Q62649 (NNAT_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neuronatin

Gene names

Name:

Nnat

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	81 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May participate in the maintenance of segment identity in the hindbrain and pituitary development, and maturation or maintenance of the overall structure of the nervous system.
Tissue specificity	Brain.
Developmental stage	Appears in the mid embryonic period and becomes abundant at E16-19. Postnatally its expression decline and only minimal levels were present in adulthood.
Sequence similarities	Belongs to the neuronatin family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	brain development Inferred from expression pattern Ref.1. Source: RGD neuron differentiation Inferred from expression pattern PubMed 8949924. Source: RGD
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform Alpha (identifier: Q62649-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform Beta (identifier: Q62649-2)

The sequence of this isoform differs from the canonical sequence as follows:
     25-51: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 81	81	Neuronatin		PRO_0000096884
Natural variations
	Alternative sequence	25 – 51	27	Missing in isoform Beta.		VSP_004334

Sequences

	Sequence		Length	Mass (Da)
	Isoform Alpha [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 067086DB1D7E3D20	FASTA	81	9,220
	10 20 30 40 50 60 MAAVAAASAE LLIIGWYIFR VLLQVFLECC IYWVGFAFRN PPGTQPIARS EVFRYSLQKL 70 80 AHTVSRTGRQ VLGERRHRAP N
	Isoform Beta [UniParc]. Checksum: 184E7C8A39406C87	FASTA	54	6,136
	10 20 30 40 50 MAAVAAASAE LLIIGWYIFR VLLQVFRYSL QKLAHTVSRT GRQVLGERRH RAPN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of a novel mRNA (neuronatin) that is highly expressed in neonatal mammalian brain." Joseph R., Dou D., Tsang W. Biochem. Biophys. Res. Commun. 201:1227-1234(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA). Strain: Fischer 344. Tissue: Brain.
[2]	"Molecular cloning of neuronatin: alternatively spliced forms of a novel mammalian developmental gene." Joseph R., Dou D., Tsang W. Nucleic Acids Symp. Ser. 30:15-15(1994) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA). Strain: Fischer 344. Tissue: Brain.
[3]	"Neuronatin mRNA: alternatively spliced forms of a novel brain-specific mammalian developmental gene." Joseph R., Dou D., Tsang W. Brain Res. 690:92-98(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA). Strain: Fischer 344. Tissue: Brain.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BETA). Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U08290 mRNA. Translation: AAA92998.1. U09785 mRNA. Translation: AAA92999.1. BC127473 mRNA. Translation: AAI27474.1.
IPI	IPI00207096. IPI00231214.
PIR	I60594. JC2325.
RefSeq	NP_001257796.1. NM_001270867.1. NP_446053.1. NM_053601.2. NP_859015.1. NM_181687.2.
UniGene	Rn.5785.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000036483.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000034166; ENSRNOP00000034212; ENSRNOG00000024923. ENSRNOT00000072502; ENSRNOP00000064325; ENSRNOG00000024923.
GeneID	94270.
KEGG	rno:94270.
UCSC	RGD:620155. rat.
Organism-specific databases
CTD	4826.
RGD	620155. Nnat.
Phylogenomic databases
eggNOG	NOG45532.
GeneTree	ENSGT00390000007412.
HOGENOM	HOG000185187.
HOVERGEN	HBG001605.
InParanoid	Q62649.
Gene expression databases
Genevestigator	Q62649.
GermOnline	ENSRNOG00000024923. Rattus norvegicus.
Family and domain databases
InterPro	IPR024885. Neuronatin. [Graphical view]
PANTHER	PTHR15285. PTHR15285. 1 hit.
ProtoNet	Search...
Other
NextBio	617903.

Entry information

Entry name

NNAT_RAT

Accession

Primary (citable) accession number: Q62649
Secondary accession number(s): A0JPK6, Q62663

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program