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Protein

Neutrophil antibiotic peptide NP-4

Gene

Np4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Active in vitro against S.aureus, fungi, Gram-positive and Gram-negative bacteria and to a lesser extent against an enveloped virus.

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin, Fungicide

Enzyme and pathway databases

ReactomeiR-RNO-1461973 Defensins
R-RNO-1462054 Alpha-defensins
R-RNO-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Neutrophil antibiotic peptide NP-4
Short name:
RatNP-4
Alternative name(s):
Neutrophil defensin 4
Gene namesi
Name:Np4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi727857 Np4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000000686720 – 62Sequence analysisAdd BLAST43
PeptideiPRO_000000686863 – 93Neutrophil antibiotic peptide NP-4Add BLAST31

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi64 ↔ 92By similarity
Disulfide bondi66 ↔ 81By similarity
Disulfide bondi71 ↔ 91By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ62714
PRIDEiQ62714

Expressioni

Tissue specificityi

Highest expression in bone marrow and to a much lesser extent in small intestine.

Gene expression databases

BgeeiENSRNOG00000028707
ExpressionAtlasiQ62714 baseline and differential
GenevisibleiQ62714 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000036962

Structurei

3D structure databases

ProteinModelPortaliQ62714
SMRiQ62714
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00730000111183
HOGENOMiHOG000233351
HOVERGENiHBG011703
InParanoidiQ62714
KOiK05230
PhylomeDBiQ62714
TreeFamiTF338414

Family and domain databases

InterProiView protein in InterPro
IPR006081 Alpha-defensin
IPR016327 Alpha-defensin_pro
IPR006080 Defensin_beta/alpha
IPR002366 Defensin_propep
PANTHERiPTHR11876 PTHR11876, 1 hit
PfamiView protein in Pfam
PF00323 Defensin_1, 1 hit
PF00879 Defensin_propep, 1 hit
PIRSFiPIRSF001875 Alpha-defensin, 1 hit
SMARTiView protein in SMART
SM00048 DEFSN, 1 hit
PROSITEiView protein in PROSITE
PS00269 DEFENSIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62714-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTLTLLITL LLLALHTQAE SPQERAKAAP DQDMVMEDQD IFISFGGYKG
60 70 80 90
TVLQDAVVKA GQACYCRIGA CVSGERLTGA CGLNGRIYRL CCR
Length:93
Mass (Da):10,110
Last modified:November 1, 1996 - v1
Checksum:iA768917212603137
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16684 mRNA Translation: AAA91972.1
U50355 Genomic DNA Translation: AAC99552.1
PIRiC60113 A61014
RefSeqiNP_775421.1, NM_173299.2
UniGeneiRn.234314

Genome annotation databases

EnsembliENSRNOT00000035128; ENSRNOP00000036962; ENSRNOG00000028707
GeneIDi286958
KEGGirno:286958
UCSCiRGD:727857 rat

Similar proteinsi

Entry informationi

Entry nameiDEF4_RAT
AccessioniPrimary (citable) accession number: Q62714
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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