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Protein

Zinc transporter 1

Gene

Slc30a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in zinc transport out of the cell.

GO - Molecular functioni

  • calcium channel inhibitor activity Source: BHF-UCL
  • zinc ion transmembrane transporter activity Source: MGI

GO - Biological processi

  • cadmium ion transmembrane transport Source: BHF-UCL
  • calcium ion import Source: BHF-UCL
  • cellular calcium ion homeostasis Source: Ensembl
  • cellular zinc ion homeostasis Source: Ensembl
  • detoxification of cadmium ion Source: BHF-UCL
  • in utero embryonic development Source: Ensembl
  • negative regulation of calcium ion import Source: Ensembl
  • negative regulation of neurotransmitter secretion Source: BHF-UCL
  • negative regulation of zinc ion transmembrane import Source: Ensembl
  • regulation of sequestering of zinc ion Source: GO_Central
  • response to zinc ion Source: GO_Central
  • zinc II ion transport Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

ReactomeiR-RNO-435368. Zinc efflux and compartmentalization by the SLC30 family.

Protein family/group databases

TCDBi2.A.4.2.3. the cation diffusion facilitator (cdf) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 1
Short name:
ZnT-1
Alternative name(s):
Solute carrier family 30 member 1
Gene namesi
Name:Slc30a1
Synonyms:Znt1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi61918. Slc30a1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 35ExtracellularSequence analysis4
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Topological domaini57 – 78CytoplasmicSequence analysisAdd BLAST22
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Topological domaini100 – 113ExtracellularSequence analysisAdd BLAST14
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Topological domaini135 – 247CytoplasmicSequence analysisAdd BLAST113
Transmembranei248 – 268HelicalSequence analysisAdd BLAST21
Topological domaini269 – 307ExtracellularSequence analysisAdd BLAST39
Transmembranei308 – 328HelicalSequence analysisAdd BLAST21
Topological domaini329 – 507CytoplasmicSequence analysisAdd BLAST179

GO - Cellular componenti

  • endoplasmic reticulum Source: GO_Central
  • Golgi apparatus Source: GO_Central
  • integral component of membrane Source: RGD
  • nuclear membrane Source: Ensembl
  • plasma membrane Source: MGI
  • T-tubule Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002060931 – 507Zinc transporter 1Add BLAST507

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi298N-linked (GlcNAc...)Sequence analysis1
Modified residuei506PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ62720.
PRIDEiQ62720.

PTM databases

iPTMnetiQ62720.
PhosphoSitePlusiQ62720.
SwissPalmiQ62720.

Expressioni

Tissue specificityi

Widely expressed. The protein is detected in duodenum and jejunum but not in ileum and colon.

Inductioni

Slightly by zinc in the intestine, but not the liver.1 Publication

Gene expression databases

BgeeiENSRNOG00000004749.
GenevisibleiQ62720. RN.

Interactioni

Subunit structurei

Multimer.Curated

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006340.

Structurei

3D structure databases

ProteinModelPortaliQ62720.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni145 – 1566 X 2 AA approximate repeats of H-GAdd BLAST12

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1483. Eukaryota.
COG1230. LUCA.
GeneTreeiENSGT00550000074381.
HOGENOMiHOG000166089.
HOVERGENiHBG000588.
InParanoidiQ62720.
KOiK14688.
OMAiSENACCR.
OrthoDBiEOG091G08R5.
PhylomeDBiQ62720.
TreeFamiTF313924.

Family and domain databases

Gene3Di1.20.1510.10. 3 hits.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 3 hits.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q62720-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCWGRNRGR LLCMLLLTFM FMVLEVVVSR VTASLAMLSD SFHMLSDVLA
60 70 80 90 100
LVVALVAERF ARRTHATQKN TFGWIRAEVM GALVNAIFLT GLCFAILLEA
110 120 130 140 150
VERFIEPHEM QQPLVVLSVG VAGLLVNVLG LCLFHHHSGE GQGAGHGHSH
160 170 180 190 200
GHGHGHLAKG ARKAGRAGGE AGAPPGRAPD QEPDQEETNT LVANTSNSNG
210 220 230 240 250
LKADQAEPEK LRSDDPVDVQ VNGNLIQESD SLESEDNRAG QLNMRGVFLH
260 270 280 290 300
VLGDALGSVI VVVNALVFYF SWKGCTEDDF CVNPCFPDPC KSSVELMNST
310 320 330 340 350
QAPMHEAGPC WVLYLDPTLC IIMVCILLYT TYPLLKESAL ILLQTVPKQI
360 370 380 390 400
DIKHLVKELR DVEGVEEVHE LHVWQLAGSR IIATAHIKCE DPASYMQVAK
410 420 430 440 450
TIKDVFHNHG IHATTIQPEF ASVGSKSSVV PCELACRTQC ALKQCCGTRP
460 470 480 490 500
QVHSGKEAEK APTVSISCLE LSENLEKKPR RTKAEGSVPA VVIEIKNVPN

KQPESSL
Length:507
Mass (Da):55,143
Last modified:November 1, 1996 - v1
Checksum:i9F9770017C2455FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17133 mRNA. Translation: AAA79234.1.
PIRiS54303.
RefSeqiNP_074044.1. NM_022853.2.
UniGeneiRn.10120.

Genome annotation databases

EnsembliENSRNOT00000006340; ENSRNOP00000006340; ENSRNOG00000004749.
GeneIDi58976.
KEGGirno:58976.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U17133 mRNA. Translation: AAA79234.1.
PIRiS54303.
RefSeqiNP_074044.1. NM_022853.2.
UniGeneiRn.10120.

3D structure databases

ProteinModelPortaliQ62720.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006340.

Protein family/group databases

TCDBi2.A.4.2.3. the cation diffusion facilitator (cdf) family.

PTM databases

iPTMnetiQ62720.
PhosphoSitePlusiQ62720.
SwissPalmiQ62720.

Proteomic databases

PaxDbiQ62720.
PRIDEiQ62720.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006340; ENSRNOP00000006340; ENSRNOG00000004749.
GeneIDi58976.
KEGGirno:58976.

Organism-specific databases

CTDi7779.
RGDi61918. Slc30a1.

Phylogenomic databases

eggNOGiKOG1483. Eukaryota.
COG1230. LUCA.
GeneTreeiENSGT00550000074381.
HOGENOMiHOG000166089.
HOVERGENiHBG000588.
InParanoidiQ62720.
KOiK14688.
OMAiSENACCR.
OrthoDBiEOG091G08R5.
PhylomeDBiQ62720.
TreeFamiTF313924.

Enzyme and pathway databases

ReactomeiR-RNO-435368. Zinc efflux and compartmentalization by the SLC30 family.

Miscellaneous databases

PROiQ62720.

Gene expression databases

BgeeiENSRNOG00000004749.
GenevisibleiQ62720. RN.

Family and domain databases

Gene3Di1.20.1510.10. 3 hits.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 3 hits.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiZNT1_RAT
AccessioniPrimary (citable) accession number: Q62720
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.