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Q62507

- COCH_MOUSE

UniProt

Q62507 - COCH_MOUSE

Protein

Cochlin

Gene

Coch

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 2 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Plays a role in the control of cell shape and motility in the trabecular meshwork.By similarity

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. defense response to bacterium Source: MGI
    2. positive regulation of innate immune response Source: MGI
    3. regulation of cell shape Source: UniProtKB
    4. sensory perception of sound Source: MGI

    Keywords - Biological processi

    Hearing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cochlin
    Alternative name(s):
    COCH-5B2
    Gene namesi
    Name:Coch
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1278313. Coch.

    Subcellular locationi

    Secretedextracellular space By similarity

    GO - Cellular componenti

    1. extracellular region Source: MGI
    2. extracellular space Source: UniProtKB-SubCell
    3. proteinaceous extracellular matrix Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 552526CochlinPRO_0000020969Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi36 ↔ 52PROSITE-ProRule annotation
    Disulfide bondi56 ↔ 76PROSITE-ProRule annotation
    Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi223 – 2231N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ62507.
    PaxDbiQ62507.
    PRIDEiQ62507.

    PTM databases

    PhosphoSiteiQ62507.

    Expressioni

    Tissue specificityi

    Expressed in inner ear structures.

    Gene expression databases

    BgeeiQ62507.
    CleanExiMM_COCH.
    GenevestigatoriQ62507.

    Interactioni

    Subunit structurei

    Interacts with SLC44A2. Interacts with ANXA2.By similarity

    Protein-protein interaction databases

    IntActiQ62507. 1 interaction.
    MINTiMINT-4091468.
    STRINGi10090.ENSMUSP00000082533.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62507.
    SMRiQ62507. Positions 31-126, 163-548.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 12394LCCLPROSITE-ProRule annotationAdd
    BLAST
    Domaini167 – 352186VWFA 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini369 – 539171VWFA 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 LCCL domain.PROSITE-ProRule annotation
    Contains 2 VWFA domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG277584.
    GeneTreeiENSGT00750000117258.
    HOGENOMiHOG000013195.
    HOVERGENiHBG005372.
    InParanoidiQ62507.
    OMAiAQKFFTA.
    OrthoDBiEOG71RXJM.
    PhylomeDBiQ62507.
    TreeFamiTF318242.

    Family and domain databases

    Gene3Di2.170.130.20. 1 hit.
    3.40.50.410. 2 hits.
    InterProiIPR004043. LCCL.
    IPR002035. VWF_A.
    [Graphical view]
    PfamiPF03815. LCCL. 1 hit.
    PF00092. VWA. 2 hits.
    [Graphical view]
    SMARTiSM00603. LCCL. 1 hit.
    SM00327. VWA. 2 hits.
    [Graphical view]
    SUPFAMiSSF53300. SSF53300. 2 hits.
    SSF69848. SSF69848. 1 hit.
    PROSITEiPS50820. LCCL. 1 hit.
    PS50234. VWFA. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q62507-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSSRIPALC LGAWLLLLLL PRFARAEGAV PIPVTCFTRG LDIRKEKADV    50
    LCPGGCSLEE FSVFGNIVYA SVSSICGAAV HRGVIGTSGG PVRVYSLPGR 100
    ENYSSVDANG IQSQMLSRWS ASFAVTKGKS STQEATGRAV STAHPPSGKR 150
    LKKTPEKKTG NKDCKADIAF LIDGSFNIGQ RRFNLQKNFV GKVALMLGIG 200
    TEGPHVGLVQ ASEHPKIEFY LKNFTSAKDV LFAIKEVGFR GGNSNTGKAL 250
    KHTAQKFFTA DTGVRKGIPK VVVVFIDGWP SDDIEEAGIV AREFGVNVFI 300
    VSVAKPIPEE LGMVQDVAFV DKAVCRNNGF FSYHMPNWFG TTKYVKPLVQ 350
    KLCTHEQMMC SKTCYNSVNI AFLIDGSSSV GDSNFRLMLE FVSNIAKTFE 400
    ISDIGAKIAA VQFTYDQRTE FSFTDYNTKE NVLAVLANIR YMSGGTATGD 450
    AIAFTVRNVF GPIRDSPNKN FLVIVTDGQS YDDVRGPAAA AHDAGITIFS 500
    VGVAWAPLDD LRDMASKPKE SHAFFTREFT GLEPIVSDVI RGICRDFLES 550
    QQ 552
    Length:552
    Mass (Da):59,950
    Last modified:December 1, 2000 - v2
    Checksum:iAD0BBB48D20055E3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF006741 mRNA. Translation: AAC39949.1.
    AK028690 mRNA. Translation: BAC26067.1.
    AK137336 mRNA. Translation: BAE23310.1.
    AK171875 mRNA. Translation: BAE42713.1.
    BC045137 mRNA. Translation: AAH45137.1.
    Z78163 mRNA. Translation: CAB01565.1.
    CCDSiCCDS25901.1.
    RefSeqiNP_001185764.1. NM_001198835.1.
    NP_031754.1. NM_007728.5.
    UniGeneiMm.21325.

    Genome annotation databases

    EnsembliENSMUST00000085412; ENSMUSP00000082533; ENSMUSG00000020953.
    ENSMUST00000164782; ENSMUSP00000128127; ENSMUSG00000020953.
    GeneIDi12810.
    KEGGimmu:12810.
    UCSCiuc007nmr.2. mouse.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    The Japanese Horseshoe Crab and Deafness - Issue 4 of November 2000

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF006741 mRNA. Translation: AAC39949.1 .
    AK028690 mRNA. Translation: BAC26067.1 .
    AK137336 mRNA. Translation: BAE23310.1 .
    AK171875 mRNA. Translation: BAE42713.1 .
    BC045137 mRNA. Translation: AAH45137.1 .
    Z78163 mRNA. Translation: CAB01565.1 .
    CCDSi CCDS25901.1.
    RefSeqi NP_001185764.1. NM_001198835.1.
    NP_031754.1. NM_007728.5.
    UniGenei Mm.21325.

    3D structure databases

    ProteinModelPortali Q62507.
    SMRi Q62507. Positions 31-126, 163-548.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q62507. 1 interaction.
    MINTi MINT-4091468.
    STRINGi 10090.ENSMUSP00000082533.

    PTM databases

    PhosphoSitei Q62507.

    Proteomic databases

    MaxQBi Q62507.
    PaxDbi Q62507.
    PRIDEi Q62507.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000085412 ; ENSMUSP00000082533 ; ENSMUSG00000020953 .
    ENSMUST00000164782 ; ENSMUSP00000128127 ; ENSMUSG00000020953 .
    GeneIDi 12810.
    KEGGi mmu:12810.
    UCSCi uc007nmr.2. mouse.

    Organism-specific databases

    CTDi 1690.
    MGIi MGI:1278313. Coch.

    Phylogenomic databases

    eggNOGi NOG277584.
    GeneTreei ENSGT00750000117258.
    HOGENOMi HOG000013195.
    HOVERGENi HBG005372.
    InParanoidi Q62507.
    OMAi AQKFFTA.
    OrthoDBi EOG71RXJM.
    PhylomeDBi Q62507.
    TreeFami TF318242.

    Miscellaneous databases

    NextBioi 282256.
    PROi Q62507.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q62507.
    CleanExi MM_COCH.
    Genevestigatori Q62507.

    Family and domain databases

    Gene3Di 2.170.130.20. 1 hit.
    3.40.50.410. 2 hits.
    InterProi IPR004043. LCCL.
    IPR002035. VWF_A.
    [Graphical view ]
    Pfami PF03815. LCCL. 1 hit.
    PF00092. VWA. 2 hits.
    [Graphical view ]
    SMARTi SM00603. LCCL. 1 hit.
    SM00327. VWA. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53300. SSF53300. 2 hits.
    SSF69848. SSF69848. 1 hit.
    PROSITEi PS50820. LCCL. 1 hit.
    PS50234. VWFA. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mapping and characterization of a novel cochlear gene in human and in mouse: a positional candidate gene for a deafness disorder, DFNA9."
      Robertson N.G., Skvorak A.B., Yin Y., Weremowicz S., Johnson K.R., Kovatch K.A., Battey J.F., Bieber F.R., Morton C.C.
      Genomics 46:345-354(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Cochlea.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cerebellum and Skin.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Olfactory epithelium.
    4. "Cloning of the genes encoding two murine and human cochlear unconventional type I myosins."
      Crozet F., El-Amraoui A., Blanchard S., Lenoir M., Ripoll C., Vago P., Hamel C., Fizames C., Levi-Acobas F., Depetris D., Mattei M.-G., Weil D., Pujol R., Petit C.
      Genomics 40:332-341(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 324-417.
      Tissue: Cochlea.

    Entry informationi

    Entry nameiCOCH_MOUSE
    AccessioniPrimary (citable) accession number: Q62507
    Secondary accession number(s): Q3TAF5, Q9QWK6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 130 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3