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Protein

Glutamate receptor ionotropic, delta-1

Gene

Grid1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei73Essential for dimerizationBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, delta-1
Short name:
GluD1
Short name:
GluR delta-1 subunit
Gene namesi
Name:Grid1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi68366 Grid1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 562ExtracellularSequence analysisAdd BLAST542
Transmembranei563 – 583HelicalSequence analysisAdd BLAST21
Topological domaini584 – 637CytoplasmicSequence analysisAdd BLAST54
Transmembranei638 – 658HelicalSequence analysisAdd BLAST21
Topological domaini659 – 830ExtracellularSequence analysisAdd BLAST172
Transmembranei831 – 851HelicalSequence analysisAdd BLAST21
Topological domaini852 – 1009CytoplasmicSequence analysisAdd BLAST158

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1681629

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001156321 – 1009Glutamate receptor ionotropic, delta-1Add BLAST989

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi80 ↔ 351By similarity
Disulfide bondi96 ↔ 128By similarity
Glycosylationi200N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi294 ↔ 306By similarity
Glycosylationi422N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi498N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ62640
PRIDEiQ62640

PTM databases

iPTMnetiQ62640
PhosphoSitePlusiQ62640

Expressioni

Tissue specificityi

Highest in the pyramidal and dentate granule cell layers of the hippocampus.1 Publication

Developmental stagei

Low in adult brain, much higher in younger animals.

Interactioni

Subunit structurei

Dimer. Interacts (via extracellular N-terminal domain) with CBLN1 (via C1q domain), and more weakly with CBLN2.By similarity

Protein-protein interaction databases

IntActiQ62640, 1 interactor
MINTiQ62640
STRINGi10116.ENSRNOP00000031478

Structurei

3D structure databases

ProteinModelPortaliQ62640
SMRiQ62640
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 436Interaction with CBLN1By similarityAdd BLAST416

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KDI7 Eukaryota
ENOG410YYDD LUCA
HOVERGENiHBG051840
InParanoidiQ62640
KOiK05206
PhylomeDBiQ62640

Family and domain databases

InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR019594 Glu/Gly-bd
IPR001508 Iono_rcpt_met
IPR001320 Iontro_rcpt
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF01094 ANF_receptor, 1 hit
PF00060 Lig_chan, 1 hit
PF10613 Lig_chan-Glu_bd, 1 hit
PRINTSiPR00177 NMDARECEPTOR
SMARTiView protein in SMART
SM00918 Lig_chan-Glu_bd, 1 hit
SM00079 PBPe, 1 hit
SUPFAMiSSF53822 SSF53822, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62640-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEALTLWLLP WICQCVTVRA DSIIHIGAIF EENAAKDDRV FQLAVSDLSL
60 70 80 90 100
NDDILQSEKI TYSIKVIEAN NPFQAVQEAC DLMTQGILAL VTSTGCASAN
110 120 130 140 150
ALQSLTDAMH IPHLFVQRNP GGSPRTACHL NPSPDGEAYT LASRPPVRLN
160 170 180 190 200
DVMLRLVTEL RWQKFVMFYD SEYDIRGLQS FLDQASRLGL DVSLQKVDKN
210 220 230 240 250
ISHVFTSLFT TMKTEELNRY RDTLRRAILL LSPQGAHSFI NEAVETNLAS
260 270 280 290 300
KDSHWVFVNE EISDPEILDL VHSALGRMTV VRQIFPSAKD NQKCMRNNHR
310 320 330 340 350
ISSLLCDPQE GYLQMLQISN LYLYDSVLML ANAFHRKLED RKWHSMASLN
360 370 380 390 400
CIRKSTKPWN GGRSMLDTIK KGHITGLTGV MEFREDSSNP YVQFEILGTT
410 420 430 440 450
YSETFGKDMR KLATWDSEKG LNGSLQERPM GSRLQGLTLK VVTVLEEPFV
460 470 480 490 500
MVAENILGQP KRYKGFSIDV LDALAKALGF KYEIYQAPDG RYGHQLHNTS
510 520 530 540 550
WNGMIGELIS KRADLAISAI TITPERESVV DFSKRYMDYS VGILIKKPEE
560 570 580 590 600
KISIFSLFAP FDFAVWACIA AAIPVVGVLI FVLNRIQAVR SQSATQPRPS
610 620 630 640 650
ASATLHSAIW IVYGAFVQQG GESSVNSVAM RIVMGSWWLF TLIVCSSYTA
660 670 680 690 700
NLAAFLTVSR MDSPVRTFQD LSKQLEMSYG TVRDSAVYEY FRAKGTNPLE
710 720 730 740 750
QDSTFAELWR TISKNGGADN CVSNPSEGIR KAKKGNYAFL WDVAVVEYAA
760 770 780 790 800
LTDDDCSVTV IGNSISSKGY GIALQHGSPY RDLFSQRILE LQDTGDLDVL
810 820 830 840 850
KQKWWPHTGR CDLTSHSSAQ TDGKSLKLHS FAGVFCILAI GLLLACLVAA
860 870 880 890 900
LELWWNSNRC HQETPKEDKE VNLEQVHRRI NSLMDEDIAH KQISPASIEL
910 920 930 940 950
SALEMGGLAP SQALEPTREY QNTQLSVSTF LPEQSSHGTS RTLSSGPSSN
960 970 980 990 1000
LPLPLSSSAT MPSIQCKHRS PNGGLFRQSP VKTPIPMSFQ PVPGGVLPEA

LDTSHGTSI
Length:1,009
Mass (Da):112,125
Last modified:November 1, 1996 - v1
Checksum:iACE950B8B335B4E2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti917T → S in CAA78936 (PubMed:8422924).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08255 mRNA Translation: AAA17828.1
Z17238 mRNA Translation: CAA78936.1
RefSeqiNP_077354.1, NM_024378.1
UniGeneiRn.10040

Genome annotation databases

GeneIDi79219
KEGGirno:79219
UCSCiRGD:68366 rat

Similar proteinsi

Entry informationi

Entry nameiGRID1_RAT
AccessioniPrimary (citable) accession number: Q62640
Secondary accession number(s): Q63225
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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