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Q62703

- RCN2_RAT

UniProt

Q62703 - RCN2_RAT

Protein

Reticulocalbin-2

Gene

Rcn2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (24 May 2005)
      Previous versions | rss
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    • Comment

    Functioni

    Not known. Binds calcium.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi77 – 88121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi113 – 124122PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi165 – 176123; possibly ancestralPROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi202 – 213124PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi243 – 254125PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi279 – 290126PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Reticulocalbin-2
    Alternative name(s):
    Calcium-binding protein ERC-55
    Taipoxin-associated calcium-binding protein 49
    Short name:
    TCBP-49
    Gene namesi
    Name:Rcn2
    Synonyms:Erc55
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 8

    Organism-specific databases

    RGDi3548. Rcn2.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 25251 PublicationAdd
    BLAST
    Chaini26 – 320295Reticulocalbin-2PRO_0000004150Add
    BLAST

    Proteomic databases

    PaxDbiQ62703.
    PRIDEiQ62703.

    PTM databases

    PhosphoSiteiQ62703.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    ArrayExpressiQ62703.
    GenevestigatoriQ62703.

    Interactioni

    Subunit structurei

    Binds the snake venom phospholipase complex taipoxin.1 Publication

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000021817.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62703.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini64 – 9936EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini100 – 13536EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini150 – 18536EF-hand 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini189 – 22436EF-hand 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini230 – 26536EF-hand 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini266 – 30136EF-hand 6PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi317 – 3204Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the CREC family.Curated
    Contains 6 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG124414.
    GeneTreeiENSGT00550000074546.
    HOGENOMiHOG000230934.
    HOVERGENiHBG002834.
    InParanoidiQ62703.
    OMAiEDYFHDE.
    OrthoDBiEOG73Z2TD.
    PhylomeDBiQ62703.

    Family and domain databases

    Gene3Di1.10.238.10. 3 hits.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view]
    PfamiPF13202. EF-hand_5. 1 hit.
    PF13499. EF-hand_7. 2 hits.
    [Graphical view]
    SMARTiSM00054. EFh. 5 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 5 hits.
    PS50222. EF_HAND_2. 5 hits.
    PS00014. ER_TARGET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q62703-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLGPRPAVL GLLLLLLLYA AVAGASKAEE LHYPQGEHRA DYDRETLLGV    50
    QEDVDEYVKL GHEEQQRRLQ SIIKKIDSDS DGFLTENELS QWIQMSFKHY 100
    AMQEAKQQFV EYDKNSDGTV TWDEYNVQMY DRVIDFDENT ALDDTEEESF 150
    RQLHLKDKKR FEKANQDSGP GLNLEEFIAF EHPEEVDYMT EFVIQEALEE 200
    HDKNGDGFVS LEEFLGDYRR DPTANEDPEW ILVEKDRFVN DYDKDSDGRL 250
    DPQELLSWVV PNNQGIAQEE ALHLIDEMDL NSDKKLSEEE ILENQDLFLT 300
    SEATDYGRQL HDDYFYHDEL 320
    Length:320
    Mass (Da):37,433
    Last modified:May 24, 2005 - v2
    Checksum:i92CCA62B17E2D1BB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti17 – 182Missing in AAA80197. (PubMed:7722520)Curated
    Sequence conflicti46 – 461T → A in AAA80197. (PubMed:7722520)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15734 mRNA. Translation: AAA80197.1.
    BC061962 mRNA. Translation: AAH61962.1.
    PIRiI56519.
    RefSeqiNP_058828.2. NM_017132.2.
    UniGeneiRn.6133.

    Genome annotation databases

    EnsembliENSRNOT00000021817; ENSRNOP00000021817; ENSRNOG00000015780.
    GeneIDi29218.
    KEGGirno:29218.
    UCSCiRGD:3548. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U15734 mRNA. Translation: AAA80197.1 .
    BC061962 mRNA. Translation: AAH61962.1 .
    PIRi I56519.
    RefSeqi NP_058828.2. NM_017132.2.
    UniGenei Rn.6133.

    3D structure databases

    ProteinModelPortali Q62703.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000021817.

    PTM databases

    PhosphoSitei Q62703.

    Proteomic databases

    PaxDbi Q62703.
    PRIDEi Q62703.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000021817 ; ENSRNOP00000021817 ; ENSRNOG00000015780 .
    GeneIDi 29218.
    KEGGi rno:29218.
    UCSCi RGD:3548. rat.

    Organism-specific databases

    CTDi 5955.
    RGDi 3548. Rcn2.

    Phylogenomic databases

    eggNOGi NOG124414.
    GeneTreei ENSGT00550000074546.
    HOGENOMi HOG000230934.
    HOVERGENi HBG002834.
    InParanoidi Q62703.
    OMAi EDYFHDE.
    OrthoDBi EOG73Z2TD.
    PhylomeDBi Q62703.

    Miscellaneous databases

    NextBioi 608405.
    PROi Q62703.

    Gene expression databases

    ArrayExpressi Q62703.
    Genevestigatori Q62703.

    Family and domain databases

    Gene3Di 1.10.238.10. 3 hits.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view ]
    Pfami PF13202. EF-hand_5. 1 hit.
    PF13499. EF-hand_7. 2 hits.
    [Graphical view ]
    SMARTi SM00054. EFh. 5 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 5 hits.
    PS50222. EF_HAND_2. 5 hits.
    PS00014. ER_TARGET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel reticular calcium binding protein is purified on taipoxin columns."
      Dodds D., Schlimgen A.K., Lu S.Y., Perin M.S.
      J. Neurochem. 64:2339-2344(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 26-38 AND 130-154, SUBUNIT.
      Strain: Sprague-Dawley.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.
    3. Lubec G., Afjehi-Sadat L.
      Submitted (NOV-2006) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 133-151, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Sprague-Dawley.
      Tissue: Spinal cord.

    Entry informationi

    Entry nameiRCN2_RAT
    AccessioniPrimary (citable) accession number: Q62703
    Secondary accession number(s): Q6P6X5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3