiQ62739. 3 interactions.
MINTiMINT-1506178.

Structurei

3D structure databases

ProteinModelPortaliQ62739.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili149 – 24496 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the SEC2 family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG299882.
HOGENOMiHOG000220814.
HOVERGENiHBG057034.
InParanoidiQ62739.
PhylomeDBiQ62739.

Family and domain databases

InterProiIPR009449. Sec2p.
[Graphical view]
PfamiPF06428. Sec2p. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62739-1 [UniParc]FASTAAdd to Basket

« Hide

MANDPLEGFH EVNLASPTSP DLLGVCDPGT QEQTTSPSVI YRPHPSTLCS    50
ATIQANALNL SDLPTQPVYS SPRHLNCAEI SNISIHVPEP ASSVASEVAA 100
GLTRFTSRKD SCNAEREFLQ GATVTEASAG NDDIFGLSTD SLSRLRSPSV 150
LEVREKGYER LKEELAKAQR ELKLKDEECE RLSKVRDQLG QELEELTASL 200
FEEAHKMVRE ANVKQATAEK QLKEAQGKID VLQAEVAALK TLVLSSSPTS 250
PTQEPLADGK TPFKGGHTRN KSTSSAMSGS HQDFSAIQAI VKDCREADLS 300
LYNEFRSWKD EPTMDRTCPF LDKIYQEDIF PCLTFAKSEL ASAVLEAVEN 350
NTLSIEPVGL QPIRFVKASA VECGGPKKCA LTGQSKPCKH RIKLGDSSSY 400
YYISPVCRYR ITSVCNFFTY IRYIQQGLVK QQDVDQMFWE VMQLRKEMSL 450
AKLGYFKEEL 460
Length:460
Mass (Da):50,951
Last modified:November 1, 1996 - v1
Checksum:iD590A8BDE2AEBB4D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U19181 mRNA. Translation: AAA67890.1.
PIRiI57546.
UniGeneiRn.31889.

Genome annotation databases

UCSCiRGD:620650. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U19181 mRNA. Translation: AAA67890.1 .
PIRi I57546.
UniGenei Rn.31889.

3D structure databases

ProteinModelPortali Q62739.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q62739. 3 interactions.
MINTi MINT-1506178.

Proteomic databases

PRIDEi Q62739.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:620650. rat.

Organism-specific databases

RGDi 620650. Rab3ip.

Phylogenomic databases

eggNOGi NOG299882.
HOGENOMi HOG000220814.
HOVERGENi HBG057034.
InParanoidi Q62739.
PhylomeDBi Q62739.

Miscellaneous databases

PROi Q62739.

Gene expression databases

Genevestigatori Q62739.

Family and domain databases

InterProi IPR009449. Sec2p.
[Graphical view ]
Pfami PF06428. Sec2p. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Interaction cloning of Rabin3, a novel protein that associates with the Ras-like GTPase Rab3A."
    Brondyk W.H., McKiernan C.J., Fortner K.A., Stabila P., Holz R.W., Macara I.G.
    Mol. Cell. Biol. 15:1137-1143(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH RAB3A AND RAB3D, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: Fischer 344.
    Tissue: Brain.
  2. "A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport."
    Hattula K., Furuhjelm J., Arffman A., Peranen J.
    Mol. Biol. Cell 13:3268-3280(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiRAB3I_RAT
AccessioniPrimary (citable) accession number: Q62739
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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