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Protein

Peptidyl-prolyl cis-trans isomerase FKBP1A

Gene

Fkbp1a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Inhibited by both FK506 and rapamycin.

GO - Molecular functioni

  • enzyme binding Source: RGD
  • FK506 binding Source: RGD
  • Hsp70 protein binding Source: RGD
  • peptidyl-prolyl cis-trans isomerase activity Source: GO_Central
  • transforming growth factor beta receptor binding Source: BHF-UCL
  • type I transforming growth factor beta receptor binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Enzyme and pathway databases

ReactomeiR-RNO-2173789. TGF-beta receptor signaling activates SMADs.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP1A (EC:5.2.1.8)
Short name:
PPIase FKBP1A
Alternative name(s):
12 kDa FK506-binding protein
Short name:
12 kDa FKBP
Short name:
FKBP-12
FK506-binding protein 1A
Short name:
FKBP-1A
Immunophilin FKBP12
Rotamase
Gene namesi
Name:Fkbp1a
Synonyms:Fkbp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi2617. Fkbp1a.

Subcellular locationi

GO - Cellular componenti

  • axon terminus Source: RGD
  • endoplasmic reticulum membrane Source: GO_Central
  • intracellular membrane-bounded organelle Source: RGD
  • sarcoplasmic reticulum membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2095.
GuidetoPHARMACOLOGYi2609.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 108107Peptidyl-prolyl cis-trans isomerase FKBP1APRO_0000075292Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei10 – 101PhosphoserineCombined sources
Modified residuei53 – 531N6-acetyllysine; alternateBy similarity
Modified residuei53 – 531N6-succinyllysine; alternateBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ62658.
PRIDEiQ62658.

PTM databases

iPTMnetiQ62658.
PhosphoSiteiQ62658.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

GenevisibleiQ62658. RN.

Interactioni

Subunit structurei

Interacts with TGFBR1; prevents TGFBR1 phosphorylation by TGFBR2 and stabilizes it in the inactive conformation (By similarity). Interacts with ACVR1B and SMAD7. Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1). Interacts directly with RYR1 and RYR3 (By similarity). Interacts directly with RYR2.By similarity1 Publication

GO - Molecular functioni

  • enzyme binding Source: RGD
  • Hsp70 protein binding Source: RGD
  • transforming growth factor beta receptor binding Source: BHF-UCL
  • type I transforming growth factor beta receptor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi247668. 1 interaction.
STRINGi10116.ENSRNOP00000012608.

Structurei

3D structure databases

ProteinModelPortaliQ62658.
SMRiQ62658. Positions 2-108.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 10889PPIase FKBP-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0544. Eukaryota.
COG0545. LUCA.
GeneTreeiENSGT00760000119159.
HOGENOMiHOG000154887.
HOVERGENiHBG051623.
InParanoidiQ62658.
KOiK09568.
OMAiDESTYPK.
OrthoDBiEOG7ZGX5T.
PhylomeDBiQ62658.

Family and domain databases

InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62658-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVQVETISS GDGRTFPKRG QTCVVHYTGM LEDGKKFDSS RDRNKPFKFT
60 70 80 90 100
LGKQEVIRGW EEGVAQMSVG QRAKLIISPD YAYGATGHPG IIPPHATLVF

DVELLKLE
Length:108
Mass (Da):11,923
Last modified:January 23, 2007 - v3
Checksum:i1C195C2A52C17666
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti89 – 891P → T in BAA13153 (PubMed:9013543).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09386 mRNA. Translation: AAA19163.1.
U69485 mRNA. Translation: AAB48933.1.
D86641 mRNA. Translation: BAA13153.1.
BC070519 mRNA. Translation: AAH70519.3.
BC126071 mRNA. Translation: AAI26072.1.
RefSeqiNP_037234.2. NM_013102.3.
UniGeneiRn.80611.

Genome annotation databases

EnsembliENSRNOT00000012608; ENSRNOP00000012608; ENSRNOG00000008822.
GeneIDi25639.
KEGGirno:25639.
UCSCiRGD:2617. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09386 mRNA. Translation: AAA19163.1.
U69485 mRNA. Translation: AAB48933.1.
D86641 mRNA. Translation: BAA13153.1.
BC070519 mRNA. Translation: AAH70519.3.
BC126071 mRNA. Translation: AAI26072.1.
RefSeqiNP_037234.2. NM_013102.3.
UniGeneiRn.80611.

3D structure databases

ProteinModelPortaliQ62658.
SMRiQ62658. Positions 2-108.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247668. 1 interaction.
STRINGi10116.ENSRNOP00000012608.

Chemistry

ChEMBLiCHEMBL2095.
GuidetoPHARMACOLOGYi2609.

PTM databases

iPTMnetiQ62658.
PhosphoSiteiQ62658.

Proteomic databases

PaxDbiQ62658.
PRIDEiQ62658.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012608; ENSRNOP00000012608; ENSRNOG00000008822.
GeneIDi25639.
KEGGirno:25639.
UCSCiRGD:2617. rat.

Organism-specific databases

CTDi2280.
RGDi2617. Fkbp1a.

Phylogenomic databases

eggNOGiKOG0544. Eukaryota.
COG0545. LUCA.
GeneTreeiENSGT00760000119159.
HOGENOMiHOG000154887.
HOVERGENiHBG051623.
InParanoidiQ62658.
KOiK09568.
OMAiDESTYPK.
OrthoDBiEOG7ZGX5T.
PhylomeDBiQ62658.

Enzyme and pathway databases

ReactomeiR-RNO-2173789. TGF-beta receptor signaling activates SMADs.

Miscellaneous databases

PROiQ62658.

Gene expression databases

GenevisibleiQ62658. RN.

Family and domain databases

InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Specific interaction of type I receptors of the TGF-beta family with the immunophilin FKBP-12."
    Wang T., Donahoe P.K., Zervos A.S.
    Science 265:674-676(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart.
  2. "Identification of a novel FK506-binding protein in rat aortic smooth muscle cells."
    Marx S.O., Jayaraman T., Mehran R., Go L.O., Wiederrecht G.J., Marks A.R.
    Circulation 92:297-297(1996)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Aortic smooth muscle.
  3. "Cyclic ADP-ribose binds to FK506-binding protein 12.6 to release Ca2+ from islet microsomes."
    Noguchi N., Takasawa S., Nata K., Tohgo A., Kato I., Ikehata F., Yonekura H., Okamoto H.
    J. Biol. Chem. 272:3133-3136(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Pancreatic islet.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Heart.
  5. "Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks."
    Guo T., Cornea R.L., Huke S., Camors E., Yang Y., Picht E., Fruen B.R., Bers D.M.
    Circ. Res. 106:1743-1752(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RYR2, TISSUE SPECIFICITY.
  6. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFKB1A_RAT
AccessioniPrimary (citable) accession number: Q62658
Secondary accession number(s): A0JN04, P97533
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.