Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q62463

- V1AR_MOUSE

UniProt

Q62463 - V1AR_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Vasopressin V1a receptor

Gene

Avpr1a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Involved in social memory formation.1 Publication

GO - Molecular functioni

  1. peptide hormone binding Source: Ensembl
  2. vasopressin receptor activity Source: InterPro

GO - Biological processi

  1. calcium-mediated signaling Source: Ensembl
  2. cellular response to water deprivation Source: Ensembl
  3. grooming behavior Source: Ensembl
  4. maternal aggressive behavior Source: Ensembl
  5. maternal behavior Source: Ensembl
  6. myotube differentiation Source: Ensembl
  7. negative regulation of female receptivity Source: Ensembl
  8. negative regulation of transmission of nerve impulse Source: Ensembl
  9. penile erection Source: Ensembl
  10. positive regulation of cell growth Source: Ensembl
  11. positive regulation of cell proliferation Source: Ensembl
  12. positive regulation of cellular pH reduction Source: Ensembl
  13. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  14. positive regulation of glutamate secretion Source: Ensembl
  15. positive regulation of heart rate Source: Ensembl
  16. positive regulation of prostaglandin biosynthetic process Source: Ensembl
  17. positive regulation of renal sodium excretion Source: Ensembl
  18. positive regulation of systemic arterial blood pressure Source: Ensembl
  19. positive regulation of vasoconstriction Source: Ensembl
  20. regulation of systemic arterial blood pressure by vasopressin Source: MGI
  21. response to corticosterone Source: Ensembl
  22. social behavior Source: Ensembl
  23. sperm ejaculation Source: Ensembl
  24. telencephalon development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.
REACT_259014. Vasopressin-like receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin V1a receptor
Short name:
V1aR
Alternative name(s):
AVPR V1a
Antidiuretic hormone receptor 1a
Vascular/hepatic-type arginine vasopressin receptor
Gene namesi
Name:Avpr1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1859216. Avpr1a.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5252ExtracellularSequence AnalysisAdd
BLAST
Transmembranei53 – 7624Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini77 – 8812CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei89 – 11022Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini111 – 12515ExtracellularSequence AnalysisAdd
BLAST
Transmembranei126 – 14722Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini148 – 16821CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei169 – 19022Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini191 – 22030ExtracellularSequence AnalysisAdd
BLAST
Transmembranei221 – 24121Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini242 – 29857CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei299 – 31820Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini319 – 33618ExtracellularSequence AnalysisAdd
BLAST
Transmembranei337 – 35620Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini357 – 42367CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasmic vesicle Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 423423Vasopressin V1a receptorPRO_0000070200Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi27 – 271N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi124 ↔ 205PROSITE-ProRule annotation
Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence Analysis
Lipidationi370 – 3701S-palmitoyl cysteineBy similarity
Lipidationi371 – 3711S-palmitoyl cysteineBy similarity
Modified residuei409 – 4091Phosphoserine1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PRIDEiQ62463.

PTM databases

PhosphoSiteiQ62463.

Expressioni

Gene expression databases

BgeeiQ62463.
CleanExiMM_AVPR1A.
ExpressionAtlasiQ62463. baseline and differential.
GenevestigatoriQ62463.

Structurei

3D structure databases

ProteinModelPortaliQ62463.
SMRiQ62463. Positions 55-392.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG299951.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiQ62463.
KOiK04226.
OMAiQLCWDIT.
OrthoDBiEOG7Z69CP.
PhylomeDBiQ62463.
TreeFamiTF106499.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR015076. DUF1856.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR001224. Vprs_V1A_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF08983. DUF1856. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00752. VASOPRSNV1AR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62463-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFPRGSHDL PAGNSSPWWP LTTEGANSSR EAAGLGEGGS PPGDVRNEEL
60 70 80 90 100
AKLEVTVLAV IFVVAVLGNS SVLLALHRTP RKTSRMHLFI RHLSLADLAV
110 120 130 140 150
AFFQVLPQLC WDITYRFRGP DWLCRVVKHL QVFAMFASSY MLVVMTADRY
160 170 180 190 200
IAVCHPLKTL QQPARRSRLM IAASWGLSFV LSIPQYFIFS VIEFEVNNGT
210 220 230 240 250
KAQDCWATFI PPWGTRAYVT WMTSGVFVVP VIILGTCYGF ICYHIWRNVR
260 270 280 290 300
GKTASRQSKG GKGSGEAAGP FHKGLLVTPC VSSVKSISRA KIRTVKMTFV
310 320 330 340 350
IVSAYILCWT PFFIVQMWSV WDTNFVWTDS ENPSTTITAL LASLNSCCNP
360 370 380 390 400
WIYMFFSGHL LQDCVQSFPC CQSIAQKFAK DDSDSMSRRQ TSYSNNRSPT
410 420
NSTGTWKDSP KSSKSIRFIP VST
Length:423
Mass (Da):47,182
Last modified:November 1, 1996 - v1
Checksum:iC75AFF1D0A082CC6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti41 – 422PP → RR.
Natural varianti55 – 551V → F.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49729 mRNA. Translation: BAA08566.1.
D49730 mRNA. Translation: BAA08567.1.
AB030013 Genomic DNA. Translation: BAA89050.1.
BC024149 mRNA. Translation: AAH24149.1.
CCDSiCCDS24215.1.
RefSeqiNP_058543.2. NM_016847.2.
UniGeneiMm.4351.

Genome annotation databases

EnsembliENSMUST00000020323; ENSMUSP00000020323; ENSMUSG00000020123.
GeneIDi54140.
KEGGimmu:54140.
UCSCiuc007hge.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49729 mRNA. Translation: BAA08566.1 .
D49730 mRNA. Translation: BAA08567.1 .
AB030013 Genomic DNA. Translation: BAA89050.1 .
BC024149 mRNA. Translation: AAH24149.1 .
CCDSi CCDS24215.1.
RefSeqi NP_058543.2. NM_016847.2.
UniGenei Mm.4351.

3D structure databases

ProteinModelPortali Q62463.
SMRi Q62463. Positions 55-392.
ModBasei Search...
MobiDBi Search...

Chemistry

GuidetoPHARMACOLOGYi 366.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q62463.

Proteomic databases

PRIDEi Q62463.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020323 ; ENSMUSP00000020323 ; ENSMUSG00000020123 .
GeneIDi 54140.
KEGGi mmu:54140.
UCSCi uc007hge.1. mouse.

Organism-specific databases

CTDi 552.
MGIi MGI:1859216. Avpr1a.

Phylogenomic databases

eggNOGi NOG299951.
GeneTreei ENSGT00760000119156.
HOGENOMi HOG000237331.
HOVERGENi HBG105710.
InParanoidi Q62463.
KOi K04226.
OMAi QLCWDIT.
OrthoDBi EOG7Z69CP.
PhylomeDBi Q62463.
TreeFami TF106499.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.
REACT_259014. Vasopressin-like receptors.

Miscellaneous databases

NextBioi 310961.
PROi Q62463.
SOURCEi Search...

Gene expression databases

Bgeei Q62463.
CleanExi MM_AVPR1A.
ExpressionAtlasi Q62463. baseline and differential.
Genevestigatori Q62463.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR015076. DUF1856.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR001224. Vprs_V1A_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
PF08983. DUF1856. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00752. VASOPRSNV1AR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Onodera Y., Maekawa K., Arai Y.
    Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Structure and sequence of the mouse V1a and V1b vasopressin receptor genes."
    Kikuchi S., Tanoue A., Goda N., Matsuo N., Tsujimoto G.
    Jpn. J. Pharmacol. 81:388-392(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  4. "Profound impairment in social recognition and reduction in anxiety-like behavior in vasopressin V1a receptor knockout mice."
    Bielsky I.F., Hu S.B., Szegda K.L., Westphal H., Young L.J.
    Neuropsychopharmacology 29:483-493(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: ROLE IN SOCIAL BEHAVIOR.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiV1AR_MOUSE
AccessioniPrimary (citable) accession number: Q62463
Secondary accession number(s): Q62464, Q9QYH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Knockout mice display deficits in individual discrimination. Male mice lacking functional AVPR1A (V1aRKO) exhibit markedly reduced anxiety-like behavior and a profound impairment in social recognition. V1aRKO performed normally on spatial and non-social olfactory learning and memory tasks.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3