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Protein

Neutrophil antibiotic peptide NP-4

Gene

Np4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Active in vitro against S.aureus, fungi, Gram-positive and Gram-negative bacteria and to a lesser extent against an enveloped virus.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin, Fungicide

Names & Taxonomyi

Protein namesi
Recommended name:
Neutrophil antibiotic peptide NP-4
Short name:
RatNP-4
Alternative name(s):
Neutrophil defensin 4
Gene namesi
Name:Np4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi727857. Np4.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • extracellular space Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Propeptidei20 – 6243Sequence analysisPRO_0000006867Add
BLAST
Peptidei63 – 9331Neutrophil antibiotic peptide NP-4PRO_0000006868Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi64 ↔ 92By similarity
Disulfide bondi66 ↔ 81By similarity
Disulfide bondi71 ↔ 91By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ62714.
PRIDEiQ62714.

Expressioni

Tissue specificityi

Highest expression in bone marrow and to a much lesser extent in small intestine.

Gene expression databases

BgeeiENSRNOG00000028707.
ExpressionAtlasiQ62714. baseline and differential.
GenevisibleiQ62714. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036962.

Structurei

3D structure databases

ProteinModelPortaliQ62714.
SMRiQ62714. Positions 63-93.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00730000111183.
HOGENOMiHOG000233351.
HOVERGENiHBG011703.
InParanoidiQ62714.
KOiK05230.
PhylomeDBiQ62714.
TreeFamiTF338414.

Family and domain databases

InterProiIPR006081. Alpha-defensin.
IPR016327. Alpha-defensin_pro.
IPR006080. Defensin_beta/alpha.
IPR002366. Defensin_propep.
[Graphical view]
PANTHERiPTHR11876. PTHR11876. 1 hit.
PfamiPF00323. Defensin_1. 1 hit.
PF00879. Defensin_propep. 1 hit.
[Graphical view]
PIRSFiPIRSF001875. Alpha-defensin. 1 hit.
SMARTiSM00048. DEFSN. 1 hit.
[Graphical view]
PROSITEiPS00269. DEFENSIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62714-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTLTLLITL LLLALHTQAE SPQERAKAAP DQDMVMEDQD IFISFGGYKG
60 70 80 90
TVLQDAVVKA GQACYCRIGA CVSGERLTGA CGLNGRIYRL CCR
Length:93
Mass (Da):10,110
Last modified:November 1, 1996 - v1
Checksum:iA768917212603137
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16684 mRNA. Translation: AAA91972.1.
U50355 Genomic DNA. Translation: AAC99552.1.
PIRiC60113. A61014.
RefSeqiNP_775421.1. NM_173299.2.
UniGeneiRn.234314.

Genome annotation databases

EnsembliENSRNOT00000035128; ENSRNOP00000036962; ENSRNOG00000028707.
GeneIDi286958.
KEGGirno:286958.
UCSCiRGD:727857. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16684 mRNA. Translation: AAA91972.1.
U50355 Genomic DNA. Translation: AAC99552.1.
PIRiC60113. A61014.
RefSeqiNP_775421.1. NM_173299.2.
UniGeneiRn.234314.

3D structure databases

ProteinModelPortaliQ62714.
SMRiQ62714. Positions 63-93.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036962.

Proteomic databases

PaxDbiQ62714.
PRIDEiQ62714.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000035128; ENSRNOP00000036962; ENSRNOG00000028707.
GeneIDi286958.
KEGGirno:286958.
UCSCiRGD:727857. rat.

Organism-specific databases

CTDi286958.
RGDi727857. Np4.

Phylogenomic databases

GeneTreeiENSGT00730000111183.
HOGENOMiHOG000233351.
HOVERGENiHBG011703.
InParanoidiQ62714.
KOiK05230.
PhylomeDBiQ62714.
TreeFamiTF338414.

Miscellaneous databases

PROiQ62714.

Gene expression databases

BgeeiENSRNOG00000028707.
ExpressionAtlasiQ62714. baseline and differential.
GenevisibleiQ62714. RN.

Family and domain databases

InterProiIPR006081. Alpha-defensin.
IPR016327. Alpha-defensin_pro.
IPR006080. Defensin_beta/alpha.
IPR002366. Defensin_propep.
[Graphical view]
PANTHERiPTHR11876. PTHR11876. 1 hit.
PfamiPF00323. Defensin_1. 1 hit.
PF00879. Defensin_propep. 1 hit.
[Graphical view]
PIRSFiPIRSF001875. Alpha-defensin. 1 hit.
SMARTiSM00048. DEFSN. 1 hit.
[Graphical view]
PROSITEiPS00269. DEFENSIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDEF4_RAT
AccessioniPrimary (citable) accession number: Q62714
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.