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Q62685 (NR1H3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Oxysterols receptor LXR-alpha
Alternative name(s):
Liver X receptor alpha
Nuclear receptor subfamily 1 group H member 3
RLD-1
Gene names
Name:Nr1h3
Synonyms:Lxra
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length445 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 By similarity.

Subunit structure

Heterodimer of LXRA and RXR By similarity.

Subcellular location

Nucleus Potential.

Tissue specificity

In adults it is expressed in spleen, pituitary, lung, liver, and fat. Weaker expression is observed in several other tissues.

Sequence similarities

Belongs to the nuclear hormone receptor family. NR1 subfamily.

Contains 1 nuclear receptor DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 445445Oxysterols receptor LXR-alpha
PRO_0000053537

Regions

DNA binding93 – 16876Nuclear receptor
Zinc finger96 – 11621NR C4-type
Zinc finger132 – 15625NR C4-type
Region213 – 432220Ligand-binding Potential

Sequences

Sequence LengthMass (Da)Tools
Q62685 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 131A84AB142AEA82

FASTA44550,555
        10         20         30         40         50         60 
MSLWLEAAVP DVSPDSATEL WKTEPQDAGD QGGNTCILRE EARMPQSTGG ALRIGLESSE 

        70         80         90        100        110        120 
PTALLPRAET LPEPTELRPQ KRKKGPAPKM LGNELCSVCG DKASAFHYNV LSCEGCKGFF 

       130        140        150        160        170        180 
RRSVIKGARY ICHSGGHCPM DTYMRRKCQE CRLRKCRHAG MREECVLSEE QIRLKKLKRQ 

       190        200        210        220        230        240 
EEEQAQATSV SPRVSSPPQV LPQLSPEQLG MIEKLVAAQQ QCNRRSFSDR LRVTPWPIAP 

       250        260        270        280        290        300 
DPQSREARQQ RFAHFTELAI VSVQEIVDFA KQLPGFLQLS REDQIALLKT SAIEVMLLET 

       310        320        330        340        350        360 
SRRYNPGSES ITFLKDFSYN REDFAKAGLQ VEFINPIFEF SRSMNELQLN DAEFALLIAI 

       370        380        390        400        410        420 
SIFSADRPNV QDQLQVERLQ HTYVEALHAY VSINHPHDRL MFPRMLMKLV SLRTLSSVHS 

       430        440 
EQVFALRLQD KKLPPLLSEI WDVHE

« Hide

References

[1]"A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily."
Apfel R.H., Benbrook D., Lernhardt E., Ortiz M.A., Salbert G., Pfahl M.
Mol. Cell. Biol. 14:7025-7035(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U11685 mRNA. Translation: AAA53633.1.
IPIIPI00207179.
PIRA56043.
UniGeneRn.11209.

3D structure databases

ProteinModelPortalQ62685.
SMRQ62685. Positions 94-179, 203-445.
ModBaseSearch...

PTM databases

PhosphoSiteQ62685.

Proteomic databases

PRIDEQ62685.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:61909. rat.

Organism-specific databases

RGD61909. Nr1h3.

Phylogenomic databases

eggNOGNOG285805.
HOGENOMHOG000220845.
HOVERGENHBG108655.
InParanoidQ62685.
OrthoDBEOG4DV5M7.

Gene expression databases

ArrayExpressQ62685.
GenevestigatorQ62685.
GermOnlineENSRNOG00000013172. Rattus norvegicus.

Family and domain databases

Gene3D1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProIPR023257. Liver_X_rcpt.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSPR02034. LIVERXRECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMSSF48508. Str_ncl_receptor. 1 hit.
PROSITEPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNR1H3_RAT
AccessionPrimary (citable) accession number: Q62685
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: April 3, 2013
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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