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Q62463

- V1AR_MOUSE

UniProt

Q62463 - V1AR_MOUSE

Protein

Vasopressin V1a receptor

Gene

Avpr1a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Involved in social memory formation.1 Publication

    GO - Molecular functioni

    1. peptide hormone binding Source: Ensembl
    2. vasopressin receptor activity Source: InterPro

    GO - Biological processi

    1. calcium-mediated signaling Source: Ensembl
    2. cellular response to water deprivation Source: Ensembl
    3. grooming behavior Source: Ensembl
    4. maternal aggressive behavior Source: Ensembl
    5. maternal behavior Source: Ensembl
    6. myotube differentiation Source: Ensembl
    7. negative regulation of female receptivity Source: Ensembl
    8. negative regulation of transmission of nerve impulse Source: Ensembl
    9. penile erection Source: Ensembl
    10. positive regulation of cell growth Source: Ensembl
    11. positive regulation of cell proliferation Source: Ensembl
    12. positive regulation of cellular pH reduction Source: Ensembl
    13. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    14. positive regulation of glutamate secretion Source: Ensembl
    15. positive regulation of heart rate Source: Ensembl
    16. positive regulation of prostaglandin biosynthetic process Source: Ensembl
    17. positive regulation of renal sodium excretion Source: Ensembl
    18. positive regulation of systemic arterial blood pressure Source: Ensembl
    19. positive regulation of vasoconstriction Source: Ensembl
    20. regulation of systemic arterial blood pressure by vasopressin Source: MGI
    21. response to corticosterone Source: Ensembl
    22. social behavior Source: Ensembl
    23. sperm ejaculation Source: Ensembl
    24. telencephalon development Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vasopressin V1a receptor
    Short name:
    V1aR
    Alternative name(s):
    AVPR V1a
    Antidiuretic hormone receptor 1a
    Vascular/hepatic-type arginine vasopressin receptor
    Gene namesi
    Name:Avpr1a
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1859216. Avpr1a.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasmic vesicle Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 423423Vasopressin V1a receptorPRO_0000070200Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi27 – 271N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi124 ↔ 205PROSITE-ProRule annotation
    Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence Analysis
    Lipidationi370 – 3701S-palmitoyl cysteineBy similarity
    Lipidationi371 – 3711S-palmitoyl cysteineBy similarity
    Modified residuei409 – 4091Phosphoserine1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    PRIDEiQ62463.

    PTM databases

    PhosphoSiteiQ62463.

    Expressioni

    Gene expression databases

    BgeeiQ62463.
    CleanExiMM_AVPR1A.
    GenevestigatoriQ62463.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62463.
    SMRiQ62463. Positions 55-353.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5252ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini77 – 8812CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini111 – 12515ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini148 – 16821CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini191 – 22030ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini242 – 29857CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini319 – 33618ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini357 – 42367CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei53 – 7624Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei89 – 11022Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei126 – 14722Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei169 – 19022Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei221 – 24121Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei299 – 31820Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei337 – 35620Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG299951.
    GeneTreeiENSGT00660000095384.
    HOGENOMiHOG000237331.
    HOVERGENiHBG105710.
    InParanoidiQ62463.
    KOiK04226.
    OMAiQLCWDIT.
    OrthoDBiEOG7Z69CP.
    PhylomeDBiQ62463.
    TreeFamiTF106499.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR015076. DUF1856.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001817. Vasoprsn_rcpt.
    IPR001224. Vprs_V1A_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    PF08983. DUF1856. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00896. VASOPRESSINR.
    PR00752. VASOPRSNV1AR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q62463-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFPRGSHDL PAGNSSPWWP LTTEGANSSR EAAGLGEGGS PPGDVRNEEL    50
    AKLEVTVLAV IFVVAVLGNS SVLLALHRTP RKTSRMHLFI RHLSLADLAV 100
    AFFQVLPQLC WDITYRFRGP DWLCRVVKHL QVFAMFASSY MLVVMTADRY 150
    IAVCHPLKTL QQPARRSRLM IAASWGLSFV LSIPQYFIFS VIEFEVNNGT 200
    KAQDCWATFI PPWGTRAYVT WMTSGVFVVP VIILGTCYGF ICYHIWRNVR 250
    GKTASRQSKG GKGSGEAAGP FHKGLLVTPC VSSVKSISRA KIRTVKMTFV 300
    IVSAYILCWT PFFIVQMWSV WDTNFVWTDS ENPSTTITAL LASLNSCCNP 350
    WIYMFFSGHL LQDCVQSFPC CQSIAQKFAK DDSDSMSRRQ TSYSNNRSPT 400
    NSTGTWKDSP KSSKSIRFIP VST 423
    Length:423
    Mass (Da):47,182
    Last modified:November 1, 1996 - v1
    Checksum:iC75AFF1D0A082CC6
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti41 – 422PP → RR.
    Natural varianti55 – 551V → F.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D49729 mRNA. Translation: BAA08566.1.
    D49730 mRNA. Translation: BAA08567.1.
    AB030013 Genomic DNA. Translation: BAA89050.1.
    BC024149 mRNA. Translation: AAH24149.1.
    CCDSiCCDS24215.1.
    RefSeqiNP_058543.2. NM_016847.2.
    UniGeneiMm.4351.

    Genome annotation databases

    EnsembliENSMUST00000020323; ENSMUSP00000020323; ENSMUSG00000020123.
    GeneIDi54140.
    KEGGimmu:54140.
    UCSCiuc007hge.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D49729 mRNA. Translation: BAA08566.1 .
    D49730 mRNA. Translation: BAA08567.1 .
    AB030013 Genomic DNA. Translation: BAA89050.1 .
    BC024149 mRNA. Translation: AAH24149.1 .
    CCDSi CCDS24215.1.
    RefSeqi NP_058543.2. NM_016847.2.
    UniGenei Mm.4351.

    3D structure databases

    ProteinModelPortali Q62463.
    SMRi Q62463. Positions 55-353.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 366.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q62463.

    Proteomic databases

    PRIDEi Q62463.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020323 ; ENSMUSP00000020323 ; ENSMUSG00000020123 .
    GeneIDi 54140.
    KEGGi mmu:54140.
    UCSCi uc007hge.1. mouse.

    Organism-specific databases

    CTDi 552.
    MGIi MGI:1859216. Avpr1a.

    Phylogenomic databases

    eggNOGi NOG299951.
    GeneTreei ENSGT00660000095384.
    HOGENOMi HOG000237331.
    HOVERGENi HBG105710.
    InParanoidi Q62463.
    KOi K04226.
    OMAi QLCWDIT.
    OrthoDBi EOG7Z69CP.
    PhylomeDBi Q62463.
    TreeFami TF106499.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 310961.
    PROi Q62463.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q62463.
    CleanExi MM_AVPR1A.
    Genevestigatori Q62463.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR015076. DUF1856.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR001817. Vasoprsn_rcpt.
    IPR001224. Vprs_V1A_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    PF08983. DUF1856. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00896. VASOPRESSINR.
    PR00752. VASOPRSNV1AR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Onodera Y., Maekawa K., Arai Y.
      Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Structure and sequence of the mouse V1a and V1b vasopressin receptor genes."
      Kikuchi S., Tanoue A., Goda N., Matsuo N., Tsujimoto G.
      Jpn. J. Pharmacol. 81:388-392(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/SvJ.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon.
    4. "Profound impairment in social recognition and reduction in anxiety-like behavior in vasopressin V1a receptor knockout mice."
      Bielsky I.F., Hu S.B., Szegda K.L., Westphal H., Young L.J.
      Neuropsychopharmacology 29:483-493(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: ROLE IN SOCIAL BEHAVIOR.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-409, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiV1AR_MOUSE
    AccessioniPrimary (citable) accession number: Q62463
    Secondary accession number(s): Q62464, Q9QYH2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Knockout mice display deficits in individual discrimination. Male mice lacking functional AVPR1A (V1aRKO) exhibit markedly reduced anxiety-like behavior and a profound impairment in social recognition. V1aRKO performed normally on spatial and non-social olfactory learning and memory tasks.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3