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Q62507

- COCH_MOUSE

UniProt

Q62507 - COCH_MOUSE

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Protein

Cochlin

Gene

Coch

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Plays a role in the control of cell shape and motility in the trabecular meshwork.By similarity

GO - Biological processi

  1. defense response to bacterium Source: MGI
  2. positive regulation of innate immune response Source: MGI
  3. regulation of cell shape Source: UniProtKB
  4. sensory perception of sound Source: MGI
Complete GO annotation...

Keywords - Biological processi

Hearing

Names & Taxonomyi

Protein namesi
Recommended name:
Cochlin
Alternative name(s):
COCH-5B2
Gene namesi
Name:Coch
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1278313. Coch.

Subcellular locationi

Secretedextracellular space By similarity

GO - Cellular componenti

  1. extracellular region Source: MGI
  2. extracellular vesicular exosome Source: Ensembl
  3. proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 552526CochlinPRO_0000020969Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi36 ↔ 52PROSITE-ProRule annotation
Disulfide bondi56 ↔ 76PROSITE-ProRule annotation
Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi223 – 2231N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ62507.
PaxDbiQ62507.
PRIDEiQ62507.

PTM databases

PhosphoSiteiQ62507.

Expressioni

Tissue specificityi

Expressed in inner ear structures.

Gene expression databases

BgeeiQ62507.
CleanExiMM_COCH.
GenevestigatoriQ62507.

Interactioni

Subunit structurei

Interacts with SLC44A2. Interacts with ANXA2.By similarity

Protein-protein interaction databases

IntActiQ62507. 1 interaction.
MINTiMINT-4091468.
STRINGi10090.ENSMUSP00000082533.

Structurei

3D structure databases

ProteinModelPortaliQ62507.
SMRiQ62507. Positions 31-126, 165-353, 369-535.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 12394LCCLPROSITE-ProRule annotationAdd
BLAST
Domaini167 – 352186VWFA 1PROSITE-ProRule annotationAdd
BLAST
Domaini369 – 539171VWFA 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 LCCL domain.PROSITE-ProRule annotation
Contains 2 VWFA domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG277584.
GeneTreeiENSGT00760000119000.
HOGENOMiHOG000013195.
HOVERGENiHBG005372.
InParanoidiQ62507.
OMAiAQKFFTA.
OrthoDBiEOG71RXJM.
PhylomeDBiQ62507.
TreeFamiTF318242.

Family and domain databases

Gene3Di2.170.130.20. 1 hit.
3.40.50.410. 2 hits.
InterProiIPR004043. LCCL.
IPR002035. VWF_A.
[Graphical view]
PfamiPF03815. LCCL. 1 hit.
PF00092. VWA. 2 hits.
[Graphical view]
SMARTiSM00603. LCCL. 1 hit.
SM00327. VWA. 2 hits.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 2 hits.
SSF69848. SSF69848. 1 hit.
PROSITEiPS50820. LCCL. 1 hit.
PS50234. VWFA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62507-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPSSRIPALC LGAWLLLLLL PRFARAEGAV PIPVTCFTRG LDIRKEKADV
60 70 80 90 100
LCPGGCSLEE FSVFGNIVYA SVSSICGAAV HRGVIGTSGG PVRVYSLPGR
110 120 130 140 150
ENYSSVDANG IQSQMLSRWS ASFAVTKGKS STQEATGRAV STAHPPSGKR
160 170 180 190 200
LKKTPEKKTG NKDCKADIAF LIDGSFNIGQ RRFNLQKNFV GKVALMLGIG
210 220 230 240 250
TEGPHVGLVQ ASEHPKIEFY LKNFTSAKDV LFAIKEVGFR GGNSNTGKAL
260 270 280 290 300
KHTAQKFFTA DTGVRKGIPK VVVVFIDGWP SDDIEEAGIV AREFGVNVFI
310 320 330 340 350
VSVAKPIPEE LGMVQDVAFV DKAVCRNNGF FSYHMPNWFG TTKYVKPLVQ
360 370 380 390 400
KLCTHEQMMC SKTCYNSVNI AFLIDGSSSV GDSNFRLMLE FVSNIAKTFE
410 420 430 440 450
ISDIGAKIAA VQFTYDQRTE FSFTDYNTKE NVLAVLANIR YMSGGTATGD
460 470 480 490 500
AIAFTVRNVF GPIRDSPNKN FLVIVTDGQS YDDVRGPAAA AHDAGITIFS
510 520 530 540 550
VGVAWAPLDD LRDMASKPKE SHAFFTREFT GLEPIVSDVI RGICRDFLES

QQ
Length:552
Mass (Da):59,950
Last modified:December 1, 2000 - v2
Checksum:iAD0BBB48D20055E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006741 mRNA. Translation: AAC39949.1.
AK028690 mRNA. Translation: BAC26067.1.
AK137336 mRNA. Translation: BAE23310.1.
AK171875 mRNA. Translation: BAE42713.1.
BC045137 mRNA. Translation: AAH45137.1.
Z78163 mRNA. Translation: CAB01565.1.
CCDSiCCDS25901.1.
RefSeqiNP_001185764.1. NM_001198835.1.
NP_031754.1. NM_007728.5.
UniGeneiMm.21325.

Genome annotation databases

EnsembliENSMUST00000085412; ENSMUSP00000082533; ENSMUSG00000020953.
ENSMUST00000164782; ENSMUSP00000128127; ENSMUSG00000020953.
GeneIDi12810.
KEGGimmu:12810.
UCSCiuc007nmr.2. mouse.

Cross-referencesi

Web resourcesi

Protein Spotlight

The Japanese Horseshoe Crab and Deafness - Issue 4 of November 2000

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF006741 mRNA. Translation: AAC39949.1 .
AK028690 mRNA. Translation: BAC26067.1 .
AK137336 mRNA. Translation: BAE23310.1 .
AK171875 mRNA. Translation: BAE42713.1 .
BC045137 mRNA. Translation: AAH45137.1 .
Z78163 mRNA. Translation: CAB01565.1 .
CCDSi CCDS25901.1.
RefSeqi NP_001185764.1. NM_001198835.1.
NP_031754.1. NM_007728.5.
UniGenei Mm.21325.

3D structure databases

ProteinModelPortali Q62507.
SMRi Q62507. Positions 31-126, 165-353, 369-535.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q62507. 1 interaction.
MINTi MINT-4091468.
STRINGi 10090.ENSMUSP00000082533.

PTM databases

PhosphoSitei Q62507.

Proteomic databases

MaxQBi Q62507.
PaxDbi Q62507.
PRIDEi Q62507.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000085412 ; ENSMUSP00000082533 ; ENSMUSG00000020953 .
ENSMUST00000164782 ; ENSMUSP00000128127 ; ENSMUSG00000020953 .
GeneIDi 12810.
KEGGi mmu:12810.
UCSCi uc007nmr.2. mouse.

Organism-specific databases

CTDi 1690.
MGIi MGI:1278313. Coch.

Phylogenomic databases

eggNOGi NOG277584.
GeneTreei ENSGT00760000119000.
HOGENOMi HOG000013195.
HOVERGENi HBG005372.
InParanoidi Q62507.
OMAi AQKFFTA.
OrthoDBi EOG71RXJM.
PhylomeDBi Q62507.
TreeFami TF318242.

Miscellaneous databases

NextBioi 282256.
PROi Q62507.
SOURCEi Search...

Gene expression databases

Bgeei Q62507.
CleanExi MM_COCH.
Genevestigatori Q62507.

Family and domain databases

Gene3Di 2.170.130.20. 1 hit.
3.40.50.410. 2 hits.
InterProi IPR004043. LCCL.
IPR002035. VWF_A.
[Graphical view ]
Pfami PF03815. LCCL. 1 hit.
PF00092. VWA. 2 hits.
[Graphical view ]
SMARTi SM00603. LCCL. 1 hit.
SM00327. VWA. 2 hits.
[Graphical view ]
SUPFAMi SSF53300. SSF53300. 2 hits.
SSF69848. SSF69848. 1 hit.
PROSITEi PS50820. LCCL. 1 hit.
PS50234. VWFA. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mapping and characterization of a novel cochlear gene in human and in mouse: a positional candidate gene for a deafness disorder, DFNA9."
    Robertson N.G., Skvorak A.B., Yin Y., Weremowicz S., Johnson K.R., Kovatch K.A., Battey J.F., Bieber F.R., Morton C.C.
    Genomics 46:345-354(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Cochlea.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum and Skin.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.
  4. "Cloning of the genes encoding two murine and human cochlear unconventional type I myosins."
    Crozet F., El-Amraoui A., Blanchard S., Lenoir M., Ripoll C., Vago P., Hamel C., Fizames C., Levi-Acobas F., Depetris D., Mattei M.-G., Weil D., Pujol R., Petit C.
    Genomics 40:332-341(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 324-417.
    Tissue: Cochlea.

Entry informationi

Entry nameiCOCH_MOUSE
AccessioniPrimary (citable) accession number: Q62507
Secondary accession number(s): Q3TAF5, Q9QWK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: December 1, 2000
Last modified: October 29, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3