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Q62632

- FSTL1_RAT

UniProt

Q62632 - FSTL1_RAT

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Protein

Follistatin-related protein 1

Gene

Fstl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. heparin binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Heparin-binding

Protein family/group databases

MEROPSiI01.967.

Names & Taxonomyi

Protein namesi
Recommended name:
Follistatin-related protein 1
Alternative name(s):
Follistatin-like protein 1
Gene namesi
Name:Fstl1
Synonyms:Frp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi68955. Fstl1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Add
BLAST
Chaini19 – 306288Follistatin-related protein 1PRO_0000010114Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi52 ↔ 82PROSITE-ProRule annotation
Disulfide bondi56 ↔ 75PROSITE-ProRule annotation
Disulfide bondi64 ↔ 96PROSITE-ProRule annotation
Glycosylationi142 – 1421N-linked (GlcNAc...)Sequence Analysis
Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ62632.
PRIDEiQ62632.

Expressioni

Gene expression databases

GenevestigatoriQ62632.

Interactioni

Subunit structurei

Interacts with SCN10A.1 Publication

Protein-protein interaction databases

IntActiQ62632. 1 interaction.
STRINGi10116.ENSRNOP00000003721.

Structurei

3D structure databases

ProteinModelPortaliQ62632.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 5124Follistatin-likeAdd
BLAST
Domaini46 – 9853Kazal-likePROSITE-ProRule annotationAdd
BLAST
Domaini142 – 17635EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini191 – 22636EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini231 – 28555VWFCAdd
BLAST

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation
Contains 1 follistatin-like domain.Curated
Contains 1 Kazal-like domain.PROSITE-ProRule annotation
Contains 1 VWFC domain.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG148270.
HOGENOMiHOG000007780.
HOVERGENiHBG051665.
InParanoidiQ62632.
PhylomeDBiQ62632.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR003645. Fol_N.
IPR015369. Follistatin/Osteonectin_EGF.
IPR002350. Kazal_dom.
[Graphical view]
PfamiPF09289. FOLN. 1 hit.
PF07648. Kazal_2. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
SM00274. FOLN. 1 hit.
SM00280. KAZAL. 1 hit.
[Graphical view]
PROSITEiPS50222. EF_HAND_2. 2 hits.
PS51465. KAZAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62632-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWKRWLALAL VTIALVHGEE EQRSKSKICA NVFCGAGREC AVTEKGEPTC
60 70 80 90 100
LCIEQCKPHK RPVCGSNGKT YLNHCELHRD ACLTGSKIQV DYDGHCKEKK
110 120 130 140 150
SVSPSASPVV CYQANRDELR RRIIQWLEAE IIPDGWFSKG SNYSEILDKY
160 170 180 190 200
FKSFDNGDSH LDSSEFLKFV EQNETAVNIT AYPNQENNKL LRGLCVDALI
210 220 230 240 250
ELSDENADWK LSFQEFLKCL NPSFNPPEKK CALEDETYAD GAETEVDCNR
260 270 280 290 300
CVCSCGHWVC TAMTCDGKNQ KGVQTHTEEE MTRYAQELQK HQGTAEKTKK

VNTKEI
Length:306
Mass (Da):34,622
Last modified:November 1, 1996 - v1
Checksum:i46E197AC7EE0F3D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06864 mRNA. Translation: AAA66063.1.
BC087014 mRNA. Translation: AAH87014.1.
PIRiS51361.
RefSeqiNP_077345.1. NM_024369.2.
UniGeneiRn.95652.

Genome annotation databases

GeneIDi79210.
KEGGirno:79210.
UCSCiRGD:68955. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06864 mRNA. Translation: AAA66063.1 .
BC087014 mRNA. Translation: AAH87014.1 .
PIRi S51361.
RefSeqi NP_077345.1. NM_024369.2.
UniGenei Rn.95652.

3D structure databases

ProteinModelPortali Q62632.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q62632. 1 interaction.
STRINGi 10116.ENSRNOP00000003721.

Protein family/group databases

MEROPSi I01.967.

Proteomic databases

PaxDbi Q62632.
PRIDEi Q62632.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 79210.
KEGGi rno:79210.
UCSCi RGD:68955. rat.

Organism-specific databases

CTDi 11167.
RGDi 68955. Fstl1.

Phylogenomic databases

eggNOGi NOG148270.
HOGENOMi HOG000007780.
HOVERGENi HBG051665.
InParanoidi Q62632.
PhylomeDBi Q62632.

Miscellaneous databases

NextBioi 614600.
PROi Q62632.

Gene expression databases

Genevestigatori Q62632.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR003645. Fol_N.
IPR015369. Follistatin/Osteonectin_EGF.
IPR002350. Kazal_dom.
[Graphical view ]
Pfami PF09289. FOLN. 1 hit.
PF07648. Kazal_2. 1 hit.
[Graphical view ]
SMARTi SM00054. EFh. 2 hits.
SM00274. FOLN. 1 hit.
SM00280. KAZAL. 1 hit.
[Graphical view ]
PROSITEi PS50222. EF_HAND_2. 2 hits.
PS51465. KAZAL_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a rat C6 glioma-secreted follistatin-related protein (FRP). Cloning and sequence of the human homologue."
    Zwijsen A., Blockx H., van Arnhem W., Willems J., Fransen L., Devos K., Raymackers J., van de Voorde A., Slegers H.
    Eur. J. Biochem. 225:937-946(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  3. "Sensory neuron proteins interact with the intracellular domains of sodium channel NaV1.8."
    Malik-Hall M., Poon W.-Y.L., Baker M.D., Wood J.N., Okuse K.
    Brain Res. Mol. Brain Res. 110:298-304(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SCN10A.

Entry informationi

Entry nameiFSTL1_RAT
AccessioniPrimary (citable) accession number: Q62632
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3