Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

HMG box-containing protein 1

Gene

Hbp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4 (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi433 – 501HMG boxAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
HMG box-containing protein 1
Alternative name(s):
HMG box transcription factor 1
High mobility group box transcription factor 1
Gene namesi
Name:Hbp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620444. Hbp1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000485491 – 513HMG box-containing protein 1Add BLAST513

Proteomic databases

PaxDbiQ62661.
PRIDEiQ62661.

PTM databases

iPTMnetiQ62661.
PhosphoSitePlusiQ62661.

Expressioni

Tissue specificityi

Highly expressed in liver, adipose tissue, lung, brain, spleen, kidney, skeletal muscle and heart.1 Publication

Developmental stagei

Not detectable in undifferentiated preadipocytes and myogenic cells. Accumulates at high levels during the terminal stages of the differentiation process.1 Publication

Inductioni

Up-regulated by insulin in differentiated cultured adipocytes.1 Publication

Interactioni

Subunit structurei

Binds TCF4 and RB1. Binds the second PAH repeat of SIN3A (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012004.

Structurei

3D structure databases

ProteinModelPortaliQ62661.
SMRiQ62661.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini202 – 343AXHAdd BLAST142

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi196 – 199Poly-Asp4
Compositional biasi393 – 429Ser-richAdd BLAST37

Phylogenomic databases

eggNOGiENOG410IFNF. Eukaryota.
ENOG410XPPV. LUCA.
HOGENOMiHOG000065753.
HOVERGENiHBG052810.
InParanoidiQ62661.
KOiK21644.
PhylomeDBiQ62661.
TreeFamiTF105381.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiView protein in InterPro
IPR003652. Ataxin_AXH_dom.
IPR036096. Ataxin_AXH_dom_sf.
IPR009071. HMG_box_dom.
IPR036910. HMG_box_dom_sf.
PfamiView protein in Pfam
PF08517. AXH. 1 hit.
PF00505. HMG_box. 1 hit.
SMARTiView protein in SMART
SM00536. AXH. 1 hit.
SM00398. HMG. 1 hit.
SUPFAMiSSF102031. SSF102031. 1 hit.
SSF47095. SSF47095. 1 hit.
PROSITEiView protein in PROSITE
PS51148. AXH. 1 hit.
PS50118. HMG_BOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q62661-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVWEVKTNQR PHAVQRLLLV MDERATGVSD SLELLQCNEN VPSSPGYNSC
60 70 80 90 100
DEHMELDDLP ELQAVQSDPT QSAIYQLSSD VSHQEYPRPS WSQNTSDIPE
110 120 130 140 150
NTHREDEVDW LTELANIATS PQSPLMQCSF YNRSSPVHII ATSKSLHSYA
160 170 180 190 200
RPPPVSSAKS GPAFPHDHWK EETPVRHERA NSESESGIFC MSSLSDDDDL
210 220 230 240 250
GWCNSWPSTV WHCFLKGTRL CFHKESKKEW QDVEDFARAA SCDEEEIQMG
260 270 280 290 300
THKGYGSDGL KLLSHEESVS FGESVLKLTF DPGTVEDGLL TVECKLDHPF
310 320 330 340 350
YVKNKGWSSF YPSLTVVQHG IPCCEIHIGD VCLPPGHPDA INFDDSGVFD
360 370 380 390 400
TFKSYDFTPM DSSAVYVLSS MARQRRASLS CGGPGTGQEF AGSEFSKSCG
410 420 430 440 450
SPGSSQLSSS SLYTKAVKSH SSGTVSATSP NKCKRPMNAF MLFAKKYRVE
460 470 480 490 500
YTQMYPGKDN RAISVILGDR WKKMKNEERR MYTLEAKALA EEQKRLNPDC
510
WKRKRTNSGS QQH
Length:513
Mass (Da):57,430
Last modified:July 19, 2005 - v2
Checksum:iCC71A0918E793036
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti144K → N in AAA53240 (PubMed:7937077).Curated1
Sequence conflicti241S → T in AAA53240 (PubMed:7937077).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09551 mRNA. Translation: AAA53240.1.
BC091165 mRNA. Translation: AAH91165.1.
PIRiI58311.
RefSeqiNP_037353.2. NM_013221.2.
UniGeneiRn.89226.

Genome annotation databases

GeneIDi27080.
KEGGirno:27080.

Similar proteinsi

Entry informationi

Entry nameiHBP1_RAT
AccessioniPrimary (citable) accession number: Q62661
Secondary accession number(s): Q5BK86
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: November 22, 2017
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome