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Q62739

- RAB3I_RAT

UniProt

Q62739 - RAB3I_RAT

Protein

Rab-3A-interacting protein

Gene

Rab3ip

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis By similarity.By similarity

    GO - Molecular functioni

    1. GTPase binding Source: RGD
    2. protein binding Source: UniProtKB
    3. Rab guanyl-nucleotide exchange factor activity Source: UniProtKB

    GO - Biological processi

    1. positive regulation of Rab GTPase activity Source: GOC
    2. protein transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Rab-3A-interacting protein
    Short name:
    Rab3A-interacting protein
    Alternative name(s):
    Rabin-3
    SSX2-interacting protein
    Gene namesi
    Name:Rab3ipBy similarity
    Synonyms:Rabin3, Rabin8
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi620650. Rab3ip.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity. Cytoplasmcytoskeleton By similarity. Cell projectionlamellipodium By similarity
    Note: Predominantly cytoplasmic but a small proportion colocalizes with SSX2 in the nucleus. Activation of protein kinase C results in redistribution to the periphery of lamellipodia. In the cytoskeleton, localizes to cortical actin By similarity.By similarity

    GO - Cellular componenti

    1. cytoskeleton Source: UniProtKB-SubCell
    2. cytosol Source: UniProtKB
    3. lamellipodium Source: UniProtKB-SubCell
    4. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cell projection, Cytoplasm, Cytoskeleton, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 460460Rab-3A-interacting proteinPRO_0000097146Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei147 – 1471PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ62739.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed. Expressed at highest level in testis.1 Publication

    Gene expression databases

    GenevestigatoriQ62739.

    Interactioni

    Subunit structurei

    Interacts with the N-terminal region of SSX2 By similarity. Interacts with the GDP-bound forms of RAB3A, RAB3D, RAB8A and RAB8B.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Exoc6Q8R3132EBI-2028671,EBI-9202179From a different organism.
    Rab11aP624924EBI-2028671,EBI-770256From a different organism.

    Protein-protein interaction databases

    IntActiQ62739. 3 interactions.
    MINTiMINT-1506178.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62739.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili149 – 24496Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SEC2 family.Sequence Analysis

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG299882.
    HOGENOMiHOG000220814.
    HOVERGENiHBG057034.
    InParanoidiQ62739.
    PhylomeDBiQ62739.

    Family and domain databases

    InterProiIPR009449. Sec2p.
    [Graphical view]
    PfamiPF06428. Sec2p. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q62739-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANDPLEGFH EVNLASPTSP DLLGVCDPGT QEQTTSPSVI YRPHPSTLCS    50
    ATIQANALNL SDLPTQPVYS SPRHLNCAEI SNISIHVPEP ASSVASEVAA 100
    GLTRFTSRKD SCNAEREFLQ GATVTEASAG NDDIFGLSTD SLSRLRSPSV 150
    LEVREKGYER LKEELAKAQR ELKLKDEECE RLSKVRDQLG QELEELTASL 200
    FEEAHKMVRE ANVKQATAEK QLKEAQGKID VLQAEVAALK TLVLSSSPTS 250
    PTQEPLADGK TPFKGGHTRN KSTSSAMSGS HQDFSAIQAI VKDCREADLS 300
    LYNEFRSWKD EPTMDRTCPF LDKIYQEDIF PCLTFAKSEL ASAVLEAVEN 350
    NTLSIEPVGL QPIRFVKASA VECGGPKKCA LTGQSKPCKH RIKLGDSSSY 400
    YYISPVCRYR ITSVCNFFTY IRYIQQGLVK QQDVDQMFWE VMQLRKEMSL 450
    AKLGYFKEEL 460
    Length:460
    Mass (Da):50,951
    Last modified:November 1, 1996 - v1
    Checksum:iD590A8BDE2AEBB4D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19181 mRNA. Translation: AAA67890.1.
    PIRiI57546.
    UniGeneiRn.31889.

    Genome annotation databases

    UCSCiRGD:620650. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19181 mRNA. Translation: AAA67890.1 .
    PIRi I57546.
    UniGenei Rn.31889.

    3D structure databases

    ProteinModelPortali Q62739.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q62739. 3 interactions.
    MINTi MINT-1506178.

    Proteomic databases

    PRIDEi Q62739.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:620650. rat.

    Organism-specific databases

    RGDi 620650. Rab3ip.

    Phylogenomic databases

    eggNOGi NOG299882.
    HOGENOMi HOG000220814.
    HOVERGENi HBG057034.
    InParanoidi Q62739.
    PhylomeDBi Q62739.

    Miscellaneous databases

    PROi Q62739.

    Gene expression databases

    Genevestigatori Q62739.

    Family and domain databases

    InterProi IPR009449. Sec2p.
    [Graphical view ]
    Pfami PF06428. Sec2p. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Interaction cloning of Rabin3, a novel protein that associates with the Ras-like GTPase Rab3A."
      Brondyk W.H., McKiernan C.J., Fortner K.A., Stabila P., Holz R.W., Macara I.G.
      Mol. Cell. Biol. 15:1137-1143(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH RAB3A AND RAB3D, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Strain: Fischer 344Imported.
      Tissue: BrainImported.
    2. "A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport."
      Hattula K., Furuhjelm J., Arffman A., Peranen J.
      Mol. Biol. Cell 13:3268-3280(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiRAB3I_RAT
    AccessioniPrimary (citable) accession number: Q62739
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3