Q62665 (LEG8_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Galectin-8
Short name=Gal-8

Alternative name(s):
30 kDa S-type lectin
RL-30

Gene names

Name:

Lgals8

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	316 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Possesses sugar binding and hemagglutination activity.
Subcellular location	Cytoplasm.
Tissue specificity	Expressed in liver, kidney, cardiac muscle, lung, and brain.
Developmental stage	Very low levels in whole embryos, high levels in adult tissues.
Domain	Contains two homologous but distinct carbohydrate-binding domains.
Sequence similarities	Contains 2 galectin domains.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Repeat
Ligand	Lectin
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	carbohydrate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 316	316	Galectin-8		PRO_0000076945
Regions
	Domain	18 – 151	134	Galectin 1
	Domain	186 – 316	131	Galectin 2
	Region	248 – 254	7	Beta-galactoside binding By similarity
Sites
	Binding site	68	1	Carbohydrate By similarity
	Binding site	78	1	Carbohydrate By similarity
	Binding site	88	1	Carbohydrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q62665 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: C04B766CFE913D59	FASTA	316	36,038
	10 20 30 40 50 60 MLSLSNLQNI IYNPTIPYVS TITEQLKPGS LIVIRGHVPK DSERFQVDFQ HGNSLKPRAD 70 80 90 100 110 120 VAFHFNPRFK RSNCIVCNTL TNEKWGWEEI THDMPFRKEK SFEIVIMVLK NKFHVAVNGK 130 140 150 160 170 180 HILLYAHRIN PEKIDTLGIF GKVNIHSIGF RFSSDLQSME TSTLGLTQIS KENIQKSGKL 190 200 210 220 230 240 HLSLPFEARL NASMGPGRTV VVKGEVNTNA TSFNVDLVAG RSRDIALHLN PRLNVKAFVR 250 260 270 280 290 300 NSFLQDAWGE EERNITCFPF SSGMYFEMII YCDVREFKVA VNGVHSLEYK HRFKDLSSID 310 TLAVDGDIRL LDVRSW

References

[1]	"Galectin-8. A new rat lectin, related to galectin-4." Hadari Y.R., Paz K., Dekel R., Mestrovic T., Accili D., Zick Y. J. Biol. Chem. 270:3447-3453(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U09824 mRNA. Translation: AAA66359.1.
IPI	IPI00207141.
PIR	A55975.
UniGene	Rn.10069.
3D structure databases
ProteinModelPortal	Q62665.
SMR	Q62665. Positions 6-150, 181-316.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000040412.
Proteomic databases
PaxDb	Q62665.
PRIDE	Q62665.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	RGD:621272. rat.
Organism-specific databases
RGD	621272. Lgals8.
Phylogenomic databases
eggNOG	NOG264430.
HOGENOM	HOG000290194.
HOVERGEN	HBG002412.
OrthoDB	EOG41NTN1.
Gene expression databases
ArrayExpress	Q62665.
Genevestigator	Q62665.
GermOnline	ENSRNOG00000018046. Rattus norvegicus.
Family and domain databases
Gene3D	2.60.120.200. 2 hits.
InterPro	IPR008985. ConA-like_lec_gl_sf. IPR013320. ConA-like_subgrp. IPR001079. Galectin_CRD. [Graphical view]
Pfam	PF00337. Gal-bind_lectin. 2 hits. [Graphical view]
SMART	SM00908. Gal-bind_lectin. 2 hits. SM00276. GLECT. 2 hits. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 2 hits.
PROSITE	PS51304. GALECTIN. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LEG8_RAT

Accession

Primary (citable) accession number: Q62665

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program