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Protein

Vasopressin V1a receptor

Gene

Avpr1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Involved in social memory formation.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-388479. Vasopressin-like receptors.
R-MMU-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Vasopressin V1a receptor
Short name:
V1aR
Alternative name(s):
AVPR V1a
Antidiuretic hormone receptor 1a
Vascular/hepatic-type arginine vasopressin receptor
Gene namesi
Name:Avpr1a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1859216. Avpr1a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 52ExtracellularSequence analysisAdd BLAST52
Transmembranei53 – 76Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini77 – 88CytoplasmicSequence analysisAdd BLAST12
Transmembranei89 – 110Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini111 – 125ExtracellularSequence analysisAdd BLAST15
Transmembranei126 – 147Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini148 – 168CytoplasmicSequence analysisAdd BLAST21
Transmembranei169 – 190Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini191 – 220ExtracellularSequence analysisAdd BLAST30
Transmembranei221 – 241Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini242 – 298CytoplasmicSequence analysisAdd BLAST57
Transmembranei299 – 318Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini319 – 336ExtracellularSequence analysisAdd BLAST18
Transmembranei337 – 356Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini357 – 423CytoplasmicSequence analysisAdd BLAST67

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3414410.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000702001 – 423Vasopressin V1a receptorAdd BLAST423

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi27N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi124 ↔ 205PROSITE-ProRule annotation
Glycosylationi198N-linked (GlcNAc...)Sequence analysis1
Lipidationi370S-palmitoyl cysteineBy similarity1
Lipidationi371S-palmitoyl cysteineBy similarity1
Modified residuei409PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ62463.
PRIDEiQ62463.

PTM databases

iPTMnetiQ62463.
PhosphoSitePlusiQ62463.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020123.
CleanExiMM_AVPR1A.
ExpressionAtlasiQ62463. baseline and differential.
GenevisibleiQ62463. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020323.

Chemistry databases

BindingDBiQ62463.

Structurei

3D structure databases

ProteinModelPortaliQ62463.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiQ62463.
KOiK04226.
OMAiVFAMFAS.
OrthoDBiEOG091G0DB6.
PhylomeDBiQ62463.
TreeFamiTF106499.

Family and domain databases

InterProiIPR015076. DUF1856.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR001224. Vprs_V1A_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF08983. DUF1856. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00752. VASOPRSNV1AR.
SMARTiSM01164. DUF1856. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62463-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFPRGSHDL PAGNSSPWWP LTTEGANSSR EAAGLGEGGS PPGDVRNEEL
60 70 80 90 100
AKLEVTVLAV IFVVAVLGNS SVLLALHRTP RKTSRMHLFI RHLSLADLAV
110 120 130 140 150
AFFQVLPQLC WDITYRFRGP DWLCRVVKHL QVFAMFASSY MLVVMTADRY
160 170 180 190 200
IAVCHPLKTL QQPARRSRLM IAASWGLSFV LSIPQYFIFS VIEFEVNNGT
210 220 230 240 250
KAQDCWATFI PPWGTRAYVT WMTSGVFVVP VIILGTCYGF ICYHIWRNVR
260 270 280 290 300
GKTASRQSKG GKGSGEAAGP FHKGLLVTPC VSSVKSISRA KIRTVKMTFV
310 320 330 340 350
IVSAYILCWT PFFIVQMWSV WDTNFVWTDS ENPSTTITAL LASLNSCCNP
360 370 380 390 400
WIYMFFSGHL LQDCVQSFPC CQSIAQKFAK DDSDSMSRRQ TSYSNNRSPT
410 420
NSTGTWKDSP KSSKSIRFIP VST
Length:423
Mass (Da):47,182
Last modified:November 1, 1996 - v1
Checksum:iC75AFF1D0A082CC6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti41 – 42PP → RR.2
Natural varianti55V → F.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49729 mRNA. Translation: BAA08566.1.
D49730 mRNA. Translation: BAA08567.1.
AB030013 Genomic DNA. Translation: BAA89050.1.
BC024149 mRNA. Translation: AAH24149.1.
CCDSiCCDS24215.1.
RefSeqiNP_058543.2. NM_016847.2.
UniGeneiMm.4351.

Genome annotation databases

EnsembliENSMUST00000020323; ENSMUSP00000020323; ENSMUSG00000020123.
GeneIDi54140.
KEGGimmu:54140.
UCSCiuc007hge.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49729 mRNA. Translation: BAA08566.1.
D49730 mRNA. Translation: BAA08567.1.
AB030013 Genomic DNA. Translation: BAA89050.1.
BC024149 mRNA. Translation: AAH24149.1.
CCDSiCCDS24215.1.
RefSeqiNP_058543.2. NM_016847.2.
UniGeneiMm.4351.

3D structure databases

ProteinModelPortaliQ62463.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020323.

Chemistry databases

BindingDBiQ62463.
ChEMBLiCHEMBL3414410.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ62463.
PhosphoSitePlusiQ62463.

Proteomic databases

PaxDbiQ62463.
PRIDEiQ62463.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020323; ENSMUSP00000020323; ENSMUSG00000020123.
GeneIDi54140.
KEGGimmu:54140.
UCSCiuc007hge.1. mouse.

Organism-specific databases

CTDi552.
MGIiMGI:1859216. Avpr1a.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119156.
HOGENOMiHOG000237331.
HOVERGENiHBG105710.
InParanoidiQ62463.
KOiK04226.
OMAiVFAMFAS.
OrthoDBiEOG091G0DB6.
PhylomeDBiQ62463.
TreeFamiTF106499.

Enzyme and pathway databases

ReactomeiR-MMU-388479. Vasopressin-like receptors.
R-MMU-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiQ62463.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020123.
CleanExiMM_AVPR1A.
ExpressionAtlasiQ62463. baseline and differential.
GenevisibleiQ62463. MM.

Family and domain databases

InterProiIPR015076. DUF1856.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR001817. Vasoprsn_rcpt.
IPR001224. Vprs_V1A_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF08983. DUF1856. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00896. VASOPRESSINR.
PR00752. VASOPRSNV1AR.
SMARTiSM01164. DUF1856. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiV1AR_MOUSE
AccessioniPrimary (citable) accession number: Q62463
Secondary accession number(s): Q62464, Q9QYH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Knockout mice display deficits in individual discrimination. Male mice lacking functional AVPR1A (V1aRKO) exhibit markedly reduced anxiety-like behavior and a profound impairment in social recognition. V1aRKO performed normally on spatial and non-social olfactory learning and memory tasks.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.