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Protein

NGFI-A-binding protein 1

Gene

Nab1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Also represses multiple types of non-EGR1 activation domains (in vitro).1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
NGFI-A-binding protein 1
Alternative name(s):
EGR-1-binding protein 1
Gene namesi
Name:Nab1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi70882 Nab1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000770411 – 485NGFI-A-binding protein 1Add BLAST485

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki126Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki129Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki143Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei171PhosphoserineBy similarity1
Modified residuei182PhosphoserineBy similarity1
Cross-linki211Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei327PhosphoserineBy similarity1
Cross-linki332Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki332Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki354Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki367Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki371Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei404PhosphoserineBy similarity1
Cross-linki452Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki463Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki475Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki478Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki478Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ62722
PRIDEiQ62722

PTM databases

iPTMnetiQ62722
PhosphoSitePlusiQ62722

Expressioni

Gene expression databases

BgeeiENSRNOG00000012959
GenevisibleiQ62722 RN

Interactioni

Subunit structurei

Homomultimers may associate with EGR1 bound to DNA.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017813

Structurei

3D structure databases

ProteinModelPortaliQ62722
SMRiQ62722
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni4 – 82NCD1Add BLAST79
Regioni220 – 309NCD2Add BLAST90
Regioni391 – 422Necessary for nuclear localizationAdd BLAST32

Domaini

The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerization.
The NAB conserved domain 2 (NCD2) is necessary for transcriptional repression.

Sequence similaritiesi

Belongs to the NAB family.Curated

Phylogenomic databases

eggNOGiKOG3835 Eukaryota
ENOG410YKFH LUCA
GeneTreeiENSGT00390000006330
HOGENOMiHOG000026777
HOVERGENiHBG003127
InParanoidiQ62722
KOiK22388
OMAiAAAQLCM
OrthoDBiEOG091G0NQE

Family and domain databases

Gene3Di3.40.390.601 hit
InterProiView protein in InterPro
IPR006986 Nab1_C
IPR006989 NAB_co-repressor_dom
IPR006988 Nab_N
IPR038398 NCD2_sf
PfamiView protein in Pfam
PF04902 Nab1, 1 hit
PF04904 NCD1, 1 hit
PF04905 NCD2, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD342192 Nab_N, 1 hit

Sequencei

Sequence statusi: Complete.

Q62722-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATALPRTLG ELQLYRILQK ANLLSYFDAF IQQGGDDVQQ LCEAGEEEFL
60 70 80 90 100
EIMALVGMAS KPLHVRRLQK ALRDWVTNPG LFNQPLTSLP VSSIPIYKLP
110 120 130 140 150
EGSPTWLGIS CNSYERSSSA REPHLKVPKC AATTCVQSLG QGKSEVGSLA
160 170 180 190 200
LQSVSESRLW QGHHTTESEH SLSPADLGSP ASPKESSEAL DAAAALSVAE
210 220 230 240 250
CVERMAPTLP KSDLNEVKEL LKNNKKLAKM IGHIFEMSDE DPHKEEEIRK
260 270 280 290 300
YSAIYGRFDS KRKDGKHLTL HELTVNEAAA QLCVKDNALL TRRDELFALA
310 320 330 340 350
RQVSREVTYK YTYRTTRLKC GERDELSPKR IKMEDGFPDF QESVPTLFQQ
360 370 380 390 400
ARAKSEELAG LSSQAEKGMA KQMELLCAQA GYERLQQERR LMAGLYRQSS
410 420 430 440 450
GEQSPDGGLP SDGSDGQGER PLNLRIPSVQ NRQPHHFVVD GELSRLYSNE
460 470 480
VKSHSSESLG ILKDYPHSAF TLEKKVIKTE PEDSR
Length:485
Mass (Da):54,026
Last modified:October 1, 2000 - v2
Checksum:iD77B85B238204677
GO

Sequence cautioni

The sequence AAC52236 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17253 mRNA Translation: AAC52236.1 Different initiation.
PIRiI59402
RefSeqiNP_074047.2, NM_022856.5
XP_006244964.1, XM_006244902.3
UniGeneiRn.10099
Rn.231200

Genome annotation databases

EnsembliENSRNOT00000017813; ENSRNOP00000017813; ENSRNOG00000012959
GeneIDi64824
KEGGirno:64824
UCSCiRGD:70882 rat

Similar proteinsi

Entry informationi

Entry nameiNAB1_RAT
AccessioniPrimary (citable) accession number: Q62722
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome