SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q62662

- FRK_RAT

UniProt

Q62662 - FRK_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Tyrosine-protein kinase FRK
Gene
Frk, Gask
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor By similarity.

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei263 – 2631ATP By similarity
Active sitei355 – 3551Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi241 – 2499ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
  3. protein tyrosine kinase activity Source: RGD
Complete GO annotation...

GO - Biological processi

  1. cell differentiation Source: RGD
  2. peptidyl-tyrosine phosphorylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase FRK (EC:2.7.10.2)
Alternative name(s):
FYN-related kinase
Gastrointestinal-associated kinase
Short name:
GASK
Gastrointestinal-associated tyrosine kinase
Short name:
GTK
Gene namesi
Name:Frk
Synonyms:Gask
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 20

Organism-specific databases

RGDi621423. Frk.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity
Note: Predominantly found in the nucleus, with a small fraction found in the cell periphery By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
  3. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 506506Tyrosine-protein kinase FRK
PRO_0000260827Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei388 – 3881Phosphotyrosine; by autocatalysis By similarity

Keywords - PTMi

Lipoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ62662.
PRIDEiQ62662.

PTM databases

PhosphoSiteiQ62662.

Expressioni

Tissue specificityi

Highly expressed in stomach, small intestine and colon. Concentrated in the brush border membranes of epithelial cells, throughout the maturation axis of the adult small intestine.2 Publications

Gene expression databases

GenevestigatoriQ62662.

Interactioni

Subunit structurei

Interacts (via the SH3-domain) with PTEN. Interacts with RB1 By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000653.

Structurei

3D structure databases

ProteinModelPortaliQ62662.
SMRiQ62662. Positions 43-495.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 11170SH3
Add
BLAST
Domaini117 – 20993SH2
Add
BLAST
Domaini235 – 492258Protein kinase
Add
BLAST

Sequence similaritiesi

Contains 1 SH2 domain.
Contains 1 SH3 domain.

Keywords - Domaini

SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00640000091347.
HOGENOMiHOG000233858.
HOVERGENiHBG008761.
InParanoidiQ62662.
KOiK08892.
OMAiVSHYTKT.
OrthoDBiEOG7GTT2V.
PhylomeDBiQ62662.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62662-1 [UniParc]FASTAAdd to Basket

« Hide

MGSVCMRLWA YLQPFLPCWS QEADKSVVIE NPGAYCPPEA NRSQGQYFVA    50
LFDYEARTAE DLSFHAGDKL QVLDTSHEGW WLARHLEKKG PGLGQQLQGY 100
IPSNYVAEDR SLQAEPWFFG AIKRADAEKQ LLYSENQTGA FLIRESESQK 150
GDFSLSVLDE GVVKHYRIRR LDEGGFFLTR RKTFSTLNEF VNYYTTTSDG 200
LCVKLEKPCL KIQVPTPFDL SYKTVDQWEI DRNSIQLLKR LGSGQFGEVW 250
EGLWNNTTPV AVKTLKPGSM DPNDFLREAQ IMKSLRHPKL IQLYAVCTLE 300
DPIYIITELM RHGSLQEYLQ NDGGSKIRLT QQVDMAAQVA SGMAYLESQN 350
YIHRDLAARN VLVGEHNIYK VADFGLARVF KVDNEDIYES KHEIKLPVKW 400
TAPEAIRTNK FSIKSDVWSF GILLYEIITY GKMPYSGMTG AQVIHMLGQN 450
YRLPQPSNCP EQFYSIMMEC WNVEPKQRPT FETLHWKLED YFEPDSSYSD 500
TNNFIN 506
Length:506
Mass (Da):58,166
Last modified:January 23, 2007 - v3
Checksum:i69F471DE4F974D82
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U09583 mRNA. Translation: AAC52725.1.
PIRiS43515.
RefSeqiNP_077344.1. NM_024368.1.
XP_006256579.1. XM_006256517.1.
UniGeneiRn.10556.

Genome annotation databases

EnsembliENSRNOT00000000653; ENSRNOP00000000653; ENSRNOG00000000543.
GeneIDi79209.
KEGGirno:79209.
UCSCiRGD:621423. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U09583 mRNA. Translation: AAC52725.1 .
PIRi S43515.
RefSeqi NP_077344.1. NM_024368.1.
XP_006256579.1. XM_006256517.1.
UniGenei Rn.10556.

3D structure databases

ProteinModelPortali Q62662.
SMRi Q62662. Positions 43-495.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000000653.

PTM databases

PhosphoSitei Q62662.

Proteomic databases

PaxDbi Q62662.
PRIDEi Q62662.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000000653 ; ENSRNOP00000000653 ; ENSRNOG00000000543 .
GeneIDi 79209.
KEGGi rno:79209.
UCSCi RGD:621423. rat.

Organism-specific databases

CTDi 2444.
RGDi 621423. Frk.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00640000091347.
HOGENOMi HOG000233858.
HOVERGENi HBG008761.
InParanoidi Q62662.
KOi K08892.
OMAi VSHYTKT.
OrthoDBi EOG7GTT2V.
PhylomeDBi Q62662.

Miscellaneous databases

NextBioi 614596.
PROi Q62662.

Gene expression databases

Genevestigatori Q62662.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTi SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The apical membranes of maturing gut columnar epithelial cells contain the enzymatically active form of a newly identified fyn-related tyrosine kinase."
    Sunitha I., Avigan M.I.
    Oncogene 13:547-559(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Small intestine.
  2. "A newly identified tyrosine kinase is preferentially expressed in the gastrointestinal tract."
    Sunitha I., Avigan M.I.
    Biochim. Biophys. Acta 1221:348-352(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Small intestine.

Entry informationi

Entry nameiFRK_RAT
AccessioniPrimary (citable) accession number: Q62662
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi