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Protein

Reticulocalbin-2

Gene

Rcn2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Not known. Binds calcium.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi77 – 88121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi113 – 124122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi165 – 176123; possibly ancestralPROSITE-ProRule annotationAdd
BLAST
Calcium bindingi202 – 213124PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi243 – 254125PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi279 – 290126PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulocalbin-2
Alternative name(s):
Calcium-binding protein ERC-55
Taipoxin-associated calcium-binding protein 49
Short name:
TCBP-49
Gene namesi
Name:Rcn2
Synonyms:Erc55
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi3548. Rcn2.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
  2. nucleolus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 25251 PublicationAdd
BLAST
Chaini26 – 320295Reticulocalbin-2PRO_0000004150Add
BLAST

Proteomic databases

PaxDbiQ62703.
PRIDEiQ62703.

PTM databases

PhosphoSiteiQ62703.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

GenevestigatoriQ62703.

Interactioni

Subunit structurei

Binds the snake venom phospholipase complex taipoxin.1 Publication

Protein-protein interaction databases

IntActiQ62703. 1 interaction.
STRINGi10116.ENSRNOP00000021817.

Structurei

3D structure databases

ProteinModelPortaliQ62703.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini64 – 9936EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini100 – 13536EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini150 – 18536EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini189 – 22436EF-hand 4PROSITE-ProRule annotationAdd
BLAST
Domaini230 – 26536EF-hand 5PROSITE-ProRule annotationAdd
BLAST
Domaini266 – 30136EF-hand 6PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi317 – 3204Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the CREC family.Curated
Contains 6 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG124414.
GeneTreeiENSGT00550000074546.
HOGENOMiHOG000230934.
HOVERGENiHBG002834.
InParanoidiQ62703.
OMAiRFEKANR.
OrthoDBiEOG73Z2TD.
PhylomeDBiQ62703.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13202. EF-hand_5. 1 hit.
PF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 5 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 5 hits.
PS50222. EF_HAND_2. 5 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62703-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLGPRPAVL GLLLLLLLYA AVAGASKAEE LHYPQGEHRA DYDRETLLGV
60 70 80 90 100
QEDVDEYVKL GHEEQQRRLQ SIIKKIDSDS DGFLTENELS QWIQMSFKHY
110 120 130 140 150
AMQEAKQQFV EYDKNSDGTV TWDEYNVQMY DRVIDFDENT ALDDTEEESF
160 170 180 190 200
RQLHLKDKKR FEKANQDSGP GLNLEEFIAF EHPEEVDYMT EFVIQEALEE
210 220 230 240 250
HDKNGDGFVS LEEFLGDYRR DPTANEDPEW ILVEKDRFVN DYDKDSDGRL
260 270 280 290 300
DPQELLSWVV PNNQGIAQEE ALHLIDEMDL NSDKKLSEEE ILENQDLFLT
310 320
SEATDYGRQL HDDYFYHDEL
Length:320
Mass (Da):37,433
Last modified:May 23, 2005 - v2
Checksum:i92CCA62B17E2D1BB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 182Missing in AAA80197 (PubMed:7722520).Curated
Sequence conflicti46 – 461T → A in AAA80197 (PubMed:7722520).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15734 mRNA. Translation: AAA80197.1.
BC061962 mRNA. Translation: AAH61962.1.
PIRiI56519.
RefSeqiNP_058828.2. NM_017132.2.
UniGeneiRn.6133.

Genome annotation databases

EnsembliENSRNOT00000021817; ENSRNOP00000021817; ENSRNOG00000015780.
GeneIDi29218.
KEGGirno:29218.
UCSCiRGD:3548. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15734 mRNA. Translation: AAA80197.1.
BC061962 mRNA. Translation: AAH61962.1.
PIRiI56519.
RefSeqiNP_058828.2. NM_017132.2.
UniGeneiRn.6133.

3D structure databases

ProteinModelPortaliQ62703.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ62703. 1 interaction.
STRINGi10116.ENSRNOP00000021817.

PTM databases

PhosphoSiteiQ62703.

Proteomic databases

PaxDbiQ62703.
PRIDEiQ62703.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021817; ENSRNOP00000021817; ENSRNOG00000015780.
GeneIDi29218.
KEGGirno:29218.
UCSCiRGD:3548. rat.

Organism-specific databases

CTDi5955.
RGDi3548. Rcn2.

Phylogenomic databases

eggNOGiNOG124414.
GeneTreeiENSGT00550000074546.
HOGENOMiHOG000230934.
HOVERGENiHBG002834.
InParanoidiQ62703.
OMAiRFEKANR.
OrthoDBiEOG73Z2TD.
PhylomeDBiQ62703.

Miscellaneous databases

NextBioi608405.
PROiQ62703.

Gene expression databases

GenevestigatoriQ62703.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13202. EF-hand_5. 1 hit.
PF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 5 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 5 hits.
PS50222. EF_HAND_2. 5 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Novel reticular calcium binding protein is purified on taipoxin columns."
    Dodds D., Schlimgen A.K., Lu S.Y., Perin M.S.
    J. Neurochem. 64:2339-2344(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 26-38 AND 130-154, SUBUNIT.
    Strain: Sprague-Dawley.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  3. Lubec G., Afjehi-Sadat L.
    Submitted (OCT-2006) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 133-151, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Spinal cord.

Entry informationi

Entry nameiRCN2_RAT
AccessioniPrimary (citable) accession number: Q62703
Secondary accession number(s): Q6P6X5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1997
Last sequence update: May 23, 2005
Last modified: March 3, 2015
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.