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Protein

Neutrophil antibiotic peptide NP-2

Gene

Defa

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Active in vitro against S.aureus, fungi, Gram-positive and Gram-negative bacteria and to a lesser extent against an enveloped virus.

GO - Biological processi

  • defense response to bacterium Source: RGD
  • defense response to fungus Source: UniProtKB-KW
  • killing of cells of other organism Source: UniProtKB-KW

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin, Fungicide

Names & Taxonomyi

Protein namesi
Recommended name:
Neutrophil antibiotic peptide NP-2
Short name:
RatNP-2
Alternative name(s):
Neutrophil defensin 2
Gene namesi
Name:Defa
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi727951 Defa

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000000686120 – 62Sequence analysisAdd BLAST43
PeptideiPRO_000000686263 – 94Neutrophil antibiotic peptide NP-2Add BLAST32

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi65 ↔ 93By similarity
Disulfide bondi67 ↔ 82By similarity
Disulfide bondi72 ↔ 92By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ62715

Expressioni

Tissue specificityi

Highest expression in bone marrow and to a much lesser extent in small intestine.

Gene expression databases

BgeeiENSRNOG00000030093
GenevisibleiQ62715 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018501

Structurei

3D structure databases

ProteinModelPortaliQ62715
SMRiQ62715
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JFE2 Eukaryota
ENOG4111A2R LUCA
GeneTreeiENSGT00910000145112
HOVERGENiHBG011703
InParanoidiQ62715
KOiK05230
OMAiEATTQKQ
OrthoDBiEOG091G19B4
PhylomeDBiQ62715
TreeFamiTF338414

Family and domain databases

InterProiView protein in InterPro
IPR006081 Alpha-defensin
IPR016327 Alpha-defensin_pro
IPR006080 Defensin_beta/alpha
IPR002366 Defensin_propep
PANTHERiPTHR11876 PTHR11876, 1 hit
PfamiView protein in Pfam
PF00323 Defensin_1, 1 hit
PF00879 Defensin_propep, 1 hit
PIRSFiPIRSF001875 Alpha-defensin, 1 hit
SMARTiView protein in SMART
SM00048 DEFSN, 1 hit
PROSITEiView protein in PROSITE
PS00269 DEFENSIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62715-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTLTLLTAL LLLALHTQAK SPQGTAEEAP DQEQLVMEDQ DISISFGGDK
60 70 80 90
GTALQDADVK AGVTCYCRST RCGFRERLSG ACGYRGRIYR LCCR
Length:94
Mass (Da):10,302
Last modified:November 1, 1996 - v1
Checksum:iC379F26D98230E6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16685 mRNA Translation: AAA91973.1
PIRiE61014
RefSeqiNP_775451.2, NM_173329.2
UniGeneiRn.91221

Genome annotation databases

EnsembliENSRNOT00000018501; ENSRNOP00000018501; ENSRNOG00000030093
GeneIDi286995
KEGGirno:286995
UCSCiRGD:727951 rat

Similar proteinsi

Entry informationi

Entry nameiDEF2_RAT
AccessioniPrimary (citable) accession number: Q62715
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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