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Protein

E3 ubiquitin-protein ligase ZFP91

Gene

Zfp91

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri313 – 33826C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri344 – 36825C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri374 – 39623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri402 – 42423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri432 – 45524C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase ZFP91 (EC:6.3.2.-)
Alternative name(s):
Penta Zf protein
Zinc finger protein 91 homolog
Short name:
Zfp-91
Zinc finger protein PZF
Gene namesi
Name:Zfp91
Synonyms:Pzf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:104854. Zfp91.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 572571E3 ubiquitin-protein ligase ZFP91PRO_0000047313Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei86 – 861PhosphoserineCombined sources
Modified residuei106 – 1061PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ62511.
PaxDbiQ62511.
PeptideAtlasiQ62511.
PRIDEiQ62511.

PTM databases

iPTMnetiQ62511.
PhosphoSiteiQ62511.

Expressioni

Tissue specificityi

Found in all the examined tissues including brain, heart, kidney, lung, liver, spleen, thymus, skeletal muscle, ovary and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000024695.
CleanExiMM_ZFP91.
ExpressionAtlasiQ62511. baseline and differential.
GenevisibleiQ62511. MM.

Interactioni

Subunit structurei

Interacts with MAP3K14/NIK.By similarity

Protein-protein interaction databases

BioGridi225146. 2 interactions.
STRINGi10090.ENSMUSP00000037971.

Structurei

3D structure databases

ProteinModelPortaliQ62511.
SMRiQ62511. Positions 315-458.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni340 – 37031Interaction with MAP3K14/NIKBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi211 – 28474Glu-richAdd
BLAST

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri313 – 33826C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri344 – 36825C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri374 – 39623C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri402 – 42423C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri432 – 45524C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063153.
HOVERGENiHBG055547.
InParanoidiQ62511.
OMAiVPFKDDP.
OrthoDBiEOG091G055J.
PhylomeDBiQ62511.
TreeFamiTF332664.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q62511-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGETEEPRS PEQQDQEGGP AAAADAASEE LRPGAAAAPA APAETASSRV
60 70 80 90 100
LRGGRDRGRT AAAAAAAAAA VSRRRKAEYP RRRRSSPSNR PPDGPGHQPA
110 120 130 140 150
AAKPPSPAQG KKSPRLQCIE KLTTDKDPKE EKEDDSVLPQ EVSITTTRAS
160 170 180 190 200
RSWRSSSRTS ISRLRDSENT RSSRSKTGSL QLVCKTEPIT DQLDYDVPEE
210 220 230 240 250
HQSPGGISSD EEEEEEEEML ISEEEIPFKD DPRDETYKPH LERETPKPRR
260 270 280 290 300
KSGKVKEEKE KKEIKVEVEV EVKEEENEIR EDEEPPRKRG RRRKDDKSPR
310 320 330 340 350
LPKRRKKPPI QYVRCEMEGC GTVLAHPRYL QHHIKYQHLL KKKYVCPHPS
360 370 380 390 400
CGRLFRLQKQ LLRHAKHHTD QRDYICEYCA RAFKSSHNLA VHRMIHTGEK
410 420 430 440 450
PLQCEICGFT CRQKASLNWH MKKHDADSFY QFSCNICGKK FEKKDSVVAH
460 470 480 490 500
KAKSHPEVLI AEALAANAGA LITSTDILGT NPEPLTQPAD GQGLPLLPEP
510 520 530 540 550
LGNSTAGECL LLEAEGMSKS YCSGTERVSL MADGKIFVGS GSSGGTEGLV
560 570
MNSDILGATT EVLIEDTDST GP
Length:572
Mass (Da):63,389
Last modified:May 29, 2007 - v3
Checksum:iC57D976BA1DC07F4
GO
Isoform 2 (identifier: Q62511-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-111: Missing.
     112-128: KSPRLQCIEKLTTDKDP → MKTKKECEEDD

Show »
Length:455
Mass (Da):51,539
Checksum:iE4FD2449854B0B13
GO

Sequence cautioni

The sequence BAC26394 differs from that shown. Reason: Frameshift at position 341. Curated
The sequence BAC34808 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC40660 differs from that shown. Reason: Frameshift at position 341. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti104 – 1041P → A in BAE41195 (PubMed:16141072).Curated
Sequence conflicti218 – 2181E → Q in BAC40660 (PubMed:16141072).Curated
Sequence conflicti256 – 2561K → T in AAA81911 (PubMed:7835706).Curated
Sequence conflicti256 – 2561K → T in AAA81913 (PubMed:7835706).Curated
Sequence conflicti297 – 2971K → R in BAC40660 (PubMed:16141072).Curated
Sequence conflicti331 – 3311Q → E in AAA81911 (PubMed:7835706).Curated
Sequence conflicti466 – 4661A → V in AAA81911 (PubMed:7835706).Curated
Sequence conflicti466 – 4661A → V in AAA81913 (PubMed:7835706).Curated
Sequence conflicti498 – 4981P → T in BAC26394 (PubMed:16141072).Curated
Sequence conflicti528 – 5292VS → LI in AAA81911 (PubMed:7835706).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 111111Missing in isoform 2. 1 PublicationVSP_025759Add
BLAST
Alternative sequencei112 – 12817KSPRL…TDKDP → MKTKKECEEDD in isoform 2. 1 PublicationVSP_025760Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05342 mRNA. Translation: AAA81911.1.
U05343 mRNA. Translation: AAA81913.1.
AK029319 mRNA. Translation: BAC26394.1. Frameshift.
AK051904 mRNA. Translation: BAC34808.1. Different initiation.
AK088933 mRNA. Translation: BAC40660.1. Frameshift.
AK147502 mRNA. Translation: BAE27956.1.
AK147560 mRNA. Translation: BAE27996.1.
AK169477 mRNA. Translation: BAE41195.1.
BC057323 mRNA. Translation: AAH57323.1.
BC064766 mRNA. Translation: AAH64766.1.
BC083000 mRNA. Translation: AAH83000.1.
CCDSiCCDS37927.1. [Q62511-1]
PIRiI48722.
I48724.
RefSeqiNP_443735.2. NM_053009.3. [Q62511-1]
UniGeneiMm.290924.
Mm.485066.

Genome annotation databases

EnsembliENSMUST00000038627; ENSMUSP00000037971; ENSMUSG00000024695. [Q62511-1]
GeneIDi109910.
KEGGimmu:109910.
UCSCiuc008gup.2. mouse. [Q62511-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05342 mRNA. Translation: AAA81911.1.
U05343 mRNA. Translation: AAA81913.1.
AK029319 mRNA. Translation: BAC26394.1. Frameshift.
AK051904 mRNA. Translation: BAC34808.1. Different initiation.
AK088933 mRNA. Translation: BAC40660.1. Frameshift.
AK147502 mRNA. Translation: BAE27956.1.
AK147560 mRNA. Translation: BAE27996.1.
AK169477 mRNA. Translation: BAE41195.1.
BC057323 mRNA. Translation: AAH57323.1.
BC064766 mRNA. Translation: AAH64766.1.
BC083000 mRNA. Translation: AAH83000.1.
CCDSiCCDS37927.1. [Q62511-1]
PIRiI48722.
I48724.
RefSeqiNP_443735.2. NM_053009.3. [Q62511-1]
UniGeneiMm.290924.
Mm.485066.

3D structure databases

ProteinModelPortaliQ62511.
SMRiQ62511. Positions 315-458.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi225146. 2 interactions.
STRINGi10090.ENSMUSP00000037971.

PTM databases

iPTMnetiQ62511.
PhosphoSiteiQ62511.

Proteomic databases

MaxQBiQ62511.
PaxDbiQ62511.
PeptideAtlasiQ62511.
PRIDEiQ62511.

Protocols and materials databases

DNASUi109910.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038627; ENSMUSP00000037971; ENSMUSG00000024695. [Q62511-1]
GeneIDi109910.
KEGGimmu:109910.
UCSCiuc008gup.2. mouse. [Q62511-1]

Organism-specific databases

CTDi80829.
MGIiMGI:104854. Zfp91.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063153.
HOVERGENiHBG055547.
InParanoidiQ62511.
OMAiVPFKDDP.
OrthoDBiEOG091G055J.
PhylomeDBiQ62511.
TreeFamiTF332664.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

ChiTaRSiZfp91. mouse.
PROiQ62511.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024695.
CleanExiMM_ZFP91.
ExpressionAtlasiQ62511. baseline and differential.
GenevisibleiQ62511. MM.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZFP91_MOUSE
AccessioniPrimary (citable) accession number: Q62511
Secondary accession number(s): Q3TEQ3
, Q3UH61, Q62509, Q6P219, Q6PG06, Q8BPY3, Q8C2B4, Q8CDZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: May 29, 2007
Last modified: September 7, 2016
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

In contrast to other E3 ubiquitin-protein ligase, does not contain any domain (RING-type zinc finger or HECT domain) known to mediate E3 ligase activity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.