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Protein

Synaptic vesicle membrane protein VAT-1 homolog

Gene

Vat1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation (By similarity). Possesses ATPase activity. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2) (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptic vesicle membrane protein VAT-1 homolog (EC:1.-.-.-)
Gene namesi
Name:Vat1
Synonyms:Vat-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1349450. Vat1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 406405Synaptic vesicle membrane protein VAT-1 homologPRO_0000160919Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei2 – 21PhosphoserineBy similarity
Modified residuei33 – 331PhosphoserineBy similarity
Modified residuei42 – 421PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ62465.
MaxQBiQ62465.
PaxDbiQ62465.
PRIDEiQ62465.
TopDownProteomicsiQ62465.

PTM databases

iPTMnetiQ62465.
PhosphoSiteiQ62465.
SwissPalmiQ62465.

Expressioni

Gene expression databases

BgeeiQ62465.
ExpressionAtlasiQ62465. baseline and differential.
GenevisibleiQ62465. MM.

Interactioni

Protein-protein interaction databases

BioGridi205084. 5 interactions.
IntActiQ62465. 5 interactions.
MINTiMINT-4997313.
STRINGi10090.ENSMUSP00000048350.

Structurei

3D structure databases

ProteinModelPortaliQ62465.
SMRiQ62465. Positions 61-398.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1198. Eukaryota.
COG0604. LUCA.
GeneTreeiENSGT00550000074483.
HOGENOMiHOG000294681.
HOVERGENiHBG002466.
InParanoidiQ62465.
OMAiFGLWQEV.
OrthoDBiEOG7VQJD4.
PhylomeDBiQ62465.
TreeFamiTF314255.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
IPR002364. Quin_OxRdtase/zeta-crystal_CS.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS01162. QOR_ZETA_CRYSTAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62465-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAEREAAEA ATVAAATEAG AETGTGAGEG APSQPPTVEV ASDPQPPPAP
60 70 80 90 100
EASASASAPP LRCLVLTGFG GYDKVKLQSR PAVPPAPGPG QLTLRVRACG
110 120 130 140 150
LNFADLMGRQ GLYDRLPPLP VTPGMEGAGV VVAVGEGVGD RKAGDRVMVL
160 170 180 190 200
NRSGMWQEEV TVPSAQTFLM PEAMTFEEAA ALLVNYITAY MVLFDFGNLR
210 220 230 240 250
PGHSVLVHMA AGGVGMAALQ LCRTVENVTV FGTASASKHE VLKENGVTHP
260 270 280 290 300
IDYHTTDYVD EIKKISPKGV DIVMDPLGGS DTAKGYHLLK PMGKVVTYGM
310 320 330 340 350
ANLLTGPKRN LMAMARTWWN QFSVTALQLL QANRAVCGFH LGYLDGEVEL
360 370 380 390 400
VNSVVTRLVA LYNQGHIKPR IDSVWPFEKV ADAMKQMQEK KNIGKVLLVP

GPEKET
Length:406
Mass (Da):43,097
Last modified:September 27, 2004 - v3
Checksum:i3F704C3667C21E37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034795 mRNA. Translation: BAC28833.1.
BC024586 mRNA. Translation: AAH24586.1.
BC025496 mRNA. Translation: AAH25496.1.
X95562 mRNA. Translation: CAA64807.1.
CCDSiCCDS25472.1.
RefSeqiNP_036167.1. NM_012037.2.
UniGeneiMm.29210.

Genome annotation databases

EnsembliENSMUST00000040430; ENSMUSP00000048350; ENSMUSG00000034993.
GeneIDi26949.
KEGGimmu:26949.
UCSCiuc007loy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034795 mRNA. Translation: BAC28833.1.
BC024586 mRNA. Translation: AAH24586.1.
BC025496 mRNA. Translation: AAH25496.1.
X95562 mRNA. Translation: CAA64807.1.
CCDSiCCDS25472.1.
RefSeqiNP_036167.1. NM_012037.2.
UniGeneiMm.29210.

3D structure databases

ProteinModelPortaliQ62465.
SMRiQ62465. Positions 61-398.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205084. 5 interactions.
IntActiQ62465. 5 interactions.
MINTiMINT-4997313.
STRINGi10090.ENSMUSP00000048350.

PTM databases

iPTMnetiQ62465.
PhosphoSiteiQ62465.
SwissPalmiQ62465.

Proteomic databases

EPDiQ62465.
MaxQBiQ62465.
PaxDbiQ62465.
PRIDEiQ62465.
TopDownProteomicsiQ62465.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040430; ENSMUSP00000048350; ENSMUSG00000034993.
GeneIDi26949.
KEGGimmu:26949.
UCSCiuc007loy.1. mouse.

Organism-specific databases

CTDi10493.
MGIiMGI:1349450. Vat1.

Phylogenomic databases

eggNOGiKOG1198. Eukaryota.
COG0604. LUCA.
GeneTreeiENSGT00550000074483.
HOGENOMiHOG000294681.
HOVERGENiHBG002466.
InParanoidiQ62465.
OMAiFGLWQEV.
OrthoDBiEOG7VQJD4.
PhylomeDBiQ62465.
TreeFamiTF314255.

Miscellaneous databases

ChiTaRSiVat1. mouse.
NextBioi304887.
PROiQ62465.
SOURCEiSearch...

Gene expression databases

BgeeiQ62465.
ExpressionAtlasiQ62465. baseline and differential.
GenevisibleiQ62465. MM.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
IPR002364. Quin_OxRdtase/zeta-crystal_CS.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS01162. QOR_ZETA_CRYSTAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II and FVB/N.
    Tissue: Mammary tumor.
  3. "Mammalian protein homologous to VAT-1 of Torpedo californica: isolation from Ehrlich ascites tumor cells, biochemical characterization, and organization of its gene."
    Hayess K., Kraft R., Sachsinger J., Janke J., Beckmann G., Rohde K., Jandrig B., Benndorf R.
    J. Cell. Biochem. 69:304-315(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 105-209, PROTEIN SEQUENCE OF 239-258; 264-308; 369-378; 386-390 AND 396-404, FUNCTION.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiVAT1_MOUSE
AccessioniPrimary (citable) accession number: Q62465
Secondary accession number(s): Q8R3G0, Q8R3T8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 27, 2004
Last modified: May 11, 2016
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.