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Q62739 (RAB3I_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Rab-3A-interacting protein

Short name=Rab3A-interacting protein
Alternative name(s):
Rabin-3
SSX2-interacting protein
Gene names
Name:Rab3ip
Synonyms:Rabin3, Rabin8
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length460 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis By similarity. Ref.2

Subunit structure

Interacts with the N-terminal region of SSX2 By similarity. Interacts with the GDP-bound forms of RAB3A, RAB3D, RAB8A and RAB8B. Ref.1 UniProtKB Q96QF0

Subcellular location

Cytoplasm By similarity. Nucleus By similarity. Cytoplasmcytoskeleton By similarity. Cell projectionlamellipodium By similarity. Note: Predominantly cytoplasmic but a small proportion colocalizes with SSX2 in the nucleus. Activation of protein kinase C results in redistribution to the periphery of lamellipodia. In the cytoskeleton, localizes to cortical actin By similarity. Ref.1

Tissue specificity

Ubiquitously expressed. Expressed at highest level in testis. Ref.1

Sequence similarities

Belongs to the SEC2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 460460Rab-3A-interacting protein
PRO_0000097146

Regions

Coiled coil149 – 24496 Potential

Amino acid modifications

Modified residue1471Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q62739 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: D590A8BDE2AEBB4D

FASTA46050,951
        10         20         30         40         50         60 
MANDPLEGFH EVNLASPTSP DLLGVCDPGT QEQTTSPSVI YRPHPSTLCS ATIQANALNL 

        70         80         90        100        110        120 
SDLPTQPVYS SPRHLNCAEI SNISIHVPEP ASSVASEVAA GLTRFTSRKD SCNAEREFLQ 

       130        140        150        160        170        180 
GATVTEASAG NDDIFGLSTD SLSRLRSPSV LEVREKGYER LKEELAKAQR ELKLKDEECE 

       190        200        210        220        230        240 
RLSKVRDQLG QELEELTASL FEEAHKMVRE ANVKQATAEK QLKEAQGKID VLQAEVAALK 

       250        260        270        280        290        300 
TLVLSSSPTS PTQEPLADGK TPFKGGHTRN KSTSSAMSGS HQDFSAIQAI VKDCREADLS 

       310        320        330        340        350        360 
LYNEFRSWKD EPTMDRTCPF LDKIYQEDIF PCLTFAKSEL ASAVLEAVEN NTLSIEPVGL 

       370        380        390        400        410        420 
QPIRFVKASA VECGGPKKCA LTGQSKPCKH RIKLGDSSSY YYISPVCRYR ITSVCNFFTY 

       430        440        450        460 
IRYIQQGLVK QQDVDQMFWE VMQLRKEMSL AKLGYFKEEL 

« Hide

References

[1]"Interaction cloning of Rabin3, a novel protein that associates with the Ras-like GTPase Rab3A."
Brondyk W.H., McKiernan C.J., Fortner K.A., Stabila P., Holz R.W., Macara I.G.
Mol. Cell. Biol. 15:1137-1143(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH RAB3A AND RAB3D, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Strain: Fischer 344.
Tissue: Brain.
[2]"A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport."
Hattula K., Furuhjelm J., Arffman A., Peranen J.
Mol. Biol. Cell 13:3268-3280(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U19181 mRNA. Translation: AAA67890.1.
PIRI57546.
UniGeneRn.31889.

3D structure databases

ProteinModelPortalQ62739.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ62739. 1 interaction.
MINTMINT-1506178.

Proteomic databases

PRIDEQ62739.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:620650. rat.

Organism-specific databases

RGD620650. Rab3ip.

Phylogenomic databases

eggNOGNOG299882.
HOGENOMHOG000220814.
HOVERGENHBG057034.
InParanoidQ62739.
PhylomeDBQ62739.

Gene expression databases

GenevestigatorQ62739.

Family and domain databases

InterProIPR009449. Sec2p.
[Graphical view]
PfamPF06428. Sec2p. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ62739.

Entry information

Entry nameRAB3I_RAT
AccessionPrimary (citable) accession number: Q62739
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families