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Protein

UDP-glucuronosyltransferase 1-9

Gene

Ugt1a9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

GO - Molecular functioni

  1. drug binding Source: MGI
  2. enzyme binding Source: MGI
  3. enzyme inhibitor activity Source: MGI
  4. fatty acid binding Source: MGI
  5. glucuronosyltransferase activity Source: GO_Central
  6. protein heterodimerization activity Source: MGI
  7. protein homodimerization activity Source: MGI
  8. protein kinase C binding Source: MGI
  9. steroid binding Source: MGI

GO - Biological processi

  1. cellular response to hormone stimulus Source: GO_Central
  2. flavonoid biosynthetic process Source: GO_Central
  3. flavonoid glucuronidation Source: GO_Central
  4. negative regulation of catalytic activity Source: GOC
  5. xenobiotic glucuronidation Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiREACT_198602. PPARA activates gene expression.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferase 1-9 (EC:2.4.1.17)
Short name:
UDPGT 1-9
Short name:
UGT1*9
Short name:
UGT1-09
Short name:
UGT1.9
Alternative name(s):
UDP-glucuronosyltransferase 1-7
Short name:
UDPGT
UDP-glucuronosyltransferase 1A9
UGT1A12
UGTP4
Gene namesi
Name:Ugt1a9
Synonyms:Ugt1, Ugt1a12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:3576092. Ugt1a9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei486 – 50621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: MGI
  2. endoplasmic reticulum membrane Source: GO_Central
  3. extracellular vesicular exosome Source: MGI
  4. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 528505UDP-glucuronosyltransferase 1-9PRO_0000036020Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
Modified residuei97 – 971N6-succinyllysine1 Publication
Glycosylationi290 – 2901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi428 – 4281N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ62452.
PRIDEiQ62452.

PTM databases

PhosphoSiteiQ62452.

Expressioni

Tissue specificityi

Highly expressed in liver and at lower levels in stomach and kidney.1 Publication

Gene expression databases

BgeeiQ62452.
GenevestigatoriQ62452.

Interactioni

Protein-protein interaction databases

IntActiQ62452. 3 interactions.
MINTiMINT-1852202.

Structurei

3D structure databases

ProteinModelPortaliQ62452.
SMRiQ62452. Positions 279-439.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDP-glycosyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220832.
HOVERGENiHBG004033.
InParanoidiQ62452.
KOiK00699.
OMAiEVINNTR.
OrthoDBiEOG7GBFWS.
TreeFamiTF315472.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: A number of isoforms may be produced. Isoforms have a different N-terminal domain and a common C-terminal domain of 245 residues.

Isoform 1 (identifier: Q62452-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPVAFPTSF FLCLLLASGL AQAGRLLVVP MDGSHWFTMQ MVVEKLIHRG
60 70 80 90 100
HEVVVVIPEV SWQLGKSLNC TVKTYSISHT LEDLDREFKY LSYTQWKTPE
110 120 130 140 150
HSIRSFLTGS ARGFFELTFS HCRSLFNDKK LVEYLKQRFF DAVFLDPFDV
160 170 180 190 200
CGLIVAKYFS LPSVIFARGV FCDYLEEGAQ CPSLPSYVPR LFSKYTDTMT
210 220 230 240 250
FKERVWNHLI YIEEHAFCSY FLRTAVEVAS EILQTPVTMT DLFSPVSIWL
260 270 280 290 300
LRTDFVLEFP RPVMPNMVFI GGINCLQKKS LSKEFEAYVN ASGEHGIVVF
310 320 330 340 350
SLGSMVSEIP EKKAMEIAEA LGRIPQTVLW RYTGTRPSNL AKNTILVKWL
360 370 380 390 400
PQNDLLGHPK TRAFITHSGS HGIYEGICNG VPMVMMPLFG DQMDNAKRME
410 420 430 440 450
TRGAGVTLNV LEMTADDLEN ALKTVINNKS YKENIMRLSS LHKDRPIEPL
460 470 480 490 500
DLAVFWVEYV MRHKGAPHLR PAAHDLTWYQ YHSLDVIGFL LAIVLTVVFI
510 520
VFKCCAYGCR KCFGGKGRVK KSHKSKTH
Length:528
Mass (Da):60,008
Last modified:July 27, 2011 - v3
Checksum:iB051E4F510EADCB4
GO

Sequence cautioni

The sequence AAA40524.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti139 – 1391F → S in AAP48599. (PubMed:14672974)Curated
Sequence conflicti139 – 1391F → S in AAI46022. (PubMed:15489334)Curated
Sequence conflicti139 – 1391F → S in AAI38700. (PubMed:15489334)Curated
Sequence conflicti179 – 1791A → G in AAP48599. (PubMed:14672974)Curated
Sequence conflicti179 – 1791A → G in AAI46022. (PubMed:15489334)Curated
Sequence conflicti179 – 1791A → G in AAI38700. (PubMed:15489334)Curated
Sequence conflicti356 – 3561L → I in AAA40524. (PubMed:8464825)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY227200 mRNA. Translation: AAP48599.1.
AC087780 Genomic DNA. No translation available.
AC087801 Genomic DNA. No translation available.
BC138699 mRNA. Translation: AAI38700.1.
BC146021 mRNA. Translation: AAI46022.1.
L27122 mRNA. Translation: AAA40524.1. Different initiation.
CCDSiCCDS15138.1. [Q62452-1]
RefSeqiNP_964006.2. NM_201644.2. [Q62452-1]
UniGeneiMm.300095.

Genome annotation databases

EnsembliENSMUST00000073772; ENSMUSP00000073444; ENSMUSG00000090175. [Q62452-1]
GeneIDi394434.
KEGGimmu:394434.
UCSCiuc007byb.1. mouse. [Q62452-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY227200 mRNA. Translation: AAP48599.1.
AC087780 Genomic DNA. No translation available.
AC087801 Genomic DNA. No translation available.
BC138699 mRNA. Translation: AAI38700.1.
BC146021 mRNA. Translation: AAI46022.1.
L27122 mRNA. Translation: AAA40524.1. Different initiation.
CCDSiCCDS15138.1. [Q62452-1]
RefSeqiNP_964006.2. NM_201644.2. [Q62452-1]
UniGeneiMm.300095.

3D structure databases

ProteinModelPortaliQ62452.
SMRiQ62452. Positions 279-439.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ62452. 3 interactions.
MINTiMINT-1852202.

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

PTM databases

PhosphoSiteiQ62452.

Proteomic databases

MaxQBiQ62452.
PRIDEiQ62452.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073772; ENSMUSP00000073444; ENSMUSG00000090175. [Q62452-1]
GeneIDi394434.
KEGGimmu:394434.
UCSCiuc007byb.1. mouse. [Q62452-1]

Organism-specific databases

CTDi54600.
MGIiMGI:3576092. Ugt1a9.

Phylogenomic databases

GeneTreeiENSGT00760000118949.
HOGENOMiHOG000220832.
HOVERGENiHBG004033.
InParanoidiQ62452.
KOiK00699.
OMAiEVINNTR.
OrthoDBiEOG7GBFWS.
TreeFamiTF315472.

Enzyme and pathway databases

ReactomeiREACT_198602. PPARA activates gene expression.

Miscellaneous databases

NextBioi405989.
PROiQ62452.
SOURCEiSearch...

Gene expression databases

BgeeiQ62452.
GenevestigatoriQ62452.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation."
    Zhang T., Haws P., Wu Q.
    Genome Res. 14:79-89(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Stomach.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Molecular cloning of two cDNAs encoding the mouse bilirubin/phenol family of UDP-glucuronosyltransferases (mUGTBr/p)."
    Kong A.N., Ma M., Tao D., Yang L.
    Pharm. Res. 10:461-465(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-528.
    Strain: BALB/c.
    Tissue: Liver.
  5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-97, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiUD19_MOUSE
AccessioniPrimary (citable) accession number: Q62452
Secondary accession number(s): A6H6W3, E9QN27, Q6XL44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: February 4, 2015
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.