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Q62507

- COCH_MOUSE

UniProt

Q62507 - COCH_MOUSE

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Protein

Cochlin

Gene
Coch
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Plays a role in the control of cell shape and motility in the trabecular meshwork By similarity.

GO - Molecular functioni

  1. protein binding Source: MGI

GO - Biological processi

  1. defense response to bacterium Source: MGI
  2. positive regulation of innate immune response Source: MGI
  3. regulation of cell shape Source: UniProtKB
  4. sensory perception of sound Source: MGI
Complete GO annotation...

Keywords - Biological processi

Hearing

Names & Taxonomyi

Protein namesi
Recommended name:
Cochlin
Alternative name(s):
COCH-5B2
Gene namesi
Name:Coch
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1278313. Coch.

Subcellular locationi

Secretedextracellular space By similarity

GO - Cellular componenti

  1. extracellular region Source: MGI
  2. extracellular space Source: UniProtKB-SubCell
  3. proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626 Reviewed predictionAdd
BLAST
Chaini27 – 552526CochlinPRO_0000020969Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi36 ↔ 52 By similarity
Disulfide bondi56 ↔ 76 By similarity
Glycosylationi102 – 1021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi223 – 2231N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ62507.
PaxDbiQ62507.
PRIDEiQ62507.

PTM databases

PhosphoSiteiQ62507.

Expressioni

Tissue specificityi

Expressed in inner ear structures.

Gene expression databases

BgeeiQ62507.
CleanExiMM_COCH.
GenevestigatoriQ62507.

Interactioni

Subunit structurei

Interacts with SLC44A2 By similarity. Interacts with ANXA2 By similarity.

Protein-protein interaction databases

IntActiQ62507. 1 interaction.
MINTiMINT-4091468.
STRINGi10090.ENSMUSP00000082533.

Structurei

3D structure databases

ProteinModelPortaliQ62507.
SMRiQ62507. Positions 31-126, 163-548.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 12394LCCLAdd
BLAST
Domaini167 – 352186VWFA 1Add
BLAST
Domaini369 – 539171VWFA 2Add
BLAST

Sequence similaritiesi

Contains 1 LCCL domain.
Contains 2 VWFA domains.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG277584.
GeneTreeiENSGT00750000117258.
HOGENOMiHOG000013195.
HOVERGENiHBG005372.
InParanoidiQ62507.
OMAiAQKFFTA.
OrthoDBiEOG71RXJM.
PhylomeDBiQ62507.
TreeFamiTF318242.

Family and domain databases

Gene3Di2.170.130.20. 1 hit.
3.40.50.410. 2 hits.
InterProiIPR004043. LCCL.
IPR002035. VWF_A.
[Graphical view]
PfamiPF03815. LCCL. 1 hit.
PF00092. VWA. 2 hits.
[Graphical view]
SMARTiSM00603. LCCL. 1 hit.
SM00327. VWA. 2 hits.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 2 hits.
SSF69848. SSF69848. 1 hit.
PROSITEiPS50820. LCCL. 1 hit.
PS50234. VWFA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62507-1 [UniParc]FASTAAdd to Basket

« Hide

MPSSRIPALC LGAWLLLLLL PRFARAEGAV PIPVTCFTRG LDIRKEKADV    50
LCPGGCSLEE FSVFGNIVYA SVSSICGAAV HRGVIGTSGG PVRVYSLPGR 100
ENYSSVDANG IQSQMLSRWS ASFAVTKGKS STQEATGRAV STAHPPSGKR 150
LKKTPEKKTG NKDCKADIAF LIDGSFNIGQ RRFNLQKNFV GKVALMLGIG 200
TEGPHVGLVQ ASEHPKIEFY LKNFTSAKDV LFAIKEVGFR GGNSNTGKAL 250
KHTAQKFFTA DTGVRKGIPK VVVVFIDGWP SDDIEEAGIV AREFGVNVFI 300
VSVAKPIPEE LGMVQDVAFV DKAVCRNNGF FSYHMPNWFG TTKYVKPLVQ 350
KLCTHEQMMC SKTCYNSVNI AFLIDGSSSV GDSNFRLMLE FVSNIAKTFE 400
ISDIGAKIAA VQFTYDQRTE FSFTDYNTKE NVLAVLANIR YMSGGTATGD 450
AIAFTVRNVF GPIRDSPNKN FLVIVTDGQS YDDVRGPAAA AHDAGITIFS 500
VGVAWAPLDD LRDMASKPKE SHAFFTREFT GLEPIVSDVI RGICRDFLES 550
QQ 552
Length:552
Mass (Da):59,950
Last modified:December 1, 2000 - v2
Checksum:iAD0BBB48D20055E3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF006741 mRNA. Translation: AAC39949.1.
AK028690 mRNA. Translation: BAC26067.1.
AK137336 mRNA. Translation: BAE23310.1.
AK171875 mRNA. Translation: BAE42713.1.
BC045137 mRNA. Translation: AAH45137.1.
Z78163 mRNA. Translation: CAB01565.1.
CCDSiCCDS25901.1.
RefSeqiNP_001185764.1. NM_001198835.1.
NP_031754.1. NM_007728.5.
UniGeneiMm.21325.

Genome annotation databases

EnsembliENSMUST00000085412; ENSMUSP00000082533; ENSMUSG00000020953.
ENSMUST00000164782; ENSMUSP00000128127; ENSMUSG00000020953.
GeneIDi12810.
KEGGimmu:12810.
UCSCiuc007nmr.2. mouse.

Cross-referencesi

Web resourcesi

Protein Spotlight

The Japanese Horseshoe Crab and Deafness - Issue 4 of November 2000

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF006741 mRNA. Translation: AAC39949.1 .
AK028690 mRNA. Translation: BAC26067.1 .
AK137336 mRNA. Translation: BAE23310.1 .
AK171875 mRNA. Translation: BAE42713.1 .
BC045137 mRNA. Translation: AAH45137.1 .
Z78163 mRNA. Translation: CAB01565.1 .
CCDSi CCDS25901.1.
RefSeqi NP_001185764.1. NM_001198835.1.
NP_031754.1. NM_007728.5.
UniGenei Mm.21325.

3D structure databases

ProteinModelPortali Q62507.
SMRi Q62507. Positions 31-126, 163-548.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q62507. 1 interaction.
MINTi MINT-4091468.
STRINGi 10090.ENSMUSP00000082533.

PTM databases

PhosphoSitei Q62507.

Proteomic databases

MaxQBi Q62507.
PaxDbi Q62507.
PRIDEi Q62507.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000085412 ; ENSMUSP00000082533 ; ENSMUSG00000020953 .
ENSMUST00000164782 ; ENSMUSP00000128127 ; ENSMUSG00000020953 .
GeneIDi 12810.
KEGGi mmu:12810.
UCSCi uc007nmr.2. mouse.

Organism-specific databases

CTDi 1690.
MGIi MGI:1278313. Coch.

Phylogenomic databases

eggNOGi NOG277584.
GeneTreei ENSGT00750000117258.
HOGENOMi HOG000013195.
HOVERGENi HBG005372.
InParanoidi Q62507.
OMAi AQKFFTA.
OrthoDBi EOG71RXJM.
PhylomeDBi Q62507.
TreeFami TF318242.

Miscellaneous databases

NextBioi 282256.
PROi Q62507.
SOURCEi Search...

Gene expression databases

Bgeei Q62507.
CleanExi MM_COCH.
Genevestigatori Q62507.

Family and domain databases

Gene3Di 2.170.130.20. 1 hit.
3.40.50.410. 2 hits.
InterProi IPR004043. LCCL.
IPR002035. VWF_A.
[Graphical view ]
Pfami PF03815. LCCL. 1 hit.
PF00092. VWA. 2 hits.
[Graphical view ]
SMARTi SM00603. LCCL. 1 hit.
SM00327. VWA. 2 hits.
[Graphical view ]
SUPFAMi SSF53300. SSF53300. 2 hits.
SSF69848. SSF69848. 1 hit.
PROSITEi PS50820. LCCL. 1 hit.
PS50234. VWFA. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mapping and characterization of a novel cochlear gene in human and in mouse: a positional candidate gene for a deafness disorder, DFNA9."
    Robertson N.G., Skvorak A.B., Yin Y., Weremowicz S., Johnson K.R., Kovatch K.A., Battey J.F., Bieber F.R., Morton C.C.
    Genomics 46:345-354(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Cochlea.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum and Skin.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.
  4. "Cloning of the genes encoding two murine and human cochlear unconventional type I myosins."
    Crozet F., El-Amraoui A., Blanchard S., Lenoir M., Ripoll C., Vago P., Hamel C., Fizames C., Levi-Acobas F., Depetris D., Mattei M.-G., Weil D., Pujol R., Petit C.
    Genomics 40:332-341(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 324-417.
    Tissue: Cochlea.

Entry informationi

Entry nameiCOCH_MOUSE
AccessioniPrimary (citable) accession number: Q62507
Secondary accession number(s): Q3TAF5, Q9QWK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: December 1, 2000
Last modified: July 9, 2014
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi