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Q62463 (V1AR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vasopressin V1a receptor

Short name=V1aR
Alternative name(s):
AVPR V1a
Antidiuretic hormone receptor 1a
Vascular/hepatic-type arginine vasopressin receptor
Gene names
Name:Avpr1a
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length423 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Involved in social memory formation. Ref.4

Subcellular location

Cell membrane; Multi-pass membrane protein.

Miscellaneous

Knockout mice display deficits in individual discrimination. Male mice lacking functional AVPR1A (V1aRKO) exhibit markedly reduced anxiety-like behavior and a profound impairment in social recognition. V1aRKO performed normally on spatial and non-social olfactory learning and memory tasks.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
Lipoprotein
Palmitate
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcalcium-mediated signaling

Inferred from electronic annotation. Source: Ensembl

cellular response to water deprivation

Inferred from electronic annotation. Source: Ensembl

grooming behavior

Inferred from electronic annotation. Source: Ensembl

maternal aggressive behavior

Inferred from electronic annotation. Source: Ensembl

maternal behavior

Inferred from electronic annotation. Source: Ensembl

myotube differentiation

Inferred from electronic annotation. Source: Ensembl

negative regulation of female receptivity

Inferred from electronic annotation. Source: Ensembl

negative regulation of transmission of nerve impulse

Inferred from electronic annotation. Source: Ensembl

penile erection

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell growth

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of cellular pH reduction

Inferred from electronic annotation. Source: Ensembl

positive regulation of cytosolic calcium ion concentration

Inferred from electronic annotation. Source: Ensembl

positive regulation of glutamate secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of heart rate

Inferred from electronic annotation. Source: Ensembl

positive regulation of prostaglandin biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of renal sodium excretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of systemic arterial blood pressure

Inferred from electronic annotation. Source: Ensembl

positive regulation of vasoconstriction

Inferred from electronic annotation. Source: Ensembl

regulation of systemic arterial blood pressure by vasopressin

Inferred from genetic interaction PubMed 12486173. Source: MGI

response to corticosterone

Inferred from electronic annotation. Source: Ensembl

social behavior

Inferred from electronic annotation. Source: Ensembl

sperm ejaculation

Inferred from electronic annotation. Source: Ensembl

telencephalon development

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasmic vesicle

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionpeptide hormone binding

Inferred from electronic annotation. Source: Ensembl

vasopressin receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 423423Vasopressin V1a receptor
PRO_0000070200

Regions

Topological domain1 – 5252Extracellular Potential
Transmembrane53 – 7624Helical; Name=1; Potential
Topological domain77 – 8812Cytoplasmic Potential
Transmembrane89 – 11022Helical; Name=2; Potential
Topological domain111 – 12515Extracellular Potential
Transmembrane126 – 14722Helical; Name=3; Potential
Topological domain148 – 16821Cytoplasmic Potential
Transmembrane169 – 19022Helical; Name=4; Potential
Topological domain191 – 22030Extracellular Potential
Transmembrane221 – 24121Helical; Name=5; Potential
Topological domain242 – 29857Cytoplasmic Potential
Transmembrane299 – 31820Helical; Name=6; Potential
Topological domain319 – 33618Extracellular Potential
Transmembrane337 – 35620Helical; Name=7; Potential
Topological domain357 – 42367Cytoplasmic Potential

Amino acid modifications

Modified residue4091Phosphoserine Ref.5
Lipidation3701S-palmitoyl cysteine By similarity
Lipidation3711S-palmitoyl cysteine By similarity
Glycosylation271N-linked (GlcNAc...) Potential
Glycosylation1981N-linked (GlcNAc...) Potential
Disulfide bond124 ↔ 205 By similarity

Natural variations

Natural variant41 – 422PP → RR.
Natural variant551V → F.

Sequences

Sequence LengthMass (Da)Tools
Q62463 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: C75AFF1D0A082CC6

FASTA42347,182
        10         20         30         40         50         60 
MSFPRGSHDL PAGNSSPWWP LTTEGANSSR EAAGLGEGGS PPGDVRNEEL AKLEVTVLAV 

        70         80         90        100        110        120 
IFVVAVLGNS SVLLALHRTP RKTSRMHLFI RHLSLADLAV AFFQVLPQLC WDITYRFRGP 

       130        140        150        160        170        180 
DWLCRVVKHL QVFAMFASSY MLVVMTADRY IAVCHPLKTL QQPARRSRLM IAASWGLSFV 

       190        200        210        220        230        240 
LSIPQYFIFS VIEFEVNNGT KAQDCWATFI PPWGTRAYVT WMTSGVFVVP VIILGTCYGF 

       250        260        270        280        290        300 
ICYHIWRNVR GKTASRQSKG GKGSGEAAGP FHKGLLVTPC VSSVKSISRA KIRTVKMTFV 

       310        320        330        340        350        360 
IVSAYILCWT PFFIVQMWSV WDTNFVWTDS ENPSTTITAL LASLNSCCNP WIYMFFSGHL 

       370        380        390        400        410        420 
LQDCVQSFPC CQSIAQKFAK DDSDSMSRRQ TSYSNNRSPT NSTGTWKDSP KSSKSIRFIP 


VST 

« Hide

References

« Hide 'large scale' references
[1]Onodera Y., Maekawa K., Arai Y.
Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Structure and sequence of the mouse V1a and V1b vasopressin receptor genes."
Kikuchi S., Tanoue A., Goda N., Matsuo N., Tsujimoto G.
Jpn. J. Pharmacol. 81:388-392(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/SvJ.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Colon.
[4]"Profound impairment in social recognition and reduction in anxiety-like behavior in vasopressin V1a receptor knockout mice."
Bielsky I.F., Hu S.B., Szegda K.L., Westphal H., Young L.J.
Neuropsychopharmacology 29:483-493(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: ROLE IN SOCIAL BEHAVIOR.
[5]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D49729 mRNA. Translation: BAA08566.1.
D49730 mRNA. Translation: BAA08567.1.
AB030013 Genomic DNA. Translation: BAA89050.1.
BC024149 mRNA. Translation: AAH24149.1.
RefSeqNP_058543.2. NM_016847.2.
UniGeneMm.4351.

3D structure databases

ProteinModelPortalQ62463.
SMRQ62463. Positions 55-392.
ModBaseSearch...
MobiDBSearch...

Chemistry

GuidetoPHARMACOLOGY366.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ62463.

Proteomic databases

PRIDEQ62463.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000020323; ENSMUSP00000020323; ENSMUSG00000020123.
GeneID54140.
KEGGmmu:54140.
UCSCuc007hge.1. mouse.

Organism-specific databases

CTD552.
MGIMGI:1859216. Avpr1a.

Phylogenomic databases

eggNOGNOG299951.
GeneTreeENSGT00660000095384.
HOGENOMHOG000237331.
HOVERGENHBG105710.
InParanoidQ62463.
KOK04226.
OMAQLCWDIT.
OrthoDBEOG7Z69CP.
PhylomeDBQ62463.
TreeFamTF106499.

Gene expression databases

BgeeQ62463.
CleanExMM_AVPR1A.
GenevestigatorQ62463.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR015076. DUF1856.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR001224. Vprs_V1A_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
PF08983. DUF1856. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00752. VASOPRSNV1AR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio310961.
PROQ62463.
SOURCESearch...

Entry information

Entry nameV1AR_MOUSE
AccessionPrimary (citable) accession number: Q62463
Secondary accession number(s): Q62464, Q9QYH2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: April 16, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries