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Protein
Submitted name:

Orphan receptor COUP-TFI

Gene

Nr2f1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • negative regulation of neuron projection development Source: RGD
  • nervous system development Source: RGD
  • positive regulation of transcription from RNA polymerase II promoter Source: RGD
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

ReceptorUniRule annotationImported

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotation

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Orphan receptor COUP-TFIImported
Gene namesi
Name:Nr2f1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi621682. Nr2f1.

Subcellular locationi

  • Nucleus SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiQ62681.

PTM databases

PhosphoSiteiQ62681.

Expressioni

Gene expression databases

GenevisibleiQ62681. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020044.

Structurei

3D structure databases

ProteinModelPortaliQ62681.
SMRiQ62681. Positions 81-161.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini80 – 15576Nuclear receptor DNA-bindingInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotationSAAS annotation
Contains nuclear receptor DNA-binding domain.SAAS annotation

Keywords - Domaini

Zinc-fingerUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOGENOMiHOG000260820.
HOVERGENiHBG005606.
KOiK08547.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR003068. COUP_TF.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01282. COUPTNFACTOR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62681-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMVVSSWRD PQDDVAGGNP GGPNPAAQAA RGGGGGEQQQ AGSGAPHTPQ
60 70 80 90 100
TPGQPGAPAT PGTAGDKGQG PPGSGQSQQH IECVVCGDKS SGKHYGQFTC
110 120 130 140 150
EGCKSFFKRS VRRNLTYTCR ANRNCPIDQH HRNQCQYCRL KKCLKVGMRR
160 170 180 190 200
EAVQRGRMPP TQPNPGQYAL TNGDPLNGHC YLSGYISLLL RAEPYPTSRY
210 220 230 240 250
GSQCMQPNNI MGIENICELA ARLLFSAVEW ARNIPFFPDL QITDQVSLLR
260 270 280 290 300
LTWSELFVLN AAQCSMPLHV AVLAAAGLHA SPMSADRVVA FMDHIRIFQE
310 320 330 340 350
QVEKLKALHV DSAEYSCLKA IVLFTSDACG LSDAAHIESL QEKSQCALEE
360 370 380 390 400
YVRSQYPNQP SRFGKLLLRL PSLRTVSSSV IEQLFFVRLV GKTPIETLIR
410
DMLLSGSSFN WPYMSIQCS
Length:419
Mass (Da):45,788
Last modified:November 1, 1996 - v1
Checksum:iF2CD0CBFA4002024
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10995 mRNA. Translation: AAA83437.1.
PIRiA57000.
I67423.
RefSeqiNP_112392.1. NM_031130.1.
UniGeneiRn.89710.

Genome annotation databases

GeneIDi81808.
KEGGirno:81808.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10995 mRNA. Translation: AAA83437.1.
PIRiA57000.
I67423.
RefSeqiNP_112392.1. NM_031130.1.
UniGeneiRn.89710.

3D structure databases

ProteinModelPortaliQ62681.
SMRiQ62681. Positions 81-161.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020044.

PTM databases

PhosphoSiteiQ62681.

Proteomic databases

PaxDbiQ62681.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi81808.
KEGGirno:81808.

Organism-specific databases

CTDi7025.
RGDi621682. Nr2f1.

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOGENOMiHOG000260820.
HOVERGENiHBG005606.
KOiK08547.

Gene expression databases

GenevisibleiQ62681. RN.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR003068. COUP_TF.
IPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01282. COUPTNFACTOR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression of nuclear hormone receptors in the rat supraoptic nucleus."
    Lopes da Silva S., Van Horssen A.M., Chang C., Burbach J.P.
    Endocrinology 136:2276-2283(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Expression screening reveals an orphan receptor chick ovalbumin upstream promoter transcription factor I as a regulator of neurite/substrate-cell contacts and cell aggregation."
    Connor H., Nornes H., Neuman T.
    J. Biol. Chem. 270:15066-15070(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: WistarImported.
    Tissue: BrainImported.

Entry informationi

Entry nameiQ62681_RAT
AccessioniPrimary (citable) accession number: Q62681
Secondary accession number(s): Q62697, Q64114
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.