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Q62635

- MUC2_RAT

UniProt

Q62635 - MUC2_RAT

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Protein

Mucin-2

Gene
Muc2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer By similarity.

GO - Molecular functioni

  1. protein binding Source: RGD
  2. protein homodimerization activity Source: RGD

GO - Biological processi

  1. cellular response to tumor necrosis factor Source: RGD
  2. response to hormone Source: RGD
  3. response to lipopolysaccharide Source: RGD
  4. response to vitamin A Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Mucin-2
Short name:
MUC-2
Alternative name(s):
Intestinal mucin-2
Gene namesi
Name:Muc2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3123. Muc2.

Subcellular locationi

Secreted
Note: In the intestine, secreted into the inner and outer mucus layers By similarity.

GO - Cellular componenti

  1. cytoplasm Source: RGD
  2. inner mucus layer Source: UniProtKB
  3. mucus layer Source: RGD
  4. nucleus Source: RGD
  5. outer mucus layer Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed predictionAdd
BLAST
Chaini21 – ›1513›1493Mucin-2PRO_0000019282Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi160 – 1601N-linked (GlcNAc...) Reviewed prediction
Glycosylationi420 – 4201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi667 – 6671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi767 – 7671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi837 – 8371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi892 – 8921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1136 – 11361N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1151 – 11511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1212 – 12121N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1227 – 12271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1243 – 12431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1350 – 13501N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

O-glycosylated By similarity.
May undergo proteolytic cleavage in the outer mucus layer of the colon, contributing to the expanded volume and loose nature of this layer which allows for bacterial colonization in contrast to the inner mucus layer which is dense and devoid of bacteria By similarity.
May undergo autocatalytic cleavage in vivo triggered by the low pH of the late secretory pathway By similarity.

Keywords - PTMi

Autocatalytic cleavage, Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ62635.

Expressioni

Tissue specificityi

Expressed in intestine and airway.

Gene expression databases

GenevestigatoriQ62635.

Interactioni

Subunit structurei

Homotrimer; disulfide-linked. Dimerizes in the endoplasmic reticulum via its C-terminal region and polymerizes via its N-terminal region by disulfide-linked trimerization. Interacts with FCGBP By similarity. Interacts with AGR2; disulfide-linked By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ62635.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 237205VWFD 1Add
BLAST
Domaini292 – 34857TILAdd
BLAST
Domaini350 – 41061VWFCAdd
BLAST
Domaini387 – 601215VWFD 2Add
BLAST
Domaini857 – 1062206VWFD 3Add
BLAST
Repeati1392 – 1407161Add
BLAST
Repeati1408 – 1423162Add
BLAST
Repeati1424 – 1434113Add
BLAST
Repeati1435 – 1445114Add
BLAST
Repeati1446 – 1456115Add
BLAST
Repeati1457 – 1467116Add
BLAST
Repeati1468 – 1478117Add
BLAST
Repeati1479 – 1489118Add
BLAST
Repeati1490 – 1500119Add
BLAST
Repeati1501 – 15111110Add
BLAST
Repeati1512 – ›1513›211

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1392 – ›1513›122Approximate repeatsAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1257 – 129236Thr-richAdd
BLAST
Compositional biasi1389 – 1512124Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 VWFC domain.
Contains 3 VWFD domains.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOVERGENiHBG004380.
PhylomeDBiQ62635.

Family and domain databases

InterProiIPR028580. MUC2.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
IPR025155. WxxW_domain.
[Graphical view]
PANTHERiPTHR11339:SF261. PTHR11339:SF261. 1 hit.
PfamiPF08742. C8. 3 hits.
PF13330. Mucin2_WxxW. 1 hit.
PF01826. TIL. 1 hit.
PF00094. VWD. 3 hits.
[Graphical view]
SMARTiSM00832. C8. 3 hits.
SM00214. VWC. 1 hit.
SM00216. VWD. 3 hits.
[Graphical view]
SUPFAMiSSF57567. SSF57567. 3 hits.
PROSITEiPS51233. VWFD. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62635-1 [UniParc]FASTAAdd to Basket

« Hide

MGLPLARLVA VCLVLALAKG LELQKEARSR NHVCSTWGDF HYKTFDGDVF     50
RFPGLCDYNF ASDCRDSYKE FAVHLKRGLD KAGGHSSIES VLITIKDDTI 100
YLTHKLAVVN GAMVSTPHYS SGLLIEKNDA YTKVYSRAGL SLMWNREDAL 150
MVELDGRFQN HTCGLCGDFN GMQANNEFLS DGIRFSAIEF GNMQKINKPE 200
VVCEDPEEVQ EPESCSEHRA ECERLLTSTA FEDCQARVPV ELYVLACMHD 250
RCQCPQGGAC ECSTLAEFSR QCSHAGGRPE NWRTASLCPK KCPGNMVYLE 300
SGSPWLDTCS HLEVSSLCEE HYMDGCFCPE GTVYDDITGS GCIPVSQCHC 350
KLHGHLYMPG QEITNDCEQC VCNAGRWMCK DLPCPETCAL EGGSHITTFD 400
GKKFTFHGDC YYVLTKTKYN DSYALLGELA SCGSTDKQTC LKTVVLLTDN 450
KKNVVAFKSG GSVLLNEMEV SLPHVAASFS IFKPSSYHIV VNTMFGLRLQ 500
IQLVPVMQLF VTLDQSAQGQ VQGLCGNFNG LESDDFMTSG GMVEATGAGF 550
ANTWKAQSSC HDKLDWLDDP CPLNIESANY AEHWCSLLKR SETPFARCHL 600
AVDPTEYYKR CKYDTCNCQN NEDCMCAALS SYARACAAKG VMLWGWRESV 650
CNKDVHACPS SQIFMYNLTT CQQTCRSISE GDTHCLKGFA PVEGCGCPDH 700
TFMDEKGRCV PLSKCSCYHH GLYLEAGDVI LRQEERCICR NGRLQCTQVK 750
LIGHTCLSPQ ILVDCNNLTA LAIREPRPTS CQTLVARYYH TECISGCVCP 800
DGLLDNGRGG CVVEDECPCI HNKQFYDSGK SIKLDCNNTC TCQKGRWECT 850
RYACHSTCSI YGSGHYITFD GKHYDFDGHC SYVAVQDYCG QNSTGSFSII 900
TENVPCGTTG VTCSKAIKIF IGGTELKLVD KHRVVKQLEE GHHVPFITRE 950
VGLYLVVEVS SGIIVIWDKK TTIFIKLDPS YKGNVCGLCG NFDDQTKNDF 1000
TTRDHMVVAS ELDFGNSWKE ASTCPDVSHN PDPCSLNPHR RSWAEKQCSI 1050
IKSDVFLACH GKVDPTVFYD ACVHDSCSCD TGGDCECFCS AVASYAQECT 1100
KAEACVFWRT PDLCPVFCDY YNPPDECEWH YEPCGNRSFE TCRTLNGIHS 1150
NISVSYLEGC YPRCPEDRPI YDEDLKKCVS GDKCGCYIED TRYPPGGSVP 1200
TDEICMSCTC TNTSEIICRP DEGKIINQTQ DGIFCYWETC GSNGTVEKHF 1250
EICVSSTLSP TSMTSFTTTS TPISTTPIST TITTTSATAT TTVPCCFWSD 1300
WINNNHPTSG NGGDRENFEH VCSAPENIEC RAATDPKLDW TELGQKVQCN 1350
VSEGLICNNE DQYGTGQFEL CYDYEIRVNC CFPMEYCLST VSPTTSTPIS 1400
STPQPTSSPT TLPTTSPLTS SATSPTTSHI TSTVSPTTSP TTSTTSPTTS 1450
PTTSTTSPTT STTSPTPSPT TSTTSPTPSP TTSTTSPTPS PTTSTTSPTT 1500
SPITSPTTST TSP 1513
Length:1,513
Mass (Da):166,038
Last modified:November 1, 1996 - v1
Checksum:i26109DCA1BE7D008
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1513 – 15131

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U07615 mRNA. Translation: AAA21655.2.
PIRiA54895.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U07615 mRNA. Translation: AAA21655.2 .
PIRi A54895.

3D structure databases

ProteinModelPortali Q62635.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q62635.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 3123. Muc2.

Phylogenomic databases

HOVERGENi HBG004380.
PhylomeDBi Q62635.

Gene expression databases

Genevestigatori Q62635.

Family and domain databases

InterProi IPR028580. MUC2.
IPR002919. TIL_dom.
IPR014853. Unchr_dom_Cys-rich.
IPR001007. VWF_C.
IPR001846. VWF_type-D.
IPR025155. WxxW_domain.
[Graphical view ]
PANTHERi PTHR11339:SF261. PTHR11339:SF261. 1 hit.
Pfami PF08742. C8. 3 hits.
PF13330. Mucin2_WxxW. 1 hit.
PF01826. TIL. 1 hit.
PF00094. VWD. 3 hits.
[Graphical view ]
SMARTi SM00832. C8. 3 hits.
SM00214. VWC. 1 hit.
SM00216. VWD. 3 hits.
[Graphical view ]
SUPFAMi SSF57567. SSF57567. 3 hits.
PROSITEi PS51233. VWFD. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of the amino-terminal region of a rat MUC 2 mucin gene homologue. Evidence for expression in both intestine and airway."
    Ohmori H., Dohrman A.F., Gallup M., Tsuda T., Kai H., Gum J.R. Jr., Kim Y.S., Basbaum C.B.
    J. Biol. Chem. 269:17833-17840(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Intestine.
  2. "Susceptibility of the cysteine-rich N-terminal and C-terminal ends of rat intestinal mucin Muc 2 to proteolytic cleavage."
    Khatri I.A., Forstner G.G., Forstner J.F.
    Biochem. J. 331:323-330(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 21-36.
    Tissue: Intestinal epithelium.

Entry informationi

Entry nameiMUC2_RAT
AccessioniPrimary (citable) accession number: Q62635
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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