Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q62639 (RHEB_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP-binding protein Rheb
Alternative name(s):
Ras homolog enriched in brain
Gene names
Name:Rheb
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length184 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Activates the protein kinase activity of mTORC1. Has low intrinsic GTPase activity By similarity.

Enzyme regulation

Alternates between an inactive form bound to GDP and an active form bound to GTP. Inactivated by TSC1-TSC2 via the GTPase activating protein (GAP) domain of TSC2 By similarity.

Subunit structure

Binds to mTORC1 in a guanyl nucleotide-independent manner. Interacts directly with MTOR, MLST8 and RPTOR. Interacts with TSC2 By similarity.

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side Potential.

Tissue specificity

Expressed at high levels in normal adult cortex as well as a number of peripheral tissues, including lung and intestine.

Post-translational modification

Farnesylation is important for efficiently activating mTORC1-mediated signaling By similarity.

Phosphorylation by MAPKAPK5 impairs GTP-binding and inactivation By similarity.

Miscellaneous

The conserved catalytic Gln-64 found in other Ras-like GTPases seems not to be involved in GTP hydrolysis in RHEB By similarity.

Sequence similarities

Belongs to the small GTPase superfamily. Rheb family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 181181GTP-binding protein Rheb
PRO_0000082710
Propeptide182 – 1843Removed in mature form By similarity
PRO_0000281367

Regions

Nucleotide binding16 – 216GTP By similarity
Nucleotide binding32 – 387GTP By similarity
Nucleotide binding149 – 1502GTP By similarity
Motif35 – 439Effector region

Sites

Metal binding201Magnesium By similarity
Metal binding381Magnesium By similarity

Amino acid modifications

Modified residue1301Phosphoserine; by MAPKAPK5 By similarity
Modified residue1811Cysteine methyl ester By similarity
Lipidation1811S-farnesyl cysteine By similarity

Secondary structure

............................ 184
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q62639 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 8F4C8080BDF92DE9

FASTA18420,479
        10         20         30         40         50         60 
MPQSKSRKIA ILGYRSVGKS SLTIQFVEGQ FVDSYDPTIE NTFTKLITVN GQEYHLQLVD 

        70         80         90        100        110        120 
TAGQDEYSIF PQTYSIDING YILVYSVTSI KSFEVIKVIH GKLLDMVGKV QIPIMLVGNK 

       130        140        150        160        170        180 
KDLHMERVIS YEEGKALAES WNAAFLESSA KENQTAVDVF RRIILEAEKI DGAASQGKSS 


CSVM 

« Hide

References

« Hide 'large scale' references
[1]"Rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein."
Yamagata K., Sanders L.K., Kaufmann W.E., Yee W., Barnes C.A., Nathans D., Worley P.F.
J. Biol. Chem. 269:16333-16339(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Hippocampus.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U08227 mRNA. Translation: AAA21380.1.
BC088857 mRNA. Translation: AAH88857.1.
PIRI55401.
RefSeqNP_037348.1. NM_013216.1.
UniGeneRn.859.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2L0XNMR-A6-174[»]
ProteinModelPortalQ62639.
SMRQ62639. Positions 2-171.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ62639.

Proteomic databases

PRIDEQ62639.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID26954.
KEGGrno:26954.

Organism-specific databases

CTD6009.
RGD621840. Rheb.

Phylogenomic databases

HOVERGENHBG009351.
KOK07208.
PhylomeDBQ62639.

Gene expression databases

GenevestigatorQ62639.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERPTHR24070. PTHR24070. 1 hit.
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00173. RAS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ62639.
NextBio608022.
PROQ62639.

Entry information

Entry nameRHEB_RAT
AccessionPrimary (citable) accession number: Q62639
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references