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Q62507 (COCH_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cochlin
Alternative name(s):
COCH-5B2
Gene names
Name:Coch
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length552 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a role in the control of cell shape and motility in the trabecular meshwork By similarity.

Subunit structure

Interacts with SLC44A2 By similarity. Interacts with ANXA2 By similarity.

Subcellular location

Secreted › extracellular space By similarity.

Tissue specificity

Expressed in inner ear structures.

Sequence similarities

Contains 1 LCCL domain.

Contains 2 VWFA domains.

Ontologies

Keywords
   Biological processHearing
   Cellular componentSecreted
   DomainRepeat
Signal
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of cell shape

Inferred from sequence or structural similarity. Source: UniProtKB

sensory perception of sound

Inferred from mutant phenotype PubMed 21073934. Source: MGI

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 552526Cochlin
PRO_0000020969

Regions

Domain30 – 12394LCCL
Domain167 – 352186VWFA 1
Domain369 – 539171VWFA 2

Amino acid modifications

Glycosylation1021N-linked (GlcNAc...) Potential
Glycosylation2231N-linked (GlcNAc...) Potential
Disulfide bond36 ↔ 52 By similarity
Disulfide bond56 ↔ 76 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q62507 [UniParc].

Last modified December 1, 2000. Version 2.
Checksum: AD0BBB48D20055E3

FASTA55259,950
        10         20         30         40         50         60 
MPSSRIPALC LGAWLLLLLL PRFARAEGAV PIPVTCFTRG LDIRKEKADV LCPGGCSLEE 

        70         80         90        100        110        120 
FSVFGNIVYA SVSSICGAAV HRGVIGTSGG PVRVYSLPGR ENYSSVDANG IQSQMLSRWS 

       130        140        150        160        170        180 
ASFAVTKGKS STQEATGRAV STAHPPSGKR LKKTPEKKTG NKDCKADIAF LIDGSFNIGQ 

       190        200        210        220        230        240 
RRFNLQKNFV GKVALMLGIG TEGPHVGLVQ ASEHPKIEFY LKNFTSAKDV LFAIKEVGFR 

       250        260        270        280        290        300 
GGNSNTGKAL KHTAQKFFTA DTGVRKGIPK VVVVFIDGWP SDDIEEAGIV AREFGVNVFI 

       310        320        330        340        350        360 
VSVAKPIPEE LGMVQDVAFV DKAVCRNNGF FSYHMPNWFG TTKYVKPLVQ KLCTHEQMMC 

       370        380        390        400        410        420 
SKTCYNSVNI AFLIDGSSSV GDSNFRLMLE FVSNIAKTFE ISDIGAKIAA VQFTYDQRTE 

       430        440        450        460        470        480 
FSFTDYNTKE NVLAVLANIR YMSGGTATGD AIAFTVRNVF GPIRDSPNKN FLVIVTDGQS 

       490        500        510        520        530        540 
YDDVRGPAAA AHDAGITIFS VGVAWAPLDD LRDMASKPKE SHAFFTREFT GLEPIVSDVI 

       550 
RGICRDFLES QQ

« Hide

References

« Hide 'large scale' references
[1]"Mapping and characterization of a novel cochlear gene in human and in mouse: a positional candidate gene for a deafness disorder, DFNA9."
Robertson N.G., Skvorak A.B., Yin Y., Weremowicz S., Johnson K.R., Kovatch K.A., Battey J.F., Bieber F.R., Morton C.C.
Genomics 46:345-354(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Cochlea.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Cerebellum and Skin.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Olfactory epithelium.
[4]"Cloning of the genes encoding two murine and human cochlear unconventional type I myosins."
Crozet F., El-Amraoui A., Blanchard S., Lenoir M., Ripoll C., Vago P., Hamel C., Fizames C., Levi-Acobas F., Depetris D., Mattei M.-G., Weil D., Pujol R., Petit C.
Genomics 40:332-341(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 324-417.
Tissue: Cochlea.
+Additional computationally mapped references.

Web resources

Protein Spotlight

The Japanese Horseshoe Crab and Deafness - Issue 4 of November 2000

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF006741 mRNA. Translation: AAC39949.1.
AK028690 mRNA. Translation: BAC26067.1.
AK137336 mRNA. Translation: BAE23310.1.
AK171875 mRNA. Translation: BAE42713.1.
BC045137 mRNA. Translation: AAH45137.1.
Z78163 mRNA. Translation: CAB01565.1.
IPIIPI00127100.
RefSeqNP_001185764.1. NM_001198835.1.
NP_031754.1. NM_007728.5.
UniGeneMm.21325.

3D structure databases

ProteinModelPortalQ62507.
SMRQ62507. Positions 31-126, 165-317, 369-535.
ModBaseSearch...

Protein-protein interaction databases

MINTMINT-4091468.
STRING10090.ENSMUSP00000082533.

PTM databases

PhosphoSiteQ62507.

Proteomic databases

PaxDbQ62507.
PRIDEQ62507.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000085412; ENSMUSP00000082533; ENSMUSG00000020953.
ENSMUST00000164782; ENSMUSP00000128127; ENSMUSG00000020953.
GeneID12810.
KEGGmmu:12810.
UCSCuc007nmr.2. mouse.

Organism-specific databases

CTD1690.
MGIMGI:1278313. Coch.

Phylogenomic databases

eggNOGNOG277584.
GeneTreeENSGT00700000104272.
HOGENOMHOG000013195.
HOVERGENHBG005372.
InParanoidQ62507.
OMAAQKFFTA.
OrthoDBEOG4TTGJ5.

Gene expression databases

BgeeQ62507.
CleanExMM_COCH.
GenevestigatorQ62507.
GermOnlineENSMUSG00000020953. Mus musculus.

Family and domain databases

Gene3D2.170.130.20. 1 hit.
3.40.50.410. 2 hits.
InterProIPR004043. LCCL.
IPR002035. VWF_A.
[Graphical view]
PfamPF03815. LCCL. 1 hit.
PF00092. VWA. 2 hits.
[Graphical view]
SMARTSM00603. LCCL. 1 hit.
SM00327. VWA. 2 hits.
[Graphical view]
SUPFAMSSF69848. LCCL. 1 hit.
PROSITEPS50820. LCCL. 1 hit.
PS50234. VWFA. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio282256.
SOURCESearch...

Entry information

Entry nameCOCH_MOUSE
AccessionPrimary (citable) accession number: Q62507
Secondary accession number(s): Q3TAF5, Q9QWK6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: December 1, 2000
Last modified: May 29, 2013
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents