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Protein

Tyrosine-protein phosphatase non-receptor type 21

Gene

Ptpn21

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1068SubstrateSequence analysis1
Active sitei1109Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei1153SubstrateBy similarity1

GO - Molecular functioni

  • protein tyrosine phosphatase activity Source: RGD

GO - Biological processi

  • cytoskeleton organization Source: RGD

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 21 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase 2E
Gene namesi
Name:Ptpn21
Synonyms:Ptp2e
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620216 Ptpn21

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002194411 – 1175Tyrosine-protein phosphatase non-receptor type 21Add BLAST1175

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei577PhosphoserineBy similarity1
Modified residuei589PhosphoserineBy similarity1
Modified residuei590PhosphoserineBy similarity1
Modified residuei637PhosphoserineCombined sources1
Modified residuei673PhosphoserineBy similarity1
Modified residuei710PhosphoserineCombined sources1
Modified residuei711PhosphoserineCombined sources1
Modified residuei798PhosphoserineBy similarity1
Modified residuei800PhosphoserineBy similarity1
Modified residuei805PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ62728
PRIDEiQ62728

PTM databases

iPTMnetiQ62728
PhosphoSitePlusiQ62728

Expressioni

Tissue specificityi

Particularly abundantly in adrenal glands.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059572

Structurei

3D structure databases

ProteinModelPortaliQ62728
SMRiQ62728
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 308FERMPROSITE-ProRule annotationAdd BLAST286
Domaini897 – 1168Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST272

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1109 – 1115Substrate bindingBy similarity7

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0792 Eukaryota
COG5599 LUCA
HOGENOMiHOG000115775
HOVERGENiHBG053757
InParanoidiQ62728
KOiK18025
PhylomeDBiQ62728

Family and domain databases

CDDicd14473 FERM_B-lobe, 1 hit
Gene3Di1.20.80.10, 1 hit
2.30.29.30, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR019749 Band_41_domain
IPR014352 FERM/acyl-CoA-bd_prot_sf
IPR035963 FERM_2
IPR019748 FERM_central
IPR019747 FERM_CS
IPR000299 FERM_domain
IPR018979 FERM_N
IPR018980 FERM_PH-like_C
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR014392 Tyr_Pase_non-rcpt_typ-14/21
IPR000387 TYR_PHOSPHATASE_dom
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF09380 FERM_C, 1 hit
PF00373 FERM_M, 1 hit
PF09379 FERM_N, 1 hit
PF00102 Y_phosphatase, 1 hit
PIRSFiPIRSF000934 Tyr-Ptase_nr14, 1 hit
PRINTSiPR00935 BAND41
PR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00295 B41, 1 hit
SM01196 FERM_C, 1 hit
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF47031 SSF47031, 1 hit
SSF52799 SSF52799, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS00660 FERM_1, 1 hit
PS00661 FERM_2, 1 hit
PS50057 FERM_3, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q62728-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPLPFGLKLK RTRRYTVSSK SCLVARIQLL NNEFVEFTLS VESTGQESLE
60 70 80 90 100
AVAQRLELRE ITYFSLWYYN KQNQRRWVDL EKPLKKQLDK HALEPTVYFG
110 120 130 140 150
VVFYVPSVSQ LQQEITRYQY YLQLKKDVLE GNLPCTLEQA IQLAGLAVQA
160 170 180 190 200
DFGDFDQYES QDFLQKFALL PVGWLQDEKL LEEAAQKVAL LHQKYRGLTA
210 220 230 240 250
PEAEMLYMQE VERMDGYGEE SYPAKDSQGS DISIGACLDG IFVKHKNGRP
260 270 280 290 300
PVVFRWHDIA NMSHNKSFFA LELANKEETI QFQTEDMETA KYVWRLCVAR
310 320 330 340 350
HKFYRLNQCN LQTQAATLNS VRRGSSSRMS LPKPQPYAMP PPPQLHYNGH
360 370 380 390 400
YTEPFASSQD NVFVPNKNGF YCHSQTSLDR TQIDLSGRIR NGSVYSAHST
410 420 430 440 450
NSLNTPQPYL QPSPMSSNPS IPGSDVMRPD YIPSHRHSAL IPPSYRPTPD
460 470 480 490 500
YESVMKRLNR GMVHADRHSH SLRNLNIGSS YAYSRPDALV YSQPEIREHP
510 520 530 540 550
HLASPQSAHY PFNLNYSFHS QAPYPYPVER RPVVGAVSVP ELTNVQLQAQ
560 570 580 590 600
DYPAPNIMRT QVYRPPPPYP YPRPANSTPD LSRHLYISSS NPDLITRRVH
610 620 630 640 650
HSVQTFQEDS LPVAHSLQEV SEPLTAARHA HLQKRNSIEI AGLTHGFEGL
660 670 680 690 700
RLKEETMSAS AADVAPRTFS AGSQSSVFSD KVKQEGTEEQ GSGGYSHKKS
710 720 730 740 750
LSDATMLIHS SEEDEDLEDD SSREHAVSEP RLTAAFSQEQ QLNYPCASVT
760 770 780 790 800
PVTGPLHIFE PKSHVTEPEK RAKDISPVHL VMETHQPRRH GLLTPSMSES
810 820 830 840 850
DLTTSGRYRA RRDSLKKRPV SDLLSGKKNT VEGLPPLGGM KKTRADAKKI
860 870 880 890 900
GPLKLAALNG LSLSRLPLPD EGKEVSTRAT NDERCKVLEQ RLEQGTVFTE
910 920 930 940 950
YERILKKRLV DGECSTARLP ENAERNRFQD VLPYDDARVE LVPTKENNTG
960 970 980 990 1000
YINASHIKVS VSGIEWDYIA TQGPLQNTCQ DFWQMVWEQG VAIIAMVTAE
1010 1020 1030 1040 1050
EEGGREKSFR YWPRLGSRHN TVTYGRFKIT TRFRTDSGCY ATTGLKMKHL
1060 1070 1080 1090 1100
LTGQERTVWH LQYTDWPEHG CPEDLKGFLS YLEEIQSVRR HTNSTSEPRS
1110 1120 1130 1140 1150
PNPPLLVHCS AGVGRTGVVI LSEIMVACLE HNEVLDIPRV LELLRQQRMM
1160 1170
LVQTLSQYTF VYRVLIQFLK SSRLI
Length:1,175
Mass (Da):133,412
Last modified:November 1, 1996 - v1
Checksum:i82A684F1C0F5ECF7
GO
Isoform 2E (identifier: Q62728-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-839: Missing.

Show »
Length:336
Mass (Da):38,487
Checksum:iCDC3DAEEBED2F49E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0004981 – 839Missing in isoform 2E. 1 PublicationAdd BLAST839

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17971 mRNA Translation: AAA62153.1
U18293 mRNA Translation: AAA62154.1
PIRiS51005
RefSeqiNP_598229.1, NM_133545.1 [Q62728-1]
UniGeneiRn.11310

Genome annotation databases

GeneIDi171070
KEGGirno:171070
UCSCiRGD:620216 rat [Q62728-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPTN21_RAT
AccessioniPrimary (citable) accession number: Q62728
Secondary accession number(s): Q62732
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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