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Protein

Cytoplasmic dynein 1 light intermediate chain 2

Gene

Dync1li2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi61 – 68ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMotor protein
Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-RNO-2132295 MHC class II antigen presentation
R-RNO-2467813 Separation of Sister Chromatids
R-RNO-2500257 Resolution of Sister Chromatid Cohesion
R-RNO-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-RNO-5663220 RHO GTPases Activate Formins
R-RNO-6807878 COPI-mediated anterograde transport
R-RNO-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-RNO-68877 Mitotic Prometaphase

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoplasmic dynein 1 light intermediate chain 2
Alternative name(s):
Dynein light intermediate chain 2, cytosolic
Short name:
LIC-2
LIC53/55
Gene namesi
Name:Dync1li2
Synonyms:Dncli2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi621130 Dync1li2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001146741 – 497Cytoplasmic dynein 1 light intermediate chain 2Add BLAST497

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei194PhosphoserineCombined sources1
Modified residuei369PhosphoserineBy similarity1
Modified residuei377PhosphoserineBy similarity1
Modified residuei383Omega-N-methylarginineBy similarity1
Modified residuei427PhosphothreonineBy similarity1
Modified residuei429PhosphoserineBy similarity1
Modified residuei432PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ62698
PRIDEiQ62698

PTM databases

iPTMnetiQ62698
PhosphoSitePlusiQ62698
SwissPalmiQ62698

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSRNOG00000025791
ExpressionAtlasiQ62698 baseline and differential
GenevisibleiQ62698 RN

Interactioni

Subunit structurei

Homodimer (By similarity). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Self-associates. Interacts with DYNC1H1; DYNC1LI1 and DYNC1LI2 bind mutually exclusive to DYNC1H1.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi249555, 1 interactor
IntActiQ62698, 1 interactor
STRINGi10116.ENSRNOP00000029646

Structurei

3D structure databases

ProteinModelPortaliQ62698
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3905 Eukaryota
ENOG410XQS4 LUCA
GeneTreeiENSGT00390000008295
HOGENOMiHOG000236263
HOVERGENiHBG005546
InParanoidiQ62698
KOiK10416
OMAiFQDYIEP
OrthoDBiEOG091G0B3J
PhylomeDBiQ62698
TreeFamiTF352602

Family and domain databases

InterProiView protein in InterPro
IPR008467 Dynein1_light_intermed_chain
IPR022780 Dynein_light_int_chain
IPR027417 P-loop_NTPase
PANTHERiPTHR12688 PTHR12688, 1 hit
PfamiView protein in Pfam
PF05783 DLIC, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits

Sequencei

Sequence statusi: Complete.

Q62698-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPVGVEKKL LLGPNGPAVA AAGDLTSEEE EGQSLWSSIL SEVSTRARSK
60 70 80 90 100
LPSGKNILVF GEDGSGKTTL MTKLQGAEHG KKGRGLEYLY LSVHDEDRDD
110 120 130 140 150
HTRCNVWILD GDLYHKGLLK FAVSAESLRE TLVIFVADMS RPWTIMESLQ
160 170 180 190 200
KWASVLREHI DKMKIPPEEM RDLERKFMKD FQDYIEPEEG CQGSPQRRGP
210 220 230 240 250
LTSGSDEDNV ALPLGDNVLT HNLGIPVLVV CTKCDAVSIL EKEHDYRDEH
260 270 280 290 300
LDFIQAHLRG FCLQYGAALI YTSVKEEKNL DLLYKYIVHK TYGFHFTIPA
310 320 330 340 350
LVVEKDAVFI PAGWDNEKKI AILHENFTTV KPEDAYEDFI VKPPVRKLVH
360 370 380 390 400
DKELAAEDEQ VFLMKQQESP ARGPSGSPRT QGRGGPASVP SASPGTSVKK
410 420 430 440 450
PDPNIKNNAA SEGVLASFFN SLLSKKTGSP GSPSAGGVQS TAKKSGTEGE
460 470 480 490
PQSFRSLTEQ CCQTGQKTVL SNVQEELDRM TRKPDSMVTN SSTENEA
Length:497
Mass (Da):54,745
Last modified:November 1, 1997 - v1
Checksum:iD4E2715880E194B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15138 mRNA Translation: AAA80334.1
PIRiI55514
RefSeqiNP_112288.1, NM_031026.1
UniGeneiRn.31981
Rn.46267

Genome annotation databases

EnsembliENSRNOT00000034472; ENSRNOP00000029646; ENSRNOG00000025791
GeneIDi81655
KEGGirno:81655
UCSCiRGD:621130 rat

Similar proteinsi

Entry informationi

Entry nameiDC1L2_RAT
AccessioniPrimary (citable) accession number: Q62698
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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