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Q626I0

- FLAD1_CAEBR

UniProt

Q626I0 - FLAD1_CAEBR

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Protein

Probable FAD synthase

Gene
CBG00973
Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme By similarity.

Catalytic activityi

ATP + FMN = diphosphate + FAD.

Cofactori

Magnesium By similarity.

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. FMN adenylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. FAD biosynthetic process Source: UniProtKB-UniPathway
  2. Mo-molybdopterin cofactor biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

ATP-binding, FAD, Flavoprotein, FMN, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00277; UER00407.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable FAD synthase (EC:2.7.7.2)
Alternative name(s):
FAD pyrophosphorylase
FMN adenylyltransferase
Flavin adenine dinucleotide synthase
Including the following 2 domains:
Molybdenum cofactor biosynthesis protein-like region
FAD synthase region
Gene namesi
ORF Names:CBG00973
OrganismiCaenorhabditis briggsae
Taxonomic identifieri6238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000008549: Chromosome II, UP000008549: Unassembled WGS sequence

Organism-specific databases

WormBaseiCBG00973; CBP00276; WBGene00024275.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 523523Probable FAD synthasePRO_0000302742Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi6238.CBG00973.

Structurei

3D structure databases

ProteinModelPortaliQ626I0.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni20 – 11192Molybdenum cofactor biosynthesis protein-likeAdd
BLAST
Regioni332 – 489158FAD synthaseAdd
BLAST

Domaini

The molybdenum cofactor biosynthesis protein-like region may not be functional.

Sequence similaritiesi

In the N-terminal section; belongs to the MoaB/Mog family.
In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.

Phylogenomic databases

eggNOGiCOG0175.
HOGENOMiHOG000007185.
KOiK00953.
OMAiSFMRINP.
OrthoDBiEOG7C5M9F.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.40.980.10. 1 hit.
InterProiIPR012183. FAD_synth_Mopterin-bd.
IPR001453. Mopterin-bd_dom.
IPR002500. PAPS_reduct.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00994. MoCF_biosynth. 1 hit.
PF01507. PAPS_reduct. 2 hits.
[Graphical view]
PIRSFiPIRSF036620. MPTbdFAD. 1 hit.
SMARTiSM00852. MoCF_biosynth. 1 hit.
[Graphical view]
SUPFAMiSSF53218. SSF53218. 2 hits.

Sequencei

Sequence statusi: Complete.

Q626I0-1 [UniParc]FASTAAdd to Basket

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MRAIFRATKR MPPGQRKTAA IVVIGDEILK GTTRDTNSHF LCKRLHKLGV    50
NIKKIAVVGD EISEISREVQ SASSAYDYVI TSGGVGPTHD DKTYLGLAHA 100
FTDQLHFSDE IRQAVNRFLP TYIDKKKSEG VEEGIEEVVR VVTEKLCTIP 150
KMSQLLWGTQ KVDGRVSTFP VVRVANVVAL PGVPKFCERA FDELQDQLFP 200
VEERQSMFFD TIYTDLDEFD FSRRLADVAA RFEEQNVQIG SYPELKNKFF 250
KTKLTIETES SESMEAVRIA LKELLVGHIV YYDSHAWTDT VAKWRAFKKR 300
ELVEAKNVDF VRKLEEAEKI VEDIVERYPL DQIALSFNGG KDCTVLLHLL 350
RLKVDEKYGA SKAIQGFHIM VEDQFPEATQ FIIDAAQFYN IQVLEFPGPL 400
KIGLAGLKKQ RPSIIPVLMG SRATDPNGKY MKTPVEWTDS DWPKVLRVCP 450
ILNWTYSDVW HMLRGLCVPY CKLYDQGYTS LGGRDNTVKH PALRIVASDG 500
KEHYLPAYKL HNDAEERSNR SNL 523
Length:523
Mass (Da):59,503
Last modified:November 23, 2004 - v1
Checksum:i5025F6031432F6A1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE600951 Genomic DNA. Translation: CAP22279.1.
RefSeqiXP_002629740.1. XM_002629694.1.

Genome annotation databases

EnsemblMetazoaiCBG00973; CBG00973; CBG00973.
GeneIDi8573234.
KEGGicbr:CBG00973.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
HE600951 Genomic DNA. Translation: CAP22279.1 .
RefSeqi XP_002629740.1. XM_002629694.1.

3D structure databases

ProteinModelPortali Q626I0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 6238.CBG00973.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai CBG00973 ; CBG00973 ; CBG00973 .
GeneIDi 8573234.
KEGGi cbr:CBG00973.

Organism-specific databases

CTDi 8573234.
WormBasei CBG00973 ; CBP00276 ; WBGene00024275 .

Phylogenomic databases

eggNOGi COG0175.
HOGENOMi HOG000007185.
KOi K00953.
OMAi SFMRINP.
OrthoDBi EOG7C5M9F.

Enzyme and pathway databases

UniPathwayi UPA00277 ; UER00407 .

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.40.980.10. 1 hit.
InterProi IPR012183. FAD_synth_Mopterin-bd.
IPR001453. Mopterin-bd_dom.
IPR002500. PAPS_reduct.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00994. MoCF_biosynth. 1 hit.
PF01507. PAPS_reduct. 2 hits.
[Graphical view ]
PIRSFi PIRSF036620. MPTbdFAD. 1 hit.
SMARTi SM00852. MoCF_biosynth. 1 hit.
[Graphical view ]
SUPFAMi SSF53218. SSF53218. 2 hits.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AF16.

Entry informationi

Entry nameiFLAD1_CAEBR
AccessioniPrimary (citable) accession number: Q626I0
Secondary accession number(s): A8WP73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 23, 2004
Last modified: January 22, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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