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Q62703

- RCN2_RAT

UniProt

Q62703 - RCN2_RAT

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Protein

Reticulocalbin-2

Gene

Rcn2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Not known. Binds calcium.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi77 – 88121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi113 – 124122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi165 – 176123; possibly ancestralPROSITE-ProRule annotationAdd
BLAST
Calcium bindingi202 – 213124PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi243 – 254125PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi279 – 290126PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulocalbin-2
Alternative name(s):
Calcium-binding protein ERC-55
Taipoxin-associated calcium-binding protein 49
Short name:
TCBP-49
Gene namesi
Name:Rcn2
Synonyms:Erc55
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 8

Organism-specific databases

RGDi3548. Rcn2.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. nucleolus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 25251 PublicationAdd
BLAST
Chaini26 – 320295Reticulocalbin-2PRO_0000004150Add
BLAST

Proteomic databases

PaxDbiQ62703.
PRIDEiQ62703.

PTM databases

PhosphoSiteiQ62703.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

GenevestigatoriQ62703.

Interactioni

Subunit structurei

Binds the snake venom phospholipase complex taipoxin.1 Publication

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021817.

Structurei

3D structure databases

ProteinModelPortaliQ62703.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini64 – 9936EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini100 – 13536EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini150 – 18536EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini189 – 22436EF-hand 4PROSITE-ProRule annotationAdd
BLAST
Domaini230 – 26536EF-hand 5PROSITE-ProRule annotationAdd
BLAST
Domaini266 – 30136EF-hand 6PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi317 – 3204Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the CREC family.Curated
Contains 6 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG124414.
GeneTreeiENSGT00550000074546.
HOGENOMiHOG000230934.
HOVERGENiHBG002834.
InParanoidiQ62703.
OMAiEDYFHDE.
OrthoDBiEOG73Z2TD.
PhylomeDBiQ62703.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13202. EF-hand_5. 1 hit.
PF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 5 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 5 hits.
PS50222. EF_HAND_2. 5 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62703-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLGPRPAVL GLLLLLLLYA AVAGASKAEE LHYPQGEHRA DYDRETLLGV
60 70 80 90 100
QEDVDEYVKL GHEEQQRRLQ SIIKKIDSDS DGFLTENELS QWIQMSFKHY
110 120 130 140 150
AMQEAKQQFV EYDKNSDGTV TWDEYNVQMY DRVIDFDENT ALDDTEEESF
160 170 180 190 200
RQLHLKDKKR FEKANQDSGP GLNLEEFIAF EHPEEVDYMT EFVIQEALEE
210 220 230 240 250
HDKNGDGFVS LEEFLGDYRR DPTANEDPEW ILVEKDRFVN DYDKDSDGRL
260 270 280 290 300
DPQELLSWVV PNNQGIAQEE ALHLIDEMDL NSDKKLSEEE ILENQDLFLT
310 320
SEATDYGRQL HDDYFYHDEL
Length:320
Mass (Da):37,433
Last modified:May 24, 2005 - v2
Checksum:i92CCA62B17E2D1BB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti17 – 182Missing in AAA80197. (PubMed:7722520)Curated
Sequence conflicti46 – 461T → A in AAA80197. (PubMed:7722520)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15734 mRNA. Translation: AAA80197.1.
BC061962 mRNA. Translation: AAH61962.1.
PIRiI56519.
RefSeqiNP_058828.2. NM_017132.2.
UniGeneiRn.6133.

Genome annotation databases

EnsembliENSRNOT00000021817; ENSRNOP00000021817; ENSRNOG00000015780.
GeneIDi29218.
KEGGirno:29218.
UCSCiRGD:3548. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15734 mRNA. Translation: AAA80197.1 .
BC061962 mRNA. Translation: AAH61962.1 .
PIRi I56519.
RefSeqi NP_058828.2. NM_017132.2.
UniGenei Rn.6133.

3D structure databases

ProteinModelPortali Q62703.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000021817.

PTM databases

PhosphoSitei Q62703.

Proteomic databases

PaxDbi Q62703.
PRIDEi Q62703.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000021817 ; ENSRNOP00000021817 ; ENSRNOG00000015780 .
GeneIDi 29218.
KEGGi rno:29218.
UCSCi RGD:3548. rat.

Organism-specific databases

CTDi 5955.
RGDi 3548. Rcn2.

Phylogenomic databases

eggNOGi NOG124414.
GeneTreei ENSGT00550000074546.
HOGENOMi HOG000230934.
HOVERGENi HBG002834.
InParanoidi Q62703.
OMAi EDYFHDE.
OrthoDBi EOG73Z2TD.
PhylomeDBi Q62703.

Miscellaneous databases

NextBioi 608405.
PROi Q62703.

Gene expression databases

Genevestigatori Q62703.

Family and domain databases

Gene3Di 1.10.238.10. 3 hits.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view ]
Pfami PF13202. EF-hand_5. 1 hit.
PF13499. EF-hand_7. 2 hits.
[Graphical view ]
SMARTi SM00054. EFh. 5 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 5 hits.
PS50222. EF_HAND_2. 5 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Novel reticular calcium binding protein is purified on taipoxin columns."
    Dodds D., Schlimgen A.K., Lu S.Y., Perin M.S.
    J. Neurochem. 64:2339-2344(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 26-38 AND 130-154, SUBUNIT.
    Strain: Sprague-Dawley.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  3. Lubec G., Afjehi-Sadat L.
    Submitted (NOV-2006) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 133-151, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Spinal cord.

Entry informationi

Entry nameiRCN2_RAT
AccessioniPrimary (citable) accession number: Q62703
Secondary accession number(s): Q6P6X5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 24, 2005
Last modified: October 29, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3