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Protein

Galectin-8

Gene

Lgals8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Possesses sugar binding and hemagglutination activity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei68 – 681CarbohydrateBy similarity
Binding sitei78 – 781CarbohydrateBy similarity
Binding sitei88 – 881CarbohydrateBy similarity

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-8
Short name:
Gal-8
Alternative name(s):
30 kDa S-type lectin
RL-30
Gene namesi
Name:Lgals8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621272. Lgals8.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Galectin-8PRO_0000076945Add
BLAST

Proteomic databases

PaxDbiQ62665.
PRIDEiQ62665.

Expressioni

Tissue specificityi

Expressed in liver, kidney, cardiac muscle, lung, and brain.

Developmental stagei

Very low levels in whole embryos, high levels in adult tissues.

Gene expression databases

GenevestigatoriQ62665.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040412.

Structurei

3D structure databases

ProteinModelPortaliQ62665.
SMRiQ62665. Positions 6-150, 181-316.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 151134Galectin 1PROSITE-ProRule annotationAdd
BLAST
Domaini186 – 316131Galectin 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni248 – 2547Beta-galactoside bindingBy similarity

Domaini

Contains two homologous but distinct carbohydrate-binding domains.

Sequence similaritiesi

Contains 2 galectin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG264430.
HOGENOMiHOG000290194.
HOVERGENiHBG002412.
InParanoidiQ62665.
PhylomeDBiQ62665.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR001079. Galectin_CRD.
[Graphical view]
PfamiPF00337. Gal-bind_lectin. 2 hits.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS51304. GALECTIN. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62665-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSLSNLQNI IYNPTIPYVS TITEQLKPGS LIVIRGHVPK DSERFQVDFQ
60 70 80 90 100
HGNSLKPRAD VAFHFNPRFK RSNCIVCNTL TNEKWGWEEI THDMPFRKEK
110 120 130 140 150
SFEIVIMVLK NKFHVAVNGK HILLYAHRIN PEKIDTLGIF GKVNIHSIGF
160 170 180 190 200
RFSSDLQSME TSTLGLTQIS KENIQKSGKL HLSLPFEARL NASMGPGRTV
210 220 230 240 250
VVKGEVNTNA TSFNVDLVAG RSRDIALHLN PRLNVKAFVR NSFLQDAWGE
260 270 280 290 300
EERNITCFPF SSGMYFEMII YCDVREFKVA VNGVHSLEYK HRFKDLSSID
310
TLAVDGDIRL LDVRSW
Length:316
Mass (Da):36,038
Last modified:November 1, 1996 - v1
Checksum:iC04B766CFE913D59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09824 mRNA. Translation: AAA66359.1.
PIRiA55975.
UniGeneiRn.10069.

Genome annotation databases

UCSCiRGD:621272. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09824 mRNA. Translation: AAA66359.1.
PIRiA55975.
UniGeneiRn.10069.

3D structure databases

ProteinModelPortaliQ62665.
SMRiQ62665. Positions 6-150, 181-316.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040412.

Proteomic databases

PaxDbiQ62665.
PRIDEiQ62665.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:621272. rat.

Organism-specific databases

RGDi621272. Lgals8.

Phylogenomic databases

eggNOGiNOG264430.
HOGENOMiHOG000290194.
HOVERGENiHBG002412.
InParanoidiQ62665.
PhylomeDBiQ62665.

Miscellaneous databases

PROiQ62665.

Gene expression databases

GenevestigatoriQ62665.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR001079. Galectin_CRD.
[Graphical view]
PfamiPF00337. Gal-bind_lectin. 2 hits.
[Graphical view]
SMARTiSM00908. Gal-bind_lectin. 2 hits.
SM00276. GLECT. 2 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.
PROSITEiPS51304. GALECTIN. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.

Entry informationi

Entry nameiLEG8_RAT
AccessioniPrimary (citable) accession number: Q62665
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: January 7, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.