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Protein
Submitted name:

Glutamate receptor ionotropic, NMDA 1

Gene

Grin1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotationImported
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Glutamate receptor ionotropic, NMDA 1Imported
Submitted name:
Glutamate receptor, ionotropic, N-methyl D-aspartate 1, isoform CRA_bImported
Submitted name:
N-methyl-D-aspartate receptor NMDAR1-3b subunitImported
Gene namesi
Name:Grin1Imported
Synonyms:NMDAR1Imported
ORF Names:rCG_45539Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi2736. Grin1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei583 – 601HelicalSequence analysisAdd BLAST19
Transmembranei656 – 678HelicalSequence analysisAdd BLAST23
Transmembranei834 – 858HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_501084488621 – 943Sequence analysisAdd BLAST923

Expressioni

Gene expression databases

BgeeiENSRNOG00000011726.

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini454 – 816PBPeInterPro annotationAdd BLAST363
Domaini460 – 528Lig_chan-Glu_bdInterPro annotationAdd BLAST69

Sequence similaritiesi

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. [View classification]SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1053. Eukaryota.
ENOG410XNUR. LUCA.
GeneTreeiENSGT00760000119186.
HOGENOMiHOG000231491.
HOVERGENiHBG052638.
OMAiSGFYHIP.
OrthoDBiEOG091G0M5H.

Family and domain databases

InterProiView protein in InterPro
IPR001828. ANF_lig-bd_rcpt.
IPR018882. CaM-bd_C0_NMDA_rcpt_NR1.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
PfamiView protein in Pfam
PF01094. ANF_receptor. 1 hit.
PF10562. CaM_bdg_C0. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
PRINTSiPR00177. NMDARECEPTOR.
SMARTiView protein in SMART
SM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequencei

Sequence statusi: Complete.

Q62648-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTMHLLTFA LLFSCSFARA ACDPKIVNIG AVLSTRKHEQ MFREAVNQAN
60 70 80 90 100
KRHGSWKIQL NATSVTHKPN AIQMALSVCE DLISSQVYAI LVSHPPTPND
110 120 130 140 150
HFTPTPVSYT AGFYRIPVLG LTTRMSIYSD KSIHLSFLRT VPPYSHQSSV
160 170 180 190 200
WFEMMRVYNW NHIILLVSDD HEGRAAQKRL ETLLEERESK SKKRNYENLD
210 220 230 240 250
QLSYDNKRGP KAEKVLQFDP GTKNVTALLM EARELEARVI ILSASEDDAA
260 270 280 290 300
TVYRAAAMLN MTGSGYVWLV GEREISGNAL RYAPDGIIGL QLINGKNESA
310 320 330 340 350
HISDAVGVVA QAVHELLEKE NITDPPRGCV GNTNIWKTGP LFKRVLMSSK
360 370 380 390 400
YADGVTGRVE FNEDGDRKFA NYSIMNLQNR KLVQVGIYNG THVIPNDRKI
410 420 430 440 450
IWPGGETEKP RGYQMSTRLK IVTIHQEPFV YVKPTMSDGT CKEEFTVNGD
460 470 480 490 500
PVKKVICTGP NDTSPGSPRH TVPQCCYGFC IDLLIKLART MNFTYEVHLV
510 520 530 540 550
ADGKFGTQER VNNSNKKEWN GMMGELLSGQ ADMIVAPLTI NNERAQYIEF
560 570 580 590 600
SKPFKYQGLT ILVKKEIPRS TLDSFMQPFQ STLWLLVGLS VHVVAVMLYL
610 620 630 640 650
LDRFSPFGRF KVNSEEEEED ALTLSSAMWF SWGVLLNSGI GEGAPRSFSA
660 670 680 690 700
RILGMVWAGF AMIIVASYTA NLAAFLVLDR PEERITGIND PRLRNPSDKF
710 720 730 740 750
IYATVKQSSV DIYFRRQVEL STMYRHMEKH NYESAAEAIQ AVRDNKLHAF
760 770 780 790 800
IWDSAVLEFE ASQKCDLVTT GELFFRSGFG IGMRKDSPWK QNVSLSILKS
810 820 830 840 850
HENGFMEDLD KTWVRYQECD SRSNAPATLT FENMAGVFML VAGGIVAGIF
860 870 880 890 900
LIFIEIAYKR HKDARRKQMQ LAFAAVNVWR KNLQDRKSGR AEPDPKKKAT
910 920 930 940
FRAITSTLAS SFKRRRSSKD TQYHPTDITG PLNLSDPSVS TVV
Length:943
Mass (Da):106,151
Last modified:November 1, 1996 - v1
Checksum:i3D521E349A5741BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07051241 Genomic DNA. No translation available.
U08266 mRNA. Translation: AAB50931.1.
CH474001 Genomic DNA. Translation: EDL93607.1.
RefSeqiNP_001257535.1. NM_001270606.1.
UniGeneiRn.9840.

Genome annotation databases

EnsembliENSRNOT00000037725; ENSRNOP00000029227; ENSRNOG00000011726.
GeneIDi24408.

Similar proteinsi

Entry informationi

Entry nameiQ62648_RAT
AccessioniPrimary (citable) accession number: Q62648
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: September 27, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported