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Protein

Msx2-interacting protein

Gene

Spen

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways, such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA.4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi1 – 574Add BLAST574

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Notch signaling pathway, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Msx2-interacting protein
Alternative name(s):
SMART/HDAC1-associated repressor protein
SPEN homolog
Gene namesi
Name:Spen
Synonyms:Kiaa0929, Mint, Sharp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1891706. Spen.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000816281 – 3644Msx2-interacting proteinAdd BLAST3644

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei99PhosphoserineBy similarity1
Modified residuei108Omega-N-methylarginineBy similarity1
Modified residuei188PhosphoserineBy similarity1
Modified residuei190PhosphoserineBy similarity1
Modified residuei310PhosphoserineBy similarity1
Modified residuei647PhosphoserineBy similarity1
Modified residuei747PhosphoserineBy similarity1
Modified residuei749PhosphoserineBy similarity1
Modified residuei758PhosphoserineBy similarity1
Modified residuei762PhosphoserineBy similarity1
Modified residuei792PhosphoserineBy similarity1
Modified residuei852PhosphoserineCombined sources1
Modified residuei855PhosphoserineCombined sources1
Modified residuei869PhosphoserineCombined sources1
Modified residuei1077PhosphoserineBy similarity1
Modified residuei1183PhosphoserineBy similarity1
Modified residuei1209PhosphoserineBy similarity1
Modified residuei1237PhosphoserineBy similarity1
Modified residuei1267PhosphoserineBy similarity1
Modified residuei1276PhosphoserineBy similarity1
Modified residuei1283PhosphoserineBy similarity1
Modified residuei1293PhosphoserineBy similarity1
Modified residuei1298PhosphoserineBy similarity1
Modified residuei1302PhosphoserineBy similarity1
Modified residuei1348PhosphoserineBy similarity1
Modified residuei1395PhosphoserineCombined sources1
Modified residuei1397PhosphoserineBy similarity1
Modified residuei1454PhosphothreonineBy similarity1
Modified residuei1456PhosphothreonineBy similarity1
Modified residuei1634PhosphothreonineBy similarity1
Modified residuei1844PhosphothreonineBy similarity1
Modified residuei1915PhosphoserineBy similarity1
Modified residuei1936PhosphoserineBy similarity1
Modified residuei1965PhosphothreonineBy similarity1
Modified residuei2128PhosphoserineBy similarity1
Modified residuei2134PhosphoserineBy similarity1
Modified residuei2171PhosphothreonineBy similarity1
Modified residuei2366PhosphoserineBy similarity1
Modified residuei2419PhosphothreonineBy similarity1
Modified residuei2450PhosphoserineBy similarity1
Modified residuei2454PhosphoserineBy similarity1
Modified residuei2458PhosphothreonineBy similarity1
Modified residuei2491PhosphoserineBy similarity1
Modified residuei2913PhosphothreonineBy similarity1
Modified residuei2925PhosphothreonineBy similarity1
Modified residuei3088Asymmetric dimethylarginineBy similarity1
Modified residuei3096Asymmetric dimethylarginineBy similarity1
Modified residuei3413PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ62504.
PeptideAtlasiQ62504.
PRIDEiQ62504.

PTM databases

iPTMnetiQ62504.
PhosphoSitePlusiQ62504.

Expressioni

Tissue specificityi

Highly expressed in testis. Expressed at lower level in brain, lung, spleen, liver and kidney. Weakly expressed in cardiac and skeletal muscles and ovary. In spleen, it is expressed in follicular B-cells, while it is weakly expressed in marginal zone B-cells.3 Publications

Interactioni

Subunit structurei

Interacts with NCOR2, HDAC1, HDAC2, RBBP4, MBD3 and MTA1L1. Interacts with the nuclear receptors RAR and PPARD. Interacts with RAR in absence of ligand. Binds to the steroid receptor RNA coactivator SRA (By similarity). Interacts with MSX2. Interacts with RBPSUH; this interaction may prevent the interaction between RBPSUH and NOTCH1. Binds to HIPK3.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207942. 1 interactor.
IntActiQ62504. 3 interactors.
MINTiMINT-4101967.
STRINGi10090.ENSMUSP00000101412.

Structurei

3D structure databases

ProteinModelPortaliQ62504.
SMRiQ62504.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 81RRM 1PROSITE-ProRule annotationAdd BLAST76
Domaini336 – 416RRM 2PROSITE-ProRule annotationAdd BLAST81
Domaini439 – 514RRM 3PROSITE-ProRule annotationAdd BLAST76
Domaini518 – 590RRM 4PROSITE-ProRule annotationAdd BLAST73
Domaini2216 – 2704RIDAdd BLAST489
Domaini3478 – 3644SPOCPROSITE-ProRule annotationAdd BLAST167

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2138 – 2462Interaction with MSX21 PublicationAdd BLAST325
Regioni2706 – 2845Interaction with RBPSUHAdd BLAST140

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili559 – 575Sequence analysisAdd BLAST17
Coiled coili822 – 850Sequence analysisAdd BLAST29
Coiled coili1185 – 1206Sequence analysisAdd BLAST22
Coiled coili1509 – 1544Sequence analysisAdd BLAST36
Coiled coili1607 – 1627Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi125 – 277Arg-richAdd BLAST153
Compositional biasi236 – 326Ser-richAdd BLAST91
Compositional biasi648 – 721Tyr-richAdd BLAST74
Compositional biasi702 – 832Arg-richAdd BLAST131
Compositional biasi2101 – 2233Ala-richAdd BLAST133
Compositional biasi2377 – 2518Pro-richAdd BLAST142
Compositional biasi2950 – 3475Pro-richAdd BLAST526

Domaini

The RID domain mediates the interaction with nuclear receptors.
The SPOC domain, which mediates the interaction with NCOR2, is essential for the repressive activity.By similarity

Sequence similaritiesi

Belongs to the RRM Spen family.Curated
Contains 4 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation
Contains 1 SPOC domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0112. Eukaryota.
ENOG410ZT33. LUCA.
HOGENOMiHOG000231295.
HOVERGENiHBG045583.
InParanoidiQ62504.
PhylomeDBiQ62504.

Family and domain databases

Gene3Di2.40.290.10. 1 hit.
3.30.70.330. 4 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR016194. SPOC-like_C_dom.
IPR012921. SPOC_C.
IPR010912. SPOC_met.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
PF07744. SPOC. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 4 hits.
[Graphical view]
SUPFAMiSSF100939. SSF100939. 1 hit.
SSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 4 hits.
PS50917. SPOC. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q62504-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVRETRHLWV GNLPENVREE KIIEHFKRYG RVESVKILPK RGSEGGVAAF
60 70 80 90 100
VDFVDIKSAQ KAHNSVNKMG DRDLRTDYNE PGTIPSAARG LDETVSIASR
110 120 130 140 150
SREVSGFRGS AGGPAYGPPP SLHAREGRYE RRLDGASDNR ERAYEHSAYG
160 170 180 190 200
HHERGTGAFD RTRHYDQDYY RDPRERTLQH GLYYTSRSRS PNRFDAHDPR
210 220 230 240 250
YEPRAREQFT LPSVVHRDIY RDDITREVRG RRPERSYQHS RSRSPHSSQS
260 270 280 290 300
RNQSPQRLAS QASRPTRSPS GSGSRSRSSS SDSISSSSSS SNTDSSDSSS
310 320 330 340 350
TASDDSPARS VQSAAVPAPT SQLLSSLEKD EPRKSFGIKV QNLPVRSIDT
360 370 380 390 400
SLKDGLFHEF KKFGKVTSVQ IHGASEERYG LVFFRQQEDQ EKALTASKGK
410 420 430 440 450
LFFGMQIEVT AWVGPETESE NEFRPLDERI DEFHPKATRT LFIGNLEKTT
460 470 480 490 500
TYHDLRNIFQ RFGEIVDIDI KKVNGVPQYA FLQYCDIASV CKAIKKMDGE
510 520 530 540 550
YLGNNRLKLG FGKSMPTNCV WLDGLSSNVS DQYLTRHFCR YGPVVKVVFD
560 570 580 590 600
RLKGMALVLY SEIEDAQAAV KETKGRKIGG NKIKVDFANR ESQLAFYHCM
610 620 630 640 650
EKSGQDMRDF YEMLTERRAG QMAQSKHEDW SADAQSPHKC REERRGSYEY
660 670 680 690 700
SQERTYYENV RTPGTYPEDS RRDYPARGRE FYSEWETYQG EYYDSRYYDE
710 720 730 740 750
PREYREYRSD PYEQDIREYS YRQRERERER ERFESDRDHE RRPIERSQSP
760 770 780 790 800
VHLRRPQSPG VSPAHSERLP SDSERRLYRR SSERSGSCSS VSPPRYDKLE
810 820 830 840 850
KARLERYTKN EKADKERTFD PERVERERRI VRKEKGEKDK AERQKRKGKA
860 870 880 890 900
HSPSSQPSET EQENDREQSP EKPRGSTKLS RDRADKEGPA KNRLELVPCV
910 920 930 940 950
VLTRVKEKEG KVIEHPPPEK LKARLGRDTT KASALDQKPQ AAQGEPAKSD
960 970 980 990 1000
PARGKALREK VLPSHAEVGE KEGRTKLRKH LKAEQTPELS ALDLEKLEAR
1010 1020 1030 1040 1050
KRRFADSGLK IEKQKPEIKK TSPETEDTRI LLKKQPDTSR DGVLLREGES
1060 1070 1080 1090 1100
ERKPVRKEIL KRESKKTKLE RLNSALSPKD CQDPAAVSAG SGSRPSSDVH
1110 1120 1130 1140 1150
AGLGELTHGS VETQETQPKK AIPSKPQPKQ LQLLENQGPE KEEVRKNYCR
1160 1170 1180 1190 1200
PREEPAEHRA GQEKPHGGNA EEKLGIDIDH TQSYRKQMEQ SRRKQRMEME
1210 1220 1230 1240 1250
IAKAEKFGSP KKDVDDYERR SLVHEVGKPP QDVTDDSPPS KKRRTDHVDF
1260 1270 1280 1290 1300
DICTKRERNY RSSRQISEDS ERTSCSPSVR HGSFHDDDDP RGSPRLVSVK
1310 1320 1330 1340 1350
GSPKGDEKGL PYPNAAVRDD PLKCNPYDSG KREQTADTAK IKLSVLNSEG
1360 1370 1380 1390 1400
EPSRWDPPMK QDPSRFDVSF PNSVIKRDSL RKRSVRDLEP GEVPSDSDED
1410 1420 1430 1440 1450
AEHRSQSPRA SSFYDSPRLS FLLRDRDQKL RERDERLASS LERNKFYSFA
1460 1470 1480 1490 1500
LDKTITPDTK ALLERAKSLS SSREENWSFL DWDSRFANFR NNKDKEKVDS
1510 1520 1530 1540 1550
APRPIPSWYM KKKKIRTDSE GKLDDKKDER REEEQERQEL FASRFLHSSI
1560 1570 1580 1590 1600
FEQDSKRLQH LERKSEESDF PPGRLYGRQA SEGANSTSDS VQEPVVLFHS
1610 1620 1630 1640 1650
RFMELTRMQQ KEKEKDQKPK EAEKQEEPET HPKTPEPAAE TKEPEPKAPV
1660 1670 1680 1690 1700
SAGLPAVTIT VVTPEPASSA PEKAEEAAEA PSPAGEKPAE PAPVSEETKL
1710 1720 1730 1740 1750
VSEPVSVPVE QPRQSDVPPG EDSRDSQDSA ALAPSAPQES AATDAVPCVN
1760 1770 1780 1790 1800
AEPLTPGTTV SQVESSVDPK PSSPQPLSKL TQRSEEAEEG KVEKPDTTPS
1810 1820 1830 1840 1850
TEPDATQNAG VASEAQPPAS EDVEANPPVA AKDRKTNKSK RSKTSVQAAA
1860 1870 1880 1890 1900
ASVVEKPVTR KSERIDREKL KRSSSPRGEA QKLLELKMEA EKITRTASKS
1910 1920 1930 1940 1950
SGGDTEHPEP SLPLSRSRRR NVRSVYATMT DHESRSPAKE PVEQPRVTRK
1960 1970 1980 1990 2000
RLERELQEAV VPPTTPRRGR PPKTRRRAEE DGEHERKEPA ETPRPAEGWR
2010 2020 2030 2040 2050
SPRSQKSAAA AGPQGKRGRN EQKVEAAAEA GAQASTREGN PKSRGEREAA
2060 2070 2080 2090 2100
SEPKRDRRDP STDKSGPDTF PVEVLERKPP EKTYKSKRGR ARSTRSGMDR
2110 2120 2130 2140 2150
AAHQRSLEMA ARAAGQAADK EAGPAAASPQ ESESPQKGSG SSPQLANNPA
2160 2170 2180 2190 2200
DPDREAEEES ASASTAPPEG TQLARQIELE QAVQNIAKLP EPSAAAASKG
2210 2220 2230 2240 2250
TATATATAAS EEPAPEHGHK PAHQASETEL AAAIGSIISD ASGEPENFSA
2260 2270 2280 2290 2300
PPSVPPGSQT HPREGMEPGL HEAESGILET GTATESSAPQ VSALDPPEGS
2310 2320 2330 2340 2350
ADTKETRGNS GDSVQEAKGS KAEVTPPRKD KGRQKTTRRR KRNANKKVVA
2360 2370 2380 2390 2400
ITETRASEAE QTQSESPAAE EATAATPEAP QEEKPSEKPP SPPAECTFDP
2410 2420 2430 2440 2450
SKTPPAESLS QENSAAEKTP CKAPVLPALP PLSQPALMDD GPQARFKVHS
2460 2470 2480 2490 2500
IIESDPVTPP SDSGIPPPTI PLVTIAKLPP PVIPGGVPHQ SPPPKVTEWI
2510 2520 2530 2540 2550
TRQEEPRAQS TPSPALPPDT KASDMDTSSS TLRKILMDPK YVSATGVTST
2560 2570 2580 2590 2600
SVTTAIAEPV SAPCLQEAPA PPCDPKHPPL EGVSAAAVPN ADTQASEVPV
2610 2620 2630 2640 2650
AADKEKVAPV IAPKITSVIS RMPVSIDLEN SQKITLAKPA PQTLTGLVSA
2660 2670 2680 2690 2700
LTGLVNVSLV PVNALKGPVK GSVATLKGLV STPAGPVNLL KGPVNVLTGP
2710 2720 2730 2740 2750
VNVLTTPVSA TVGTVNAAPG PVTAACGVTA TTGTAAVTGA VTAPAAKGKQ
2760 2770 2780 2790 2800
RASSNENSRF HPGSMSVIDD RPADTGSGAG LRVNTSEGVV LLSYSGQKTE
2810 2820 2830 2840 2850
GPQRISAKIS QIPPASAMDI EFQQSVSKSQ VKADSITPTQ SAPKGPQTPS
2860 2870 2880 2890 2900
AFANVAAHST LVLTAQTYNA SPVISSVKTD RPSLEKPEPI HLSVSTPVTQ
2910 2920 2930 2940 2950
GGTVKVLTQG INTPPVLVHN QLVLTPSIVT TNKKLADPVT LKIETKVLQP
2960 2970 2980 2990 3000
ANLGPTLTPH HPPALPSKLP AEVNHVPSGP STPADRTIAH LATPKPDTHS
3010 3020 3030 3040 3050
PRPTGPTPGL FPRPCHPSST TSTALSTNAT VMLAAGIPVP QFISSIHPEQ
3060 3070 3080 3090 3100
SVIMPPHSIT QTVSLGHLSQ GEVRMSTPTL PSITYSIRPE TLHSPRAPLQ
3110 3120 3130 3140 3150
PQQIEARAPQ RVGTPQPATT GVPALATQHP PEEEVHYHLP VARAAAPVQS
3160 3170 3180 3190 3200
EVLVMQSEYR LHPYTVPRDV RIMVHPHVTA VSEQPRATEG VVKVPPANKA
3210 3220 3230 3240 3250
PQQLVKEAVK TSDAKAVPAP APVPVPVPVP TPAPPPHGEA RILTVTPSSQ
3260 3270 3280 3290 3300
LQGLPLTPPV VVTHGVQIVH SSGELFQEYR YGDVRTYHAP AQQLTHTQFP
3310 3320 3330 3340 3350
VASSISLASR TKTSAQVPPE GEPLQSTQSA QPAPSTQATQ PIPPAPPCQP
3360 3370 3380 3390 3400
SQLSQPAQPP SGKIPQVSQE AKGTQTGGVE QTRLPAIPTN RPSEPHAQLQ
3410 3420 3430 3440 3450
RAPVETAQPA HPSPVSVSMK PDLPSPLSSQ AAPKQPLFVP ANSGPSTPPG
3460 3470 3480 3490 3500
LALPHAEVQP APKQESSPHG TPQRPVDMVQ LLKKYPIVWQ GLLALKNDTA
3510 3520 3530 3540 3550
AVQLHFVSGN NVLAHRSLPL SEGGPPLRIA QRMRLEASQL EGVARRMTVE
3560 3570 3580 3590 3600
TDYCLLLALP CGRDQEDVVS QTESLKAAFI TYLQAKQAAG IINVPNPGSN
3610 3620 3630 3640
QPAYVLQIFP PCEFSESHLS RLAPDLLASI SNISPHLMIV IASV
Length:3,644
Mass (Da):398,754
Last modified:October 10, 2003 - v2
Checksum:i9C7EC49A81A7DA4A
GO
Isoform 2 (identifier: Q62504-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     618-640: Missing.

Note: No experimental confirmation available.
Show »
Length:3,621
Mass (Da):396,203
Checksum:i878136C0D8CF0D22
GO
Isoform 3 (identifier: Q62504-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3318-3322: PPEGE → RKPAFF
     3550-3552: ETD → RLE
     3553-3644: Missing.

Note: No experimental confirmation available.
Show »
Length:3,553
Mass (Da):389,153
Checksum:i5915CA253DD7270B
GO

Sequence cautioni

The sequence AAD55931 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB01562 differs from that shown. Reason: Frameshift at positions 446 and 561.Curated
The sequence CAB01562 differs from that shown. Reason: Erroneous termination at position 394. Translated as Leu.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti366V → E in CAB01562 (PubMed:9119401).Curated1
Sequence conflicti394L → B in CAB01562 (PubMed:9119401).Curated1
Sequence conflicti409V → E in CAB01562 (PubMed:9119401).Curated1
Sequence conflicti413V → E in CAB01562 (PubMed:9119401).Curated1
Sequence conflicti430I → K in CAB01562 (PubMed:9119401).Curated1
Sequence conflicti454 – 462DLRNIFQRF → EPSETSFSAL in CAB01562 (PubMed:9119401).Curated9
Sequence conflicti511F → L in CAB01562 (PubMed:9119401).Curated1
Sequence conflicti527S → P in CAB01562 (PubMed:9119401).Curated1
Sequence conflicti537H → N in CAB01562 (PubMed:9119401).Curated1
Sequence conflicti566A → V in CAB01562 (PubMed:9119401).Curated1
Sequence conflicti569A → V in CAB01562 (PubMed:9119401).Curated1
Sequence conflicti573 – 577TKGRK → DQGQE in CAB01562 (PubMed:9119401).Curated5
Sequence conflicti754R → G in BAB32786 (Ref. 3) Curated1
Sequence conflicti1524D → A in BAB32786 (Ref. 3) Curated1
Sequence conflicti1560H → Y in BAB32786 (Ref. 3) Curated1
Sequence conflicti1570F → L in BAB32786 (Ref. 3) Curated1
Sequence conflicti1574R → G in BAB32786 (Ref. 3) Curated1
Sequence conflicti1609Q → R in BAB32786 (Ref. 3) Curated1
Sequence conflicti1659I → V in BAB32786 (Ref. 3) Curated1
Sequence conflicti1669S → F in BAB32786 (Ref. 3) Curated1
Sequence conflicti1705V → A in BAB32786 (Ref. 3) Curated1
Sequence conflicti1815A → V in BAB32786 (Ref. 3) Curated1
Sequence conflicti2097G → A in BAB32786 (Ref. 3) Curated1
Sequence conflicti2201 – 2202Missing in BAB32786 (Ref. 3) Curated2
Sequence conflicti2322A → V in BAB32786 (Ref. 3) Curated1
Sequence conflicti2385P → Q in BAB32786 (Ref. 3) Curated1
Sequence conflicti2502R → K in BAB32786 (Ref. 3) Curated1
Sequence conflicti2505E → K in BAB32786 (Ref. 3) Curated1
Sequence conflicti2519D → N in BAB32786 (Ref. 3) Curated1
Sequence conflicti2554T → S in BAB32786 (Ref. 3) Curated1
Sequence conflicti2679 – 2688LVSTPAGPVN → VGEHPWWARD in BAB32786 (Ref. 3) Curated10
Sequence conflicti3010L → P in BAB32786 (Ref. 3) Curated1
Sequence conflicti3010L → P in BAC65684 (PubMed:12693553).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti348I → T.2 Publications1
Natural varianti762S → F.1 Publication1
Natural varianti773S → F.1 Publication1
Natural varianti933S → L.1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008564618 – 640Missing in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_0138023318 – 3322PPEGE → RKPAFF in isoform 3. 1 Publication5
Alternative sequenceiVSP_0138033550 – 3552ETD → RLE in isoform 3. 1 Publication3
Alternative sequenceiVSP_0138043553 – 3644Missing in isoform 3. 1 PublicationAdd BLAST92

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BY726481 mRNA. No translation available.
AF156529 mRNA. Translation: AAD55931.1. Different initiation.
AB055980 mRNA. Translation: BAB32786.1.
Z78160 mRNA. Translation: CAB01562.1. Sequence problems.
AK122402 Transcribed RNA. Translation: BAC65684.3.
RefSeqiNP_062737.2. NM_019763.2.
UniGeneiMm.299906.

Genome annotation databases

GeneIDi56381.
KEGGimmu:56381.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BY726481 mRNA. No translation available.
AF156529 mRNA. Translation: AAD55931.1. Different initiation.
AB055980 mRNA. Translation: BAB32786.1.
Z78160 mRNA. Translation: CAB01562.1. Sequence problems.
AK122402 Transcribed RNA. Translation: BAC65684.3.
RefSeqiNP_062737.2. NM_019763.2.
UniGeneiMm.299906.

3D structure databases

ProteinModelPortaliQ62504.
SMRiQ62504.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207942. 1 interactor.
IntActiQ62504. 3 interactors.
MINTiMINT-4101967.
STRINGi10090.ENSMUSP00000101412.

PTM databases

iPTMnetiQ62504.
PhosphoSitePlusiQ62504.

Proteomic databases

PaxDbiQ62504.
PeptideAtlasiQ62504.
PRIDEiQ62504.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi56381.
KEGGimmu:56381.

Organism-specific databases

CTDi23013.
MGIiMGI:1891706. Spen.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG0112. Eukaryota.
ENOG410ZT33. LUCA.
HOGENOMiHOG000231295.
HOVERGENiHBG045583.
InParanoidiQ62504.
PhylomeDBiQ62504.

Miscellaneous databases

ChiTaRSiSpen. mouse.
PROiQ62504.
SOURCEiSearch...

Family and domain databases

Gene3Di2.40.290.10. 1 hit.
3.30.70.330. 4 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR016194. SPOC-like_C_dom.
IPR012921. SPOC_C.
IPR010912. SPOC_met.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
PF07744. SPOC. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 4 hits.
[Graphical view]
SUPFAMiSSF100939. SSF100939. 1 hit.
SSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 4 hits.
PS50917. SPOC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMINT_MOUSE
AccessioniPrimary (citable) accession number: Q62504
Secondary accession number(s): Q80TN9, Q99PS4, Q9QZW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: November 2, 2016
This is version 153 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.