Q62463 (V1AR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Vasopressin V1a receptor
Short name=V1aR

Alternative name(s):
AVPR V1a
Antidiuretic hormone receptor 1a
Vascular/hepatic-type arginine vasopressin receptor

Gene names

Name:

Avpr1a

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	423 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Involved in social memory formation. Ref.4
Subcellular location	Cell membrane; Multi-pass membrane protein.
Miscellaneous	Knockout mice display deficits in individual discrimination. Male mice lacking functional AVPR1A (V1aRKO) exhibit markedly reduced anxiety-like behavior and a profound impairment in social recognition. V1aRKO performed normally on spatial and non-social olfactory learning and memory tasks.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Lipoprotein Palmitate Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	calcium-mediated signaling Inferred from electronic annotation. Source: Compara cellular response to water deprivation Inferred from electronic annotation. Source: Compara elevation of cytosolic calcium ion concentration Inferred from electronic annotation. Source: Compara grooming behavior Inferred from electronic annotation. Source: Compara maternal aggressive behavior Inferred from electronic annotation. Source: Compara maternal behavior Inferred from electronic annotation. Source: Compara myotube differentiation Inferred from electronic annotation. Source: Compara negative regulation of female receptivity Inferred from electronic annotation. Source: Compara negative regulation of transmission of nerve impulse Inferred from electronic annotation. Source: Compara penile erection Inferred from electronic annotation. Source: Compara positive regulation of cell growth Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of cellular pH reduction Inferred from electronic annotation. Source: Compara positive regulation of glutamate secretion Inferred from electronic annotation. Source: Compara positive regulation of heart rate Inferred from electronic annotation. Source: Compara positive regulation of prostaglandin biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of renal sodium excretion Inferred from electronic annotation. Source: Compara positive regulation of systemic arterial blood pressure Inferred from electronic annotation. Source: Compara positive regulation of vasoconstriction Inferred from electronic annotation. Source: Compara regulation of systemic arterial blood pressure by vasopressin Inferred from genetic interaction PubMed 12486173. Source: MGI response to corticosterone stimulus Inferred from electronic annotation. Source: Compara social behavior Inferred from electronic annotation. Source: Compara sperm ejaculation Inferred from electronic annotation. Source: Compara telencephalon development Inferred from electronic annotation. Source: Compara
Cellular_component	cytoplasmic vesicle Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	peptide hormone binding Inferred from electronic annotation. Source: Compara vasopressin receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 423	423	Vasopressin V1a receptor		PRO_0000070200
Regions
	Topological domain	1 – 52	52	Extracellular Potential
	Transmembrane	53 – 76	24	Helical; Name=1; Potential
	Topological domain	77 – 88	12	Cytoplasmic Potential
	Transmembrane	89 – 110	22	Helical; Name=2; Potential
	Topological domain	111 – 125	15	Extracellular Potential
	Transmembrane	126 – 147	22	Helical; Name=3; Potential
	Topological domain	148 – 168	21	Cytoplasmic Potential
	Transmembrane	169 – 190	22	Helical; Name=4; Potential
	Topological domain	191 – 220	30	Extracellular Potential
	Transmembrane	221 – 241	21	Helical; Name=5; Potential
	Topological domain	242 – 298	57	Cytoplasmic Potential
	Transmembrane	299 – 318	20	Helical; Name=6; Potential
	Topological domain	319 – 336	18	Extracellular Potential
	Transmembrane	337 – 356	20	Helical; Name=7; Potential
	Topological domain	357 – 423	67	Cytoplasmic Potential
Amino acid modifications
	Modified residue	409	1	Phosphoserine Ref.5
	Lipidation	370	1	S-palmitoyl cysteine By similarity
	Lipidation	371	1	S-palmitoyl cysteine By similarity
	Glycosylation	27	1	N-linked (GlcNAc...) Potential
	Glycosylation	198	1	N-linked (GlcNAc...) Potential
	Disulfide bond	124 ↔ 205		By similarity
Natural variations
	Natural variant	41 – 42	2	PP → RR.
	Natural variant	55	1	V → F.

Sequences

	Sequence		Length	Mass (Da)
	Q62463 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: C75AFF1D0A082CC6	FASTA	423	47,182
	10 20 30 40 50 60 MSFPRGSHDL PAGNSSPWWP LTTEGANSSR EAAGLGEGGS PPGDVRNEEL AKLEVTVLAV 70 80 90 100 110 120 IFVVAVLGNS SVLLALHRTP RKTSRMHLFI RHLSLADLAV AFFQVLPQLC WDITYRFRGP 130 140 150 160 170 180 DWLCRVVKHL QVFAMFASSY MLVVMTADRY IAVCHPLKTL QQPARRSRLM IAASWGLSFV 190 200 210 220 230 240 LSIPQYFIFS VIEFEVNNGT KAQDCWATFI PPWGTRAYVT WMTSGVFVVP VIILGTCYGF 250 260 270 280 290 300 ICYHIWRNVR GKTASRQSKG GKGSGEAAGP FHKGLLVTPC VSSVKSISRA KIRTVKMTFV 310 320 330 340 350 360 IVSAYILCWT PFFIVQMWSV WDTNFVWTDS ENPSTTITAL LASLNSCCNP WIYMFFSGHL 370 380 390 400 410 420 LQDCVQSFPC CQSIAQKFAK DDSDSMSRRQ TSYSNNRSPT NSTGTWKDSP KSSKSIRFIP VST

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Onodera Y., Maekawa K., Arai Y. Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Structure and sequence of the mouse V1a and V1b vasopressin receptor genes." Kikuchi S., Tanoue A., Goda N., Matsuo N., Tsujimoto G. Jpn. J. Pharmacol. 81:388-392(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 129/SvJ.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Colon.
[4]	"Profound impairment in social recognition and reduction in anxiety-like behavior in vasopressin V1a receptor knockout mice." Bielsky I.F., Hu S.B., Szegda K.L., Westphal H., Young L.J. Neuropsychopharmacology 29:483-493(2004) [PubMed] [Europe PMC] [Abstract] Cited for: ROLE IN SOCIAL BEHAVIOR.
[5]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D49729 mRNA. Translation: BAA08566.1. D49730 mRNA. Translation: BAA08567.1. AB030013 Genomic DNA. Translation: BAA89050.1. BC024149 mRNA. Translation: AAH24149.1.
IPI	IPI00312866.
RefSeq	NP_058543.2. NM_016847.2.
UniGene	Mm.4351.
3D structure databases
ProteinModelPortal	Q62463.
SMR	Q62463. Positions 55-392.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q62463.
Proteomic databases
PRIDE	Q62463.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000020323; ENSMUSP00000020323; ENSMUSG00000020123.
GeneID	54140.
KEGG	mmu:54140.
Organism-specific databases
CTD	552.
MGI	MGI:1859216. Avpr1a.
Phylogenomic databases
eggNOG	NOG299951.
GeneTree	ENSGT00660000095384.
HOGENOM	HOG000237331.
HOVERGEN	HBG105710.
InParanoid	Q62463.
KO	K04226.
OMA	QLCWDIT.
OrthoDB	EOG4KSPJT.
Gene expression databases
ArrayExpress	Q62463.
Bgee	Q62463.
CleanEx	MM_AVPR1A.
Genevestigator	Q62463.
GermOnline	ENSMUSG00000020123. Mus musculus.
Family and domain databases
InterPro	IPR015076. DUF1856. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR001817. Vasoprsn_rcpt. IPR001224. Vprs_V1A_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. PF08983. DUF1856. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00896. VASOPRESSINR. PR00752. VASOPRSNV1AR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	310961.
SOURCE	Search...

Entry information

Entry name

V1AR_MOUSE

Accession

Primary (citable) accession number: Q62463
Secondary accession number(s): Q62464, Q9QYH2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	May 1, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program