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Protein

Peptidyl-prolyl cis-trans isomerase FKBP1A

Gene

Fkbp1a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).By similarity

Enzyme regulationi

Inhibited by both FK506 and rapamycin.

GO - Molecular functioni

  • activin binding Source: Ensembl
  • enzyme binding Source: RGD
  • FK506 binding Source: RGD
  • Hsp70 protein binding Source: RGD
  • ion channel binding Source: Ensembl
  • peptidyl-prolyl cis-trans isomerase activity Source: GO_Central
  • protein homodimerization activity Source: Ensembl
  • signal transducer activity Source: Ensembl
  • SMAD binding Source: Ensembl
  • transforming growth factor beta receptor binding Source: BHF-UCL
  • type I transforming growth factor beta receptor binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Rotamase

Enzyme and pathway databases

ReactomeiR-RNO-2173789. TGF-beta receptor signaling activates SMADs.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP1A (EC:5.2.1.8By similarity)
Short name:
PPIase FKBP1A
Alternative name(s):
12 kDa FK506-binding protein
Short name:
12 kDa FKBP
Short name:
FKBP-12
FK506-binding protein 1A
Short name:
FKBP-1A
Immunophilin FKBP12
Rotamase
Gene namesi
Name:Fkbp1a
Synonyms:Fkbp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi2617. Fkbp1a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Sarcoplasmic reticulum

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2095.
GuidetoPHARMACOLOGYi2609.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000752921 – 108Peptidyl-prolyl cis-trans isomerase FKBP1AAdd BLAST108

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineCombined sources1
Modified residuei53N6-acetyllysine; alternateBy similarity1
Modified residuei53N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ62658.
PRIDEiQ62658.

PTM databases

iPTMnetiQ62658.
PhosphoSitePlusiQ62658.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSRNOG00000008822.
GenevisibleiQ62658. RN.

Interactioni

Subunit structurei

Interacts with TGFBR1; prevents TGFBR1 phosphorylation by TGFBR2 and stabilizes it in the inactive conformation (By similarity). Interacts with ACVR1B and SMAD7. Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1) (By similarity). Interacts directly with RYR2 (PubMed:20431056). Interacts directly with RYR3 (By similarity). Interacts directly with RYR1 (By similarity).By similarity1 Publication

GO - Molecular functioni

  • activin binding Source: Ensembl
  • enzyme binding Source: RGD
  • Hsp70 protein binding Source: RGD
  • ion channel binding Source: Ensembl
  • protein homodimerization activity Source: Ensembl
  • SMAD binding Source: Ensembl
  • transforming growth factor beta receptor binding Source: BHF-UCL
  • type I transforming growth factor beta receptor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi247668. 1 interactor.
CORUMiQ62658.
STRINGi10116.ENSRNOP00000012608.

Structurei

3D structure databases

ProteinModelPortaliQ62658.
SMRiQ62658.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 108PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST89

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0544. Eukaryota.
COG0545. LUCA.
GeneTreeiENSGT00760000119159.
HOGENOMiHOG000154887.
HOVERGENiHBG051623.
InParanoidiQ62658.
KOiK09568.
OMAiRVIAGWD.
OrthoDBiEOG091G02W1.
PhylomeDBiQ62658.

Family and domain databases

InterProiView protein in InterPro
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiView protein in Pfam
PF00254. FKBP_C. 1 hit.
PROSITEiView protein in PROSITE
PS50059. FKBP_PPIASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q62658-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVQVETISS GDGRTFPKRG QTCVVHYTGM LEDGKKFDSS RDRNKPFKFT
60 70 80 90 100
LGKQEVIRGW EEGVAQMSVG QRAKLIISPD YAYGATGHPG IIPPHATLVF

DVELLKLE
Length:108
Mass (Da):11,923
Last modified:January 23, 2007 - v3
Checksum:i1C195C2A52C17666
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti89P → T in BAA13153 (PubMed:9013543).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09386 mRNA. Translation: AAA19163.1.
U69485 mRNA. Translation: AAB48933.1.
D86641 mRNA. Translation: BAA13153.1.
BC070519 mRNA. Translation: AAH70519.3.
BC126071 mRNA. Translation: AAI26072.1.
RefSeqiNP_037234.2. NM_013102.3.
UniGeneiRn.80611.

Genome annotation databases

EnsembliENSRNOT00000012608; ENSRNOP00000012608; ENSRNOG00000008822.
GeneIDi25639.
KEGGirno:25639.
UCSCiRGD:2617. rat.

Similar proteinsi

Entry informationi

Entry nameiFKB1A_RAT
AccessioniPrimary (citable) accession number: Q62658
Secondary accession number(s): A0JN04, P97533
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: September 27, 2017
This is version 139 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families