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Q62726 (ICK_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase ICK
EC=2.7.11.22
Alternative name(s):
Intestinal cell kinase
MAK-related kinase
Short name=MRK
Gene names
Name:Ick
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length629 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in cardiac development. Ref.1

Catalytic activity

ATP + a protein = ADP + a phosphoprotein. Ref.1

Cofactor

Magnesium. Ref.1

Subcellular location

Cytoplasm Ref.1.

Tissue specificity

Expressed in embryonic heart from day 11. Highly expressed in the uterus and at lower levels in brain, heart, lung, kidney, skeletal muscle, ovary and liver in adult tissues. Ref.1

Post-translational modification

Autophosphorylated on serine and threonine residues. May play a role in enzyme activation. Ref.1 UniProtKB Q9NYX3

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 629629Serine/threonine-protein kinase ICK
PRO_0000086009

Regions

Domain4 – 284281Protein kinase
Nucleotide binding10 – 189ATP By similarity UniProtKB P06493

Sites

Active site1251Proton acceptor By similarity UniProtKB P06493
Binding site331ATP By similarity UniProtKB Q9NYX3

Amino acid modifications

Modified residue1571Phosphothreonine By similarity UniProtKB Q9NYX3
Modified residue1591Phosphotyrosine By similarity UniProtKB Q9NYX3

Sequences

Sequence LengthMass (Da)Tools
Q62726 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: AA4143D73F891E8B

FASTA62970,569
        10         20         30         40         50         60 
MNRYTTIKQL GDGTYGSVLL GRSIESGELI AIKKMKRKFY SWEECMNLRE VKSLKKLNHA 

        70         80         90        100        110        120 
NIVKLKEVIR ENDHLYFIFE YMKENLYQLI KERNKLFPES AIRNIMYQIL QGLAFIHKHG 

       130        140        150        160        170        180 
FFHRDLKPEN LLCMGPELVK IADFGLAREI RSRPPYTDYV STRWYRAPEV LLRSTNYSSP 

       190        200        210        220        230        240 
IDVWAVGCIM AEVYTLRPLF PGASEIDTIF KICQVLGTPK KTDWPEGYQL SSAMNFIWPQ 

       250        260        270        280        290        300 
CIPNNLKTLI PNASSEAIQL LRDLLQWDPK KRPTASQALR YPYFQIGHPL GISTQDSGKP 

       310        320        330        340        350        360 
QKDVQDKTGP PPYVKPAPPA QAPTKAHTLI SSRPNQASQP HQHFVYPYKG EASRTEQLSH 

       370        380        390        400        410        420 
VQEGQPNPPF FPSLHNKNLP PKILAGLEQK SGDMKPKSRR RWGLISRSTK GSDDWADLAD 

       430        440        450        460        470        480 
LDFSSSLTRI DVKNKKRQSD DPLCRFESVL DLKPSEPVGT GTSVSTQASS QRRDTPTLQS 

       490        500        510        520        530        540 
TAKQHYLKHS RYLPGINIRN GVLPNPGKDF LPSSSWSSSG LSGKSSGTVS VVSKITSVGS 

       550        560        570        580        590        600 
GSTSSTGLTG SYIPSFLKKE VGSVMQRVQL APLAAPSPGY SSLKAVRPHP GRPFFHTQPR 

       610        620 
STPGLIPRPP AVQPVHGRID WSSKYPSRR

« Hide

References

[1]"Molecular cloning of a novel serine/threonine kinase, MRK, possibly involved in cardiac development."
Abe S., Yagi T., Ishiyama S., Hiroe M., Marumo F., Ikawa Y.
Oncogene 11:2187-2195(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AUTOPHOSPHORYLATION.
Tissue: Heart.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D26178 mRNA. Translation: BAA05166.1.
IPIIPI00326779.
RefSeqNP_620241.1. NM_138886.1.
UniGeneRn.3750.

3D structure databases

ProteinModelPortalQ62726.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000012257.

PTM databases

PhosphoSiteQ62726.

Proteomic databases

PaxDbQ62726.
PRIDEQ62726.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID84411.
KEGGrno:84411.
UCSCRGD:71050. rat.

Organism-specific databases

CTD22858.
RGD71050. Ick.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233024.
HOVERGENHBG014652.
InParanoidQ62726.
KOK08828.
OrthoDBEOG46DM2D.

Gene expression databases

GenevestigatorQ62726.
GermOnlineENSRNOG00000008691. Rattus norvegicus.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. Kinase_like. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio616888.

Entry information

Entry nameICK_RAT
AccessionPrimary (citable) accession number: Q62726
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: November 1, 1996
Last modified: May 1, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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