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Q62665

- LEG8_RAT

UniProt

Q62665 - LEG8_RAT

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Protein

Galectin-8

Gene
Lgals8
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Possesses sugar binding and hemagglutination activity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei68 – 681Carbohydrate By similarity
Binding sitei78 – 781Carbohydrate By similarity
Binding sitei88 – 881Carbohydrate By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-8
Short name:
Gal-8
Alternative name(s):
30 kDa S-type lectin
RL-30
Gene namesi
Name:Lgals8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi621272. Lgals8.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Galectin-8PRO_0000076945Add
BLAST

Proteomic databases

PaxDbiQ62665.
PRIDEiQ62665.

Expressioni

Tissue specificityi

Expressed in liver, kidney, cardiac muscle, lung, and brain.

Developmental stagei

Very low levels in whole embryos, high levels in adult tissues.

Gene expression databases

GenevestigatoriQ62665.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040412.

Structurei

3D structure databases

ProteinModelPortaliQ62665.
SMRiQ62665. Positions 6-150, 181-316.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 151134Galectin 1Add
BLAST
Domaini186 – 316131Galectin 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni248 – 2547Beta-galactoside binding By similarity

Domaini

Contains two homologous but distinct carbohydrate-binding domains.

Sequence similaritiesi

Contains 2 galectin domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG264430.
HOGENOMiHOG000290194.
HOVERGENiHBG002412.
PhylomeDBiQ62665.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR001079. Galectin_CRD.
[Graphical view]
PfamiPF00337. Gal-bind_lectin. 2 hits.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS51304. GALECTIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62665-1 [UniParc]FASTAAdd to Basket

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MLSLSNLQNI IYNPTIPYVS TITEQLKPGS LIVIRGHVPK DSERFQVDFQ    50
HGNSLKPRAD VAFHFNPRFK RSNCIVCNTL TNEKWGWEEI THDMPFRKEK 100
SFEIVIMVLK NKFHVAVNGK HILLYAHRIN PEKIDTLGIF GKVNIHSIGF 150
RFSSDLQSME TSTLGLTQIS KENIQKSGKL HLSLPFEARL NASMGPGRTV 200
VVKGEVNTNA TSFNVDLVAG RSRDIALHLN PRLNVKAFVR NSFLQDAWGE 250
EERNITCFPF SSGMYFEMII YCDVREFKVA VNGVHSLEYK HRFKDLSSID 300
TLAVDGDIRL LDVRSW 316
Length:316
Mass (Da):36,038
Last modified:November 1, 1996 - v1
Checksum:iC04B766CFE913D59
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U09824 mRNA. Translation: AAA66359.1.
PIRiA55975.
UniGeneiRn.10069.

Genome annotation databases

UCSCiRGD:621272. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U09824 mRNA. Translation: AAA66359.1 .
PIRi A55975.
UniGenei Rn.10069.

3D structure databases

ProteinModelPortali Q62665.
SMRi Q62665. Positions 6-150, 181-316.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000040412.

Proteomic databases

PaxDbi Q62665.
PRIDEi Q62665.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:621272. rat.

Organism-specific databases

RGDi 621272. Lgals8.

Phylogenomic databases

eggNOGi NOG264430.
HOGENOMi HOG000290194.
HOVERGENi HBG002412.
PhylomeDBi Q62665.

Miscellaneous databases

PROi Q62665.

Gene expression databases

Genevestigatori Q62665.

Family and domain databases

Gene3Di 2.60.120.200. 2 hits.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR001079. Galectin_CRD.
[Graphical view ]
Pfami PF00337. Gal-bind_lectin. 2 hits.
[Graphical view ]
SMARTi SM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 2 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 2 hits.
PROSITEi PS51304. GALECTIN. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.

Entry informationi

Entry nameiLEG8_RAT
AccessioniPrimary (citable) accession number: Q62665
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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