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Protein

Neutrophil antibiotic peptide NP-2

Gene

Defa

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Active in vitro against S.aureus, fungi, Gram-positive and Gram-negative bacteria and to a lesser extent against an enveloped virus.

GO - Biological processi

  • defense response to bacterium Source: RGD
  • defense response to fungus Source: UniProtKB-KW
  • killing of cells of other organism Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin, Fungicide

Enzyme and pathway databases

ReactomeiR-RNO-1461973. Defensins.
R-RNO-1462054. Alpha-defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Neutrophil antibiotic peptide NP-2
Short name:
RatNP-2
Alternative name(s):
Neutrophil defensin 2
Gene namesi
Name:Defa
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi727951. Defa.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Propeptidei20 – 6243Sequence analysisPRO_0000006861Add
BLAST
Peptidei63 – 9432Neutrophil antibiotic peptide NP-2PRO_0000006862Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi65 ↔ 93By similarity
Disulfide bondi67 ↔ 82By similarity
Disulfide bondi72 ↔ 92By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ62715.
PRIDEiQ62715.

Expressioni

Tissue specificityi

Highest expression in bone marrow and to a much lesser extent in small intestine.

Gene expression databases

GenevisibleiQ62715. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018501.

Structurei

3D structure databases

ProteinModelPortaliQ62715.
SMRiQ62715. Positions 63-94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JFE2. Eukaryota.
ENOG4111A2R. LUCA.
GeneTreeiENSGT00730000111183.
HOVERGENiHBG011703.
InParanoidiQ62715.
KOiK05230.
OMAiQARIVCH.
OrthoDBiEOG75TMFQ.
PhylomeDBiQ62715.
TreeFamiTF338414.

Family and domain databases

InterProiIPR006081. Alpha-defensin.
IPR016327. Alpha-defensin_pro.
IPR006080. Defensin_beta/alpha.
IPR002366. Defensin_propep.
[Graphical view]
PANTHERiPTHR11876. PTHR11876. 1 hit.
PfamiPF00323. Defensin_1. 1 hit.
PF00879. Defensin_propep. 1 hit.
[Graphical view]
PIRSFiPIRSF001875. Alpha-defensin. 1 hit.
SMARTiSM00048. DEFSN. 1 hit.
[Graphical view]
PROSITEiPS00269. DEFENSIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62715-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTLTLLTAL LLLALHTQAK SPQGTAEEAP DQEQLVMEDQ DISISFGGDK
60 70 80 90
GTALQDADVK AGVTCYCRST RCGFRERLSG ACGYRGRIYR LCCR
Length:94
Mass (Da):10,302
Last modified:November 1, 1996 - v1
Checksum:iC379F26D98230E6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16685 mRNA. Translation: AAA91973.1.
PIRiE61014.
RefSeqiNP_775451.2. NM_173329.2.
UniGeneiRn.91221.

Genome annotation databases

EnsembliENSRNOT00000018501; ENSRNOP00000018501; ENSRNOG00000030093.
GeneIDi286995.
KEGGirno:286995.
UCSCiRGD:727951. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16685 mRNA. Translation: AAA91973.1.
PIRiE61014.
RefSeqiNP_775451.2. NM_173329.2.
UniGeneiRn.91221.

3D structure databases

ProteinModelPortaliQ62715.
SMRiQ62715. Positions 63-94.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018501.

Proteomic databases

PaxDbiQ62715.
PRIDEiQ62715.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018501; ENSRNOP00000018501; ENSRNOG00000030093.
GeneIDi286995.
KEGGirno:286995.
UCSCiRGD:727951. rat.

Organism-specific databases

CTDi1670.
RGDi727951. Defa.

Phylogenomic databases

eggNOGiENOG410JFE2. Eukaryota.
ENOG4111A2R. LUCA.
GeneTreeiENSGT00730000111183.
HOVERGENiHBG011703.
InParanoidiQ62715.
KOiK05230.
OMAiQARIVCH.
OrthoDBiEOG75TMFQ.
PhylomeDBiQ62715.
TreeFamiTF338414.

Enzyme and pathway databases

ReactomeiR-RNO-1461973. Defensins.
R-RNO-1462054. Alpha-defensins.

Miscellaneous databases

PROiQ62715.

Gene expression databases

GenevisibleiQ62715. RN.

Family and domain databases

InterProiIPR006081. Alpha-defensin.
IPR016327. Alpha-defensin_pro.
IPR006080. Defensin_beta/alpha.
IPR002366. Defensin_propep.
[Graphical view]
PANTHERiPTHR11876. PTHR11876. 1 hit.
PfamiPF00323. Defensin_1. 1 hit.
PF00879. Defensin_propep. 1 hit.
[Graphical view]
PIRSFiPIRSF001875. Alpha-defensin. 1 hit.
SMARTiSM00048. DEFSN. 1 hit.
[Graphical view]
PROSITEiPS00269. DEFENSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Rat neutrophil defensins. Precursor structures and expression during neutrophilic myelopoiesis."
    Yount N.Y., Wang M.-S.C., Yuan J., Banaiee N., Ouellette A.J., Selsted M.E.
    J. Immunol. 155:4476-4484(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Bone marrow.
  2. "Polymorphic expression of defensins in neutrophils from outbred rats."
    Eisenhauer P.B., Harwig S.S.S.L., Szklarek D., Ganz T., Lehrer R.I.
    Infect. Immun. 58:3899-3902(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 63-94.
    Strain: Sprague-Dawley.
    Tissue: Neutrophil.

Entry informationi

Entry nameiDEF2_RAT
AccessioniPrimary (citable) accession number: Q62715
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.