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Q62665

- LEG8_RAT

UniProt

Q62665 - LEG8_RAT

Protein

Galectin-8

Gene

Lgals8

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Possesses sugar binding and hemagglutination activity.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei68 – 681CarbohydrateBy similarity
    Binding sitei78 – 781CarbohydrateBy similarity
    Binding sitei88 – 881CarbohydrateBy similarity

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro

    Keywords - Ligandi

    Lectin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Galectin-8
    Short name:
    Gal-8
    Alternative name(s):
    30 kDa S-type lectin
    RL-30
    Gene namesi
    Name:Lgals8
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi621272. Lgals8.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 316316Galectin-8PRO_0000076945Add
    BLAST

    Proteomic databases

    PaxDbiQ62665.
    PRIDEiQ62665.

    Expressioni

    Tissue specificityi

    Expressed in liver, kidney, cardiac muscle, lung, and brain.

    Developmental stagei

    Very low levels in whole embryos, high levels in adult tissues.

    Gene expression databases

    GenevestigatoriQ62665.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000040412.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62665.
    SMRiQ62665. Positions 6-150, 181-316.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini18 – 151134Galectin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini186 – 316131Galectin 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni248 – 2547Beta-galactoside bindingBy similarity

    Domaini

    Contains two homologous but distinct carbohydrate-binding domains.

    Sequence similaritiesi

    Contains 2 galectin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG264430.
    HOGENOMiHOG000290194.
    HOVERGENiHBG002412.
    PhylomeDBiQ62665.

    Family and domain databases

    Gene3Di2.60.120.200. 2 hits.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001079. Galectin_CRD.
    [Graphical view]
    PfamiPF00337. Gal-bind_lectin. 2 hits.
    [Graphical view]
    SMARTiSM00908. Gal-bind_lectin. 2 hits.
    SM00276. GLECT. 2 hits.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 2 hits.
    PROSITEiPS51304. GALECTIN. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q62665-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSLSNLQNI IYNPTIPYVS TITEQLKPGS LIVIRGHVPK DSERFQVDFQ    50
    HGNSLKPRAD VAFHFNPRFK RSNCIVCNTL TNEKWGWEEI THDMPFRKEK 100
    SFEIVIMVLK NKFHVAVNGK HILLYAHRIN PEKIDTLGIF GKVNIHSIGF 150
    RFSSDLQSME TSTLGLTQIS KENIQKSGKL HLSLPFEARL NASMGPGRTV 200
    VVKGEVNTNA TSFNVDLVAG RSRDIALHLN PRLNVKAFVR NSFLQDAWGE 250
    EERNITCFPF SSGMYFEMII YCDVREFKVA VNGVHSLEYK HRFKDLSSID 300
    TLAVDGDIRL LDVRSW 316
    Length:316
    Mass (Da):36,038
    Last modified:November 1, 1996 - v1
    Checksum:iC04B766CFE913D59
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U09824 mRNA. Translation: AAA66359.1.
    PIRiA55975.
    UniGeneiRn.10069.

    Genome annotation databases

    UCSCiRGD:621272. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U09824 mRNA. Translation: AAA66359.1 .
    PIRi A55975.
    UniGenei Rn.10069.

    3D structure databases

    ProteinModelPortali Q62665.
    SMRi Q62665. Positions 6-150, 181-316.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000040412.

    Proteomic databases

    PaxDbi Q62665.
    PRIDEi Q62665.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:621272. rat.

    Organism-specific databases

    RGDi 621272. Lgals8.

    Phylogenomic databases

    eggNOGi NOG264430.
    HOGENOMi HOG000290194.
    HOVERGENi HBG002412.
    PhylomeDBi Q62665.

    Miscellaneous databases

    PROi Q62665.

    Gene expression databases

    Genevestigatori Q62665.

    Family and domain databases

    Gene3Di 2.60.120.200. 2 hits.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001079. Galectin_CRD.
    [Graphical view ]
    Pfami PF00337. Gal-bind_lectin. 2 hits.
    [Graphical view ]
    SMARTi SM00908. Gal-bind_lectin. 2 hits.
    SM00276. GLECT. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 2 hits.
    PROSITEi PS51304. GALECTIN. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Liver.

    Entry informationi

    Entry nameiLEG8_RAT
    AccessioniPrimary (citable) accession number: Q62665
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3