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Q62728

- PTN21_RAT

UniProt

Q62728 - PTN21_RAT

Protein

Tyrosine-protein phosphatase non-receptor type 21

Gene

Ptpn21

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei1068 – 10681SubstrateSequence Analysis
    Active sitei1109 – 11091Phosphocysteine intermediatePROSITE-ProRule annotation
    Binding sitei1153 – 11531SubstrateBy similarity

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: RGD

    GO - Biological processi

    1. cytoskeleton organization Source: RGD
    2. peptidyl-tyrosine dephosphorylation Source: GOC

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein phosphatase non-receptor type 21 (EC:3.1.3.48)
    Alternative name(s):
    Protein-tyrosine phosphatase 2E
    Gene namesi
    Name:Ptpn21
    Synonyms:Ptp2e
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi620216. Ptpn21.

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. cytoskeleton Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11751175Tyrosine-protein phosphatase non-receptor type 21PRO_0000219441Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei577 – 5771PhosphoserineBy similarity
    Modified residuei637 – 6371PhosphoserineBy similarity
    Modified residuei805 – 8051PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ62728.

    PTM databases

    PhosphoSiteiQ62728.

    Expressioni

    Tissue specificityi

    Particularly abundantly in adrenal glands.

    Gene expression databases

    GenevestigatoriQ62728.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000059572.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62728.
    SMRiQ62728. Positions 883-1172.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini23 – 308286FERMPROSITE-ProRule annotationAdd
    BLAST
    Domaini897 – 1168272Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1109 – 11157Substrate bindingBy similarity

    Sequence similaritiesi

    Contains 1 FERM domain.PROSITE-ProRule annotation
    Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5599.
    HOGENOMiHOG000115775.
    HOVERGENiHBG053757.
    InParanoidiQ62728.
    KOiK18025.
    PhylomeDBiQ62728.

    Family and domain databases

    Gene3Di1.20.80.10. 1 hit.
    2.30.29.30. 1 hit.
    3.90.190.10. 1 hit.
    InterProiIPR019749. Band_41_domain.
    IPR019750. Band_41_fam.
    IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
    IPR019748. FERM_central.
    IPR019747. FERM_CS.
    IPR000299. FERM_domain.
    IPR018979. FERM_N.
    IPR018980. FERM_PH-like_C.
    IPR011993. PH_like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR014392. Tyr_Pase_non-rcpt_typ-14/21.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF09380. FERM_C. 1 hit.
    PF00373. FERM_M. 1 hit.
    PF09379. FERM_N. 1 hit.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000934. Tyr-Ptase_nr14. 1 hit.
    PRINTSiPR00935. BAND41.
    PR00700. PRTYPHPHTASE.
    SMARTiSM00295. B41. 1 hit.
    SM00194. PTPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF47031. SSF47031. 1 hit.
    SSF52799. SSF52799. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS00660. FERM_1. 1 hit.
    PS00661. FERM_2. 1 hit.
    PS50057. FERM_3. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q62728-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPLPFGLKLK RTRRYTVSSK SCLVARIQLL NNEFVEFTLS VESTGQESLE     50
    AVAQRLELRE ITYFSLWYYN KQNQRRWVDL EKPLKKQLDK HALEPTVYFG 100
    VVFYVPSVSQ LQQEITRYQY YLQLKKDVLE GNLPCTLEQA IQLAGLAVQA 150
    DFGDFDQYES QDFLQKFALL PVGWLQDEKL LEEAAQKVAL LHQKYRGLTA 200
    PEAEMLYMQE VERMDGYGEE SYPAKDSQGS DISIGACLDG IFVKHKNGRP 250
    PVVFRWHDIA NMSHNKSFFA LELANKEETI QFQTEDMETA KYVWRLCVAR 300
    HKFYRLNQCN LQTQAATLNS VRRGSSSRMS LPKPQPYAMP PPPQLHYNGH 350
    YTEPFASSQD NVFVPNKNGF YCHSQTSLDR TQIDLSGRIR NGSVYSAHST 400
    NSLNTPQPYL QPSPMSSNPS IPGSDVMRPD YIPSHRHSAL IPPSYRPTPD 450
    YESVMKRLNR GMVHADRHSH SLRNLNIGSS YAYSRPDALV YSQPEIREHP 500
    HLASPQSAHY PFNLNYSFHS QAPYPYPVER RPVVGAVSVP ELTNVQLQAQ 550
    DYPAPNIMRT QVYRPPPPYP YPRPANSTPD LSRHLYISSS NPDLITRRVH 600
    HSVQTFQEDS LPVAHSLQEV SEPLTAARHA HLQKRNSIEI AGLTHGFEGL 650
    RLKEETMSAS AADVAPRTFS AGSQSSVFSD KVKQEGTEEQ GSGGYSHKKS 700
    LSDATMLIHS SEEDEDLEDD SSREHAVSEP RLTAAFSQEQ QLNYPCASVT 750
    PVTGPLHIFE PKSHVTEPEK RAKDISPVHL VMETHQPRRH GLLTPSMSES 800
    DLTTSGRYRA RRDSLKKRPV SDLLSGKKNT VEGLPPLGGM KKTRADAKKI 850
    GPLKLAALNG LSLSRLPLPD EGKEVSTRAT NDERCKVLEQ RLEQGTVFTE 900
    YERILKKRLV DGECSTARLP ENAERNRFQD VLPYDDARVE LVPTKENNTG 950
    YINASHIKVS VSGIEWDYIA TQGPLQNTCQ DFWQMVWEQG VAIIAMVTAE 1000
    EEGGREKSFR YWPRLGSRHN TVTYGRFKIT TRFRTDSGCY ATTGLKMKHL 1050
    LTGQERTVWH LQYTDWPEHG CPEDLKGFLS YLEEIQSVRR HTNSTSEPRS 1100
    PNPPLLVHCS AGVGRTGVVI LSEIMVACLE HNEVLDIPRV LELLRQQRMM 1150
    LVQTLSQYTF VYRVLIQFLK SSRLI 1175
    Length:1,175
    Mass (Da):133,412
    Last modified:November 1, 1996 - v1
    Checksum:i82A684F1C0F5ECF7
    GO
    Isoform 2E (identifier: Q62728-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-839: Missing.

    Show »
    Length:336
    Mass (Da):38,487
    Checksum:iCDC3DAEEBED2F49E
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 839839Missing in isoform 2E. 1 PublicationVSP_000498Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U17971 mRNA. Translation: AAA62153.1.
    U18293 mRNA. Translation: AAA62154.1.
    PIRiS51005.
    RefSeqiNP_598229.1. NM_133545.1. [Q62728-1]
    UniGeneiRn.11310.

    Genome annotation databases

    GeneIDi171070.
    KEGGirno:171070.
    UCSCiRGD:620216. rat. [Q62728-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U17971 mRNA. Translation: AAA62153.1 .
    U18293 mRNA. Translation: AAA62154.1 .
    PIRi S51005.
    RefSeqi NP_598229.1. NM_133545.1. [Q62728-1 ]
    UniGenei Rn.11310.

    3D structure databases

    ProteinModelPortali Q62728.
    SMRi Q62728. Positions 883-1172.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000059572.

    PTM databases

    PhosphoSitei Q62728.

    Proteomic databases

    PRIDEi Q62728.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 171070.
    KEGGi rno:171070.
    UCSCi RGD:620216. rat. [Q62728-1 ]

    Organism-specific databases

    CTDi 11099.
    RGDi 620216. Ptpn21.

    Phylogenomic databases

    eggNOGi COG5599.
    HOGENOMi HOG000115775.
    HOVERGENi HBG053757.
    InParanoidi Q62728.
    KOi K18025.
    PhylomeDBi Q62728.

    Miscellaneous databases

    NextBioi 621667.
    PROi Q62728.

    Gene expression databases

    Genevestigatori Q62728.

    Family and domain databases

    Gene3Di 1.20.80.10. 1 hit.
    2.30.29.30. 1 hit.
    3.90.190.10. 1 hit.
    InterProi IPR019749. Band_41_domain.
    IPR019750. Band_41_fam.
    IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
    IPR019748. FERM_central.
    IPR019747. FERM_CS.
    IPR000299. FERM_domain.
    IPR018979. FERM_N.
    IPR018980. FERM_PH-like_C.
    IPR011993. PH_like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR014392. Tyr_Pase_non-rcpt_typ-14/21.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF09380. FERM_C. 1 hit.
    PF00373. FERM_M. 1 hit.
    PF09379. FERM_N. 1 hit.
    PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000934. Tyr-Ptase_nr14. 1 hit.
    PRINTSi PR00935. BAND41.
    PR00700. PRTYPHPHTASE.
    SMARTi SM00295. B41. 1 hit.
    SM00194. PTPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47031. SSF47031. 1 hit.
    SSF52799. SSF52799. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS00660. FERM_1. 1 hit.
    PS00661. FERM_2. 1 hit.
    PS50057. FERM_3. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel protein tyrosine phosphatase with sequence homology to the cytoskeletal proteins of the band 4.1 family."
      L'Abbe D., Banville D., Tong Y., Stocco R., Masson S., Ma S., Fantus G., Shen S.H.
      FEBS Lett. 356:351-356(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2E).
      Strain: Sprague-Dawley.

    Entry informationi

    Entry nameiPTN21_RAT
    AccessioniPrimary (citable) accession number: Q62728
    Secondary accession number(s): Q62732
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3