##gff-version 3 Q62711 UniProtKB Chain 1 772 . . . ID=PRO_0000306829;Note=1-phosphatidylinositol 4%2C5-bisphosphate phosphodiesterase delta-4 Q62711 UniProtKB Domain 16 124 . . . Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00145 Q62711 UniProtKB Domain 134 169 . . . Note=EF-hand 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448 Q62711 UniProtKB Domain 170 205 . . . Note=EF-hand 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448 Q62711 UniProtKB Domain 203 237 . . . Note=EF-hand 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448 Q62711 UniProtKB Domain 290 435 . . . Note=PI-PLC X-box;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00270 Q62711 UniProtKB Domain 503 619 . . . Note=PI-PLC Y-box;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00271 Q62711 UniProtKB Domain 619 746 . . . Note=C2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00041 Q62711 UniProtKB Region 26 53 . . . Note=Substrate binding;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q62711 UniProtKB Region 445 486 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q62711 UniProtKB Motif 213 243 . . . Note=GBA;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q9BRC7 Q62711 UniProtKB Motif 741 744 . . . Note=PDZ-binding Q62711 UniProtKB Compositional bias 468 486 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q62711 UniProtKB Active site 305 305 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00270 Q62711 UniProtKB Active site 350 350 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00270 Q62711 UniProtKB Binding site 147 147 . . . Ontology_term=ECO:0000305;evidence=ECO:0000305 Q62711 UniProtKB Binding site 149 149 . . . Ontology_term=ECO:0000305;evidence=ECO:0000305 Q62711 UniProtKB Binding site 151 151 . . . Ontology_term=ECO:0000305;evidence=ECO:0000305 Q62711 UniProtKB Binding site 153 153 . . . Ontology_term=ECO:0000305;evidence=ECO:0000305 Q62711 UniProtKB Binding site 158 158 . . . Ontology_term=ECO:0000305;evidence=ECO:0000305 Q62711 UniProtKB Binding site 183 183 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448 Q62711 UniProtKB Binding site 185 185 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448 Q62711 UniProtKB Binding site 187 187 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448 Q62711 UniProtKB Binding site 189 189 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448 Q62711 UniProtKB Binding site 194 194 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00448 Q62711 UniProtKB Binding site 306 306 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q62711 UniProtKB Binding site 335 335 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q62711 UniProtKB Binding site 337 337 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q62711 UniProtKB Binding site 433 433 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q62711 UniProtKB Binding site 435 435 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q62711 UniProtKB Binding site 532 532 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q62711 UniProtKB Binding site 559 559 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q62711 UniProtKB Binding site 662 662 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q62711 UniProtKB Binding site 686 686 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q62711 UniProtKB Binding site 715 715 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q62711 UniProtKB Binding site 716 716 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q62711 UniProtKB Modified residue 445 445 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22673903;Dbxref=PMID:22673903 Q62711 UniProtKB Modified residue 458 458 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:22673903;Dbxref=PMID:22673903 Q62711 UniProtKB Alternative sequence 424 487 . . . ID=VSP_028507;Note=In isoform 4. EQLRGKILVKGKKLRTIEVVESDKEEEELEKDEGSDLDPASAELDMQSQPESQEQASGNKSKNK->VMKCPMSCLLICVHVLAQAPNSIPESILLPKR;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q62711 UniProtKB Alternative sequence 487 487 . . . ID=VSP_028508;Note=In isoform 2. K->KVMKCPMSCLLICVHVLAQAPNSIPESILLP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8550568;Dbxref=PMID:8550568 Q62711 UniProtKB Alternative sequence 487 487 . . . ID=VSP_028509;Note=In isoform 3. K->KAPNSIPESILLP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:8550568;Dbxref=PMID:8550568 Q62711 UniProtKB Mutagenesis 36 36 . . . Note=Only retains weak enzyme activity and abolishes the ability of isoform 4 to act as a negative regulator. R->G;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9915823;Dbxref=PMID:9915823 Q62711 UniProtKB Mutagenesis 714 714 . . . Note=Abolishes affinity for POPC/POPS in the absence of Ca(2+)%3B when associated with E-718. K->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11706040;Dbxref=PMID:11706040 Q62711 UniProtKB Mutagenesis 717 717 . . . Note=Induces a larger Ca(2+)-dependence. S->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11706040;Dbxref=PMID:11706040 Q62711 UniProtKB Mutagenesis 718 718 . . . Note=Abolishes affinity for POPC/POPS in the absence of Ca(2+)%3B when associated with E-714. R->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:11706040;Dbxref=PMID:11706040 Q62711 UniProtKB Sequence conflict 395 395 . . . Note=M->ML;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q62711 UniProtKB Sequence conflict 416 416 . . . Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q62711 UniProtKB Sequence conflict 425 425 . . . Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q62711 UniProtKB Sequence conflict 757 757 . . . Note=I->H;Ontology_term=ECO:0000305;evidence=ECO:0000305