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Q62728

- PTN21_RAT

UniProt

Q62728 - PTN21_RAT

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Protein
Tyrosine-protein phosphatase non-receptor type 21
Gene
Ptpn21, Ptp2e
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1068 – 10681Substrate Reviewed prediction
Active sitei1109 – 11091Phosphocysteine intermediate By similarity
Binding sitei1153 – 11531Substrate By similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: RGD

GO - Biological processi

  1. cytoskeleton organization Source: RGD
  2. peptidyl-tyrosine dephosphorylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 21 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase 2E
Gene namesi
Name:Ptpn21
Synonyms:Ptp2e
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620216. Ptpn21.

Subcellular locationi

Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11751175Tyrosine-protein phosphatase non-receptor type 21
PRO_0000219441Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei577 – 5771Phosphoserine By similarity
Modified residuei637 – 6371Phosphoserine By similarity
Modified residuei805 – 8051Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ62728.

PTM databases

PhosphoSiteiQ62728.

Expressioni

Tissue specificityi

Particularly abundantly in adrenal glands.

Gene expression databases

GenevestigatoriQ62728.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059572.

Structurei

3D structure databases

ProteinModelPortaliQ62728.
SMRiQ62728. Positions 883-1172.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 308286FERM
Add
BLAST
Domaini897 – 1168272Tyrosine-protein phosphatase
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1109 – 11157Substrate binding By similarity

Sequence similaritiesi

Contains 1 FERM domain.

Phylogenomic databases

eggNOGiCOG5599.
HOGENOMiHOG000115775.
HOVERGENiHBG053757.
InParanoidiQ62728.
KOiK18025.
PhylomeDBiQ62728.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR019750. Band_41_fam.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR014392. Tyr_Pase_non-rcpt_typ-14/21.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF000934. Tyr-Ptase_nr14. 1 hit.
PRINTSiPR00935. BAND41.
PR00700. PRTYPHPHTASE.
SMARTiSM00295. B41. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q62728-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPLPFGLKLK RTRRYTVSSK SCLVARIQLL NNEFVEFTLS VESTGQESLE     50
AVAQRLELRE ITYFSLWYYN KQNQRRWVDL EKPLKKQLDK HALEPTVYFG 100
VVFYVPSVSQ LQQEITRYQY YLQLKKDVLE GNLPCTLEQA IQLAGLAVQA 150
DFGDFDQYES QDFLQKFALL PVGWLQDEKL LEEAAQKVAL LHQKYRGLTA 200
PEAEMLYMQE VERMDGYGEE SYPAKDSQGS DISIGACLDG IFVKHKNGRP 250
PVVFRWHDIA NMSHNKSFFA LELANKEETI QFQTEDMETA KYVWRLCVAR 300
HKFYRLNQCN LQTQAATLNS VRRGSSSRMS LPKPQPYAMP PPPQLHYNGH 350
YTEPFASSQD NVFVPNKNGF YCHSQTSLDR TQIDLSGRIR NGSVYSAHST 400
NSLNTPQPYL QPSPMSSNPS IPGSDVMRPD YIPSHRHSAL IPPSYRPTPD 450
YESVMKRLNR GMVHADRHSH SLRNLNIGSS YAYSRPDALV YSQPEIREHP 500
HLASPQSAHY PFNLNYSFHS QAPYPYPVER RPVVGAVSVP ELTNVQLQAQ 550
DYPAPNIMRT QVYRPPPPYP YPRPANSTPD LSRHLYISSS NPDLITRRVH 600
HSVQTFQEDS LPVAHSLQEV SEPLTAARHA HLQKRNSIEI AGLTHGFEGL 650
RLKEETMSAS AADVAPRTFS AGSQSSVFSD KVKQEGTEEQ GSGGYSHKKS 700
LSDATMLIHS SEEDEDLEDD SSREHAVSEP RLTAAFSQEQ QLNYPCASVT 750
PVTGPLHIFE PKSHVTEPEK RAKDISPVHL VMETHQPRRH GLLTPSMSES 800
DLTTSGRYRA RRDSLKKRPV SDLLSGKKNT VEGLPPLGGM KKTRADAKKI 850
GPLKLAALNG LSLSRLPLPD EGKEVSTRAT NDERCKVLEQ RLEQGTVFTE 900
YERILKKRLV DGECSTARLP ENAERNRFQD VLPYDDARVE LVPTKENNTG 950
YINASHIKVS VSGIEWDYIA TQGPLQNTCQ DFWQMVWEQG VAIIAMVTAE 1000
EEGGREKSFR YWPRLGSRHN TVTYGRFKIT TRFRTDSGCY ATTGLKMKHL 1050
LTGQERTVWH LQYTDWPEHG CPEDLKGFLS YLEEIQSVRR HTNSTSEPRS 1100
PNPPLLVHCS AGVGRTGVVI LSEIMVACLE HNEVLDIPRV LELLRQQRMM 1150
LVQTLSQYTF VYRVLIQFLK SSRLI 1175
Length:1,175
Mass (Da):133,412
Last modified:November 1, 1996 - v1
Checksum:i82A684F1C0F5ECF7
GO
Isoform 2E (identifier: Q62728-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-839: Missing.

Show »
Length:336
Mass (Da):38,487
Checksum:iCDC3DAEEBED2F49E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 839839Missing in isoform 2E.
VSP_000498Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U17971 mRNA. Translation: AAA62153.1.
U18293 mRNA. Translation: AAA62154.1.
PIRiS51005.
RefSeqiNP_598229.1. NM_133545.1. [Q62728-1]
UniGeneiRn.11310.

Genome annotation databases

GeneIDi171070.
KEGGirno:171070.
UCSCiRGD:620216. rat. [Q62728-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U17971 mRNA. Translation: AAA62153.1 .
U18293 mRNA. Translation: AAA62154.1 .
PIRi S51005.
RefSeqi NP_598229.1. NM_133545.1. [Q62728-1 ]
UniGenei Rn.11310.

3D structure databases

ProteinModelPortali Q62728.
SMRi Q62728. Positions 883-1172.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000059572.

PTM databases

PhosphoSitei Q62728.

Proteomic databases

PRIDEi Q62728.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 171070.
KEGGi rno:171070.
UCSCi RGD:620216. rat. [Q62728-1 ]

Organism-specific databases

CTDi 11099.
RGDi 620216. Ptpn21.

Phylogenomic databases

eggNOGi COG5599.
HOGENOMi HOG000115775.
HOVERGENi HBG053757.
InParanoidi Q62728.
KOi K18025.
PhylomeDBi Q62728.

Miscellaneous databases

NextBioi 621667.
PROi Q62728.

Gene expression databases

Genevestigatori Q62728.

Family and domain databases

Gene3Di 1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
3.90.190.10. 1 hit.
InterProi IPR019749. Band_41_domain.
IPR019750. Band_41_fam.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR014392. Tyr_Pase_non-rcpt_typ-14/21.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000934. Tyr-Ptase_nr14. 1 hit.
PRINTSi PR00935. BAND41.
PR00700. PRTYPHPHTASE.
SMARTi SM00295. B41. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF47031. SSF47031. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of a novel protein tyrosine phosphatase with sequence homology to the cytoskeletal proteins of the band 4.1 family."
    L'Abbe D., Banville D., Tong Y., Stocco R., Masson S., Ma S., Fantus G., Shen S.H.
    FEBS Lett. 356:351-356(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2E).
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiPTN21_RAT
AccessioniPrimary (citable) accession number: Q62728
Secondary accession number(s): Q62732
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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