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Q62632

- FSTL1_RAT

UniProt

Q62632 - FSTL1_RAT

Protein

Follistatin-related protein 1

Gene

Fstl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. heparin binding Source: UniProtKB-KW

    Keywords - Ligandi

    Heparin-binding

    Protein family/group databases

    MEROPSiI01.967.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Follistatin-related protein 1
    Alternative name(s):
    Follistatin-like protein 1
    Gene namesi
    Name:Fstl1
    Synonyms:Frp
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi68955. Fstl1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Add
    BLAST
    Chaini19 – 306288Follistatin-related protein 1PRO_0000010114Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi52 ↔ 82PROSITE-ProRule annotation
    Disulfide bondi56 ↔ 75PROSITE-ProRule annotation
    Disulfide bondi64 ↔ 96PROSITE-ProRule annotation
    Glycosylationi142 – 1421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ62632.
    PRIDEiQ62632.

    Expressioni

    Gene expression databases

    GenevestigatoriQ62632.

    Interactioni

    Subunit structurei

    Interacts with SCN10A.1 Publication

    Protein-protein interaction databases

    IntActiQ62632. 1 interaction.
    STRINGi10116.ENSRNOP00000003721.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62632.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 5124Follistatin-likeAdd
    BLAST
    Domaini46 – 9853Kazal-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini142 – 17635EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini191 – 22636EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini231 – 28555VWFCAdd
    BLAST

    Sequence similaritiesi

    Contains 2 EF-hand domains.PROSITE-ProRule annotation
    Contains 1 follistatin-like domain.Curated
    Contains 1 Kazal-like domain.PROSITE-ProRule annotation
    Contains 1 VWFC domain.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG148270.
    HOGENOMiHOG000007780.
    HOVERGENiHBG051665.
    PhylomeDBiQ62632.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR002048. EF_hand_dom.
    IPR003645. Fol_N.
    IPR015369. Follistatin/Osteonectin_EGF.
    IPR002350. Kazal_dom.
    [Graphical view]
    PfamiPF09289. FOLN. 1 hit.
    PF07648. Kazal_2. 1 hit.
    [Graphical view]
    SMARTiSM00054. EFh. 2 hits.
    SM00274. FOLN. 1 hit.
    SM00280. KAZAL. 1 hit.
    [Graphical view]
    PROSITEiPS50222. EF_HAND_2. 2 hits.
    PS51465. KAZAL_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q62632-1 [UniParc]FASTAAdd to Basket

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    MWKRWLALAL VTIALVHGEE EQRSKSKICA NVFCGAGREC AVTEKGEPTC    50
    LCIEQCKPHK RPVCGSNGKT YLNHCELHRD ACLTGSKIQV DYDGHCKEKK 100
    SVSPSASPVV CYQANRDELR RRIIQWLEAE IIPDGWFSKG SNYSEILDKY 150
    FKSFDNGDSH LDSSEFLKFV EQNETAVNIT AYPNQENNKL LRGLCVDALI 200
    ELSDENADWK LSFQEFLKCL NPSFNPPEKK CALEDETYAD GAETEVDCNR 250
    CVCSCGHWVC TAMTCDGKNQ KGVQTHTEEE MTRYAQELQK HQGTAEKTKK 300
    VNTKEI 306
    Length:306
    Mass (Da):34,622
    Last modified:November 1, 1996 - v1
    Checksum:i46E197AC7EE0F3D4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U06864 mRNA. Translation: AAA66063.1.
    BC087014 mRNA. Translation: AAH87014.1.
    PIRiS51361.
    RefSeqiNP_077345.1. NM_024369.2.
    UniGeneiRn.95652.

    Genome annotation databases

    GeneIDi79210.
    KEGGirno:79210.
    UCSCiRGD:68955. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U06864 mRNA. Translation: AAA66063.1 .
    BC087014 mRNA. Translation: AAH87014.1 .
    PIRi S51361.
    RefSeqi NP_077345.1. NM_024369.2.
    UniGenei Rn.95652.

    3D structure databases

    ProteinModelPortali Q62632.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q62632. 1 interaction.
    STRINGi 10116.ENSRNOP00000003721.

    Protein family/group databases

    MEROPSi I01.967.

    Proteomic databases

    PaxDbi Q62632.
    PRIDEi Q62632.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 79210.
    KEGGi rno:79210.
    UCSCi RGD:68955. rat.

    Organism-specific databases

    CTDi 11167.
    RGDi 68955. Fstl1.

    Phylogenomic databases

    eggNOGi NOG148270.
    HOGENOMi HOG000007780.
    HOVERGENi HBG051665.
    PhylomeDBi Q62632.

    Miscellaneous databases

    NextBioi 614600.
    PROi Q62632.

    Gene expression databases

    Genevestigatori Q62632.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR002048. EF_hand_dom.
    IPR003645. Fol_N.
    IPR015369. Follistatin/Osteonectin_EGF.
    IPR002350. Kazal_dom.
    [Graphical view ]
    Pfami PF09289. FOLN. 1 hit.
    PF07648. Kazal_2. 1 hit.
    [Graphical view ]
    SMARTi SM00054. EFh. 2 hits.
    SM00274. FOLN. 1 hit.
    SM00280. KAZAL. 1 hit.
    [Graphical view ]
    PROSITEi PS50222. EF_HAND_2. 2 hits.
    PS51465. KAZAL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a rat C6 glioma-secreted follistatin-related protein (FRP). Cloning and sequence of the human homologue."
      Zwijsen A., Blockx H., van Arnhem W., Willems J., Fransen L., Devos K., Raymackers J., van de Voorde A., Slegers H.
      Eur. J. Biochem. 225:937-946(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.
    3. "Sensory neuron proteins interact with the intracellular domains of sodium channel NaV1.8."
      Malik-Hall M., Poon W.-Y.L., Baker M.D., Wood J.N., Okuse K.
      Brain Res. Mol. Brain Res. 110:298-304(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SCN10A.

    Entry informationi

    Entry nameiFSTL1_RAT
    AccessioniPrimary (citable) accession number: Q62632
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3