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Q62726

- ICK_RAT

UniProt

Q62726 - ICK_RAT

Protein

Serine/threonine-protein kinase ICK

Gene

Ick

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    May play a role in cardiac development.1 Publication

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Cofactori

    Magnesium.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei33 – 331ATPBy similarityPROSITE-ProRule annotation
    Active sitei125 – 1251Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 189ATPBy similarityPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
    3. metal ion binding Source: UniProtKB-KW
    4. protein serine/threonine kinase activity Source: UniProtKB

    GO - Biological processi

    1. intracellular signal transduction Source: UniProtKB
    2. multicellular organismal development Source: UniProtKB-KW
    3. protein phosphorylation Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase ICK (EC:2.7.11.22)
    Alternative name(s):
    Intestinal cell kinase
    MAK-related kinase
    Short name:
    MRK
    Gene namesi
    Name:Ick
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi71050. Ick.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 629629Serine/threonine-protein kinase ICKPRO_0000086009Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei157 – 1571PhosphothreonineBy similarity
    Modified residuei159 – 1591PhosphotyrosineBy similarity

    Post-translational modificationi

    Autophosphorylated on serine and threonine residues. May play a role in enzyme activation.By similarity1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ62726.
    PRIDEiQ62726.

    PTM databases

    PhosphoSiteiQ62726.

    Expressioni

    Tissue specificityi

    Expressed in embryonic heart from day 11. Highly expressed in the uterus and at lower levels in brain, heart, lung, kidney, skeletal muscle, ovary and liver in adult tissues.1 Publication

    Gene expression databases

    GenevestigatoriQ62726.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000012257.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62726.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 284281Protein kinaseCuratedPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233024.
    HOVERGENiHBG014652.
    InParanoidiQ62726.
    KOiK08828.
    PhylomeDBiQ62726.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q62726-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNRYTTIKQL GDGTYGSVLL GRSIESGELI AIKKMKRKFY SWEECMNLRE    50
    VKSLKKLNHA NIVKLKEVIR ENDHLYFIFE YMKENLYQLI KERNKLFPES 100
    AIRNIMYQIL QGLAFIHKHG FFHRDLKPEN LLCMGPELVK IADFGLAREI 150
    RSRPPYTDYV STRWYRAPEV LLRSTNYSSP IDVWAVGCIM AEVYTLRPLF 200
    PGASEIDTIF KICQVLGTPK KTDWPEGYQL SSAMNFIWPQ CIPNNLKTLI 250
    PNASSEAIQL LRDLLQWDPK KRPTASQALR YPYFQIGHPL GISTQDSGKP 300
    QKDVQDKTGP PPYVKPAPPA QAPTKAHTLI SSRPNQASQP HQHFVYPYKG 350
    EASRTEQLSH VQEGQPNPPF FPSLHNKNLP PKILAGLEQK SGDMKPKSRR 400
    RWGLISRSTK GSDDWADLAD LDFSSSLTRI DVKNKKRQSD DPLCRFESVL 450
    DLKPSEPVGT GTSVSTQASS QRRDTPTLQS TAKQHYLKHS RYLPGINIRN 500
    GVLPNPGKDF LPSSSWSSSG LSGKSSGTVS VVSKITSVGS GSTSSTGLTG 550
    SYIPSFLKKE VGSVMQRVQL APLAAPSPGY SSLKAVRPHP GRPFFHTQPR 600
    STPGLIPRPP AVQPVHGRID WSSKYPSRR 629
    Length:629
    Mass (Da):70,569
    Last modified:November 1, 1996 - v1
    Checksum:iAA4143D73F891E8B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D26178 mRNA. Translation: BAA05166.1.
    RefSeqiNP_620241.1. NM_138886.1.
    UniGeneiRn.3750.

    Genome annotation databases

    GeneIDi84411.
    KEGGirno:84411.
    UCSCiRGD:71050. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D26178 mRNA. Translation: BAA05166.1 .
    RefSeqi NP_620241.1. NM_138886.1.
    UniGenei Rn.3750.

    3D structure databases

    ProteinModelPortali Q62726.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000012257.

    PTM databases

    PhosphoSitei Q62726.

    Proteomic databases

    PaxDbi Q62726.
    PRIDEi Q62726.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 84411.
    KEGGi rno:84411.
    UCSCi RGD:71050. rat.

    Organism-specific databases

    CTDi 22858.
    RGDi 71050. Ick.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233024.
    HOVERGENi HBG014652.
    InParanoidi Q62726.
    KOi K08828.
    PhylomeDBi Q62726.

    Miscellaneous databases

    NextBioi 616888.
    PROi Q62726.

    Gene expression databases

    Genevestigatori Q62726.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a novel serine/threonine kinase, MRK, possibly involved in cardiac development."
      Abe S., Yagi T., Ishiyama S., Hiroe M., Marumo F., Ikawa Y.
      Oncogene 11:2187-2195(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AUTOPHOSPHORYLATION.
      Tissue: HeartImported.

    Entry informationi

    Entry nameiICK_RAT
    AccessioniPrimary (citable) accession number: Q62726
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3