Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interleukin-1 receptor-like 1

Gene

Il1rl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function (By similarity).By similarity
Isoform B: Inhibits IL-33 signaling.By similarity

GO - Molecular functioni

GO - Biological processi

  • cellular response to peptide Source: RGD
  • negative regulation of cell proliferation Source: RGD

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor-like 1
Alternative name(s):
Fit-1
Fos-responsive gene 1 protein
Gene namesi
Name:Il1rl1
Synonyms:Fit1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2894 Il1rl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 331ExtracellularSequence analysisAdd BLAST305
Transmembranei332 – 354HelicalSequence analysisAdd BLAST23
Topological domaini355 – 566CytoplasmicSequence analysisAdd BLAST212

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001544427 – 566Interleukin-1 receptor-like 1Add BLAST540

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi42 ↔ 93PROSITE-ProRule annotation
Glycosylationi107N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi117 ↔ 157PROSITE-ProRule annotation
Disulfide bondi139 ↔ 187PROSITE-ProRule annotation
Glycosylationi146N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi194N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi225N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi240 ↔ 307PROSITE-ProRule annotation
Disulfide bondi243 ↔ 286PROSITE-ProRule annotation
Glycosylationi258N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi277N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ62611
PRIDEiQ62611

PTM databases

PhosphoSitePlusiQ62611

Expressioni

Tissue specificityi

Isoform A is detected in spleen, lung, bone marrow and lymh node. Isoform B is predominant in fibroblasts.

Inductioni

By FOS.

Interactioni

Subunit structurei

Interacts with MYD88, IRAK1, IRAK4, and TRAF6 (By similarity). Bound to its ligand IL-33, interacts with IL1RAP to form the minimal interleukin-33 signaling complex with a 1:1:1 stoichiometry. Interacts with KIT (bound to KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020144

Structurei

3D structure databases

ProteinModelPortaliQ62611
SMRiQ62611
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 109Ig-like C2-type 1Add BLAST83
Domaini120 – 207Ig-like C2-type 2Add BLAST88
Domaini217 – 323Ig-like C2-type 3Add BLAST107
Domaini379 – 542TIRPROSITE-ProRule annotationAdd BLAST164

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni204 – 216Flexible linkerBy similarityAdd BLAST13

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPTT Eukaryota
ENOG4110Z8K LUCA
HOGENOMiHOG000113054
HOVERGENiHBG098401
InParanoidiQ62611
KOiK05171
PhylomeDBiQ62611

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.40.50.10140, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR015621 IL-1_rcpt_fam
IPR004074 IL-1_rcpt_I/II-typ
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf
PANTHERiPTHR11890 PTHR11890, 1 hit
PfamiView protein in Pfam
PF01582 TIR, 1 hit
PRINTSiPR01536 INTRLKN1R12F
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 2 hits
SM00255 TIR, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS50104 TIR, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

Isoform A (identifier: Q62611-1) [UniParc]FASTAAdd to basket
Also known as: Membrane-bound, Fit-1M

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIGKWRMGLW ALAILTVPMY FIVTEGRKTS WGLENEALIV RCPQRGGAIN
60 70 80 90 100
PVEWYYSNTN ERIPTQKRNR IFVSRDRLKF LPAKVEDSGI YTCVIRSPES
110 120 130 140 150
IKTGSLNVTI YKRPPNCKIP DYMMYSTVDG SDKNSKITCP TIALYNWTAP
160 170 180 190 200
VQWFKNCKAL QGPRFRAHMS YLFIDKVSHV DEGDYTCRFT HTENGTNYIV
210 220 230 240 250
TATRSFTVEE KGFSTFPVIT NPPHNYTVEV EIGKTANIAC SACFGTASQF
260 270 280 290 300
VAVLWQINKT RIGSFGKARI QEEKGPNKSS SNGMICLTSL LRITGVTDKD
310 320 330 340 350
FSLKYDCVAM NHHGVIRHPV RLRRKQPIDH QSTYYIVAGC SLLLMFINVL
360 370 380 390 400
VIVLKVFWIE VALFWRDIMA PYKTQNDGKL YDAYIIYPRV FRGSAAGTGS
410 420 430 440 450
VEYFVHYTLP DVLENKCGYK LCIYGRDLLP GQDAATVVES SIQNSRRQVF
460 470 480 490 500
VLAPHMMHSK EFAYEQEIAL HSALIQNNSK VILIEMEPMG EASRLQLGDL
510 520 530 540 550
QDSLQHLVKM QGTIKWREDH VADKQSLSSK FWKHVRYQMP VPKRPPKMAS
560
VAAPLSGKVC LDLKHF
Length:566
Mass (Da):64,406
Last modified:November 1, 1996 - v1
Checksum:i50554A29437A0C31
GO
Isoform B (identifier: Q62611-2) [UniParc]FASTAAdd to basket
Also known as: Soluble, Fit-1S

The sequence of this isoform differs from the canonical sequence as follows:
     328-336: IDHQSTYYI → SKECLSQIA
     337-566: Missing.

Show »
Length:336
Mass (Da):38,090
Checksum:i61C6A6FA8FE319D2
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002670328 – 336IDHQSTYYI → SKECLSQIA in isoform B. 1 Publication9
Alternative sequenceiVSP_002671337 – 566Missing in isoform B. 1 PublicationAdd BLAST230

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04317 mRNA Translation: AAA18480.1
U04319 mRNA Translation: AAA67172.1
PIRiS42632
S42633
RefSeqiNP_001121161.1, NM_001127689.1 [Q62611-1]
NP_037169.1, NM_013037.1 [Q62611-2]
UniGeneiRn.10072

Genome annotation databases

GeneIDi25556
KEGGirno:25556
UCSCiRGD:2894 rat [Q62611-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiILRL1_RAT
AccessioniPrimary (citable) accession number: Q62611
Secondary accession number(s): Q62612
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health