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Protein

Cytoplasmic dynein 1 light intermediate chain 2

Gene

Dync1li2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi61 – 688ATPSequence analysis

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • microtubule motor activity Source: RGD

GO - Biological processi

  • centrosome localization Source: Ensembl
  • microtubule-based movement Source: RGD
  • microtubule cytoskeleton organization Source: Ensembl
  • retrograde axonal transport Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-2132295. MHC class II antigen presentation.
R-RNO-6807878. COPI-mediated anterograde transport.
R-RNO-6811436. COPI-independent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoplasmic dynein 1 light intermediate chain 2
Alternative name(s):
Dynein light intermediate chain 2, cytosolic
Short name:
LIC-2
LIC53/55
Gene namesi
Name:Dync1li2
Synonyms:Dncli2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi621130. Dync1li2.

Subcellular locationi

GO - Cellular componenti

  • axon cytoplasm Source: GOC
  • centrosome Source: Ensembl
  • cytoplasmic dynein complex Source: RGD
  • membrane Source: Ensembl
  • microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Cytoplasmic dynein 1 light intermediate chain 2PRO_0000114674Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei194 – 1941PhosphoserineCombined sources
Modified residuei369 – 3691PhosphoserineBy similarity
Modified residuei377 – 3771PhosphoserineBy similarity
Modified residuei380 – 3801PhosphothreonineBy similarity
Modified residuei391 – 3911PhosphoserineBy similarity
Modified residuei393 – 3931PhosphoserineBy similarity
Modified residuei427 – 4271PhosphothreonineBy similarity
Modified residuei429 – 4291PhosphoserineBy similarity
Modified residuei432 – 4321PhosphoserineBy similarity
Modified residuei445 – 4451PhosphoserineBy similarity
Modified residuei491 – 4911PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ62698.
PRIDEiQ62698.

PTM databases

iPTMnetiQ62698.
PhosphoSiteiQ62698.
SwissPalmiQ62698.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

ExpressionAtlasiQ62698. baseline and differential.
GenevisibleiQ62698. RN.

Interactioni

Subunit structurei

Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Self-associates. Interacts with DYNC1H1; DYNC1LI1 and DYNC1LI2 bind mutually exclusive to DYNC1H1.By similarity1 Publication

Protein-protein interaction databases

IntActiQ62698. 1 interaction.
MINTiMINT-241863.
STRINGi10116.ENSRNOP00000029646.

Structurei

3D structure databases

ProteinModelPortaliQ62698.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3905. Eukaryota.
ENOG410XQS4. LUCA.
GeneTreeiENSGT00390000008295.
HOGENOMiHOG000236263.
HOVERGENiHBG005546.
InParanoidiQ62698.
KOiK10416.
OMAiKKPDPNM.
OrthoDBiEOG7V7668.
PhylomeDBiQ62698.
TreeFamiTF352602.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR008467. Dynein1_light_intermed_chain.
IPR022780. Dynein_light_int_chain.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR12688. PTHR12688. 2 hits.
PfamiPF05783. DLIC. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

Q62698-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPVGVEKKL LLGPNGPAVA AAGDLTSEEE EGQSLWSSIL SEVSTRARSK
60 70 80 90 100
LPSGKNILVF GEDGSGKTTL MTKLQGAEHG KKGRGLEYLY LSVHDEDRDD
110 120 130 140 150
HTRCNVWILD GDLYHKGLLK FAVSAESLRE TLVIFVADMS RPWTIMESLQ
160 170 180 190 200
KWASVLREHI DKMKIPPEEM RDLERKFMKD FQDYIEPEEG CQGSPQRRGP
210 220 230 240 250
LTSGSDEDNV ALPLGDNVLT HNLGIPVLVV CTKCDAVSIL EKEHDYRDEH
260 270 280 290 300
LDFIQAHLRG FCLQYGAALI YTSVKEEKNL DLLYKYIVHK TYGFHFTIPA
310 320 330 340 350
LVVEKDAVFI PAGWDNEKKI AILHENFTTV KPEDAYEDFI VKPPVRKLVH
360 370 380 390 400
DKELAAEDEQ VFLMKQQESP ARGPSGSPRT QGRGGPASVP SASPGTSVKK
410 420 430 440 450
PDPNIKNNAA SEGVLASFFN SLLSKKTGSP GSPSAGGVQS TAKKSGTEGE
460 470 480 490
PQSFRSLTEQ CCQTGQKTVL SNVQEELDRM TRKPDSMVTN SSTENEA
Length:497
Mass (Da):54,745
Last modified:November 1, 1997 - v1
Checksum:iD4E2715880E194B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15138 mRNA. Translation: AAA80334.1.
PIRiI55514.
RefSeqiNP_112288.1. NM_031026.1.
UniGeneiRn.31981.

Genome annotation databases

EnsembliENSRNOT00000034472; ENSRNOP00000029646; ENSRNOG00000025791.
GeneIDi81655.
KEGGirno:81655.
UCSCiRGD:621130. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15138 mRNA. Translation: AAA80334.1.
PIRiI55514.
RefSeqiNP_112288.1. NM_031026.1.
UniGeneiRn.31981.

3D structure databases

ProteinModelPortaliQ62698.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ62698. 1 interaction.
MINTiMINT-241863.
STRINGi10116.ENSRNOP00000029646.

PTM databases

iPTMnetiQ62698.
PhosphoSiteiQ62698.
SwissPalmiQ62698.

Proteomic databases

PaxDbiQ62698.
PRIDEiQ62698.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000034472; ENSRNOP00000029646; ENSRNOG00000025791.
GeneIDi81655.
KEGGirno:81655.
UCSCiRGD:621130. rat.

Organism-specific databases

CTDi1783.
RGDi621130. Dync1li2.

Phylogenomic databases

eggNOGiKOG3905. Eukaryota.
ENOG410XQS4. LUCA.
GeneTreeiENSGT00390000008295.
HOGENOMiHOG000236263.
HOVERGENiHBG005546.
InParanoidiQ62698.
KOiK10416.
OMAiKKPDPNM.
OrthoDBiEOG7V7668.
PhylomeDBiQ62698.
TreeFamiTF352602.

Enzyme and pathway databases

ReactomeiR-RNO-2132295. MHC class II antigen presentation.
R-RNO-6807878. COPI-mediated anterograde transport.
R-RNO-6811436. COPI-independent Golgi-to-ER retrograde traffic.

Miscellaneous databases

PROiQ62698.

Gene expression databases

ExpressionAtlasiQ62698. baseline and differential.
GenevisibleiQ62698. RN.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR008467. Dynein1_light_intermed_chain.
IPR022780. Dynein_light_int_chain.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR12688. PTHR12688. 2 hits.
PfamiPF05783. DLIC. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular analysis of a cytoplasmic dynein light intermediate chain reveals homology to a family of ATPases."
    Hughes S.M., Vaughan K.T., Herskovits J.S., Vallee R.B.
    J. Cell Sci. 108:17-24(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Light intermediate chain 1 defines a functional subfraction of cytoplasmic dynein which binds to pericentrin."
    Tynan S.H., Purohit A., Doxsey S.J., Vallee R.B.
    J. Biol. Chem. 275:32763-32768(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-194, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDC1L2_RAT
AccessioniPrimary (citable) accession number: Q62698
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 6, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.