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Protein

Reticulocalbin-2

Gene

Rcn2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Not known. Binds calcium.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi77 – 881PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi113 – 1242PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi165 – 1763; possibly ancestralPROSITE-ProRule annotationAdd BLAST12
Calcium bindingi202 – 2134PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi243 – 2545PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi279 – 2906PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulocalbin-2
Alternative name(s):
Calcium-binding protein ERC-55
Taipoxin-associated calcium-binding protein 49
Short name:
TCBP-49
Gene namesi
Name:Rcn2
Synonyms:Erc55
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi3548. Rcn2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 251 PublicationAdd BLAST25
ChainiPRO_000000415026 – 320Reticulocalbin-2Add BLAST295

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei140PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ62703.
PRIDEiQ62703.

PTM databases

iPTMnetiQ62703.
PhosphoSitePlusiQ62703.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSRNOG00000015780.
GenevisibleiQ62703. RN.

Interactioni

Subunit structurei

Binds the snake venom phospholipase complex taipoxin.1 Publication

Protein-protein interaction databases

CORUMiQ62703.
IntActiQ62703. 1 interactor.
STRINGi10116.ENSRNOP00000021817.

Structurei

3D structure databases

ProteinModelPortaliQ62703.
SMRiQ62703.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 99EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini100 – 135EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini150 – 185EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini189 – 224EF-hand 4PROSITE-ProRule annotationAdd BLAST36
Domaini230 – 265EF-hand 5PROSITE-ProRule annotationAdd BLAST36
Domaini266 – 301EF-hand 6PROSITE-ProRule annotationAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi317 – 320Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the CREC family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG4223. Eukaryota.
ENOG410XRVE. LUCA.
GeneTreeiENSGT00550000074546.
HOGENOMiHOG000230934.
HOVERGENiHBG002834.
InParanoidiQ62703.
OMAiSWDEYNI.
OrthoDBiEOG091G0GUL.
PhylomeDBiQ62703.

Family and domain databases

InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
PfamiView protein in Pfam
PF13202. EF-hand_5. 4 hits.
SMARTiView protein in SMART
SM00054. EFh. 5 hits.
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 5 hits.
PS50222. EF_HAND_2. 5 hits.
PS00014. ER_TARGET. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62703-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLGPRPAVL GLLLLLLLYA AVAGASKAEE LHYPQGEHRA DYDRETLLGV
60 70 80 90 100
QEDVDEYVKL GHEEQQRRLQ SIIKKIDSDS DGFLTENELS QWIQMSFKHY
110 120 130 140 150
AMQEAKQQFV EYDKNSDGTV TWDEYNVQMY DRVIDFDENT ALDDTEEESF
160 170 180 190 200
RQLHLKDKKR FEKANQDSGP GLNLEEFIAF EHPEEVDYMT EFVIQEALEE
210 220 230 240 250
HDKNGDGFVS LEEFLGDYRR DPTANEDPEW ILVEKDRFVN DYDKDSDGRL
260 270 280 290 300
DPQELLSWVV PNNQGIAQEE ALHLIDEMDL NSDKKLSEEE ILENQDLFLT
310 320
SEATDYGRQL HDDYFYHDEL
Length:320
Mass (Da):37,433
Last modified:May 24, 2005 - v2
Checksum:i92CCA62B17E2D1BB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17 – 18Missing in AAA80197 (PubMed:7722520).Curated2
Sequence conflicti46T → A in AAA80197 (PubMed:7722520).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15734 mRNA. Translation: AAA80197.1.
BC061962 mRNA. Translation: AAH61962.1.
PIRiI56519.
RefSeqiNP_058828.2. NM_017132.2.
UniGeneiRn.6133.

Genome annotation databases

EnsembliENSRNOT00000021817; ENSRNOP00000021817; ENSRNOG00000015780.
GeneIDi29218.
KEGGirno:29218.
UCSCiRGD:3548. rat.

Similar proteinsi

Entry informationi

Entry nameiRCN2_RAT
AccessioniPrimary (citable) accession number: Q62703
Secondary accession number(s): Q6P6X5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 24, 2005
Last modified: September 27, 2017
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families