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Q62728 (PTN21_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Tyrosine-protein phosphatase non-receptor type 21
EC=3.1.3.48
Alternative name(s):
Protein-tyrosine phosphatase 2E
Gene names
Name:Ptpn21
Synonyms:Ptp2e
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length1175 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subcellular location

Cytoplasm › cytoskeleton By similarity.

Tissue specificity

Particularly abundantly in adrenal glands.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.

Contains 1 FERM domain.

Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
   Coding sequence diversityAlternative splicing
   Molecular functionHydrolase
Protein phosphatase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcytoskeleton organization

Non-traceable author statement Ref.1. Source: RGD

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

cytoskeleton

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprotein tyrosine phosphatase activity

Inferred from direct assay Ref.1. Source: RGD

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q62728-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2E (identifier: Q62728-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-839: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11751175Tyrosine-protein phosphatase non-receptor type 21
PRO_0000219441

Regions

Domain23 – 308286FERM
Domain897 – 1168272Tyrosine-protein phosphatase
Region1109 – 11157Substrate binding By similarity

Sites

Active site11091Phosphocysteine intermediate By similarity
Binding site10681Substrate Potential
Binding site11531Substrate By similarity

Amino acid modifications

Modified residue6371Phosphoserine By similarity
Modified residue7961Phosphoserine By similarity
Modified residue8211Phosphoserine By similarity

Natural variations

Alternative sequence1 – 839839Missing in isoform 2E.
VSP_000498

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 82A684F1C0F5ECF7

FASTA1,175133,412
        10         20         30         40         50         60 
MPLPFGLKLK RTRRYTVSSK SCLVARIQLL NNEFVEFTLS VESTGQESLE AVAQRLELRE 

        70         80         90        100        110        120 
ITYFSLWYYN KQNQRRWVDL EKPLKKQLDK HALEPTVYFG VVFYVPSVSQ LQQEITRYQY 

       130        140        150        160        170        180 
YLQLKKDVLE GNLPCTLEQA IQLAGLAVQA DFGDFDQYES QDFLQKFALL PVGWLQDEKL 

       190        200        210        220        230        240 
LEEAAQKVAL LHQKYRGLTA PEAEMLYMQE VERMDGYGEE SYPAKDSQGS DISIGACLDG 

       250        260        270        280        290        300 
IFVKHKNGRP PVVFRWHDIA NMSHNKSFFA LELANKEETI QFQTEDMETA KYVWRLCVAR 

       310        320        330        340        350        360 
HKFYRLNQCN LQTQAATLNS VRRGSSSRMS LPKPQPYAMP PPPQLHYNGH YTEPFASSQD 

       370        380        390        400        410        420 
NVFVPNKNGF YCHSQTSLDR TQIDLSGRIR NGSVYSAHST NSLNTPQPYL QPSPMSSNPS 

       430        440        450        460        470        480 
IPGSDVMRPD YIPSHRHSAL IPPSYRPTPD YESVMKRLNR GMVHADRHSH SLRNLNIGSS 

       490        500        510        520        530        540 
YAYSRPDALV YSQPEIREHP HLASPQSAHY PFNLNYSFHS QAPYPYPVER RPVVGAVSVP 

       550        560        570        580        590        600 
ELTNVQLQAQ DYPAPNIMRT QVYRPPPPYP YPRPANSTPD LSRHLYISSS NPDLITRRVH 

       610        620        630        640        650        660 
HSVQTFQEDS LPVAHSLQEV SEPLTAARHA HLQKRNSIEI AGLTHGFEGL RLKEETMSAS 

       670        680        690        700        710        720 
AADVAPRTFS AGSQSSVFSD KVKQEGTEEQ GSGGYSHKKS LSDATMLIHS SEEDEDLEDD 

       730        740        750        760        770        780 
SSREHAVSEP RLTAAFSQEQ QLNYPCASVT PVTGPLHIFE PKSHVTEPEK RAKDISPVHL 

       790        800        810        820        830        840 
VMETHQPRRH GLLTPSMSES DLTTSGRYRA RRDSLKKRPV SDLLSGKKNT VEGLPPLGGM 

       850        860        870        880        890        900 
KKTRADAKKI GPLKLAALNG LSLSRLPLPD EGKEVSTRAT NDERCKVLEQ RLEQGTVFTE 

       910        920        930        940        950        960 
YERILKKRLV DGECSTARLP ENAERNRFQD VLPYDDARVE LVPTKENNTG YINASHIKVS 

       970        980        990       1000       1010       1020 
VSGIEWDYIA TQGPLQNTCQ DFWQMVWEQG VAIIAMVTAE EEGGREKSFR YWPRLGSRHN 

      1030       1040       1050       1060       1070       1080 
TVTYGRFKIT TRFRTDSGCY ATTGLKMKHL LTGQERTVWH LQYTDWPEHG CPEDLKGFLS 

      1090       1100       1110       1120       1130       1140 
YLEEIQSVRR HTNSTSEPRS PNPPLLVHCS AGVGRTGVVI LSEIMVACLE HNEVLDIPRV 

      1150       1160       1170 
LELLRQQRMM LVQTLSQYTF VYRVLIQFLK SSRLI

« Hide

Isoform 2E [UniParc].

Checksum: CDC3DAEEBED2F49E
Show »

FASTA33638,487

References

[1]"Identification of a novel protein tyrosine phosphatase with sequence homology to the cytoskeletal proteins of the band 4.1 family."
L'Abbe D., Banville D., Tong Y., Stocco R., Masson S., Ma S., Fantus G., Shen S.H.
FEBS Lett. 356:351-356(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2E).
Strain: Sprague-Dawley.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U17971 mRNA. Translation: AAA62153.1.
U18293 mRNA. Translation: AAA62154.1.
IPIIPI00208094.
IPI00231266.
PIRS51005.
RefSeqNP_598229.1. NM_133545.1.
UniGeneRn.11310.

3D structure databases

ProteinModelPortalQ62728.
SMRQ62728. Positions 883-1172.
ModBaseSearch...

PTM databases

PhosphoSiteQ62728.

Proteomic databases

PRIDEQ62728.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID171070.
KEGGrno:171070.
UCSCRGD:620216. rat.

Organism-specific databases

CTD11099.
RGD620216. Ptpn21.

Phylogenomic databases

eggNOGCOG5599.
HOGENOMHOG000115775.
HOVERGENHBG053757.
InParanoidQ62728.
KOK01104.
OrthoDBEOG46MBHR.

Gene expression databases

ArrayExpressQ62728.
GenevestigatorQ62728.
GermOnlineENSRNOG00000003982. Rattus norvegicus.

Family and domain databases

Gene3D1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
InterProIPR019749. Band_41_domain.
IPR019750. Band_41_fam.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
IPR019748. FERM_central.
IPR019747. FERM_CS.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011993. PH_like_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR014392. Tyr_Pase_non-rcpt_typ-14/21.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFPIRSF000934. Tyr-Ptase_nr14. 1 hit.
PRINTSPR00935. BAND41.
PR00700. PRTYPHPHTASE.
SMARTSM00295. B41. 1 hit.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMSSF47031. FERM_3-hlx. 1 hit.
PROSITEPS00660. FERM_1. 1 hit.
PS00661. FERM_2. 1 hit.
PS50057. FERM_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio621667.

Entry information

Entry namePTN21_RAT
AccessionPrimary (citable) accession number: Q62728
Secondary accession number(s): Q62732
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 3, 2013
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents