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Protein

Integrin alpha-2

Gene

Itga2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Integrin alpha-2/beta-1 is a collagen receptor, being responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. It is also a receptor for laminins, collagen C-propeptides and E-cadherin. Mice homozygous for a null mutation in the alpha-2 die very early in embryogenesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi496 – 504Sequence analysis9
Calcium bindingi560 – 568Sequence analysis9
Calcium bindingi624 – 632Sequence analysis9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-216083. Integrin cell surface interactions.
R-MMU-3000157. Laminin interactions.
R-MMU-3000170. Syndecan interactions.
R-MMU-3000178. ECM proteoglycans.
R-MMU-447041. CHL1 interactions.
R-MMU-8874081. MET activates PTK2 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-2
Alternative name(s):
CD49 antigen-like family member B
Collagen receptor
Platelet membrane glycoprotein Ia
Short name:
GPIa
VLA-2 subunit alpha
CD_antigen: CD49b
Gene namesi
Name:Itga2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:96600. Itga2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 1129ExtracellularSequence analysisAdd BLAST1103
Transmembranei1130 – 1151HelicalSequence analysisAdd BLAST22
Topological domaini1152 – 1178CytoplasmicSequence analysisAdd BLAST27

GO - Cellular componenti

  • axon terminus Source: Ensembl
  • basal part of cell Source: MGI
  • cell surface Source: UniProtKB
  • external side of plasma membrane Source: MGI
  • focal adhesion Source: MGI
  • integrin alpha2-beta1 complex Source: MGI
  • nucleus Source: Ensembl
  • perinuclear region of cytoplasm Source: Ensembl
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26By similarityAdd BLAST26
ChainiPRO_000001623427 – 1178Integrin alpha-2Add BLAST1152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi80 ↔ 89By similarity
Glycosylationi102N-linked (GlcNAc...)Sequence analysis1
Glycosylationi109N-linked (GlcNAc...)Sequence analysis1
Glycosylationi429N-linked (GlcNAc...)Sequence analysis1
Glycosylationi457N-linked (GlcNAc...)Sequence analysis1
Glycosylationi472N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi677 ↔ 734By similarity
Glycosylationi696N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi786 ↔ 792By similarity
Disulfide bondi862 ↔ 873By similarity
Disulfide bondi1016 ↔ 1047By similarity
Disulfide bondi1052 ↔ 1057By similarity
Glycosylationi1054N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1071N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1078N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ62469.
PaxDbiQ62469.
PeptideAtlasiQ62469.
PRIDEiQ62469.

PTM databases

iPTMnetiQ62469.
PhosphoSitePlusiQ62469.

Expressioni

Gene expression databases

BgeeiENSMUSG00000015533.
CleanExiMM_ITGA2.
GenevisibleiQ62469. MM.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5 and RAB21.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ62469. 1 interactor.
MINTiMINT-1866744.
STRINGi10090.ENSMUSP00000053891.

Structurei

3D structure databases

ProteinModelPortaliQ62469.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati31 – 89FG-GAP 1PROSITE-ProRule annotationAdd BLAST59
Repeati98 – 158FG-GAP 2PROSITE-ProRule annotationAdd BLAST61
Domaini185 – 362VWFAPROSITE-ProRule annotationAdd BLAST178
Repeati363 – 417FG-GAP 3PROSITE-ProRule annotationAdd BLAST55
Repeati420 – 472FG-GAP 4PROSITE-ProRule annotationAdd BLAST53
Repeati474 – 536FG-GAP 5PROSITE-ProRule annotationAdd BLAST63
Repeati537 – 595FG-GAP 6PROSITE-ProRule annotationAdd BLAST59
Repeati601 – 661FG-GAP 7PROSITE-ProRule annotationAdd BLAST61

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi480 – 482Cell attachment siteSequence analysis3
Motifi1154 – 1158GFFKR motif5

Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated
Contains 7 FG-GAP repeats.PROSITE-ProRule annotation
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3637. Eukaryota.
ENOG410XPVZ. LUCA.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000059610.
HOVERGENiHBG006185.
InParanoidiQ62469.
KOiK06481.
OMAiTATCEKL.
OrthoDBiEOG091G00TK.
TreeFamiTF105391.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 1 hit.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62469-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPGQAGGAL LLRLLMLVQG ILNCLAYNVG LPGAKIFSGP SSEQFGYSVQ
60 70 80 90 100
QLTNPQGNWL LVGSPWSGFP ENRMGDVYKC PVDLPTATCE KLNLQNSASI
110 120 130 140 150
SNVTEIKTNM SLGLTLTRNP GTGGFLTCGP LWAHQCGNQY YATGICSDVS
160 170 180 190 200
PDFQFLTSFS PAVQACPSLV DVVVVCDESN SIYPWEAVKN FLVKFVTGLD
210 220 230 240 250
IGPKKTQVAL IQYANEPRII FNLNDFETKE DMVQATSETR QHGGDLTNTF
260 270 280 290 300
RAIEFARDYA YSQTSGGRPG ATKVMVVVTD GESHDGSKLK TVIQQCNDDE
310 320 330 340 350
ILRFGIAVLG YLNRNALDTK NLIKEIKAIA STPTERYFFN VADEAALLEK
360 370 380 390 400
AGTLGEQIFS IEGTVQGGDN FQMEMAQVGF SADYAPQNDI LMLGAVGAFD
410 420 430 440 450
WSGTLVQETS HKPVIFPKQA FDQVLQDRNH SSFLGYSVAA ISTEDGVHFV
460 470 480 490 500
AGAPRANYTG QIVLYSVNKQ GNVTVIQSHR GDQIGSYFGS VLCSVDVDKD
510 520 530 540 550
TITDVLLVGA PTYMNDLKKE EGKVYLFTIT KGILNQHQFL EGPEGTGNAR
560 570 580 590 600
FGSAIAALSD INMDGFNDVI VGSPVENENS GAVYIYNGHQ GTIRTKYSQK
610 620 630 640 650
ILGSNGAFRR HLQFFGRSLD GYGDLNGDSI TDVSIGALGQ VIQLWSQSIA
660 670 680 690 700
DVAIEALFTP DKITLLNKDA KITLKLCFRA EFRPAGQNNQ VAILFNMTLD
710 720 730 740 750
ADGHSSRVTS RGVFRENSER FLQKNMVVNE VQKCSEHHIS IQKPSDVVNP
760 770 780 790 800
LDLRVDISLE NPGTSPALEA YSETVKVFSI PFYKECGSDG ICISDLILDV
810 820 830 840 850
QQLPAIQTQS FIVSNQNKRL TFSVILKNRG ESAYNTVVLA EFSENLFFAS
860 870 880 890 900
FSMPVDGTEV TCEVGSSQKS VTCDVGYPAL KSEQQVTFTI NFDFNLQNLQ
910 920 930 940 950
NQAAINFQAF SESQETNKAD NSVSLTIPLL YDAELHLTRS TNINFYEISS
960 970 980 990 1000
DENAPSVIKS VEDIGPKFIF SLKVTAGSAP VSMALVTIHI PQYTKEKNPL
1010 1020 1030 1040 1050
LYLTGIQTDQ AGDISCTAEI NPLKLPHTAP SVSFKNENFR HTKELDCRTT
1060 1070 1080 1090 1100
SCSNITCWLK DLHMKAEYFI NVTTRVWNRT FAASTFQTVQ LTAAAEIDTH
1110 1120 1130 1140 1150
NPQLFVIEEN AVTIPLMIMK PTEKAEVPTG VIIGSIIAGI LLLLAMTAGL
1160 1170
WKLGFFKRQY KKMGQNPDEM DETTELNS
Length:1,178
Mass (Da):128,955
Last modified:July 27, 2011 - v2
Checksum:i62FAEA820242A9B6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13R → Q in CAA82877 (PubMed:8081889).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z29987 mRNA. Translation: CAA82877.1.
CH466568 Genomic DNA. Translation: EDL18370.1.
BC065139 mRNA. Translation: AAH65139.1.
X75427 mRNA. Translation: CAA53178.1.
CCDSiCCDS26787.1.
PIRiS44142.
RefSeqiNP_032422.2. NM_008396.2.
UniGeneiMm.5007.

Genome annotation databases

EnsembliENSMUST00000056117; ENSMUSP00000053891; ENSMUSG00000015533.
GeneIDi16398.
KEGGimmu:16398.
UCSCiuc007rxw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z29987 mRNA. Translation: CAA82877.1.
CH466568 Genomic DNA. Translation: EDL18370.1.
BC065139 mRNA. Translation: AAH65139.1.
X75427 mRNA. Translation: CAA53178.1.
CCDSiCCDS26787.1.
PIRiS44142.
RefSeqiNP_032422.2. NM_008396.2.
UniGeneiMm.5007.

3D structure databases

ProteinModelPortaliQ62469.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ62469. 1 interactor.
MINTiMINT-1866744.
STRINGi10090.ENSMUSP00000053891.

PTM databases

iPTMnetiQ62469.
PhosphoSitePlusiQ62469.

Proteomic databases

MaxQBiQ62469.
PaxDbiQ62469.
PeptideAtlasiQ62469.
PRIDEiQ62469.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056117; ENSMUSP00000053891; ENSMUSG00000015533.
GeneIDi16398.
KEGGimmu:16398.
UCSCiuc007rxw.1. mouse.

Organism-specific databases

CTDi3673.
MGIiMGI:96600. Itga2.

Phylogenomic databases

eggNOGiKOG3637. Eukaryota.
ENOG410XPVZ. LUCA.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000059610.
HOVERGENiHBG006185.
InParanoidiQ62469.
KOiK06481.
OMAiTATCEKL.
OrthoDBiEOG091G00TK.
TreeFamiTF105391.

Enzyme and pathway databases

ReactomeiR-MMU-216083. Integrin cell surface interactions.
R-MMU-3000157. Laminin interactions.
R-MMU-3000170. Syndecan interactions.
R-MMU-3000178. ECM proteoglycans.
R-MMU-447041. CHL1 interactions.
R-MMU-8874081. MET activates PTK2 signaling.

Miscellaneous databases

PROiQ62469.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015533.
CleanExiMM_ITGA2.
GenevisibleiQ62469. MM.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 1 hit.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITA2_MOUSE
AccessioniPrimary (citable) accession number: Q62469
Secondary accession number(s): Q62163, Q6P1C7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 148 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.