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Protein

Vasopressin V1a receptor

Gene

Avpr1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Involved in social memory formation.1 Publication

Miscellaneous

Knockout mice display deficits in individual discrimination. Male mice lacking functional AVPR1A (V1aRKO) exhibit markedly reduced anxiety-like behavior and a profound impairment in social recognition. V1aRKO performed normally on spatial and non-social olfactory learning and memory tasks.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin V1a receptor
Short name:
V1aR
Alternative name(s):
AVPR V1a
Antidiuretic hormone receptor 1a
Vascular/hepatic-type arginine vasopressin receptor
Gene namesi
Name:Avpr1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1859216 Avpr1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 52ExtracellularSequence analysisAdd BLAST52
Transmembranei53 – 76Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini77 – 88CytoplasmicSequence analysisAdd BLAST12
Transmembranei89 – 110Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini111 – 125ExtracellularSequence analysisAdd BLAST15
Transmembranei126 – 147Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini148 – 168CytoplasmicSequence analysisAdd BLAST21
Transmembranei169 – 190Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini191 – 220ExtracellularSequence analysisAdd BLAST30
Transmembranei221 – 241Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini242 – 298CytoplasmicSequence analysisAdd BLAST57
Transmembranei299 – 318Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini319 – 336ExtracellularSequence analysisAdd BLAST18
Transmembranei337 – 356Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini357 – 423CytoplasmicSequence analysisAdd BLAST67

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3414410

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000702001 – 423Vasopressin V1a receptorAdd BLAST423

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi27N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi124 ↔ 205PROSITE-ProRule annotation
Glycosylationi198N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi370S-palmitoyl cysteineBy similarity1
Lipidationi371S-palmitoyl cysteineBy similarity1
Modified residuei409PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ62463
PRIDEiQ62463

PTM databases

iPTMnetiQ62463
PhosphoSitePlusiQ62463

Expressioni

Gene expression databases

BgeeiENSMUSG00000020123
CleanExiMM_AVPR1A
ExpressionAtlasiQ62463 baseline and differential
GenevisibleiQ62463 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020323

Chemistry databases

BindingDBiQ62463

Structurei

3D structure databases

ProteinModelPortaliQ62463
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119156
HOGENOMiHOG000237331
HOVERGENiHBG105710
InParanoidiQ62463
KOiK04226
OMAiVFAMFAS
OrthoDBiEOG091G0DB6
PhylomeDBiQ62463
TreeFamiTF106499

Family and domain databases

CDDicd15385 7tmA_V1aR, 1 hit
InterProiView protein in InterPro
IPR015076 DUF1856
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001817 Vasoprsn_rcpt
IPR001224 Vprs_V1A_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PF08983 DUF1856, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00896 VASOPRESSINR
PR00752 VASOPRSNV1AR
SMARTiView protein in SMART
SM01164 DUF1856, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q62463-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFPRGSHDL PAGNSSPWWP LTTEGANSSR EAAGLGEGGS PPGDVRNEEL
60 70 80 90 100
AKLEVTVLAV IFVVAVLGNS SVLLALHRTP RKTSRMHLFI RHLSLADLAV
110 120 130 140 150
AFFQVLPQLC WDITYRFRGP DWLCRVVKHL QVFAMFASSY MLVVMTADRY
160 170 180 190 200
IAVCHPLKTL QQPARRSRLM IAASWGLSFV LSIPQYFIFS VIEFEVNNGT
210 220 230 240 250
KAQDCWATFI PPWGTRAYVT WMTSGVFVVP VIILGTCYGF ICYHIWRNVR
260 270 280 290 300
GKTASRQSKG GKGSGEAAGP FHKGLLVTPC VSSVKSISRA KIRTVKMTFV
310 320 330 340 350
IVSAYILCWT PFFIVQMWSV WDTNFVWTDS ENPSTTITAL LASLNSCCNP
360 370 380 390 400
WIYMFFSGHL LQDCVQSFPC CQSIAQKFAK DDSDSMSRRQ TSYSNNRSPT
410 420
NSTGTWKDSP KSSKSIRFIP VST
Length:423
Mass (Da):47,182
Last modified:November 1, 1996 - v1
Checksum:iC75AFF1D0A082CC6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti41 – 42PP → RR. 2
Natural varianti55V → F. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49729 mRNA Translation: BAA08566.1
D49730 mRNA Translation: BAA08567.1
AB030013 Genomic DNA Translation: BAA89050.1
BC024149 mRNA Translation: AAH24149.1
CCDSiCCDS24215.1
RefSeqiNP_058543.2, NM_016847.2
UniGeneiMm.4351

Genome annotation databases

EnsembliENSMUST00000020323; ENSMUSP00000020323; ENSMUSG00000020123
GeneIDi54140
KEGGimmu:54140
UCSCiuc007hge.1 mouse

Similar proteinsi

Entry informationi

Entry nameiV1AR_MOUSE
AccessioniPrimary (citable) accession number: Q62463
Secondary accession number(s): Q62464, Q9QYH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: June 20, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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