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Q62730

- DHB2_RAT

UniProt

Q62730 - DHB2_RAT

Protein

Estradiol 17-beta-dehydrogenase 2

Gene

Hsd17b2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Favors the oxidation of estradiol and testosterone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH By similarity.By similarity

    Catalytic activityi

    17-beta-estradiol + NAD(P)+ = estrone + NAD(P)H.
    Testosterone + NAD+ = androstenedione + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei220 – 2201SubstrateBy similarity
    Active sitei233 – 2331Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi83 – 11230NADBy similarityAdd
    BLAST

    GO - Molecular functioni

    1. estradiol 17-beta-dehydrogenase activity Source: RGD
    2. testosterone dehydrogenase (NAD+) activity Source: RGD

    GO - Biological processi

    1. androgen biosynthetic process Source: RGD
    2. bone development Source: RGD
    3. cellular response to metal ion Source: RGD
    4. estrogen biosynthetic process Source: RGD

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Estradiol 17-beta-dehydrogenase 2 (EC:1.1.1.62)
    Alternative name(s):
    17-beta-hydroxysteroid dehydrogenase type 2
    Short name:
    17-beta-HSD 2
    Testosterone 17-beta-dehydrogenase (EC:1.1.1.239)
    Gene namesi
    Name:Hsd17b2
    Synonyms:Edh17b2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi621803. Hsd17b2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. intracellular membrane-bounded organelle Source: RGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 381381Estradiol 17-beta-dehydrogenase 2PRO_0000054572Add
    BLAST

    Proteomic databases

    PaxDbiQ62730.
    PRIDEiQ62730.

    Expressioni

    Tissue specificityi

    Highest expression in placenta.

    Gene expression databases

    GenevestigatoriQ62730.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4566728.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62730.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 2421Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1028.
    HOVERGENiHBG005482.
    InParanoidiQ62730.
    KOiK13368.
    PhylomeDBiQ62730.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view]
    PfamiPF00106. adh_short. 1 hit.
    [Graphical view]
    PRINTSiPR00081. GDHRDH.
    PR00080. SDRFAMILY.
    PROSITEiPS00061. ADH_SHORT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q62730-1 [UniParc]FASTAAdd to Basket

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    MNPFSSESAW LCLTATAVLG GMLLCKAWSS GQLRSQVVCL AGLWGGACLL    50
    SLSLLCSLFL LSVSCFFLLY VSSSDQDLLP VDQKAVLVTG ADSGFGHALA 100
    KHLDKLGFTV FAGVLDKEGP GAEELRKNCS ERLSVLQMDV TKPEQIKDVH 150
    SEVAEKIQDK GLWAVVNNAG VLHFPIDGEL IPMTVYRKCM AVNFFGAVEV 200
    TKVFLPLLRK SKGRLVNVSS MGAMIPFQMV AAYASTKAAI SMFSAVIRQE 250
    LAKWGVKVVT IHPGGFQTNI VGSQDSWDKM EKEILDHFSK EIQENYGQEY 300
    VHTQKLALPV MREMSNPDIT PVLRDIQHAI CAKNPSSFYC SGRMTYLWIC 350
    FAAYSPISLL DYILKNYFTP KLMPRALRTA S 381
    Length:381
    Mass (Da):41,967
    Last modified:November 1, 1996 - v1
    Checksum:i8E1D08DF345DE136
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X91234 mRNA. Translation: CAA62617.1.
    RefSeqiNP_077367.1. NM_024391.1.
    UniGeneiRn.10515.

    Genome annotation databases

    GeneIDi79243.
    KEGGirno:79243.
    UCSCiRGD:621803. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X91234 mRNA. Translation: CAA62617.1 .
    RefSeqi NP_077367.1. NM_024391.1.
    UniGenei Rn.10515.

    3D structure databases

    ProteinModelPortali Q62730.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4566728.

    Chemistry

    ChEMBLi CHEMBL1914268.

    Proteomic databases

    PaxDbi Q62730.
    PRIDEi Q62730.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 79243.
    KEGGi rno:79243.
    UCSCi RGD:621803. rat.

    Organism-specific databases

    CTDi 3294.
    RGDi 621803. Hsd17b2.

    Phylogenomic databases

    eggNOGi COG1028.
    HOVERGENi HBG005482.
    InParanoidi Q62730.
    KOi K13368.
    PhylomeDBi Q62730.

    Miscellaneous databases

    NextBioi 614690.
    PROi Q62730.

    Gene expression databases

    Genevestigatori Q62730.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR002198. DH_sc/Rdtase_SDR.
    IPR002347. Glc/ribitol_DH.
    IPR016040. NAD(P)-bd_dom.
    IPR020904. Sc_DH/Rdtase_CS.
    [Graphical view ]
    Pfami PF00106. adh_short. 1 hit.
    [Graphical view ]
    PRINTSi PR00081. GDHRDH.
    PR00080. SDRFAMILY.
    PROSITEi PS00061. ADH_SHORT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of rat 17 beta-hydroxysteroid dehydrogenase type 2 and characterization of tissue distribution and catalytic activity of rat type 1 and type 2 enzymes."
      Akinola L.A., Poutanen M., Vihko R.
      Endocrinology 137:1572-1579(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Placenta.

    Entry informationi

    Entry nameiDHB2_RAT
    AccessioniPrimary (citable) accession number: Q62730
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3