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Protein

Sodium-dependent neutral amino acid transporter B(0)AT3

Gene

Slc6a18

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Functions as a sodium and chloride-dependent neutral amino acid transporter.By similarity

GO - Molecular functioni

GO - Biological processi

  • hyperosmotic response Source: RGD
  • response to osmotic stress Source: RGD
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Neurotransmitter transport, Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent neutral amino acid transporter B(0)AT3
Alternative name(s):
Renal osmotic stress-induced Na-Cl organic solute cotransporter
Short name:
ROSIT
Sodium- and chloride-dependent transporter XTRP2
Solute carrier family 6 member 18
System B(0) neutral amino acid transporter AT3
Gene namesi
Name:Slc6a18
Synonyms:Xtrp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi69352. Slc6a18.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626CytoplasmicSequence analysisAdd
BLAST
Transmembranei27 – 4721Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini48 – 525ExtracellularSequence analysis
Transmembranei53 – 7321Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini74 – 10532CytoplasmicSequence analysisAdd
BLAST
Transmembranei106 – 12621Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini127 – 17751ExtracellularSequence analysisAdd
BLAST
Transmembranei178 – 19821Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini199 – 2068CytoplasmicSequence analysis
Transmembranei207 – 22721Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini228 – 25528ExtracellularSequence analysisAdd
BLAST
Transmembranei256 – 27621Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini277 – 29014CytoplasmicSequence analysisAdd
BLAST
Transmembranei291 – 31121Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini312 – 39786ExtracellularSequence analysisAdd
BLAST
Transmembranei398 – 41821Helical; Name=8Sequence analysisAdd
BLAST
Topological domaini419 – 44224CytoplasmicSequence analysisAdd
BLAST
Transmembranei443 – 46321Helical; Name=9Sequence analysisAdd
BLAST
Topological domaini464 – 4729ExtracellularSequence analysis
Transmembranei473 – 49321Helical; Name=10Sequence analysisAdd
BLAST
Topological domaini494 – 52027CytoplasmicSequence analysisAdd
BLAST
Transmembranei521 – 54121Helical; Name=11Sequence analysisAdd
BLAST
Topological domaini542 – 57130ExtracellularSequence analysisAdd
BLAST
Transmembranei572 – 59221Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini593 – 61523CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 615615Sodium-dependent neutral amino acid transporter B(0)AT3PRO_0000214808Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi143 – 1431N-linked (GlcNAc...)Curated
Glycosylationi167 – 1671N-linked (GlcNAc...)Curated
Glycosylationi353 – 3531N-linked (GlcNAc...)Curated

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ62687.

PTM databases

iPTMnetiQ62687.

Expressioni

Tissue specificityi

Expressed in renal cortex but not in brain, heart, colon, liver, stomach, or skeletal muscle.1 Publication

Inductioni

By renal osmotic stress.1 Publication

Interactioni

Subunit structurei

Associates with TMEM27. TMEM27 association is required for functional expression in kidney.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022346.

Structurei

3D structure databases

ProteinModelPortaliQ62687.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiQ62687.
KOiK05048.
PhylomeDBiQ62687.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002438. Na/ntran_symport_orphan.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 2 hits.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01206. ORPHTRNSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62687-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQASGMDPL VDIEDERPKW DNKLQYLLSC IGFAVGLGNI WRFPYLCHTH
60 70 80 90 100
GGGAFLIPYF IALVFEGIPL FYIELAIGQR LRRGSIGVWK TISPYLGGVG
110 120 130 140 150
LGCFSVSFLV SLYYNTILLW VLWFFLNSFQ HPLPWSTCPL DLNRTGFVQE
160 170 180 190 200
CQSSGTVSYF WYRQTLNITS DISNTGTIQW KLFLCLVACW TTVYLCVIRG
210 220 230 240 250
IESTGKVIYF TALFPYLVLT IFLIRGLTLP GATEGLTYLF TPNMKILQNS
260 270 280 290 300
RVWLDAATQI FFSLSLAFGG HIAFASYNQP RNNCEKDAVT IALVNSMTSL
310 320 330 340 350
YASITIFSIM GFKASNDYGR CLDRNILSLI NEFDFPELSI SRDEYPSVLM
360 370 380 390 400
YLNATQPERV ARLPLKTCHL EDFLDKSASG PGLAFIVFTE AVLHMPGASV
410 420 430 440 450
WSVLFFGMLF TLGLSSMFGN MEGVITPLFD MGILPKGVPK ETMTGVVCFI
460 470 480 490 500
CFLSAICFTL QSGSYWLEIF DSFAASLNLI IFAFMEVVGV IHVYGIKRFC
510 520 530 540 550
DDIEWMTGRR PSLYWQVTWR VVSPMLLFGI FLSYIVLLAQ SSPSYKAWNP
560 570 580 590 600
QYEHFPSREE KLYPGWVQVT CVLLSFLPSL WVPGIALAQL LFQYRQRWKN
610
THLESALKPQ ESRGC
Length:615
Mass (Da):69,556
Last modified:November 1, 1996 - v1
Checksum:iF41E7DE1DC276918
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12973 mRNA. Translation: AAC13771.1.
RefSeqiNP_058859.1. NM_017163.1.
UniGeneiRn.9998.

Genome annotation databases

GeneIDi29323.
KEGGirno:29323.
UCSCiRGD:69352. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12973 mRNA. Translation: AAC13771.1.
RefSeqiNP_058859.1. NM_017163.1.
UniGeneiRn.9998.

3D structure databases

ProteinModelPortaliQ62687.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022346.

PTM databases

iPTMnetiQ62687.

Proteomic databases

PaxDbiQ62687.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29323.
KEGGirno:29323.
UCSCiRGD:69352. rat.

Organism-specific databases

CTDi348932.
RGDi69352. Slc6a18.

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiQ62687.
KOiK05048.
PhylomeDBiQ62687.

Miscellaneous databases

PROiQ62687.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002438. Na/ntran_symport_orphan.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 2 hits.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01206. ORPHTRNSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular characterization of ROSIT, a renal osmotic stress-induced Na(+)-Cl(-)-organic solute cotransporter."
    Wasserman J.C., Delpire E., Tonidandel W., Kojima R., Gullans S.R.
    Am. J. Physiol. 267:F688-F694(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
    Strain: Sprague-Dawley1 Publication.
    Tissue: Kidney cortex1 Publication.

Entry informationi

Entry nameiS6A18_RAT
AccessioniPrimary (citable) accession number: Q62687
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.