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Q62452 (UD19_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UDP-glucuronosyltransferase 1-9

Short name=UDPGT 1-9
Short name=UGT1*9
Short name=UGT1-09
Short name=UGT1.9
EC=2.4.1.17
Alternative name(s):
UDP-glucuronosyltransferase 1-7
Short name=UDPGT
UDP-glucuronosyltransferase 1A9
UGT1A12
UGTP4
Gene names
Name:Ugt1a9
Synonyms:Ugt1, Ugt1a12
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length528 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Catalytic activity

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

Subcellular location

Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.

Tissue specificity

Highly expressed in liver and at lower levels in stomach and kidney. Ref.1

Sequence similarities

Belongs to the UDP-glycosyltransferase family.

Sequence caution

The sequence AAA40524.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   Coding sequence diversityAlternative splicing
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionGlycosyltransferase
Transferase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionglucuronosyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select]

Note: A number of isoforms may be produced. Isoforms have a different N-terminal domain and a common C-terminal domain of 245 residues.
Isoform 1 (identifier: Q62452-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 528505UDP-glucuronosyltransferase 1-9
PRO_0000036020

Regions

Transmembrane486 – 50621Helical; Potential

Amino acid modifications

Modified residue971N6-succinyllysine Ref.5
Glycosylation691N-linked (GlcNAc...) Potential
Glycosylation2901N-linked (GlcNAc...) Potential
Glycosylation4281N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict1391F → S in AAP48599. Ref.1
Sequence conflict1391F → S in AAI46022. Ref.3
Sequence conflict1391F → S in AAI38700. Ref.3
Sequence conflict1791A → G in AAP48599. Ref.1
Sequence conflict1791A → G in AAI46022. Ref.3
Sequence conflict1791A → G in AAI38700. Ref.3
Sequence conflict3561L → I in AAA40524. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: B051E4F510EADCB4

FASTA52860,008
        10         20         30         40         50         60 
MAPVAFPTSF FLCLLLASGL AQAGRLLVVP MDGSHWFTMQ MVVEKLIHRG HEVVVVIPEV 

        70         80         90        100        110        120 
SWQLGKSLNC TVKTYSISHT LEDLDREFKY LSYTQWKTPE HSIRSFLTGS ARGFFELTFS 

       130        140        150        160        170        180 
HCRSLFNDKK LVEYLKQRFF DAVFLDPFDV CGLIVAKYFS LPSVIFARGV FCDYLEEGAQ 

       190        200        210        220        230        240 
CPSLPSYVPR LFSKYTDTMT FKERVWNHLI YIEEHAFCSY FLRTAVEVAS EILQTPVTMT 

       250        260        270        280        290        300 
DLFSPVSIWL LRTDFVLEFP RPVMPNMVFI GGINCLQKKS LSKEFEAYVN ASGEHGIVVF 

       310        320        330        340        350        360 
SLGSMVSEIP EKKAMEIAEA LGRIPQTVLW RYTGTRPSNL AKNTILVKWL PQNDLLGHPK 

       370        380        390        400        410        420 
TRAFITHSGS HGIYEGICNG VPMVMMPLFG DQMDNAKRME TRGAGVTLNV LEMTADDLEN 

       430        440        450        460        470        480 
ALKTVINNKS YKENIMRLSS LHKDRPIEPL DLAVFWVEYV MRHKGAPHLR PAAHDLTWYQ 

       490        500        510        520 
YHSLDVIGFL LAIVLTVVFI VFKCCAYGCR KCFGGKGRVK KSHKSKTH 

« Hide

References

« Hide 'large scale' references
[1]"Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation."
Zhang T., Haws P., Wu Q.
Genome Res. 14:79-89(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Stomach.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Molecular cloning of two cDNAs encoding the mouse bilirubin/phenol family of UDP-glucuronosyltransferases (mUGTBr/p)."
Kong A.N., Ma M., Tao D., Yang L.
Pharm. Res. 10:461-465(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-528.
Strain: BALB/c.
Tissue: Liver.
[5]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-97, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY227200 mRNA. Translation: AAP48599.1.
AC087780 Genomic DNA. No translation available.
AC087801 Genomic DNA. No translation available.
BC138699 mRNA. Translation: AAI38700.1.
BC146021 mRNA. Translation: AAI46022.1.
L27122 mRNA. Translation: AAA40524.1. Different initiation.
CCDSCCDS15138.1. [Q62452-1]
RefSeqNP_964006.2. NM_201644.2. [Q62452-1]
UniGeneMm.300095.

3D structure databases

ProteinModelPortalQ62452.
SMRQ62452. Positions 279-439.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ62452. 3 interactions.
MINTMINT-1852202.

Protein family/group databases

CAZyGT1. Glycosyltransferase Family 1.

PTM databases

PhosphoSiteQ62452.

Proteomic databases

MaxQBQ62452.
PRIDEQ62452.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000073772; ENSMUSP00000073444; ENSMUSG00000090175. [Q62452-1]
GeneID394434.
KEGGmmu:394434.
UCSCuc007byb.1. mouse. [Q62452-1]

Organism-specific databases

CTD54600.
MGIMGI:3576092. Ugt1a9.

Phylogenomic databases

GeneTreeENSGT00640000091365.
HOGENOMHOG000220832.
HOVERGENHBG004033.
KOK00699.
OMALISHTSI.
OrthoDBEOG7GBFWS.
TreeFamTF315472.

Gene expression databases

BgeeQ62452.
GenevestigatorQ62452.

Family and domain databases

InterProIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERPTHR11926. PTHR11926. 1 hit.
PfamPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio405989.
PROQ62452.
SOURCESearch...

Entry information

Entry nameUD19_MOUSE
AccessionPrimary (citable) accession number: Q62452
Secondary accession number(s): A6H6W3, E9QN27, Q6XL44
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot