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Protein

Sex-determining region Y protein

Gene

Sry

Organism
Mus spretus (Western Mediterranean mouse) (Algerian mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Transcriptional regulator that controls a genetic switch in male development. It is responsible for initiating male sex determination. SRY HMG box recognizes DNA by partial intercalation in the minor groove. Promotes DNA bending (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi5 – 73HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

  • calmodulin binding Source: UniProtKB-KW
  • DNA binding Source: MGI
  • protein heterodimerization activity Source: MGI
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: MGI

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • male gonad development Source: MGI
  • male sex determination Source: MGI
  • negative regulation of gene expression Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • sex determination Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, Calmodulin-binding, DNA-binding
Biological processDifferentiation, Sexual differentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Sex-determining region Y protein
Alternative name(s):
Testis-determining factor
Gene namesi
Name:Sry
Synonyms:Tdf
OrganismiMus spretus (Western Mediterranean mouse) (Algerian mouse)
Taxonomic identifieri10096 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:98660. Sry.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000486891 – 355Sex-determining region Y proteinAdd BLAST355

Post-translational modificationi

Acetylation of Lys-81 contributes to its nuclear localization and enhances its interaction with KPNB1. Deacetylated by HDAC3.By similarity

Keywords - PTMi

Acetylation

Interactioni

GO - Molecular functioni

  • calmodulin binding Source: UniProtKB-KW
  • protein heterodimerization activity Source: MGI

Structurei

3D structure databases

ProteinModelPortaliQ62563.
SMRiQ62563.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The Gln- and His-rich domain may mediate protein-protein interactions.

Sequence similaritiesi

Belongs to the SRY family.Curated

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiView protein in InterPro
IPR009071. HMG_box_dom.
IPR036910. HMG_box_dom_sf.
IPR017253. SRY.
PANTHERiPTHR10270:SF199. PTHR10270:SF199. 3 hits.
PfamiView protein in Pfam
PF00505. HMG_box. 1 hit.
SMARTiView protein in SMART
SM00398. HMG. 1 hit.
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiView protein in PROSITE
PS50118. HMG_BOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q62563-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGHVKRPMN AFMVWSRGER HKLAQQNPSM QNTEISKQLG CRWKSLTEAE
60 70 80 90 100
KRPFFQEAQR LKTLHREKYP NYKYQPHRRA KVSQRSGILQ PRVASTKLYN
110 120 130 140 150
LLQWDRNPHA ITYRQDWSRA AHLYSKNQQS FYLQPVDIPT GHPQQQQQQF
160 170 180 190 200
HNHHQQKQQF HDHHQQKQQF HDHHQQQQQF HDHQQQQQQF HDHQQQKQQF
210 220 230 240 250
HDHQQQQQQF HDHHHQQQQQ QFHDHHHHQQ QQQQFHDHHQ QKQQFHDHHQ
260 270 280 290 300
QQQQQQFHDH PQQQQQFHDH PQQKQQFHDH HHHQQQKQQF HDHHQQKQQF
310 320 330 340 350
HDHHQQQQQF HDHQQQQQQQ QFHDQQLTYL LTADITGEHT PYQEHLSKAL

WLAVS
Length:355
Mass (Da):44,260
Last modified:July 15, 1998 - v2
Checksum:i0903265F7A173EFC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti274K → R. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70659 Genomic DNA. Translation: AAC53449.1.
AF009521 Genomic DNA. Translation: AAC53452.1.
L29544 Genomic DNA. Translation: AAA40102.1.
PIRiT47235.

Similar proteinsi

Entry informationi

Entry nameiSRY_MUSSP
AccessioniPrimary (citable) accession number: Q62563
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: November 22, 2017
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families