Reviewed, UniProtKB/Swiss-Prot Q62520 (ZIC2_MOUSE)

Names and origin

Protein names

Recommended name:
    Zinc finger protein ZIC 2
Alternative name(s):
    Zinc finger protein of the cerebellum 2

Gene names

Name:

Zic2

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	530 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in cerebellar development. Ref.3
Subcellular location	Nucleus.
Tissue specificity	CNS. A high level expression is seen in the cerebellum.
Sequence similarities	Belongs to the GLI C2H2-type zinc-finger protein family. Contains 5 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	cell differentiation Inferred from mutant phenotype. Source: MGI central nervous system development Ref.3 Inferred from genetic interaction. Source: MGI neural tube closure Inferred from mutant phenotype. Source: MGI pigmentation during development Inferred from mutant phenotype. Source: MGI
Cellular component	nucleus Inferred from direct assay. Source: MGI
Molecular function	DNA binding Inferred from direct assay. Source: MGI protein binding Inferred from physical interaction. Source: IntAct zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
GLI1	P08151	1	EBI-308076,EBI-308084	From a different organism.
Gli2	Q8K0K3	1	EBI-308076,EBI-308039
GLI3	P10071	2	EBI-308076,EBI-308055	From a different organism.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 530	530	Zinc finger protein ZIC 2		PRO_0000047248
Regions
	Zinc finger	256 – 291	36	C2H2-type 1; atypical
	Zinc finger	300 – 327	28	C2H2-type 2; atypical
	Zinc finger	333 – 357	25	C2H2-type 3
	Zinc finger	363 – 387	25	C2H2-type 4
	Zinc finger	393 – 415	23	C2H2-type 5
	Compositional bias	20 – 23	4	Poly-His
	Compositional bias	25 – 33	9	Poly-Ala
	Compositional bias	89 – 97	9	Poly-Ala
	Compositional bias	227 – 231	5	Poly-Ala
	Compositional bias	232 – 239	8	Poly-His
	Compositional bias	456 – 470	15	Poly-Ala
	Compositional bias	492 – 506	15	Poly-Gly

Sequences

	Sequence		Length	Mass (Da)
	Q62520-1 [UniParc]. Last modified October 24, 2003. Version 2. Checksum: BE8B476E81B1E40B	FASTA	530	54,954
	10 20 30 40 50 60 MLLDAGPQFP AIGVGSFARH HHHSAAAAAA AAAEMQDREL SLAAAQNGFV DSAAAHMGAF 70 80 90 100 110 120 KLNPGAHELS PGQSSAFTSQ GPGAYPGSAA AAAAAAALGP HAAHVGSYSG PPFNSTRDFL 130 140 150 160 170 180 FRSRGFGDSA PGGGQHGLFG PGAGGLHHAH SDAQGHLLFP GLPPEQHGPH ASQNVLNGQM 190 200 210 220 230 240 RLGLPGEVFG RSEQYRQVAS PRTDPYSAAQ LHNQYGPMNM NMGMNMAAAA AHHHHHHHHP 250 260 270 280 290 300 GAFFRYMRQQ CIKQELICKW IDPEQLSNPK KSCNKTFSTM HELVTHVSVE HVGGPEQSNH 310 320 330 340 350 360 VCFWEECPRE GKPFKAKYKL VNHIRVHTGE KPFPCPFPGC GKVFARSENL KIHKRTHTGE 370 380 390 400 410 420 KPFQCEFEGC DRRFANSSDR KKHMHVHTSD KPYLCKMCDK SYTHPSSLRK HMKVHESSPQ 430 440 450 460 470 480 GSESSPAASS GYESSTPPGL VSPSAEPQSS SNLSPAAAAA AAAAAAAAAA VSAVHRGAGS 490 500 510 520 530 GSSGSGGGSA AGSGGGGGGA GGGGGGSSGG GSGTTGGHSG LSSNFNEWYV

References

[1]	"The mouse zic gene family. Homologues of the Drosophila pair-rule gene odd-paired." Aruga J., Nagai T., Tokuyama T., Hayashizaki Y., Okazaki Y., Chapman V.M., Mikoshiba K. J. Biol. Chem. 271:1043-1047(1996) [PubMed: 8557628] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Cerebellum.
[2]	Aruga J. Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 488-512.
[3]	"Zic2 controls cerebellar development in cooperation with Zic1." Aruga J., Inoue T., Hoshino J., Mikoshiba K. J. Neurosci. 22:218-225(2002) [PubMed: 11756505] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D70848 mRNA. Translation: BAA11115.2.
IPI	IPI00127145.
UniGene	Mm.308936
3D structure databases
HSSP	HSSP built from PDB template 1SP2 based on UniProtKB P08047.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q62520. 3 interactions.
PTM databases
PhosphoSite	Q62520.
Genome annotation databases
Ensembl	ENSMUSG00000061524. Mus musculus. [Contig view]
Organism-specific databases
MGI	MGI:106679. Zic2.
Phylogenomic databases
HOGENOM	Q62520.
HOVERGEN	Q62520.
Gene expression databases
ArrayExpress	Q62520.
Bgee	Q62520.
CleanEx	MM_ZIC2.
GermOnline	ENSMUSG00000061524. Mus musculus.
Family and domain databases
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 2 hits.
Pfam	PF00096. zf-C2H2. 3 hits. [Graphical view]
ProDom	PD000003. Znf_C2H2. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00355. ZnF_C2H2. 5 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 3 hits. PS50157. ZINC_FINGER_C2H2_2. 4 hits. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

ZIC2_MOUSE

Accession

Primary (citable) accession number: Q62520

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	October 24, 2003
Last modified:	June 16, 2009
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)