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Protein

Neuronatin

Gene

Nnat

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May participate in the maintenance of segment identity in the hindbrain and pituitary development, and maturation or maintenance of the overall structure of the nervous system.

GO - Biological processi

  • brain development Source: RGD
  • neuron differentiation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronatin
Gene namesi
Name:Nnat
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi620155. Nnat.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8181NeuronatinPRO_0000096884Add
BLAST

Proteomic databases

PaxDbiQ62649.

Expressioni

Tissue specificityi

Brain.

Developmental stagei

Appears in the mid embryonic period and becomes abundant at E16-19. Postnatally its expression decline and only minimal levels were present in adulthood.

Gene expression databases

GenevisibleiQ62649. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064325.

Family & Domainsi

Sequence similaritiesi

Belongs to the neuronatin family.Curated

Phylogenomic databases

eggNOGiENOG410JDHY. Eukaryota.
ENOG41117T6. LUCA.
GeneTreeiENSGT00390000007412.
HOGENOMiHOG000185187.
HOVERGENiHBG001605.
InParanoidiQ62649.
OMAiMGERRQR.
OrthoDBiEOG79KPJR.
PhylomeDBiQ62649.

Family and domain databases

InterProiIPR024885. Neuronatin.
[Graphical view]
PANTHERiPTHR15285. PTHR15285. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Alpha (identifier: Q62649-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVAAASAE LLIIGWYIFR VLLQVFLECC IYWVGFAFRN PPGTQPIARS
60 70 80
EVFRYSLQKL AHTVSRTGRQ VLGERRHRAP N
Length:81
Mass (Da):9,220
Last modified:November 1, 1996 - v1
Checksum:i067086DB1D7E3D20
GO
Isoform Beta (identifier: Q62649-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-51: Missing.

Show »
Length:54
Mass (Da):6,136
Checksum:i184E7C8A39406C87
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei25 – 5127Missing in isoform Beta. 3 PublicationsVSP_004334Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08290 mRNA. Translation: AAA92998.1.
U09785 mRNA. Translation: AAA92999.1.
BC127473 mRNA. Translation: AAI27474.1.
PIRiI60594.
JC2325.
RefSeqiNP_001257796.1. NM_001270867.1.
NP_446053.1. NM_053601.2. [Q62649-1]
NP_859015.1. NM_181687.2. [Q62649-2]
UniGeneiRn.5785.

Genome annotation databases

EnsembliENSRNOT00000034166; ENSRNOP00000034212; ENSRNOG00000024923. [Q62649-2]
ENSRNOT00000072502; ENSRNOP00000064325; ENSRNOG00000024923. [Q62649-1]
GeneIDi94270.
KEGGirno:94270.
UCSCiRGD:620155. rat. [Q62649-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08290 mRNA. Translation: AAA92998.1.
U09785 mRNA. Translation: AAA92999.1.
BC127473 mRNA. Translation: AAI27474.1.
PIRiI60594.
JC2325.
RefSeqiNP_001257796.1. NM_001270867.1.
NP_446053.1. NM_053601.2. [Q62649-1]
NP_859015.1. NM_181687.2. [Q62649-2]
UniGeneiRn.5785.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000064325.

Proteomic databases

PaxDbiQ62649.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000034166; ENSRNOP00000034212; ENSRNOG00000024923. [Q62649-2]
ENSRNOT00000072502; ENSRNOP00000064325; ENSRNOG00000024923. [Q62649-1]
GeneIDi94270.
KEGGirno:94270.
UCSCiRGD:620155. rat. [Q62649-1]

Organism-specific databases

CTDi4826.
RGDi620155. Nnat.

Phylogenomic databases

eggNOGiENOG410JDHY. Eukaryota.
ENOG41117T6. LUCA.
GeneTreeiENSGT00390000007412.
HOGENOMiHOG000185187.
HOVERGENiHBG001605.
InParanoidiQ62649.
OMAiMGERRQR.
OrthoDBiEOG79KPJR.
PhylomeDBiQ62649.

Miscellaneous databases

NextBioi617903.
PROiQ62649.

Gene expression databases

GenevisibleiQ62649. RN.

Family and domain databases

InterProiIPR024885. Neuronatin.
[Graphical view]
PANTHERiPTHR15285. PTHR15285. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a novel mRNA (neuronatin) that is highly expressed in neonatal mammalian brain."
    Joseph R., Dou D., Tsang W.
    Biochem. Biophys. Res. Commun. 201:1227-1234(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA).
    Strain: Fischer 344.
    Tissue: Brain.
  2. "Molecular cloning of neuronatin: alternatively spliced forms of a novel mammalian developmental gene."
    Joseph R., Dou D., Tsang W.
    Nucleic Acids Symp. Ser. 30:15-15(1994)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA).
    Strain: Fischer 344.
    Tissue: Brain.
  3. "Neuronatin mRNA: alternatively spliced forms of a novel brain-specific mammalian developmental gene."
    Joseph R., Dou D., Tsang W.
    Brain Res. 690:92-98(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA).
    Strain: Fischer 344.
    Tissue: Brain.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BETA).
    Tissue: Brain.

Entry informationi

Entry nameiNNAT_RAT
AccessioniPrimary (citable) accession number: Q62649
Secondary accession number(s): A0JPK6, Q62663
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.