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Q626I0

- FLAD1_CAEBR

UniProt

Q626I0 - FLAD1_CAEBR

Protein

Probable FAD synthase

Gene

CBG00973

Organism
Caenorhabditis briggsae
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.By similarity

    Catalytic activityi

    ATP + FMN = diphosphate + FAD.

    Cofactori

    Magnesium.By similarity

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. FMN adenylyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. FAD biosynthetic process Source: UniProtKB-UniPathway
    2. Mo-molybdopterin cofactor biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    ATP-binding, FAD, Flavoprotein, FMN, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00277; UER00407.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable FAD synthase (EC:2.7.7.2)
    Alternative name(s):
    FAD pyrophosphorylase
    FMN adenylyltransferase
    Flavin adenine dinucleotide synthase
    Including the following 2 domains:
    Molybdenum cofactor biosynthesis protein-like region
    FAD synthase region
    Gene namesi
    ORF Names:CBG00973
    OrganismiCaenorhabditis briggsae
    Taxonomic identifieri6238 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
    ProteomesiUP000008549: Chromosome II, UP000008549: Unassembled WGS sequence

    Organism-specific databases

    WormBaseiCBG00973; CBP00276; WBGene00024275.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 523523Probable FAD synthasePRO_0000302742Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi6238.CBG00973.

    Structurei

    3D structure databases

    ProteinModelPortaliQ626I0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni20 – 11192Molybdenum cofactor biosynthesis protein-likeAdd
    BLAST
    Regioni332 – 489158FAD synthaseAdd
    BLAST

    Domaini

    The molybdenum cofactor biosynthesis protein-like region may not be functional.

    Sequence similaritiesi

    In the N-terminal section; belongs to the MoaB/Mog family.Curated
    In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0175.
    HOGENOMiHOG000007185.
    KOiK00953.
    OMAiSFMRINP.
    OrthoDBiEOG7C5M9F.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.40.980.10. 1 hit.
    InterProiIPR012183. FAD_synth_Mopterin-bd.
    IPR001453. Mopterin-bd_dom.
    IPR002500. PAPS_reduct.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00994. MoCF_biosynth. 1 hit.
    PF01507. PAPS_reduct. 2 hits.
    [Graphical view]
    PIRSFiPIRSF036620. MPTbdFAD. 1 hit.
    SMARTiSM00852. MoCF_biosynth. 1 hit.
    [Graphical view]
    SUPFAMiSSF53218. SSF53218. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q626I0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRAIFRATKR MPPGQRKTAA IVVIGDEILK GTTRDTNSHF LCKRLHKLGV    50
    NIKKIAVVGD EISEISREVQ SASSAYDYVI TSGGVGPTHD DKTYLGLAHA 100
    FTDQLHFSDE IRQAVNRFLP TYIDKKKSEG VEEGIEEVVR VVTEKLCTIP 150
    KMSQLLWGTQ KVDGRVSTFP VVRVANVVAL PGVPKFCERA FDELQDQLFP 200
    VEERQSMFFD TIYTDLDEFD FSRRLADVAA RFEEQNVQIG SYPELKNKFF 250
    KTKLTIETES SESMEAVRIA LKELLVGHIV YYDSHAWTDT VAKWRAFKKR 300
    ELVEAKNVDF VRKLEEAEKI VEDIVERYPL DQIALSFNGG KDCTVLLHLL 350
    RLKVDEKYGA SKAIQGFHIM VEDQFPEATQ FIIDAAQFYN IQVLEFPGPL 400
    KIGLAGLKKQ RPSIIPVLMG SRATDPNGKY MKTPVEWTDS DWPKVLRVCP 450
    ILNWTYSDVW HMLRGLCVPY CKLYDQGYTS LGGRDNTVKH PALRIVASDG 500
    KEHYLPAYKL HNDAEERSNR SNL 523
    Length:523
    Mass (Da):59,503
    Last modified:November 23, 2004 - v1
    Checksum:i5025F6031432F6A1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE600951 Genomic DNA. Translation: CAP22279.1.
    RefSeqiXP_002629740.1. XM_002629694.1.

    Genome annotation databases

    EnsemblMetazoaiCBG00973; CBG00973; CBG00973.
    GeneIDi8573234.
    KEGGicbr:CBG00973.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HE600951 Genomic DNA. Translation: CAP22279.1 .
    RefSeqi XP_002629740.1. XM_002629694.1.

    3D structure databases

    ProteinModelPortali Q626I0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 6238.CBG00973.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai CBG00973 ; CBG00973 ; CBG00973 .
    GeneIDi 8573234.
    KEGGi cbr:CBG00973.

    Organism-specific databases

    CTDi 8573234.
    WormBasei CBG00973 ; CBP00276 ; WBGene00024275 .

    Phylogenomic databases

    eggNOGi COG0175.
    HOGENOMi HOG000007185.
    KOi K00953.
    OMAi SFMRINP.
    OrthoDBi EOG7C5M9F.

    Enzyme and pathway databases

    UniPathwayi UPA00277 ; UER00407 .

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.40.980.10. 1 hit.
    InterProi IPR012183. FAD_synth_Mopterin-bd.
    IPR001453. Mopterin-bd_dom.
    IPR002500. PAPS_reduct.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00994. MoCF_biosynth. 1 hit.
    PF01507. PAPS_reduct. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF036620. MPTbdFAD. 1 hit.
    SMARTi SM00852. MoCF_biosynth. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53218. SSF53218. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AF16.

    Entry informationi

    Entry nameiFLAD1_CAEBR
    AccessioniPrimary (citable) accession number: Q626I0
    Secondary accession number(s): A8WP73
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programCaenorhabditis annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3