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Protein

Neutrophil antibiotic peptide NP-2

Gene

Defa

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Active in vitro against S.aureus, fungi, Gram-positive and Gram-negative bacteria and to a lesser extent against an enveloped virus.

GO - Biological processi

  • defense response to bacterium Source: RGD
  • defense response to fungus Source: UniProtKB-KW
  • killing of cells of other organism Source: UniProtKB-KW

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin, Fungicide

Enzyme and pathway databases

ReactomeiR-RNO-1461973. Defensins.
R-RNO-1462054. Alpha-defensins.
R-RNO-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Neutrophil antibiotic peptide NP-2
Short name:
RatNP-2
Alternative name(s):
Neutrophil defensin 2
Gene namesi
Name:Defa
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi727951. Defa.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000000686120 – 62Sequence analysisAdd BLAST43
PeptideiPRO_000000686263 – 94Neutrophil antibiotic peptide NP-2Add BLAST32

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi65 ↔ 93By similarity
Disulfide bondi67 ↔ 82By similarity
Disulfide bondi72 ↔ 92By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ62715.
PRIDEiQ62715.

Expressioni

Tissue specificityi

Highest expression in bone marrow and to a much lesser extent in small intestine.

Gene expression databases

BgeeiENSRNOG00000030093.
GenevisibleiQ62715. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018501.

Structurei

3D structure databases

ProteinModelPortaliQ62715.
SMRiQ62715.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JFE2. Eukaryota.
ENOG4111A2R. LUCA.
GeneTreeiENSGT00730000111183.
HOVERGENiHBG011703.
InParanoidiQ62715.
KOiK05230.
OMAiEATTQKQ.
OrthoDBiEOG091G19B4.
PhylomeDBiQ62715.
TreeFamiTF338414.

Family and domain databases

InterProiView protein in InterPro
IPR006081. Alpha-defensin.
IPR016327. Alpha-defensin_pro.
IPR006080. Defensin_beta/alpha.
IPR002366. Defensin_propep.
PANTHERiPTHR11876. PTHR11876. 1 hit.
PfamiView protein in Pfam
PF00323. Defensin_1. 1 hit.
PF00879. Defensin_propep. 1 hit.
PIRSFiPIRSF001875. Alpha-defensin. 1 hit.
SMARTiView protein in SMART
SM00048. DEFSN. 1 hit.
PROSITEiView protein in PROSITE
PS00269. DEFENSIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62715-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTLTLLTAL LLLALHTQAK SPQGTAEEAP DQEQLVMEDQ DISISFGGDK
60 70 80 90
GTALQDADVK AGVTCYCRST RCGFRERLSG ACGYRGRIYR LCCR
Length:94
Mass (Da):10,302
Last modified:November 1, 1996 - v1
Checksum:iC379F26D98230E6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16685 mRNA. Translation: AAA91973.1.
PIRiE61014.
RefSeqiNP_775451.2. NM_173329.2.
UniGeneiRn.91221.

Genome annotation databases

EnsembliENSRNOT00000018501; ENSRNOP00000018501; ENSRNOG00000030093.
GeneIDi286995.
KEGGirno:286995.
UCSCiRGD:727951. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiDEF2_RAT
AccessioniPrimary (citable) accession number: Q62715
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 7, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families