Q62632 (FSTL1_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Follistatin-related protein 1

Alternative name(s):
Follistatin-like protein 1

Gene names

Name:	Fstl1
Synonyms:	Frp

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	306 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin.
Subunit structure	Interacts with SCN10A. Ref.3
Subcellular location	Secreted.
Sequence similarities	Contains 2 EF-hand domains. Contains 1 follistatin-like domain. Contains 1 Kazal-like domain. Contains 1 VWFC domain.

Ontologies

Keywords
Cellular component	Secreted
Domain	Repeat Signal
Ligand	Heparin-binding
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro heparin binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18
	Chain	19 – 306	288	Follistatin-related protein 1		PRO_0000010114
Regions
	Domain	28 – 51	24	Follistatin-like
	Domain	46 – 98	53	Kazal-like
	Domain	142 – 176	35	EF-hand 1
	Domain	191 – 226	36	EF-hand 2
	Domain	231 – 285	55	VWFC
Amino acid modifications
	Glycosylation	142	1	N-linked (GlcNAc...) Potential
	Glycosylation	173	1	N-linked (GlcNAc...) Potential
	Glycosylation	178	1	N-linked (GlcNAc...) Potential
	Disulfide bond	52 ↔ 82		By similarity
	Disulfide bond	56 ↔ 75		By similarity
	Disulfide bond	64 ↔ 96		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q62632 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 46E197AC7EE0F3D4	FASTA	306	34,622
	10 20 30 40 50 60 MWKRWLALAL VTIALVHGEE EQRSKSKICA NVFCGAGREC AVTEKGEPTC LCIEQCKPHK 70 80 90 100 110 120 RPVCGSNGKT YLNHCELHRD ACLTGSKIQV DYDGHCKEKK SVSPSASPVV CYQANRDELR 130 140 150 160 170 180 RRIIQWLEAE IIPDGWFSKG SNYSEILDKY FKSFDNGDSH LDSSEFLKFV EQNETAVNIT 190 200 210 220 230 240 AYPNQENNKL LRGLCVDALI ELSDENADWK LSFQEFLKCL NPSFNPPEKK CALEDETYAD 250 260 270 280 290 300 GAETEVDCNR CVCSCGHWVC TAMTCDGKNQ KGVQTHTEEE MTRYAQELQK HQGTAEKTKK VNTKEI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of a rat C6 glioma-secreted follistatin-related protein (FRP). Cloning and sequence of the human homologue." Zwijsen A., Blockx H., van Arnhem W., Willems J., Fransen L., Devos K., Raymackers J., van de Voorde A., Slegers H. Eur. J. Biochem. 225:937-946(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE. Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart.
[3]	"Sensory neuron proteins interact with the intracellular domains of sodium channel NaV1.8." Malik-Hall M., Poon W.-Y.L., Baker M.D., Wood J.N., Okuse K. Brain Res. Mol. Brain Res. 110:298-304(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SCN10A.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U06864 mRNA. Translation: AAA66063.1. BC087014 mRNA. Translation: AAH87014.1.
IPI	IPI00207063.
PIR	S51361.
RefSeq	NP_077345.1. NM_024369.2.
UniGene	Rn.95652.
3D structure databases
ProteinModelPortal	Q62632.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q62632. 1 interaction.
STRING	10116.ENSRNOP00000003721.
Protein family/group databases
MEROPS	I01.967.
Proteomic databases
PaxDb	Q62632.
PRIDE	Q62632.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	79210.
KEGG	rno:79210.
UCSC	RGD:68955. rat.
Organism-specific databases
CTD	11167.
RGD	68955. Fstl1.
Phylogenomic databases
eggNOG	NOG148270.
HOGENOM	HOG000007780.
HOVERGEN	HBG051665.
Gene expression databases
ArrayExpress	Q62632.
Genevestigator	Q62632.
Family and domain databases
Gene3D	1.10.238.10. 1 hit.
InterPro	IPR011992. EF-hand-like_dom. IPR002048. EF_hand_dom. IPR003645. Fol_N. IPR015369. Follistatin/Osteonectin_EGF. IPR002350. Kazal_dom. [Graphical view]
Pfam	PF09289. FOLN. 1 hit. PF07648. Kazal_2. 1 hit. [Graphical view]
SMART	SM00054. EFh. 2 hits. SM00274. FOLN. 1 hit. SM00280. KAZAL. 1 hit. [Graphical view]
PROSITE	PS50222. EF_HAND_2. 2 hits. PS00282. KAZAL_1. False negative. PS51465. KAZAL_2. 1 hit. PS01208. VWFC_1. False negative. PS50184. VWFC_2. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	614600.

Entry information

Entry name

FSTL1_RAT

Accession

Primary (citable) accession number: Q62632

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program