Q62658 (FKB1A_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP1A
Short name=PPIase FKBP1A
EC=5.2.1.8

Alternative name(s):
12 kDa FK506-binding protein
Short name=12 kDa FKBP
Short name=FKBP-12
FK506-binding protein 1A
Short name=FKBP-1A
Immunophilin FKBP12
Rotamase

Gene names

Name:	Fkbp1a
Synonyms:	Fkbp1

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	108 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May play a role in modulation of ryanodine receptor isoform-1 (RYR-1), a component of the calcium release channel of skeletal muscle sarcoplasmic reticulum. There are four molecules of FKBP1A per skeletal muscle RYR. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides By similarity.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Enzyme regulation	Inhibited by both FK506 and rapamycin.
Subunit structure	Interacts with TGFBR1; prevents TGFBR1 phosphorylation by TGFBR2 and stabilizes it in the inactive conformation By similarity. Interacts with ACVR1B and SMAD7 By similarity.
Subcellular location	Cytoplasm.
Tissue specificity	Ubiquitous.
Sequence similarities	Belongs to the FKBP-type PPIase family. FKBP1 subfamily. Contains 1 PPIase FKBP-type domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Isomerase Rotamase
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	negative regulation of protein phosphatase type 2B activity Inferred from Biological aspect of Ancestor. Source: RefGenome protein folding Inferred from electronic annotation. Source: UniProtKB-KW regulation of ryanodine-sensitive calcium-release channel activity Inferred from Biological aspect of Ancestor. Source: RefGenome response to iron ion Inferred from expression pattern. Source: RGD
Cellular component	axon terminus Inferred from direct assay. Source: RGD cytosol Inferred from Biological aspect of Ancestor. Source: RefGenome microsome Inferred from direct assay Ref.3. Source: RGD sarcoplasmic reticulum membrane Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular function	FK506 binding Inferred from direct assay Ref.3. Source: RGD Hsp70 protein binding Inferred from physical interaction. Source: RGD peptidyl-prolyl cis-trans isomerase activity Inferred from Biological aspect of Ancestor. Source: RefGenome type I transforming growth factor beta receptor binding Inferred from direct assay Ref.1. Source: BHF-UCL
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 108	107	Peptidyl-prolyl cis-trans isomerase FKBP1A		PRO_0000075292
Regions
	Domain	20 – 108	89	PPIase FKBP-type
Amino acid modifications
	Modified residue	9	1	Phosphoserine By similarity
	Modified residue	53	1	N6-acetyllysine By similarity
Experimental info
	Sequence conflict	89	1	P → T in BAA13153. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q62658 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 1C195C2A52C17666	FASTA	108	11,923
	10 20 30 40 50 60 MGVQVETISS GDGRTFPKRG QTCVVHYTGM LEDGKKFDSS RDRNKPFKFT LGKQEVIRGW 70 80 90 100 EEGVAQMSVG QRAKLIISPD YAYGATGHPG IIPPHATLVF DVELLKLE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Specific interaction of type I receptors of the TGF-beta family with the immunophilin FKBP-12." Wang T., Donahoe P.K., Zervos A.S. Science 265:674-676(1994) [PubMed: 7518616] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart.
[2]	"Identification of a novel FK506-binding protein in rat aortic smooth muscle cells." Marx S.O., Jayaraman T., Mehran R., Go L.O., Wiederrecht G.J., Marks A.R. Circulation 92:297-297(1996) Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Aortic smooth muscle.
[3]	"Cyclic ADP-ribose binds to FK506-binding protein 12.6 to release Ca2+ from islet microsomes." Noguchi N., Takasawa S., Nata K., Tohgo A., Kato I., Ikehata F., Yonekura H., Okamoto H. J. Biol. Chem. 272:3133-3136(1997) [PubMed: 9013543] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Wistar. Tissue: Pancreatic islet.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Heart.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U09386 mRNA. Translation: AAA19163.1. U69485 mRNA. Translation: AAB48933.1. D86641 mRNA. Translation: BAA13153.1. BC070519 mRNA. Translation: AAH70519.3. BC126071 mRNA. Translation: AAI26072.1.
IPI	IPI00231434.
RefSeq	NP_037234.2. NM_013102.2.
UniGene	Rn.80611.
3D structure databases
ProteinModelPortal	Q62658.
SMR	Q62658. Positions 2-108.
ModBase	Search...
Protein-protein interaction databases
STRING	Q62658.
PTM databases
PhosphoSite	Q62658.
Proteomic databases
PRIDE	Q62658.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000012608; ENSRNOP00000012608; ENSRNOG00000008822.
GeneID	25639.
KEGG	rno:25639.
UCSC	NM_013102. rat.
Organism-specific databases
CTD	2280.
RGD	2617. Fkbp1a.
Phylogenomic databases
eggNOG	roNOG17185.
GeneTree	ENSGT00550000074272.
HOVERGEN	HBG051623.
InParanoid	Q62658.
OMA	DFAYGNK.
OrthoDB	EOG42NJ1X.
PhylomeDB	Q62658.
Gene expression databases
ArrayExpress	Q62658.
Genevestigator	Q62658.
GermOnline	ENSRNOG00000008822. Rattus norvegicus.
Family and domain databases
InterPro	IPR023566. PPIase_FKBP. IPR001179. PPIase_FKBP_dom. [Graphical view]
KO	K09568.
PANTHER	PTHR10516. PPIase_FKBP. 1 hit.
Pfam	PF00254. FKBP_C. 1 hit. [Graphical view]
PROSITE	PS50059. FKBP_PPIASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	607471.

Entry information

Entry name

FKB1A_RAT

Accession

Primary (citable) accession number: Q62658
Secondary accession number(s): A0JN04, P97533

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	January 23, 2007
Last modified:	November 16, 2011
This is version 86 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program