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Protein

Interleukin-1 receptor-like 1

Gene

Il1rl1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function (By similarity).By similarity
Isoform B: Inhibits IL-33 signaling.By similarity

GO - Molecular functioni

GO - Biological processi

  • cellular response to peptide Source: RGD
  • negative regulation of cell proliferation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor-like 1
Alternative name(s):
Fit-1
Fos-responsive gene 1 protein
Gene namesi
Name:Il1rl1
Synonyms:Fit1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2894. Il1rl1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 331305ExtracellularSequence analysisAdd
BLAST
Transmembranei332 – 35423HelicalSequence analysisAdd
BLAST
Topological domaini355 – 566212CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: RGD
  • external side of plasma membrane Source: MGI
  • extracellular space Source: RGD
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 566540Interleukin-1 receptor-like 1PRO_0000015444Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi42 ↔ 93PROSITE-ProRule annotation
Glycosylationi107 – 1071N-linked (GlcNAc...)Sequence analysis
Disulfide bondi117 ↔ 157PROSITE-ProRule annotation
Disulfide bondi139 ↔ 187PROSITE-ProRule annotation
Glycosylationi146 – 1461N-linked (GlcNAc...)Sequence analysis
Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence analysis
Glycosylationi225 – 2251N-linked (GlcNAc...)Sequence analysis
Disulfide bondi240 ↔ 307PROSITE-ProRule annotation
Disulfide bondi243 ↔ 286PROSITE-ProRule annotation
Glycosylationi258 – 2581N-linked (GlcNAc...)Sequence analysis
Glycosylationi277 – 2771N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ62611.
PRIDEiQ62611.

PTM databases

PhosphoSiteiQ62611.

Expressioni

Tissue specificityi

Isoform A is detected in spleen, lung, bone marrow and lymh node. Isoform B is predominant in fibroblasts.

Inductioni

By FOS.

Interactioni

Subunit structurei

Interacts with MYD88, IRAK1, IRAK4, and TRAF6 (By similarity). Bound to its ligand IL-33, interacts with IL1RAP to form the minimal interleukin-33 signaling complex with a 1:1:1 stoechiometry. Interacts with KIT (bound to KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020144.

Structurei

3D structure databases

ProteinModelPortaliQ62611.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 10983Ig-like C2-type 1Add
BLAST
Domaini120 – 20788Ig-like C2-type 2Add
BLAST
Domaini217 – 323107Ig-like C2-type 3Add
BLAST
Domaini379 – 542164TIRPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni204 – 21613Flexible linkerBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPTT. Eukaryota.
ENOG4110Z8K. LUCA.
HOGENOMiHOG000113054.
HOVERGENiHBG098401.
InParanoidiQ62611.
KOiK05171.
PhylomeDBiQ62611.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR015621. IL-1_rcpt_fam.
IPR004074. IL-1_rcpt_I/II-typ.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF01582. TIR. 1 hit.
[Graphical view]
PRINTSiPR01536. INTRLKN1R12F.
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

Isoform A (identifier: Q62611-1) [UniParc]FASTAAdd to basket

Also known as: Membrane-bound, Fit-1M

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIGKWRMGLW ALAILTVPMY FIVTEGRKTS WGLENEALIV RCPQRGGAIN
60 70 80 90 100
PVEWYYSNTN ERIPTQKRNR IFVSRDRLKF LPAKVEDSGI YTCVIRSPES
110 120 130 140 150
IKTGSLNVTI YKRPPNCKIP DYMMYSTVDG SDKNSKITCP TIALYNWTAP
160 170 180 190 200
VQWFKNCKAL QGPRFRAHMS YLFIDKVSHV DEGDYTCRFT HTENGTNYIV
210 220 230 240 250
TATRSFTVEE KGFSTFPVIT NPPHNYTVEV EIGKTANIAC SACFGTASQF
260 270 280 290 300
VAVLWQINKT RIGSFGKARI QEEKGPNKSS SNGMICLTSL LRITGVTDKD
310 320 330 340 350
FSLKYDCVAM NHHGVIRHPV RLRRKQPIDH QSTYYIVAGC SLLLMFINVL
360 370 380 390 400
VIVLKVFWIE VALFWRDIMA PYKTQNDGKL YDAYIIYPRV FRGSAAGTGS
410 420 430 440 450
VEYFVHYTLP DVLENKCGYK LCIYGRDLLP GQDAATVVES SIQNSRRQVF
460 470 480 490 500
VLAPHMMHSK EFAYEQEIAL HSALIQNNSK VILIEMEPMG EASRLQLGDL
510 520 530 540 550
QDSLQHLVKM QGTIKWREDH VADKQSLSSK FWKHVRYQMP VPKRPPKMAS
560
VAAPLSGKVC LDLKHF
Length:566
Mass (Da):64,406
Last modified:November 1, 1996 - v1
Checksum:i50554A29437A0C31
GO
Isoform B (identifier: Q62611-2) [UniParc]FASTAAdd to basket

Also known as: Soluble, Fit-1S

The sequence of this isoform differs from the canonical sequence as follows:
     328-336: IDHQSTYYI → SKECLSQIA
     337-566: Missing.

Show »
Length:336
Mass (Da):38,090
Checksum:i61C6A6FA8FE319D2
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei328 – 3369IDHQSTYYI → SKECLSQIA in isoform B. 1 PublicationVSP_002670
Alternative sequencei337 – 566230Missing in isoform B. 1 PublicationVSP_002671Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04317 mRNA. Translation: AAA18480.1.
U04319 mRNA. Translation: AAA67172.1.
PIRiS42632.
S42633.
RefSeqiNP_001121161.1. NM_001127689.1. [Q62611-1]
NP_037169.1. NM_013037.1. [Q62611-2]
UniGeneiRn.10072.

Genome annotation databases

GeneIDi25556.
KEGGirno:25556.
UCSCiRGD:2894. rat. [Q62611-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04317 mRNA. Translation: AAA18480.1.
U04319 mRNA. Translation: AAA67172.1.
PIRiS42632.
S42633.
RefSeqiNP_001121161.1. NM_001127689.1. [Q62611-1]
NP_037169.1. NM_013037.1. [Q62611-2]
UniGeneiRn.10072.

3D structure databases

ProteinModelPortaliQ62611.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020144.

PTM databases

PhosphoSiteiQ62611.

Proteomic databases

PaxDbiQ62611.
PRIDEiQ62611.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25556.
KEGGirno:25556.
UCSCiRGD:2894. rat. [Q62611-1]

Organism-specific databases

CTDi9173.
RGDi2894. Il1rl1.

Phylogenomic databases

eggNOGiENOG410IPTT. Eukaryota.
ENOG4110Z8K. LUCA.
HOGENOMiHOG000113054.
HOVERGENiHBG098401.
InParanoidiQ62611.
KOiK05171.
PhylomeDBiQ62611.

Miscellaneous databases

NextBioi607125.
PROiQ62611.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR015621. IL-1_rcpt_fam.
IPR004074. IL-1_rcpt_I/II-typ.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF01582. TIR. 1 hit.
[Graphical view]
PRINTSiPR01536. INTRLKN1R12F.
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Alternative promoter usage of the Fos-responsive gene Fit-1 generates mRNA isoforms coding for either secreted or membrane-bound proteins related to the IL-1 receptor."
    Bergers G., Reikersdorfer A., Braselmann S., Graninger P., Busslinger M.
    EMBO J. 13:1176-1188(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).

Entry informationi

Entry nameiILRL1_RAT
AccessioniPrimary (citable) accession number: Q62611
Secondary accession number(s): Q62612
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.