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Q62703 (RCN2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Reticulocalbin-2
Alternative name(s):
Calcium-binding protein ERC-55
Taipoxin-associated calcium-binding protein 49
Short name=TCBP-49
Gene names
Name:Rcn2
Synonyms:Erc55
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length320 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Not known. Binds calcium.

Subunit structure

Binds the snake venom phospholipase complex taipoxin. Ref.1

Subcellular location

Endoplasmic reticulum lumen.

Tissue specificity

Ubiquitous.

Sequence similarities

Belongs to the CREC family.

Contains 6 EF-hand domains.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
   DomainRepeat
Signal
   LigandCalcium
Metal-binding
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Ref.1
Chain26 – 320295Reticulocalbin-2
PRO_0000004150

Regions

Domain64 – 9936EF-hand 1
Domain100 – 13536EF-hand 2
Domain150 – 18536EF-hand 3
Domain189 – 22436EF-hand 4
Domain230 – 26536EF-hand 5
Domain266 – 30136EF-hand 6
Calcium binding77 – 88121 Potential
Calcium binding113 – 124122 Potential
Calcium binding165 – 176123; possibly ancestral Potential
Calcium binding202 – 213124 Potential
Calcium binding243 – 254125 Potential
Calcium binding279 – 290126 Potential
Motif317 – 3204Prevents secretion from ER Potential

Experimental info

Sequence conflict17 – 182Missing in AAA80197. Ref.1
Sequence conflict461T → A in AAA80197. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q62703 [UniParc].

Last modified May 24, 2005. Version 2.
Checksum: 92CCA62B17E2D1BB

FASTA32037,433
        10         20         30         40         50         60 
MRLGPRPAVL GLLLLLLLYA AVAGASKAEE LHYPQGEHRA DYDRETLLGV QEDVDEYVKL 

        70         80         90        100        110        120 
GHEEQQRRLQ SIIKKIDSDS DGFLTENELS QWIQMSFKHY AMQEAKQQFV EYDKNSDGTV 

       130        140        150        160        170        180 
TWDEYNVQMY DRVIDFDENT ALDDTEEESF RQLHLKDKKR FEKANQDSGP GLNLEEFIAF 

       190        200        210        220        230        240 
EHPEEVDYMT EFVIQEALEE HDKNGDGFVS LEEFLGDYRR DPTANEDPEW ILVEKDRFVN 

       250        260        270        280        290        300 
DYDKDSDGRL DPQELLSWVV PNNQGIAQEE ALHLIDEMDL NSDKKLSEEE ILENQDLFLT 

       310        320 
SEATDYGRQL HDDYFYHDEL 

« Hide

References

« Hide 'large scale' references
[1]"Novel reticular calcium binding protein is purified on taipoxin columns."
Dodds D., Schlimgen A.K., Lu S.Y., Perin M.S.
J. Neurochem. 64:2339-2344(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 26-38 AND 130-154, SUBUNIT.
Strain: Sprague-Dawley.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Prostate.
[3]Lubec G., Afjehi-Sadat L.
Submitted (NOV-2006) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 133-151, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: Sprague-Dawley.
Tissue: Spinal cord.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U15734 mRNA. Translation: AAA80197.1.
BC061962 mRNA. Translation: AAH61962.1.
PIRI56519.
RefSeqNP_058828.2. NM_017132.2.
UniGeneRn.6133.

3D structure databases

ProteinModelPortalQ62703.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000021817.

PTM databases

PhosphoSiteQ62703.

Proteomic databases

PaxDbQ62703.
PRIDEQ62703.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000021817; ENSRNOP00000021817; ENSRNOG00000015780.
GeneID29218.
KEGGrno:29218.
UCSCRGD:3548. rat.

Organism-specific databases

CTD5955.
RGD3548. Rcn2.

Phylogenomic databases

eggNOGNOG124414.
GeneTreeENSGT00550000074546.
HOGENOMHOG000230934.
HOVERGENHBG002834.
InParanoidQ62703.
OMAEDYFHDE.
OrthoDBEOG73Z2TD.
PhylomeDBQ62703.

Gene expression databases

ArrayExpressQ62703.
GenevestigatorQ62703.

Family and domain databases

Gene3D1.10.238.10. 3 hits.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamPF13202. EF-hand_5. 1 hit.
PF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTSM00054. EFh. 5 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 5 hits.
PS50222. EF_HAND_2. 5 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio608405.
PROQ62703.

Entry information

Entry nameRCN2_RAT
AccessionPrimary (citable) accession number: Q62703
Secondary accession number(s): Q6P6X5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 24, 2005
Last modified: May 14, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families