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Protein

Tyrosine-protein kinase FRK

Gene

Frk

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor (By similarity).By similarity

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei263ATPPROSITE-ProRule annotation1
Active sitei355Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi241 – 249ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase FRK (EC:2.7.10.2)
Alternative name(s):
FYN-related kinase
Gastrointestinal-associated kinase
Short name:
GASK
Gastrointestinal-associated tyrosine kinase
Short name:
GTK
Gene namesi
Name:Frk
Synonyms:Gask
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi621423. Frk.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Predominantly found in the nucleus, with a small fraction found in the cell periphery.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002608271 – 506Tyrosine-protein kinase FRKAdd BLAST506

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei179PhosphothreonineBy similarity1
Modified residuei388Phosphotyrosine; by autocatalysisBy similarity1

Keywords - PTMi

Lipoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ62662.
PRIDEiQ62662.

PTM databases

iPTMnetiQ62662.
PhosphoSitePlusiQ62662.

Expressioni

Tissue specificityi

Highly expressed in stomach, small intestine and colon. Concentrated in the brush border membranes of epithelial cells, throughout the maturation axis of the adult small intestine.2 Publications

Gene expression databases

BgeeiENSRNOG00000000543.
GenevisibleiQ62662. RN.

Interactioni

Subunit structurei

Interacts (via the SH3-domain) with PTEN. Interacts with RB1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000653.

Structurei

3D structure databases

ProteinModelPortaliQ62662.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 111SH3PROSITE-ProRule annotationAdd BLAST70
Domaini117 – 209SH2PROSITE-ProRule annotationAdd BLAST93
Domaini235 – 492Protein kinasePROSITE-ProRule annotationAdd BLAST258

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain, SH3 domain

Phylogenomic databases

eggNOGiKOG0197. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118938.
HOGENOMiHOG000233858.
HOVERGENiHBG008761.
InParanoidiQ62662.
KOiK08892.
OMAiIRTNKFS.
OrthoDBiEOG091G0D46.
PhylomeDBiQ62662.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62662-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSVCMRLWA YLQPFLPCWS QEADKSVVIE NPGAYCPPEA NRSQGQYFVA
60 70 80 90 100
LFDYEARTAE DLSFHAGDKL QVLDTSHEGW WLARHLEKKG PGLGQQLQGY
110 120 130 140 150
IPSNYVAEDR SLQAEPWFFG AIKRADAEKQ LLYSENQTGA FLIRESESQK
160 170 180 190 200
GDFSLSVLDE GVVKHYRIRR LDEGGFFLTR RKTFSTLNEF VNYYTTTSDG
210 220 230 240 250
LCVKLEKPCL KIQVPTPFDL SYKTVDQWEI DRNSIQLLKR LGSGQFGEVW
260 270 280 290 300
EGLWNNTTPV AVKTLKPGSM DPNDFLREAQ IMKSLRHPKL IQLYAVCTLE
310 320 330 340 350
DPIYIITELM RHGSLQEYLQ NDGGSKIRLT QQVDMAAQVA SGMAYLESQN
360 370 380 390 400
YIHRDLAARN VLVGEHNIYK VADFGLARVF KVDNEDIYES KHEIKLPVKW
410 420 430 440 450
TAPEAIRTNK FSIKSDVWSF GILLYEIITY GKMPYSGMTG AQVIHMLGQN
460 470 480 490 500
YRLPQPSNCP EQFYSIMMEC WNVEPKQRPT FETLHWKLED YFEPDSSYSD

TNNFIN
Length:506
Mass (Da):58,166
Last modified:January 23, 2007 - v3
Checksum:i69F471DE4F974D82
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09583 mRNA. Translation: AAC52725.1.
PIRiS43515.
RefSeqiNP_077344.1. NM_024368.1.
XP_006256579.1. XM_006256517.3.
UniGeneiRn.10556.

Genome annotation databases

EnsembliENSRNOT00000000653; ENSRNOP00000000653; ENSRNOG00000000543.
GeneIDi79209.
KEGGirno:79209.
UCSCiRGD:621423. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09583 mRNA. Translation: AAC52725.1.
PIRiS43515.
RefSeqiNP_077344.1. NM_024368.1.
XP_006256579.1. XM_006256517.3.
UniGeneiRn.10556.

3D structure databases

ProteinModelPortaliQ62662.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000653.

PTM databases

iPTMnetiQ62662.
PhosphoSitePlusiQ62662.

Proteomic databases

PaxDbiQ62662.
PRIDEiQ62662.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000000653; ENSRNOP00000000653; ENSRNOG00000000543.
GeneIDi79209.
KEGGirno:79209.
UCSCiRGD:621423. rat.

Organism-specific databases

CTDi2444.
RGDi621423. Frk.

Phylogenomic databases

eggNOGiKOG0197. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118938.
HOGENOMiHOG000233858.
HOVERGENiHBG008761.
InParanoidiQ62662.
KOiK08892.
OMAiIRTNKFS.
OrthoDBiEOG091G0D46.
PhylomeDBiQ62662.

Enzyme and pathway databases

ReactomeiR-RNO-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiQ62662.

Gene expression databases

BgeeiENSRNOG00000000543.
GenevisibleiQ62662. RN.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFRK_RAT
AccessioniPrimary (citable) accession number: Q62662
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.