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Protein

Integrin alpha-2

Gene

Itga2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Integrin alpha-2/beta-1 is a collagen receptor, being responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. It is also a receptor for laminins, collagen C-propeptides and E-cadherin. Mice homozygous for a null mutation in the alpha-2 die very early in embryogenesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi496 – 5049Sequence analysis
Calcium bindingi560 – 5689Sequence analysis
Calcium bindingi624 – 6329Sequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-216083. Integrin cell surface interactions.
R-MMU-3000157. Laminin interactions.
R-MMU-3000170. Syndecan interactions.
R-MMU-3000178. ECM proteoglycans.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-2
Alternative name(s):
CD49 antigen-like family member B
Collagen receptor
Platelet membrane glycoprotein Ia
Short name:
GPIa
VLA-2 subunit alpha
CD_antigen: CD49b
Gene namesi
Name:Itga2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:96600. Itga2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 11291103ExtracellularSequence analysisAdd
BLAST
Transmembranei1130 – 115122HelicalSequence analysisAdd
BLAST
Topological domaini1152 – 117827CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • axon terminus Source: Ensembl
  • basal part of cell Source: MGI
  • cell surface Source: UniProtKB
  • external side of plasma membrane Source: MGI
  • focal adhesion Source: MGI
  • integrin alpha2-beta1 complex Source: MGI
  • nucleus Source: Ensembl
  • perinuclear region of cytoplasm Source: Ensembl
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626By similarityAdd
BLAST
Chaini27 – 11781152Integrin alpha-2PRO_0000016234Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi80 ↔ 89By similarity
Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence analysis
Glycosylationi109 – 1091N-linked (GlcNAc...)Sequence analysis
Glycosylationi429 – 4291N-linked (GlcNAc...)Sequence analysis
Glycosylationi457 – 4571N-linked (GlcNAc...)Sequence analysis
Glycosylationi472 – 4721N-linked (GlcNAc...)Sequence analysis
Disulfide bondi677 ↔ 734By similarity
Glycosylationi696 – 6961N-linked (GlcNAc...)Sequence analysis
Disulfide bondi786 ↔ 792By similarity
Disulfide bondi862 ↔ 873By similarity
Disulfide bondi1016 ↔ 1047By similarity
Disulfide bondi1052 ↔ 1057By similarity
Glycosylationi1054 – 10541N-linked (GlcNAc...)Sequence analysis
Glycosylationi1071 – 10711N-linked (GlcNAc...)Sequence analysis
Glycosylationi1078 – 10781N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ62469.
PaxDbiQ62469.
PRIDEiQ62469.

PTM databases

PhosphoSiteiQ62469.

Expressioni

Gene expression databases

BgeeiQ62469.
CleanExiMM_ITGA2.
GenevisibleiQ62469. MM.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Alpha-2 associates with beta-1. Interacts with HPS5 and RAB21.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ62469. 1 interaction.
MINTiMINT-1866744.
STRINGi10090.ENSMUSP00000053891.

Structurei

3D structure databases

ProteinModelPortaliQ62469.
SMRiQ62469. Positions 165-363.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati31 – 8959FG-GAP 1Add
BLAST
Repeati98 – 15861FG-GAP 2Add
BLAST
Domaini185 – 362178VWFAPROSITE-ProRule annotationAdd
BLAST
Repeati363 – 41755FG-GAP 3Add
BLAST
Repeati420 – 47455FG-GAP 4Add
BLAST
Repeati475 – 53662FG-GAP 5Add
BLAST
Repeati537 – 59559FG-GAP 6Add
BLAST
Repeati601 – 66161FG-GAP 7Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi480 – 4823Cell attachment siteSequence analysis
Motifi1154 – 11585GFFKR motif

Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated
Contains 7 FG-GAP repeats.Curated
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3637. Eukaryota.
ENOG410XPVZ. LUCA.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000059610.
HOVERGENiHBG006185.
InParanoidiQ62469.
KOiK06481.
OMAiTATCEKL.
OrthoDBiEOG71RXHT.
TreeFamiTF105391.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 1 hit.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62469-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPGQAGGAL LLRLLMLVQG ILNCLAYNVG LPGAKIFSGP SSEQFGYSVQ
60 70 80 90 100
QLTNPQGNWL LVGSPWSGFP ENRMGDVYKC PVDLPTATCE KLNLQNSASI
110 120 130 140 150
SNVTEIKTNM SLGLTLTRNP GTGGFLTCGP LWAHQCGNQY YATGICSDVS
160 170 180 190 200
PDFQFLTSFS PAVQACPSLV DVVVVCDESN SIYPWEAVKN FLVKFVTGLD
210 220 230 240 250
IGPKKTQVAL IQYANEPRII FNLNDFETKE DMVQATSETR QHGGDLTNTF
260 270 280 290 300
RAIEFARDYA YSQTSGGRPG ATKVMVVVTD GESHDGSKLK TVIQQCNDDE
310 320 330 340 350
ILRFGIAVLG YLNRNALDTK NLIKEIKAIA STPTERYFFN VADEAALLEK
360 370 380 390 400
AGTLGEQIFS IEGTVQGGDN FQMEMAQVGF SADYAPQNDI LMLGAVGAFD
410 420 430 440 450
WSGTLVQETS HKPVIFPKQA FDQVLQDRNH SSFLGYSVAA ISTEDGVHFV
460 470 480 490 500
AGAPRANYTG QIVLYSVNKQ GNVTVIQSHR GDQIGSYFGS VLCSVDVDKD
510 520 530 540 550
TITDVLLVGA PTYMNDLKKE EGKVYLFTIT KGILNQHQFL EGPEGTGNAR
560 570 580 590 600
FGSAIAALSD INMDGFNDVI VGSPVENENS GAVYIYNGHQ GTIRTKYSQK
610 620 630 640 650
ILGSNGAFRR HLQFFGRSLD GYGDLNGDSI TDVSIGALGQ VIQLWSQSIA
660 670 680 690 700
DVAIEALFTP DKITLLNKDA KITLKLCFRA EFRPAGQNNQ VAILFNMTLD
710 720 730 740 750
ADGHSSRVTS RGVFRENSER FLQKNMVVNE VQKCSEHHIS IQKPSDVVNP
760 770 780 790 800
LDLRVDISLE NPGTSPALEA YSETVKVFSI PFYKECGSDG ICISDLILDV
810 820 830 840 850
QQLPAIQTQS FIVSNQNKRL TFSVILKNRG ESAYNTVVLA EFSENLFFAS
860 870 880 890 900
FSMPVDGTEV TCEVGSSQKS VTCDVGYPAL KSEQQVTFTI NFDFNLQNLQ
910 920 930 940 950
NQAAINFQAF SESQETNKAD NSVSLTIPLL YDAELHLTRS TNINFYEISS
960 970 980 990 1000
DENAPSVIKS VEDIGPKFIF SLKVTAGSAP VSMALVTIHI PQYTKEKNPL
1010 1020 1030 1040 1050
LYLTGIQTDQ AGDISCTAEI NPLKLPHTAP SVSFKNENFR HTKELDCRTT
1060 1070 1080 1090 1100
SCSNITCWLK DLHMKAEYFI NVTTRVWNRT FAASTFQTVQ LTAAAEIDTH
1110 1120 1130 1140 1150
NPQLFVIEEN AVTIPLMIMK PTEKAEVPTG VIIGSIIAGI LLLLAMTAGL
1160 1170
WKLGFFKRQY KKMGQNPDEM DETTELNS
Length:1,178
Mass (Da):128,955
Last modified:July 27, 2011 - v2
Checksum:i62FAEA820242A9B6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131R → Q in CAA82877 (PubMed:8081889).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z29987 mRNA. Translation: CAA82877.1.
CH466568 Genomic DNA. Translation: EDL18370.1.
BC065139 mRNA. Translation: AAH65139.1.
X75427 mRNA. Translation: CAA53178.1.
CCDSiCCDS26787.1.
PIRiS44142.
RefSeqiNP_032422.2. NM_008396.2.
UniGeneiMm.5007.

Genome annotation databases

EnsembliENSMUST00000056117; ENSMUSP00000053891; ENSMUSG00000015533.
GeneIDi16398.
KEGGimmu:16398.
UCSCiuc007rxw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z29987 mRNA. Translation: CAA82877.1.
CH466568 Genomic DNA. Translation: EDL18370.1.
BC065139 mRNA. Translation: AAH65139.1.
X75427 mRNA. Translation: CAA53178.1.
CCDSiCCDS26787.1.
PIRiS44142.
RefSeqiNP_032422.2. NM_008396.2.
UniGeneiMm.5007.

3D structure databases

ProteinModelPortaliQ62469.
SMRiQ62469. Positions 165-363.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ62469. 1 interaction.
MINTiMINT-1866744.
STRINGi10090.ENSMUSP00000053891.

PTM databases

PhosphoSiteiQ62469.

Proteomic databases

MaxQBiQ62469.
PaxDbiQ62469.
PRIDEiQ62469.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056117; ENSMUSP00000053891; ENSMUSG00000015533.
GeneIDi16398.
KEGGimmu:16398.
UCSCiuc007rxw.1. mouse.

Organism-specific databases

CTDi3673.
MGIiMGI:96600. Itga2.

Phylogenomic databases

eggNOGiKOG3637. Eukaryota.
ENOG410XPVZ. LUCA.
GeneTreeiENSGT00760000118782.
HOGENOMiHOG000059610.
HOVERGENiHBG006185.
InParanoidiQ62469.
KOiK06481.
OMAiTATCEKL.
OrthoDBiEOG71RXHT.
TreeFamiTF105391.

Enzyme and pathway databases

ReactomeiR-MMU-216083. Integrin cell surface interactions.
R-MMU-3000157. Laminin interactions.
R-MMU-3000170. Syndecan interactions.
R-MMU-3000178. ECM proteoglycans.

Miscellaneous databases

NextBioi289545.
PROiQ62469.
SOURCEiSearch...

Gene expression databases

BgeeiQ62469.
CleanExiMM_ITGA2.
GenevisibleiQ62469. MM.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 1 hit.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The mouse VLA-2 homologue supports collagen and laminin adhesion but not virus binding."
    Edelman J.M., Chan B.M., Uniyal S., Onodera H., Wang D.Z., Damjanovich L., Latzer D.B., Finberg R.W., Bergelson J.M.
    Cell Adhes. Commun. 2:131-143(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6 X CBA.
    Tissue: Lung.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Eye.
  4. "Complex patterns of expression suggest extensive roles for the alpha 2 beta 1 integrin in murine development."
    Wu J.E., Santoro S.A.
    Dev. Dyn. 199:292-314(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 450-1178.
    Tissue: Lung.
  5. "Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins."
    Pellinen T., Arjonen A., Vuoriluoto K., Kallio K., Fransen J.A.M., Ivaska J.
    J. Cell Biol. 173:767-780(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RAB21.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Lung and Spleen.

Entry informationi

Entry nameiITA2_MOUSE
AccessioniPrimary (citable) accession number: Q62469
Secondary accession number(s): Q62163, Q6P1C7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 27, 2011
Last modified: March 16, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.