Q62472 (VNS2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Vomeronasal secretory protein 2

Alternative name(s):
Lipocalin-4
Vomeronasal secretory protein II
Short name=VNSP II

Gene names

Name:

Lcn4

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	185 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Transport of lipophilic molecules, possible pheromone-carrier.
Subcellular location	Secreted.
Tissue specificity	Specifically expressed in vomeronasal and posterior glands of the nasal septum, the ducts of which open into the lumen of the vomeronasal organ.
Sequence similarities	Belongs to the calycin superfamily. Lipocalin family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Secreted
Domain	Signal
Ligand	Pheromone-binding
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	pheromone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 185	166	Vomeronasal secretory protein 2		PRO_0000017979
Amino acid modifications
	Disulfide bond	80 ↔ 172		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q62472 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: D93702D4FA5344AB	FASTA	185	21,399
	10 20 30 40 50 60 MKSLLLTVTL SSLVATLQTY DDLPFISEED KLSGVWFIKA TVSQRREVEG ETLVAFPIKF 70 80 90 100 110 120 TCPEEGTLEL RHTLASKGEC INVGIRLQRT EEPGQYSAFW GHTLFYIYDL PVKDHYIIYC 130 140 150 160 170 180 ESHPFQKISQ FGYLIGKYPE ENQDTLEVFK EFIQHKGFLQ EKIGVPEQRD RCIPIHDSAH QDHKC

References

[1]	"Possible pheromone-carrier function of two lipocalin proteins in the vomeronasal organ." Miyawaki A., Matsushita F., Ryo Y., Mikoshiba K. EMBO J. 13:5835-5842(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: ddY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D38581 mRNA. Translation: BAA07582.1.
IPI	IPI00126095.
PIR	S51803.
RefSeq	NP_034825.1. NM_010695.1.
UniGene	Mm.123925.
3D structure databases
ProteinModelPortal	Q62472.
SMR	Q62472. Positions 32-174.
ModBase	Search...
Proteomic databases
PRIDE	Q62472.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000028283; ENSMUSP00000028283; ENSMUSG00000026919.
GeneID	16821.
KEGG	mmu:16821.
Organism-specific databases
CTD	16821.
MGI	MGI:102668. Lcn4.
Phylogenomic databases
GeneTree	ENSGT00440000033563.
HOGENOM	HOG000231562.
HOVERGEN	HBG094901.
InParanoid	Q62472.
OMA	IPIHDSA.
OrthoDB	EOG4NP74J.
Gene expression databases
ArrayExpress	Q62472.
Bgee	Q62472.
CleanEx	MM_LCN4.
Genevestigator	Q62472.
GermOnline	ENSMUSG00000026919. Mus musculus.
Family and domain databases
Gene3D	2.40.128.20. 1 hit.
InterPro	IPR012674. Calycin. IPR011038. Calycin-like. IPR000566. Lipocln_cytosolic_FA-bd_dom. IPR002450. von_Ebner_gland. [Graphical view]
Pfam	PF00061. Lipocalin. 1 hit. [Graphical view]
PRINTS	PR01175. VNEBNERGLAND.
SUPFAM	SSF50814. Calycin. 1 hit.
PROSITE	PS00213. LIPOCALIN. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	290716.
SOURCE	Search...

Entry information

Entry name

VNS2_MOUSE

Accession

Primary (citable) accession number: Q62472

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program