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Q626I0 (FLAD1_CAEBR) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable FAD synthase

EC=2.7.7.2
Alternative name(s):
FAD pyrophosphorylase
FMN adenylyltransferase
Flavin adenine dinucleotide synthase

Including the following 2 domains:

  1. Molybdenum cofactor biosynthesis protein-like region
  2. FAD synthase region
Gene names
ORF Names:CBG00973
OrganismCaenorhabditis briggsae [Reference proteome]
Taxonomic identifier6238 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length523 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme By similarity.

Catalytic activity

ATP + FMN = diphosphate + FAD.

Cofactor

Magnesium By similarity.

Pathway

Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.

Domain

The molybdenum cofactor biosynthesis protein-like region may not be functional.

Sequence similarities

In the N-terminal section; belongs to the MoaB/Mog family.

In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 523523Probable FAD synthase
PRO_0000302742

Regions

Region20 – 11192Molybdenum cofactor biosynthesis protein-like
Region332 – 489158FAD synthase

Sequences

Sequence LengthMass (Da)Tools
Q626I0 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 5025F6031432F6A1

FASTA52359,503
        10         20         30         40         50         60 
MRAIFRATKR MPPGQRKTAA IVVIGDEILK GTTRDTNSHF LCKRLHKLGV NIKKIAVVGD 

        70         80         90        100        110        120 
EISEISREVQ SASSAYDYVI TSGGVGPTHD DKTYLGLAHA FTDQLHFSDE IRQAVNRFLP 

       130        140        150        160        170        180 
TYIDKKKSEG VEEGIEEVVR VVTEKLCTIP KMSQLLWGTQ KVDGRVSTFP VVRVANVVAL 

       190        200        210        220        230        240 
PGVPKFCERA FDELQDQLFP VEERQSMFFD TIYTDLDEFD FSRRLADVAA RFEEQNVQIG 

       250        260        270        280        290        300 
SYPELKNKFF KTKLTIETES SESMEAVRIA LKELLVGHIV YYDSHAWTDT VAKWRAFKKR 

       310        320        330        340        350        360 
ELVEAKNVDF VRKLEEAEKI VEDIVERYPL DQIALSFNGG KDCTVLLHLL RLKVDEKYGA 

       370        380        390        400        410        420 
SKAIQGFHIM VEDQFPEATQ FIIDAAQFYN IQVLEFPGPL KIGLAGLKKQ RPSIIPVLMG 

       430        440        450        460        470        480 
SRATDPNGKY MKTPVEWTDS DWPKVLRVCP ILNWTYSDVW HMLRGLCVPY CKLYDQGYTS 

       490        500        510        520 
LGGRDNTVKH PALRIVASDG KEHYLPAYKL HNDAEERSNR SNL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HE600951 Genomic DNA. Translation: CAP22279.1.
RefSeqXP_002629740.1. XM_002629694.1.

3D structure databases

ProteinModelPortalQ626I0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING6238.CBG00973.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaCBG00973; CBG00973; CBG00973.
GeneID8573234.
KEGGcbr:CBG00973.

Organism-specific databases

CTD8573234.
WormBaseCBG00973; CBP00276; WBGene00024275.

Phylogenomic databases

eggNOGCOG0175.
HOGENOMHOG000007185.
KOK00953.
OMASFMRINP.
OrthoDBEOG7C5M9F.

Enzyme and pathway databases

UniPathwayUPA00277; UER00407.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
3.40.980.10. 1 hit.
InterProIPR012183. FAD_synth_Mopterin-bd.
IPR001453. Mopterin-bd_dom.
IPR002500. PAPS_reduct.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamPF00994. MoCF_biosynth. 1 hit.
PF01507. PAPS_reduct. 2 hits.
[Graphical view]
PIRSFPIRSF036620. MPTbdFAD. 1 hit.
SMARTSM00852. MoCF_biosynth. 1 hit.
[Graphical view]
SUPFAMSSF53218. SSF53218. 2 hits.
ProtoNetSearch...

Entry information

Entry nameFLAD1_CAEBR
AccessionPrimary (citable) accession number: Q626I0
Secondary accession number(s): A8WP73
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 23, 2004
Last modified: January 22, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways