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Q62728

- PTN21_RAT

UniProt

Q62728 - PTN21_RAT

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Protein

Tyrosine-protein phosphatase non-receptor type 21

Gene

Ptpn21

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1068 – 10681SubstrateSequence Analysis
Active sitei1109 – 11091Phosphocysteine intermediatePROSITE-ProRule annotation
Binding sitei1153 – 11531SubstrateBy similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: RGD

GO - Biological processi

  1. cytoskeleton organization Source: RGD
  2. peptidyl-tyrosine dephosphorylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 21 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase 2E
Gene namesi
Name:Ptpn21
Synonyms:Ptp2e
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620216. Ptpn21.

Subcellular locationi

Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11751175Tyrosine-protein phosphatase non-receptor type 21PRO_0000219441Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei577 – 5771PhosphoserineBy similarity
Modified residuei637 – 6371PhosphoserineBy similarity
Modified residuei805 – 8051PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ62728.

PTM databases

PhosphoSiteiQ62728.

Expressioni

Tissue specificityi

Particularly abundantly in adrenal glands.

Gene expression databases

GenevestigatoriQ62728.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000059572.

Structurei

3D structure databases

ProteinModelPortaliQ62728.
SMRiQ62728. Positions 883-1172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 308286FERMPROSITE-ProRule annotationAdd
BLAST
Domaini897 – 1168272Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1109 – 11157Substrate bindingBy similarity

Sequence similaritiesi

Contains 1 FERM domain.PROSITE-ProRule annotation
Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5599.
HOGENOMiHOG000115775.
HOVERGENiHBG053757.
InParanoidiQ62728.
KOiK18025.
PhylomeDBiQ62728.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR019750. Band_41_fam.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR014392. Tyr_Pase_non-rcpt_typ-14/21.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF000934. Tyr-Ptase_nr14. 1 hit.
PRINTSiPR00935. BAND41.
PR00700. PRTYPHPHTASE.
SMARTiSM00295. B41. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q62728-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPLPFGLKLK RTRRYTVSSK SCLVARIQLL NNEFVEFTLS VESTGQESLE
60 70 80 90 100
AVAQRLELRE ITYFSLWYYN KQNQRRWVDL EKPLKKQLDK HALEPTVYFG
110 120 130 140 150
VVFYVPSVSQ LQQEITRYQY YLQLKKDVLE GNLPCTLEQA IQLAGLAVQA
160 170 180 190 200
DFGDFDQYES QDFLQKFALL PVGWLQDEKL LEEAAQKVAL LHQKYRGLTA
210 220 230 240 250
PEAEMLYMQE VERMDGYGEE SYPAKDSQGS DISIGACLDG IFVKHKNGRP
260 270 280 290 300
PVVFRWHDIA NMSHNKSFFA LELANKEETI QFQTEDMETA KYVWRLCVAR
310 320 330 340 350
HKFYRLNQCN LQTQAATLNS VRRGSSSRMS LPKPQPYAMP PPPQLHYNGH
360 370 380 390 400
YTEPFASSQD NVFVPNKNGF YCHSQTSLDR TQIDLSGRIR NGSVYSAHST
410 420 430 440 450
NSLNTPQPYL QPSPMSSNPS IPGSDVMRPD YIPSHRHSAL IPPSYRPTPD
460 470 480 490 500
YESVMKRLNR GMVHADRHSH SLRNLNIGSS YAYSRPDALV YSQPEIREHP
510 520 530 540 550
HLASPQSAHY PFNLNYSFHS QAPYPYPVER RPVVGAVSVP ELTNVQLQAQ
560 570 580 590 600
DYPAPNIMRT QVYRPPPPYP YPRPANSTPD LSRHLYISSS NPDLITRRVH
610 620 630 640 650
HSVQTFQEDS LPVAHSLQEV SEPLTAARHA HLQKRNSIEI AGLTHGFEGL
660 670 680 690 700
RLKEETMSAS AADVAPRTFS AGSQSSVFSD KVKQEGTEEQ GSGGYSHKKS
710 720 730 740 750
LSDATMLIHS SEEDEDLEDD SSREHAVSEP RLTAAFSQEQ QLNYPCASVT
760 770 780 790 800
PVTGPLHIFE PKSHVTEPEK RAKDISPVHL VMETHQPRRH GLLTPSMSES
810 820 830 840 850
DLTTSGRYRA RRDSLKKRPV SDLLSGKKNT VEGLPPLGGM KKTRADAKKI
860 870 880 890 900
GPLKLAALNG LSLSRLPLPD EGKEVSTRAT NDERCKVLEQ RLEQGTVFTE
910 920 930 940 950
YERILKKRLV DGECSTARLP ENAERNRFQD VLPYDDARVE LVPTKENNTG
960 970 980 990 1000
YINASHIKVS VSGIEWDYIA TQGPLQNTCQ DFWQMVWEQG VAIIAMVTAE
1010 1020 1030 1040 1050
EEGGREKSFR YWPRLGSRHN TVTYGRFKIT TRFRTDSGCY ATTGLKMKHL
1060 1070 1080 1090 1100
LTGQERTVWH LQYTDWPEHG CPEDLKGFLS YLEEIQSVRR HTNSTSEPRS
1110 1120 1130 1140 1150
PNPPLLVHCS AGVGRTGVVI LSEIMVACLE HNEVLDIPRV LELLRQQRMM
1160 1170
LVQTLSQYTF VYRVLIQFLK SSRLI
Length:1,175
Mass (Da):133,412
Last modified:November 1, 1996 - v1
Checksum:i82A684F1C0F5ECF7
GO
Isoform 2E (identifier: Q62728-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-839: Missing.

Show »
Length:336
Mass (Da):38,487
Checksum:iCDC3DAEEBED2F49E
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 839839Missing in isoform 2E. 1 PublicationVSP_000498Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U17971 mRNA. Translation: AAA62153.1.
U18293 mRNA. Translation: AAA62154.1.
PIRiS51005.
RefSeqiNP_598229.1. NM_133545.1. [Q62728-1]
UniGeneiRn.11310.

Genome annotation databases

GeneIDi171070.
KEGGirno:171070.
UCSCiRGD:620216. rat. [Q62728-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U17971 mRNA. Translation: AAA62153.1 .
U18293 mRNA. Translation: AAA62154.1 .
PIRi S51005.
RefSeqi NP_598229.1. NM_133545.1. [Q62728-1 ]
UniGenei Rn.11310.

3D structure databases

ProteinModelPortali Q62728.
SMRi Q62728. Positions 883-1172.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000059572.

PTM databases

PhosphoSitei Q62728.

Proteomic databases

PRIDEi Q62728.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 171070.
KEGGi rno:171070.
UCSCi RGD:620216. rat. [Q62728-1 ]

Organism-specific databases

CTDi 11099.
RGDi 620216. Ptpn21.

Phylogenomic databases

eggNOGi COG5599.
HOGENOMi HOG000115775.
HOVERGENi HBG053757.
InParanoidi Q62728.
KOi K18025.
PhylomeDBi Q62728.

Miscellaneous databases

NextBioi 621667.
PROi Q62728.

Gene expression databases

Genevestigatori Q62728.

Family and domain databases

Gene3Di 1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
3.90.190.10. 1 hit.
InterProi IPR019749. Band_41_domain.
IPR019750. Band_41_fam.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR014392. Tyr_Pase_non-rcpt_typ-14/21.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000934. Tyr-Ptase_nr14. 1 hit.
PRINTSi PR00935. BAND41.
PR00700. PRTYPHPHTASE.
SMARTi SM00295. B41. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF47031. SSF47031. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of a novel protein tyrosine phosphatase with sequence homology to the cytoskeletal proteins of the band 4.1 family."
    L'Abbe D., Banville D., Tong Y., Stocco R., Masson S., Ma S., Fantus G., Shen S.H.
    FEBS Lett. 356:351-356(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2E).
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiPTN21_RAT
AccessioniPrimary (citable) accession number: Q62728
Secondary accession number(s): Q62732
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3