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Protein

Synaptic vesicle membrane protein VAT-1 homolog

Gene

Vat1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation (By similarity). Possesses ATPase activity. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2) (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptic vesicle membrane protein VAT-1 homolog (EC:1.-.-.-)
Gene namesi
Name:Vat1
Synonyms:Vat-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1349450. Vat1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001609192 – 406Synaptic vesicle membrane protein VAT-1 homologAdd BLAST405

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineBy similarity1
Modified residuei33PhosphoserineBy similarity1
Modified residuei42PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ62465.
MaxQBiQ62465.
PaxDbiQ62465.
PRIDEiQ62465.
TopDownProteomicsiQ62465.

PTM databases

iPTMnetiQ62465.
PhosphoSitePlusiQ62465.
SwissPalmiQ62465.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034993.
ExpressionAtlasiQ62465. baseline and differential.
GenevisibleiQ62465. MM.

Interactioni

Protein-protein interaction databases

BioGridi205084. 5 interactors.
IntActiQ62465. 5 interactors.
MINTiMINT-4997313.
STRINGi10090.ENSMUSP00000048350.

Structurei

3D structure databases

ProteinModelPortaliQ62465.
SMRiQ62465.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1198. Eukaryota.
COG0604. LUCA.
GeneTreeiENSGT00550000074483.
HOGENOMiHOG000294681.
HOVERGENiHBG002466.
InParanoidiQ62465.
OMAiFGLWQEV.
OrthoDBiEOG091G0EEJ.
PhylomeDBiQ62465.
TreeFamiTF314255.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
IPR002364. Quin_OxRdtase/zeta-crystal_CS.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS01162. QOR_ZETA_CRYSTAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62465-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAEREAAEA ATVAAATEAG AETGTGAGEG APSQPPTVEV ASDPQPPPAP
60 70 80 90 100
EASASASAPP LRCLVLTGFG GYDKVKLQSR PAVPPAPGPG QLTLRVRACG
110 120 130 140 150
LNFADLMGRQ GLYDRLPPLP VTPGMEGAGV VVAVGEGVGD RKAGDRVMVL
160 170 180 190 200
NRSGMWQEEV TVPSAQTFLM PEAMTFEEAA ALLVNYITAY MVLFDFGNLR
210 220 230 240 250
PGHSVLVHMA AGGVGMAALQ LCRTVENVTV FGTASASKHE VLKENGVTHP
260 270 280 290 300
IDYHTTDYVD EIKKISPKGV DIVMDPLGGS DTAKGYHLLK PMGKVVTYGM
310 320 330 340 350
ANLLTGPKRN LMAMARTWWN QFSVTALQLL QANRAVCGFH LGYLDGEVEL
360 370 380 390 400
VNSVVTRLVA LYNQGHIKPR IDSVWPFEKV ADAMKQMQEK KNIGKVLLVP

GPEKET
Length:406
Mass (Da):43,097
Last modified:September 27, 2004 - v3
Checksum:i3F704C3667C21E37
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034795 mRNA. Translation: BAC28833.1.
BC024586 mRNA. Translation: AAH24586.1.
BC025496 mRNA. Translation: AAH25496.1.
X95562 mRNA. Translation: CAA64807.1.
CCDSiCCDS25472.1.
RefSeqiNP_036167.1. NM_012037.2.
UniGeneiMm.29210.

Genome annotation databases

EnsembliENSMUST00000040430; ENSMUSP00000048350; ENSMUSG00000034993.
GeneIDi26949.
KEGGimmu:26949.
UCSCiuc007loy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034795 mRNA. Translation: BAC28833.1.
BC024586 mRNA. Translation: AAH24586.1.
BC025496 mRNA. Translation: AAH25496.1.
X95562 mRNA. Translation: CAA64807.1.
CCDSiCCDS25472.1.
RefSeqiNP_036167.1. NM_012037.2.
UniGeneiMm.29210.

3D structure databases

ProteinModelPortaliQ62465.
SMRiQ62465.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205084. 5 interactors.
IntActiQ62465. 5 interactors.
MINTiMINT-4997313.
STRINGi10090.ENSMUSP00000048350.

PTM databases

iPTMnetiQ62465.
PhosphoSitePlusiQ62465.
SwissPalmiQ62465.

Proteomic databases

EPDiQ62465.
MaxQBiQ62465.
PaxDbiQ62465.
PRIDEiQ62465.
TopDownProteomicsiQ62465.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040430; ENSMUSP00000048350; ENSMUSG00000034993.
GeneIDi26949.
KEGGimmu:26949.
UCSCiuc007loy.1. mouse.

Organism-specific databases

CTDi10493.
MGIiMGI:1349450. Vat1.

Phylogenomic databases

eggNOGiKOG1198. Eukaryota.
COG0604. LUCA.
GeneTreeiENSGT00550000074483.
HOGENOMiHOG000294681.
HOVERGENiHBG002466.
InParanoidiQ62465.
OMAiFGLWQEV.
OrthoDBiEOG091G0EEJ.
PhylomeDBiQ62465.
TreeFamiTF314255.

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiVat1. mouse.
PROiQ62465.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034993.
ExpressionAtlasiQ62465. baseline and differential.
GenevisibleiQ62465. MM.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
IPR002364. Quin_OxRdtase/zeta-crystal_CS.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS01162. QOR_ZETA_CRYSTAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVAT1_MOUSE
AccessioniPrimary (citable) accession number: Q62465
Secondary accession number(s): Q8R3G0, Q8R3T8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 27, 2004
Last modified: November 30, 2016
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.