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Protein

Ileal sodium/bile acid cotransporter

Gene

Slc10a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism (By similarity).By similarity

GO - Molecular functioni

  • bile acid:sodium symporter activity Source: RGD

GO - Biological processi

  • bile acid and bile salt transport Source: RGD
  • bile acid metabolic process Source: RGD
  • sodium ion transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Ileal sodium/bile acid cotransporter
Alternative name(s):
Apical sodium-dependent bile acid transporter
Short name:
ASBT
Ileal Na(+)/bile acid cotransporter
Ileal sodium-dependent bile acid transporter
Short name:
IBAT
Short name:
ISBT
Na(+)-dependent ileal bile acid transporter
Sodium/taurocholate-cotransporting polypeptide, ileal
Solute carrier family 10 member 2
Gene namesi
Name:Slc10a2
Synonyms:Ntcp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi3682. Slc10a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828ExtracellularSequence analysisAdd
BLAST
Transmembranei29 – 4921HelicalSequence analysisAdd
BLAST
Topological domaini50 – 8738CytoplasmicSequence analysisAdd
BLAST
Transmembranei88 – 10821HelicalSequence analysisAdd
BLAST
Topological domaini109 – 12618ExtracellularSequence analysisAdd
BLAST
Transmembranei127 – 14721HelicalSequence analysisAdd
BLAST
Topological domaini148 – 15710CytoplasmicSequence analysis
Transmembranei158 – 17821HelicalSequence analysisAdd
BLAST
Topological domaini179 – 19517ExtracellularSequence analysisAdd
BLAST
Transmembranei196 – 21621HelicalSequence analysisAdd
BLAST
Topological domaini217 – 2248CytoplasmicSequence analysis
Transmembranei225 – 24521HelicalSequence analysisAdd
BLAST
Topological domaini246 – 28439ExtracellularSequence analysisAdd
BLAST
Transmembranei285 – 30521HelicalSequence analysisAdd
BLAST
Topological domaini306 – 34843CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • apical plasma membrane Source: RGD
  • integral component of plasma membrane Source: GO_Central
  • nucleus Source: RGD
  • proteasome complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2073686.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 348348Ileal sodium/bile acid cotransporterPRO_0000052342Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence analysis
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence analysis
Modified residuei335 – 3351PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ62633.

PTM databases

iPTMnetiQ62633.
PhosphoSiteiQ62633.

Expressioni

Developmental stagei

Transcriptionally regulated increases in mRNA and protein levels at the time of weaning.

Interactioni

Subunit structurei

Monomer and homodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054127.

Chemistry

BindingDBiQ62633.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2718. Eukaryota.
COG0385. LUCA.
HOGENOMiHOG000234524.
HOVERGENiHBG006537.
InParanoidiQ62633.
KOiK14342.
OrthoDBiEOG7XWPNW.
PhylomeDBiQ62633.
TreeFamiTF315811.

Family and domain databases

InterProiIPR002657. BilAc:Na_symport/Acr3.
IPR004710. Bilac:Na_transpt.
IPR030207. SLC10A2.
[Graphical view]
PANTHERiPTHR10361. PTHR10361. 1 hit.
PTHR10361:SF19. PTHR10361:SF19. 1 hit.
PfamiPF01758. SBF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00841. bass. 1 hit.

Sequencei

Sequence statusi: Complete.

Q62633-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNSSVCSPN ATFCEGDSCL VTESNFNAIL STVMSTVLTI LLAMVMFSMG
60 70 80 90 100
CNVEINKFLG HIKRPWGIFV GFLCQFGIMP LTGFILSVAS GILPVQAVVV
110 120 130 140 150
LIMGCCPGGT GSNILAYWID GDMDLSVSMT TCSTLLALGM MPLCLFIYTK
160 170 180 190 200
MWVDSGTIVI PYDSIGISLV ALVIPVSIGM FVNHKWPQKA KIILKIGSIA
210 220 230 240 250
GAILIVLIAV VGGILYQSAW IIEPKLWIIG TIFPIAGYSL GFFLARLAGQ
260 270 280 290 300
PWYRCRTVAL ETGMQNTQLC STIVQLSFSP EDLNLVFTFP LIYTVFQLVF
310 320 330 340
AAIILGMYVT YKKCHGKNDA EFLEKTDNDM DPMPSFQETN KGFQPDEK
Length:348
Mass (Da):38,024
Last modified:November 1, 1996 - v1
Checksum:iD4C38CF136D1143B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07183 mRNA. Translation: AAC53101.1.
RefSeqiNP_058918.1. NM_017222.2.
UniGeneiRn.85891.

Genome annotation databases

GeneIDi29500.
KEGGirno:29500.
UCSCiRGD:3682. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07183 mRNA. Translation: AAC53101.1.
RefSeqiNP_058918.1. NM_017222.2.
UniGeneiRn.85891.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054127.

Chemistry

BindingDBiQ62633.
ChEMBLiCHEMBL2073686.

PTM databases

iPTMnetiQ62633.
PhosphoSiteiQ62633.

Proteomic databases

PaxDbiQ62633.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29500.
KEGGirno:29500.
UCSCiRGD:3682. rat.

Organism-specific databases

CTDi6555.
RGDi3682. Slc10a2.

Phylogenomic databases

eggNOGiKOG2718. Eukaryota.
COG0385. LUCA.
HOGENOMiHOG000234524.
HOVERGENiHBG006537.
InParanoidiQ62633.
KOiK14342.
OrthoDBiEOG7XWPNW.
PhylomeDBiQ62633.
TreeFamiTF315811.

Miscellaneous databases

PROiQ62633.

Family and domain databases

InterProiIPR002657. BilAc:Na_symport/Acr3.
IPR004710. Bilac:Na_transpt.
IPR030207. SLC10A2.
[Graphical view]
PANTHERiPTHR10361. PTHR10361. 1 hit.
PTHR10361:SF19. PTHR10361:SF19. 1 hit.
PfamiPF01758. SBF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00841. bass. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Cloning and molecular characterization of the ontogeny of a rat ileal sodium-dependent bile acid transporter."
    Shneider B.L., Dawson P.A., Christie D.M., Hardikar W., Wong M.H., Suchy F.J.
    J. Clin. Invest. 95:745-754(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Ileum.

Entry informationi

Entry nameiNTCP2_RAT
AccessioniPrimary (citable) accession number: Q62633
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.