Reviewed,
UniProtKB/Swiss-Prot Q62658 (FKB1A_RAT)
Last modified
November 24, 2009.
Version 67.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Peptidyl-prolyl cis-trans isomerase FKBP1A Short name=PPIase FKBP1A EC=5.2.1.8 Alternative name(s): FK506-binding protein 1A Short name=FKBP-1A Rotamase Immunophilin FKBP12 Short name=12 kDa FKBP Short name=FKBP-12 | ||||
| Gene names |
| ||||
| Organism | Rattus norvegicus (Rat) | ||||
| Taxonomic identifier | 10116 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 108 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | May play a role in modulation of ryanodine receptor isoform-1 (RYR-1), a component of the calcium release channel of skeletal muscle sarcoplasmic reticulum. There are four molecules of FKBP12 per skeletal muscle RYR. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. |
| Catalytic activity | Peptidylproline (omega=180) = peptidylproline (omega=0). |
| Enzyme regulation | Inhibited by both FK506 and rapamycin. |
| Subcellular location | |
| Tissue specificity | Ubiquitous. |
| Sequence similarities | Belongs to the FKBP-type PPIase family. FKBP1 subfamily. Contains 1 PPIase FKBP-type domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Molecular function | Isomerase Rotamase |
| PTM | Acetylation Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | protein folding Inferred from electronic annotation. Source: UniProtKB-KW response to iron ionInferred from expression pattern. Source: RGD |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell microsome Ref.3Inferred from direct assay. Source: RGD nerve terminalInferred from direct assay. Source: RGD |
| Molecular function | FK506 binding Ref.3 Inferred from direct assay. Source: RGD peptidyl-prolyl cis-trans isomerase activityInferred from electronic annotation. Source: UniProtKB-KW type I transforming growth factor beta receptor binding Ref.1Inferred from direct assay. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed By similarity | ||||||
| Chain | 2 – 108 | 107 | Peptidyl-prolyl cis-trans isomerase FKBP1A | PRO_0000075292 | |||||
Regions | |||||||||
| Domain | 20 – 108 | 89 | PPIase FKBP-type | ||||||
Amino acid modifications | |||||||||
| Modified residue | 9 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 53 | 1 | N6-acetyllysine By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 89 | 1 | P → T in BAA13153. Ref.3 | ||||||
Sequences
References
| « Hide 'large scale' references | |
| [1] | "Specific interaction of type I receptors of the TGF-beta family with the immunophilin FKBP-12." Wang T., Donahoe P.K., Zervos A.S. Science 265:674-676(1994) [PubMed: 7518616] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart. |
| [2] | "Identification of a novel FK506-binding protein in rat aortic smooth muscle cells." Marx S.O., Jayaraman T., Mehran R., Go L.O., Wiederrecht G.J., Marks A.R. Circulation 92:297-297(1996) Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Aortic smooth muscle. |
| [3] | "Cyclic ADP-ribose binds to FK506-binding protein 12.6 to release Ca2+ from islet microsomes." Noguchi N., Takasawa S., Nata K., Tohgo A., Kato I., Ikehata F., Yonekura H., Okamoto H. J. Biol. Chem. 272:3133-3136(1997) [PubMed: 9013543] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Wistar. Tissue: Pancreatic islet. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Heart. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U09386 mRNA. Translation: AAA19163.1. U69485 mRNA. Translation: AAB48933.1. D86641 mRNA. Translation: BAA13153.1. BC070519 mRNA. Translation: AAH70519.3. BC126071 mRNA. Translation: AAI26072.1. | |
| IPI | IPI00231434. |
| RefSeq | NP_037234.2. |
| UniGene | Rn.80611 |
3D structure databases | |
| SMR | Q62658. Positions 2-108. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q62658. |
Proteomic databases | |
| PRIDE | Q62658. |
Genome annotation databases | |
| Ensembl | ENSRNOT00000012608; ENSRNOP00000012608; ENSRNOG00000008822; Rattus norvegicus. [Genome view] |
| GeneID | 25639. |
| KEGG | rno:25639. |
| UCSC | NM_013102. rat. |
Organism-specific databases | |
| CTD | 25639. |
| RGD | 2617. Fkbp1a. |
Phylogenomic databases | |
| HOVERGEN | Q62658. |
| OMA | IAGVIFY |
| OrthoDB | EOG91C9FN |
Enzyme and pathway databases | |
| BRENDA | 5.2.1.8. 248. |
Gene expression databases | |
| ArrayExpress | Q62658. |
| Genevestigator | Q62658. |
| GermOnline | ENSRNOG00000008822. Rattus norvegicus. |
Family and domain databases | |
| InterPro | IPR001179. PPIase_FKBP. [Graphical view] |
| PANTHER | PTHR10516. PPIase_FKBP. 1 hit. |
| Pfam | PF00254. FKBP_C. 1 hit. [Graphical view] |
| PROSITE | PS50059. FKBP_PPIASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 607471. |
Entry information
| Entry name | FKB1A_RAT | ||||||||
| Accession | Primary (citable) accession number: Q62658 Secondary accession number(s): A0JN04, P97533 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

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