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Protein

Serine/threonine-protein kinase ICK

Gene

Ick

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for ciliogenesis, particularly in neuronal and retinal progenitor cells (By similarity). Phosphorylates KIF3A (By similarity). Involved in the control of ciliary length (By similarity). Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (By similarity). May play a role in cardiac development (PubMed:8570168). Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activity (By similarity).1 PublicationBy similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication

Cofactori

Mg2+1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATPPROSITE-ProRule annotationBy similarity1
Active sitei125Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Kinase, Serine/threonine-protein kinase, Transferase
Biological processCilium biogenesis/degradation
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase ICK (EC:2.7.11.11 Publication)
Alternative name(s):
Intestinal cell kinase
MAK-related kinase
Short name:
MRK
Gene namesi
Name:Ick
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi71050 Ick

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000860091 – 629Serine/threonine-protein kinase ICKAdd BLAST629

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei157PhosphothreonineBy similarity1
Modified residuei159PhosphotyrosineBy similarity1

Post-translational modificationi

Autophosphorylated on serine and threonine residues. May play a role in enzyme activation.By similarity1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ62726
PRIDEiQ62726

PTM databases

iPTMnetiQ62726
PhosphoSitePlusiQ62726

Expressioni

Tissue specificityi

Expressed in embryonic heart from day 11. Highly expressed in the uterus and at lower levels in brain, heart, lung, kidney, skeletal muscle, ovary and liver in adult tissues.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012257

Structurei

3D structure databases

ProteinModelPortaliQ62726
SMRiQ62726
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 284Protein kinasePROSITE-ProRule annotationCuratedAdd BLAST281

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0661 Eukaryota
ENOG410XPBB LUCA
HOGENOMiHOG000233024
HOVERGENiHBG014652
InParanoidiQ62726
KOiK08828
PhylomeDBiQ62726

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q62726-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNRYTTIKQL GDGTYGSVLL GRSIESGELI AIKKMKRKFY SWEECMNLRE
60 70 80 90 100
VKSLKKLNHA NIVKLKEVIR ENDHLYFIFE YMKENLYQLI KERNKLFPES
110 120 130 140 150
AIRNIMYQIL QGLAFIHKHG FFHRDLKPEN LLCMGPELVK IADFGLAREI
160 170 180 190 200
RSRPPYTDYV STRWYRAPEV LLRSTNYSSP IDVWAVGCIM AEVYTLRPLF
210 220 230 240 250
PGASEIDTIF KICQVLGTPK KTDWPEGYQL SSAMNFIWPQ CIPNNLKTLI
260 270 280 290 300
PNASSEAIQL LRDLLQWDPK KRPTASQALR YPYFQIGHPL GISTQDSGKP
310 320 330 340 350
QKDVQDKTGP PPYVKPAPPA QAPTKAHTLI SSRPNQASQP HQHFVYPYKG
360 370 380 390 400
EASRTEQLSH VQEGQPNPPF FPSLHNKNLP PKILAGLEQK SGDMKPKSRR
410 420 430 440 450
RWGLISRSTK GSDDWADLAD LDFSSSLTRI DVKNKKRQSD DPLCRFESVL
460 470 480 490 500
DLKPSEPVGT GTSVSTQASS QRRDTPTLQS TAKQHYLKHS RYLPGINIRN
510 520 530 540 550
GVLPNPGKDF LPSSSWSSSG LSGKSSGTVS VVSKITSVGS GSTSSTGLTG
560 570 580 590 600
SYIPSFLKKE VGSVMQRVQL APLAAPSPGY SSLKAVRPHP GRPFFHTQPR
610 620
STPGLIPRPP AVQPVHGRID WSSKYPSRR
Length:629
Mass (Da):70,569
Last modified:November 1, 1996 - v1
Checksum:iAA4143D73F891E8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26178 mRNA Translation: BAA05166.1
RefSeqiNP_620241.1, NM_138886.1
UniGeneiRn.3750

Genome annotation databases

GeneIDi84411
KEGGirno:84411
UCSCiRGD:71050 rat

Similar proteinsi

Entry informationi

Entry nameiICK_RAT
AccessioniPrimary (citable) accession number: Q62726
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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