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Protein

Contactin-3

Gene

Cntn3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity.1 Publication

GO - Biological processi

  • nervous system development Source: RGD
  • single organismal cell-cell adhesion Source: RGD
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Contactin-3
Alternative name(s):
Brain-derived immunoglobulin superfamily protein 1
Short name:
BIG-1
Gene namesi
Name:Cntn3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi3253. Cntn3.

Subcellular locationi

GO - Cellular componenti

  • anchored component of plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001470920 – 1002Contactin-3Add BLAST983
PropeptideiPRO_00000147101003 – 1028Removed in mature formSequence analysisAdd BLAST26

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 100PROSITE-ProRule annotation
Glycosylationi65N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi144 ↔ 196PROSITE-ProRule annotation
Glycosylationi193N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi249 ↔ 297PROSITE-ProRule annotation
Disulfide bondi339 ↔ 386PROSITE-ProRule annotation
Glycosylationi377N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi431 ↔ 479PROSITE-ProRule annotation
Glycosylationi468N-linked (GlcNAc...)Sequence analysis1
Glycosylationi489N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi521 ↔ 577PROSITE-ProRule annotation
Glycosylationi538N-linked (GlcNAc...)Sequence analysis1
Glycosylationi765N-linked (GlcNAc...)Sequence analysis1
Glycosylationi860N-linked (GlcNAc...)Sequence analysis1
Glycosylationi895N-linked (GlcNAc...)Sequence analysis1
Glycosylationi913N-linked (GlcNAc...)Sequence analysis1
Glycosylationi931N-linked (GlcNAc...)Sequence analysis1
Glycosylationi956N-linked (GlcNAc...)Sequence analysis1
Lipidationi1002GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ62682.
PRIDEiQ62682.

Expressioni

Tissue specificityi

Specifically expressed in brain. Not expressed in peripheral tissues such as heart, lung, liver, spleen, kidney and skeletal muscle. In brain, it is restricted to subsets of neurons such as Purkinje cells of the cerebellum, granule cells of the dentate gyrus, and neurons in the superficial layers of the cerebral cortex.1 Publication

Developmental stagei

Weakly or not expressed from E12 to E20. Expressed at much higher level from postnatal day 2, reaching a maximum level in adult brain.1 Publication

Gene expression databases

BgeeiENSRNOG00000006144.
GenevisibleiQ62682. RN.

Interactioni

Subunit structurei

Interacts with PTPRG.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008221.

Structurei

3D structure databases

ProteinModelPortaliQ62682.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 117Ig-like C2-type 1Add BLAST92
Domaini122 – 208Ig-like C2-type 2Add BLAST87
Domaini227 – 313Ig-like C2-type 3Add BLAST87
Domaini318 – 402Ig-like C2-type 4Add BLAST85
Domaini408 – 497Ig-like C2-type 5Add BLAST90
Domaini499 – 593Ig-like C2-type 6Add BLAST95
Domaini600 – 698Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST99
Domaini703 – 800Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST98
Domaini805 – 901Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST97
Domaini902 – 998Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST97

Sequence similaritiesi

Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
GeneTreeiENSGT00760000118840.
HOGENOMiHOG000059617.
HOVERGENiHBG051047.
InParanoidiQ62682.
KOiK06761.
OMAiPQINWRR.
OrthoDBiEOG091G00X7.
PhylomeDBiQ62682.

Family and domain databases

CDDicd00063. FN3. 4 hits.
Gene3Di2.60.40.10. 10 hits.
InterProiIPR032995. Contactin-3.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10489:SF695. PTHR10489:SF695. 1 hit.
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 6 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62682-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLSWKQLIL LSFIGCLAGE LLLQGPVFVK EPSNSIFPVG SEDKKITLNC
60 70 80 90 100
EARGNPSPHY RWQLNGSDID TSLDHRYKLN GGNLIVINPN RNWDTGSYQC
110 120 130 140 150
FATNSLGTIV SREAKLQFAY LENFKSRMRS RVSVREGQGV VLLCGPPPHS
160 170 180 190 200
GELSYAWVFN EYPSFVEEDS RRFVSQETGH LYIAKVEPSD VGNYTCVVTS
210 220 230 240 250
TVTNARVLGS PTPLVLRSDG VMGEYEPKIE LQFPETLPAA KGSTVKLECF
260 270 280 290 300
ALGNPVPQIN WRRSDGMPFP TKIKLRKFNG VLEIPNFQQE DTGSYECIAE
310 320 330 340 350
NSRGKNVARG RLTYYAKPYW VQLLKDVETA VEDSLYWECR ASGKPKPSYR
360 370 380 390 400
WLKNGDALVL EERIQIENGA LTIANLNVSD SGMFQCIAEN KHGLIYSSAE
410 420 430 440 450
LKVLASAPDF SRNPMKKMIQ VQVGSLVILD CKPSASPRAL SFWKKGDTVV
460 470 480 490 500
REQARISLLN DGGLKIMNVT KADAGIYTCI AENQFGKANG TTQLVVTEPT
510 520 530 540 550
RIILAPSNMD VAVGESIILP CQVQHDPLLD IMFAWYFNGT LTDFKKDGSH
560 570 580 590 600
FEKVGGSSSG DLMIRNIQLK HSGKYVCMVQ TGVDSVSSAA ELIVRGSPGP
610 620 630 640 650
PENVKVDEIT DTTAQLSWTE GTDSHSPVIS YAVQARTPFS VGWQNVRTVP
660 670 680 690 700
EAIDGKTRTA TVVELNPWVE YEFRVVASNK IGGGEPSLPS EKVRTEEAAP
710 720 730 740 750
EVAPSEVSGG GGSRSELVIT WDPVPEELQN GGGFGYVVAF RPLGVTTWIQ
760 770 780 790 800
TVVTSPDNPR YVFRNESIVP FSPYEVKVGV YNNKGEGPFS PVTTVFSAEE
810 820 830 840 850
EPTVAPSHIS AHSLSSSEIE VSWNTIPWKS SNGRLLGYEV RYWNNGGEEE
860 870 880 890 900
SSSKVKVAGN QTSAVLRGLK SNLAYYTAVR AYNTAGAGPF SATVNATTKK
910 920 930 940 950
TPPSQPPGNV VWNATDTKVL LNWEQVKALE NESEVTGYKV FYRTSSQNNV
960 970 980 990 1000
QVLNTNKTSA ELLLPIKEDY IIEVKATTDG GDGTSSEQIR IPRITSMDAR
1010 1020
GSTSAISDIH PVSGYISVLL FFIVNALW
Length:1,028
Mass (Da):112,789
Last modified:November 1, 1996 - v1
Checksum:i49A2367D3D3BC10B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11031 mRNA. Translation: AAA63607.1.
PIRiI58164.
RefSeqiNP_062202.1. NM_019329.2.
XP_006237030.1. XM_006236968.3.
UniGeneiRn.10043.

Genome annotation databases

EnsembliENSRNOT00000008221; ENSRNOP00000008221; ENSRNOG00000006144.
GeneIDi54279.
KEGGirno:54279.
UCSCiRGD:3253. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11031 mRNA. Translation: AAA63607.1.
PIRiI58164.
RefSeqiNP_062202.1. NM_019329.2.
XP_006237030.1. XM_006236968.3.
UniGeneiRn.10043.

3D structure databases

ProteinModelPortaliQ62682.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008221.

Proteomic databases

PaxDbiQ62682.
PRIDEiQ62682.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000008221; ENSRNOP00000008221; ENSRNOG00000006144.
GeneIDi54279.
KEGGirno:54279.
UCSCiRGD:3253. rat.

Organism-specific databases

CTDi5067.
RGDi3253. Cntn3.

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
GeneTreeiENSGT00760000118840.
HOGENOMiHOG000059617.
HOVERGENiHBG051047.
InParanoidiQ62682.
KOiK06761.
OMAiPQINWRR.
OrthoDBiEOG091G00X7.
PhylomeDBiQ62682.

Miscellaneous databases

PROiQ62682.

Gene expression databases

BgeeiENSRNOG00000006144.
GenevisibleiQ62682. RN.

Family and domain databases

CDDicd00063. FN3. 4 hits.
Gene3Di2.60.40.10. 10 hits.
InterProiIPR032995. Contactin-3.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10489:SF695. PTHR10489:SF695. 1 hit.
PfamiPF00041. fn3. 3 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 6 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNTN3_RAT
AccessioniPrimary (citable) accession number: Q62682
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.