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Q62632 (FSTL1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Follistatin-related protein 1
Alternative name(s):
Follistatin-like protein 1
Gene names
Name:Fstl1
Synonyms:Frp
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length306 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin.

Subunit structure

Interacts with SCN10A. Ref.3

Subcellular location

Secreted.

Sequence similarities

Contains 2 EF-hand domains.

Contains 1 follistatin-like domain.

Contains 1 Kazal-like domain.

Contains 1 VWFC domain.

Ontologies

Keywords
   Cellular componentSecreted
   DomainRepeat
Signal
   LigandHeparin-binding
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

heparin binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818
Chain19 – 306288Follistatin-related protein 1
PRO_0000010114

Regions

Domain28 – 5124Follistatin-like
Domain46 – 9853Kazal-like
Domain142 – 17635EF-hand 1
Domain191 – 22636EF-hand 2
Domain231 – 28555VWFC

Amino acid modifications

Glycosylation1421N-linked (GlcNAc...) Potential
Glycosylation1731N-linked (GlcNAc...) Potential
Glycosylation1781N-linked (GlcNAc...) Potential
Disulfide bond52 ↔ 82 By similarity
Disulfide bond56 ↔ 75 By similarity
Disulfide bond64 ↔ 96 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q62632 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 46E197AC7EE0F3D4

FASTA30634,622
        10         20         30         40         50         60 
MWKRWLALAL VTIALVHGEE EQRSKSKICA NVFCGAGREC AVTEKGEPTC LCIEQCKPHK 

        70         80         90        100        110        120 
RPVCGSNGKT YLNHCELHRD ACLTGSKIQV DYDGHCKEKK SVSPSASPVV CYQANRDELR 

       130        140        150        160        170        180 
RRIIQWLEAE IIPDGWFSKG SNYSEILDKY FKSFDNGDSH LDSSEFLKFV EQNETAVNIT 

       190        200        210        220        230        240 
AYPNQENNKL LRGLCVDALI ELSDENADWK LSFQEFLKCL NPSFNPPEKK CALEDETYAD 

       250        260        270        280        290        300 
GAETEVDCNR CVCSCGHWVC TAMTCDGKNQ KGVQTHTEEE MTRYAQELQK HQGTAEKTKK 


VNTKEI 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of a rat C6 glioma-secreted follistatin-related protein (FRP). Cloning and sequence of the human homologue."
Zwijsen A., Blockx H., van Arnhem W., Willems J., Fransen L., Devos K., Raymackers J., van de Voorde A., Slegers H.
Eur. J. Biochem. 225:937-946(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart.
[3]"Sensory neuron proteins interact with the intracellular domains of sodium channel NaV1.8."
Malik-Hall M., Poon W.-Y.L., Baker M.D., Wood J.N., Okuse K.
Brain Res. Mol. Brain Res. 110:298-304(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SCN10A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U06864 mRNA. Translation: AAA66063.1.
BC087014 mRNA. Translation: AAH87014.1.
PIRS51361.
RefSeqNP_077345.1. NM_024369.2.
UniGeneRn.95652.

3D structure databases

ProteinModelPortalQ62632.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ62632. 1 interaction.
STRING10116.ENSRNOP00000003721.

Protein family/group databases

MEROPSI01.967.

Proteomic databases

PaxDbQ62632.
PRIDEQ62632.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID79210.
KEGGrno:79210.
UCSCRGD:68955. rat.

Organism-specific databases

CTD11167.
RGD68955. Fstl1.

Phylogenomic databases

eggNOGNOG148270.
HOGENOMHOG000007780.
HOVERGENHBG051665.
PhylomeDBQ62632.

Gene expression databases

GenevestigatorQ62632.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR003645. Fol_N.
IPR015369. Follistatin/Osteonectin_EGF.
IPR002350. Kazal_dom.
[Graphical view]
PfamPF09289. FOLN. 1 hit.
PF07648. Kazal_2. 1 hit.
[Graphical view]
SMARTSM00054. EFh. 2 hits.
SM00274. FOLN. 1 hit.
SM00280. KAZAL. 1 hit.
[Graphical view]
PROSITEPS50222. EF_HAND_2. 2 hits.
PS51465. KAZAL_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio614600.
PROQ62632.

Entry information

Entry nameFSTL1_RAT
AccessionPrimary (citable) accession number: Q62632
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families