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Q62687 (S6A18_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Sodium-dependent neutral amino acid transporter B(0)AT3
Alternative name(s):
Renal osmotic stress-induced Na-Cl organic solute cotransporter
Short name=ROSIT
Sodium- and chloride-dependent transporter XTRP2
Solute carrier family 6 member 18
System B(0) neutral amino acid transporter AT3
Gene names
Name:Slc6a18
Synonyms:Xtrp2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length615 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Functions as a sodium and chloride-dependent neutral amino acid transporter By similarity.

Subunit structure

Associates with TMEM27 By similarity. TMEM27 association is required for functional expression in kidney By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Probable.

Tissue specificity

Expressed in renal cortex but not in brain, heart, colon, liver, stomach, or skeletal muscle. Ref.1

Induction

By renal osmotic stress. Ref.1

Sequence similarities

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A18 subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 615615Sodium-dependent neutral amino acid transporter B(0)AT3
PRO_0000214808

Regions

Topological domain1 – 2626Cytoplasmic Potential
Transmembrane27 – 4721Helical; Name=1; Potential
Topological domain48 – 525Extracellular Potential
Transmembrane53 – 7321Helical; Name=2; Potential
Topological domain74 – 10532Cytoplasmic Potential
Transmembrane106 – 12621Helical; Name=3; Potential
Topological domain127 – 17751Extracellular Potential
Transmembrane178 – 19821Helical; Name=4; Potential
Topological domain199 – 2068Cytoplasmic Potential
Transmembrane207 – 22721Helical; Name=5; Potential
Topological domain228 – 25528Extracellular Potential
Transmembrane256 – 27621Helical; Name=6; Potential
Topological domain277 – 29014Cytoplasmic Potential
Transmembrane291 – 31121Helical; Name=7; Potential
Topological domain312 – 39786Extracellular Potential
Transmembrane398 – 41821Helical; Name=8; Potential
Topological domain419 – 44224Cytoplasmic Potential
Transmembrane443 – 46321Helical; Name=9; Potential
Topological domain464 – 4729Extracellular Potential
Transmembrane473 – 49321Helical; Name=10; Potential
Topological domain494 – 52027Cytoplasmic Potential
Transmembrane521 – 54121Helical; Name=11; Potential
Topological domain542 – 57130Extracellular Potential
Transmembrane572 – 59221Helical; Name=12; Potential
Topological domain593 – 61523Cytoplasmic Potential

Amino acid modifications

Glycosylation1431N-linked (GlcNAc...) Potential
Glycosylation1671N-linked (GlcNAc...) Potential
Glycosylation3531N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q62687 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: F41E7DE1DC276918

FASTA61569,556
        10         20         30         40         50         60 
MAQASGMDPL VDIEDERPKW DNKLQYLLSC IGFAVGLGNI WRFPYLCHTH GGGAFLIPYF 

        70         80         90        100        110        120 
IALVFEGIPL FYIELAIGQR LRRGSIGVWK TISPYLGGVG LGCFSVSFLV SLYYNTILLW 

       130        140        150        160        170        180 
VLWFFLNSFQ HPLPWSTCPL DLNRTGFVQE CQSSGTVSYF WYRQTLNITS DISNTGTIQW 

       190        200        210        220        230        240 
KLFLCLVACW TTVYLCVIRG IESTGKVIYF TALFPYLVLT IFLIRGLTLP GATEGLTYLF 

       250        260        270        280        290        300 
TPNMKILQNS RVWLDAATQI FFSLSLAFGG HIAFASYNQP RNNCEKDAVT IALVNSMTSL 

       310        320        330        340        350        360 
YASITIFSIM GFKASNDYGR CLDRNILSLI NEFDFPELSI SRDEYPSVLM YLNATQPERV 

       370        380        390        400        410        420 
ARLPLKTCHL EDFLDKSASG PGLAFIVFTE AVLHMPGASV WSVLFFGMLF TLGLSSMFGN 

       430        440        450        460        470        480 
MEGVITPLFD MGILPKGVPK ETMTGVVCFI CFLSAICFTL QSGSYWLEIF DSFAASLNLI 

       490        500        510        520        530        540 
IFAFMEVVGV IHVYGIKRFC DDIEWMTGRR PSLYWQVTWR VVSPMLLFGI FLSYIVLLAQ 

       550        560        570        580        590        600 
SSPSYKAWNP QYEHFPSREE KLYPGWVQVT CVLLSFLPSL WVPGIALAQL LFQYRQRWKN 

       610 
THLESALKPQ ESRGC

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References

[1]"Molecular characterization of ROSIT, a renal osmotic stress-induced Na(+)-Cl(-)-organic solute cotransporter."
Wasserman J.C., Delpire E., Tonidandel W., Kojima R., Gullans S.R.
Am. J. Physiol. 267:F688-F694(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
Strain: Sprague-Dawley.
Tissue: Kidney cortex.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U12973 mRNA. Translation: AAC13771.1.
IPIIPI00207180.
RefSeqNP_058859.1. NM_017163.1.
UniGeneRn.9998.

3D structure databases

ProteinModelPortalQ62687.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID29323.
KEGGrno:29323.
UCSCRGD:69352. rat.

Organism-specific databases

CTD348932.
RGD69352. Slc6a18.

Phylogenomic databases

eggNOGCOG0733.
HOGENOMHOG000116406.
HOVERGENHBG071421.
InParanoidQ62687.
KOK05048.
OrthoDBEOG4D7Z57.

Gene expression databases

ArrayExpressQ62687.
GenevestigatorQ62687.
GermOnlineENSRNOG00000016253. Rattus norvegicus.

Family and domain databases

InterProIPR000175. Na/ntran_symport.
IPR002438. Na/ntran_symport_orphan.
[Graphical view]
PANTHERPTHR11616. PTHR11616. 1 hit.
PfamPF00209. SNF. 1 hit.
[Graphical view]
PRINTSPR00176. NANEUSMPORT.
PR01206. ORPHTRNSPORT.
PROSITEPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio608781.

Entry information

Entry nameS6A18_RAT
AccessionPrimary (citable) accession number: Q62687
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: November 1, 1996
Last modified: April 3, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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