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Protein

Zona pellucida-binding protein 1

Gene

Zpbp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in acrosome compaction and sperm morphogenesis. Is implicated in sperm-oocyte interaction during fertilization.1 Publication

GO - Biological processi

  • acrosome assembly Source: MGI
  • binding of sperm to zona pellucida Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Zona pellucida-binding protein 1
Alternative name(s):
Inner acrosomal membrane IAM381 Publication
Sp38
Gene namesi
Name:Zpbp
Synonyms:Zpbp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1855701. Zpbp.

Subcellular locationi

GO - Cellular componenti

  • acrosomal membrane Source: UniProtKB-SubCell
  • acrosomal vesicle Source: MGI
  • cell body Source: MGI
  • extracellular region Source: UniProtKB-SubCell
  • nucleus Source: MGI
  • zona pellucida receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane, Secreted

Pathology & Biotechi

Disruption phenotypei

Male mice are infertile with abnormal round-headed sperm morphology and no forward sperm motility.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 44Sequence analysisAdd BLAST44
ChainiPRO_000004159945 – 350Zona pellucida-binding protein 1Add BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi113N-linked (GlcNAc...)Sequence analysis1
Glycosylationi186N-linked (GlcNAc...)Sequence analysis1
Glycosylationi339N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.2 Publications

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ62522.
PRIDEiQ62522.

PTM databases

PhosphoSitePlusiQ62522.

Expressioni

Tissue specificityi

Expressed in testis (at protein level) (PubMed:19204925). Expressed in male germ cells (PubMed:17664285).2 Publications

Developmental stagei

Barely detectable at 11 days postpartum (dpp), very strong signal from 20 dpp until adulthood (PubMed:19204925). Expressed from the mid-pachytene spermatocyte stage to the early elongating spermatid stage (PubMed:17664285, PubMed:19204925).2 Publications

Gene expression databases

BgeeiENSMUSG00000020193.
CleanExiMM_ZPBP.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020413.

Structurei

3D structure databases

ProteinModelPortaliQ62522.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IEJM. Eukaryota.
ENOG410YN9Q. LUCA.
HOVERGENiHBG106672.
InParanoidiQ62522.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR013783. Ig-like_fold.
IPR010857. Sp38-bd.
[Graphical view]
PANTHERiPTHR15443. PTHR15443. 1 hit.
PfamiPF07354. Sp38. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62522-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEALAPGRAP RGRRRAGASG SVLSPLSLAA VLLCALLRAP PAVGHLARLP
60 70 80 90 100
RSIHLTQDSL KIVGSTHFPV SVYVMLHQKS PHVLCVTQRL RNTELVDPSF
110 120 130 140 150
QWHGPKGKLV SENTTAQVTS TGSLIFQSFE ETMSGVYTCF LEYKPTVEES
160 170 180 190 200
IKNLQLKYIV YAYREPRFYY QFTARYHAAP CNSIYNISFE KKLLQILSKL
210 220 230 240 250
VLDLSCEISL IKSECHRVKM QRAGLQNELF FTFSVASIDT EKGSKPCTDH
260 270 280 290 300
SCEASKRLSK AKNLIERFFI QQVEVLGKRA EPLPEIYYIE GTLQMVWVNR
310 320 330 340 350
CFPGYGINVL KHPKCPECCV VCSPGSFNPR DGTHCLQCNN SLVYGAKTCM
Length:350
Mass (Da):39,232
Last modified:October 11, 2004 - v2
Checksum:iCABD14DAE1C76EE8
GO

Sequence cautioni

The sequence BAA04494 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17569 mRNA. Translation: BAA04494.1. Different initiation.
AK006274 mRNA. Translation: BAB24497.1.
AK018889 mRNA. Translation: BAB31476.1.
AK018921 mRNA. Translation: BAB31483.1.
AK029541 mRNA. Translation: BAC26504.1.
RefSeqiNP_056600.1. NM_015785.2.
UniGeneiMm.9500.

Genome annotation databases

GeneIDi53604.
KEGGimmu:53604.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17569 mRNA. Translation: BAA04494.1. Different initiation.
AK006274 mRNA. Translation: BAB24497.1.
AK018889 mRNA. Translation: BAB31476.1.
AK018921 mRNA. Translation: BAB31483.1.
AK029541 mRNA. Translation: BAC26504.1.
RefSeqiNP_056600.1. NM_015785.2.
UniGeneiMm.9500.

3D structure databases

ProteinModelPortaliQ62522.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020413.

PTM databases

PhosphoSitePlusiQ62522.

Proteomic databases

PaxDbiQ62522.
PRIDEiQ62522.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi53604.
KEGGimmu:53604.

Organism-specific databases

CTDi11055.
MGIiMGI:1855701. Zpbp.

Phylogenomic databases

eggNOGiENOG410IEJM. Eukaryota.
ENOG410YN9Q. LUCA.
HOVERGENiHBG106672.
InParanoidiQ62522.

Miscellaneous databases

ChiTaRSiZpbp. mouse.
PROiQ62522.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020193.
CleanExiMM_ZPBP.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR013783. Ig-like_fold.
IPR010857. Sp38-bd.
[Graphical view]
PANTHERiPTHR15443. PTHR15443. 1 hit.
PfamiPF07354. Sp38. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZPBP1_MOUSE
AccessioniPrimary (citable) accession number: Q62522
Secondary accession number(s): Q9CR97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: November 30, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.