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Q62665 (LEG8_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Galectin-8

Short name=Gal-8
Alternative name(s):
30 kDa S-type lectin
RL-30
Gene names
Name:Lgals8
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Possesses sugar binding and hemagglutination activity.

Subcellular location

Cytoplasm.

Tissue specificity

Expressed in liver, kidney, cardiac muscle, lung, and brain.

Developmental stage

Very low levels in whole embryos, high levels in adult tissues.

Domain

Contains two homologous but distinct carbohydrate-binding domains.

Sequence similarities

Contains 2 galectin domains.

Ontologies

Keywords
   Cellular componentCytoplasm
   DomainRepeat
   LigandLectin
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncarbohydrate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 316316Galectin-8
PRO_0000076945

Regions

Domain18 – 151134Galectin 1
Domain186 – 316131Galectin 2
Region248 – 2547Beta-galactoside binding By similarity

Sites

Binding site681Carbohydrate By similarity
Binding site781Carbohydrate By similarity
Binding site881Carbohydrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q62665 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: C04B766CFE913D59

FASTA31636,038
        10         20         30         40         50         60 
MLSLSNLQNI IYNPTIPYVS TITEQLKPGS LIVIRGHVPK DSERFQVDFQ HGNSLKPRAD 

        70         80         90        100        110        120 
VAFHFNPRFK RSNCIVCNTL TNEKWGWEEI THDMPFRKEK SFEIVIMVLK NKFHVAVNGK 

       130        140        150        160        170        180 
HILLYAHRIN PEKIDTLGIF GKVNIHSIGF RFSSDLQSME TSTLGLTQIS KENIQKSGKL 

       190        200        210        220        230        240 
HLSLPFEARL NASMGPGRTV VVKGEVNTNA TSFNVDLVAG RSRDIALHLN PRLNVKAFVR 

       250        260        270        280        290        300 
NSFLQDAWGE EERNITCFPF SSGMYFEMII YCDVREFKVA VNGVHSLEYK HRFKDLSSID 

       310 
TLAVDGDIRL LDVRSW 

« Hide

References

[1]"Galectin-8. A new rat lectin, related to galectin-4."
Hadari Y.R., Paz K., Dekel R., Mestrovic T., Accili D., Zick Y.
J. Biol. Chem. 270:3447-3453(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U09824 mRNA. Translation: AAA66359.1.
PIRA55975.
UniGeneRn.10069.

3D structure databases

ProteinModelPortalQ62665.
SMRQ62665. Positions 6-150, 181-316.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000040412.

Proteomic databases

PaxDbQ62665.
PRIDEQ62665.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:621272. rat.

Organism-specific databases

RGD621272. Lgals8.

Phylogenomic databases

eggNOGNOG264430.
HOGENOMHOG000290194.
HOVERGENHBG002412.
PhylomeDBQ62665.

Gene expression databases

GenevestigatorQ62665.

Family and domain databases

Gene3D2.60.120.200. 2 hits.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR001079. Galectin_CRD.
[Graphical view]
PfamPF00337. Gal-bind_lectin. 2 hits.
[Graphical view]
SMARTSM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 2 hits.
[Graphical view]
SUPFAMSSF49899. SSF49899. 2 hits.
PROSITEPS51304. GALECTIN. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

PROQ62665.

Entry information

Entry nameLEG8_RAT
AccessionPrimary (citable) accession number: Q62665
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families