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Protein

Sodium-dependent neutral amino acid transporter B(0)AT3

Gene

Slc6a18

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Functions as a sodium and chloride-dependent neutral amino acid transporter.By similarity

GO - Molecular functioni

GO - Biological processi

  • amino acid transmembrane transport Source: RGD
  • hyperosmotic response Source: RGD
  • response to osmotic stress Source: RGD

Keywordsi

Biological processAmino-acid transport, Neurotransmitter transport, Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent neutral amino acid transporter B(0)AT3
Alternative name(s):
Renal osmotic stress-induced Na-Cl organic solute cotransporter
Short name:
ROSIT
Sodium- and chloride-dependent transporter XTRP2
Solute carrier family 6 member 18
System B(0) neutral amino acid transporter AT3
Gene namesi
Name:Slc6a18
Synonyms:Xtrp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi69352 Slc6a18

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26CytoplasmicSequence analysisAdd BLAST26
Transmembranei27 – 47Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini48 – 52ExtracellularSequence analysis5
Transmembranei53 – 73Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini74 – 105CytoplasmicSequence analysisAdd BLAST32
Transmembranei106 – 126Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini127 – 177ExtracellularSequence analysisAdd BLAST51
Transmembranei178 – 198Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini199 – 206CytoplasmicSequence analysis8
Transmembranei207 – 227Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini228 – 255ExtracellularSequence analysisAdd BLAST28
Transmembranei256 – 276Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini277 – 290CytoplasmicSequence analysisAdd BLAST14
Transmembranei291 – 311Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini312 – 397ExtracellularSequence analysisAdd BLAST86
Transmembranei398 – 418Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini419 – 442CytoplasmicSequence analysisAdd BLAST24
Transmembranei443 – 463Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini464 – 472ExtracellularSequence analysis9
Transmembranei473 – 493Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini494 – 520CytoplasmicSequence analysisAdd BLAST27
Transmembranei521 – 541Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini542 – 571ExtracellularSequence analysisAdd BLAST30
Transmembranei572 – 592Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini593 – 615CytoplasmicSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002148081 – 615Sodium-dependent neutral amino acid transporter B(0)AT3Add BLAST615

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi143N-linked (GlcNAc...) asparagineCurated1
Glycosylationi167N-linked (GlcNAc...) asparagineCurated1
Glycosylationi353N-linked (GlcNAc...) asparagineCurated1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ62687

PTM databases

iPTMnetiQ62687
PhosphoSitePlusiQ62687

Expressioni

Tissue specificityi

Expressed in renal cortex but not in brain, heart, colon, liver, stomach, or skeletal muscle.1 Publication

Inductioni

By renal osmotic stress.1 Publication

Interactioni

Subunit structurei

Associates with TMEM27. TMEM27 association is required for functional expression in kidney.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022346

Structurei

3D structure databases

ProteinModelPortaliQ62687
SMRiQ62687
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3659 Eukaryota
COG0733 LUCA
HOGENOMiHOG000116406
HOVERGENiHBG071421
InParanoidiQ62687
KOiK05048
PhylomeDBiQ62687

Family and domain databases

InterProiView protein in InterPro
IPR000175 Na/ntran_symport
IPR002438 Na/ntran_symport_orphan
IPR037272 SNS_sf
PANTHERiPTHR11616 PTHR11616, 1 hit
PfamiView protein in Pfam
PF00209 SNF, 1 hit
PRINTSiPR00176 NANEUSMPORT
PR01206 ORPHTRNSPORT
SUPFAMiSSF161070 SSF161070, 2 hits
PROSITEiView protein in PROSITE
PS00610 NA_NEUROTRAN_SYMP_1, 1 hit
PS00754 NA_NEUROTRAN_SYMP_2, 1 hit
PS50267 NA_NEUROTRAN_SYMP_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q62687-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQASGMDPL VDIEDERPKW DNKLQYLLSC IGFAVGLGNI WRFPYLCHTH
60 70 80 90 100
GGGAFLIPYF IALVFEGIPL FYIELAIGQR LRRGSIGVWK TISPYLGGVG
110 120 130 140 150
LGCFSVSFLV SLYYNTILLW VLWFFLNSFQ HPLPWSTCPL DLNRTGFVQE
160 170 180 190 200
CQSSGTVSYF WYRQTLNITS DISNTGTIQW KLFLCLVACW TTVYLCVIRG
210 220 230 240 250
IESTGKVIYF TALFPYLVLT IFLIRGLTLP GATEGLTYLF TPNMKILQNS
260 270 280 290 300
RVWLDAATQI FFSLSLAFGG HIAFASYNQP RNNCEKDAVT IALVNSMTSL
310 320 330 340 350
YASITIFSIM GFKASNDYGR CLDRNILSLI NEFDFPELSI SRDEYPSVLM
360 370 380 390 400
YLNATQPERV ARLPLKTCHL EDFLDKSASG PGLAFIVFTE AVLHMPGASV
410 420 430 440 450
WSVLFFGMLF TLGLSSMFGN MEGVITPLFD MGILPKGVPK ETMTGVVCFI
460 470 480 490 500
CFLSAICFTL QSGSYWLEIF DSFAASLNLI IFAFMEVVGV IHVYGIKRFC
510 520 530 540 550
DDIEWMTGRR PSLYWQVTWR VVSPMLLFGI FLSYIVLLAQ SSPSYKAWNP
560 570 580 590 600
QYEHFPSREE KLYPGWVQVT CVLLSFLPSL WVPGIALAQL LFQYRQRWKN
610
THLESALKPQ ESRGC
Length:615
Mass (Da):69,556
Last modified:November 1, 1996 - v1
Checksum:iF41E7DE1DC276918
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12973 mRNA Translation: AAC13771.1
RefSeqiNP_058859.1, NM_017163.1
UniGeneiRn.9998

Genome annotation databases

GeneIDi29323
KEGGirno:29323
UCSCiRGD:69352 rat

Similar proteinsi

Entry informationi

Entry nameiS6A18_RAT
AccessioniPrimary (citable) accession number: Q62687
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health