Reviewed, UniProtKB/Swiss-Prot Q62452 (UD19_MOUSE)

Names and origin

Protein names

Recommended name:
    UDP-glucuronosyltransferase 1-9
    EC=2.4.1.17
Alternative name(s):
    UDP-glucuronosyltransferase 1-7
      Short name=UDPGT
    UGT1*9
    UGT1-09
      Short name=UGT1.9
    UGT1A9
    UGT1A12
    UGTP4

Gene names

Name:	Ugt1a9
Synonyms:	Ugt1, Ugt1a12

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	528 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Microsome. Endoplasmic reticulum membrane; Single-pass membrane protein Potential.
Tissue specificity	Highly expressed in liver. Ref.1
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Coding sequence diversity	Alternative splicing
Domain	Signal Transmembrane
Molecular function	Glycosyltransferase Transferase
PTM	Acetylation Glycoprotein
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucuronosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select]

Note: A number of isoforms may be produced. Isoforms have a different N-terminal domain and a common C-terminal domain of 245 residues.

Isoform 1 (identifier: Q62452-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 528	505	UDP-glucuronosyltransferase 1-9		PRO_0000036020
Regions
	Transmembrane	486 – 506	21	Potential
Amino acid modifications
	Modified residue	348	1	N6-acetyllysine Ref.3
	Glycosylation	69	1	N-linked (GlcNAc...) Potential
	Glycosylation	290	1	N-linked (GlcNAc...) Potential
	Glycosylation	428	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	139	1	F → S in AAP48599. Ref.1
	Sequence conflict	179	1	A → G in AAP48599. Ref.1
	Sequence conflict	356	1	I → L in AAP48599. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 9, 2007. Version 2. Checksum: 338C5228A4FE8F3C	FASTA	528	60,008
	10 20 30 40 50 60 MAPVAFPTSF FLCLLLASGL AQAGRLLVVP MDGSHWFTMQ MVVEKLIHRG HEVVVVIPEV 70 80 90 100 110 120 SWQLGKSLNC TVKTYSISHT LEDLDREFKY LSYTQWKTPE HSIRSFLTGS ARGFFELTFS 130 140 150 160 170 180 HCRSLFNDKK LVEYLKQRFF DAVFLDPFDV CGLIVAKYFS LPSVIFARGV FCDYLEEGAQ 190 200 210 220 230 240 CPSLPSYVPR LFSKYTDTMT FKERVWNHLI YIEEHAFCSY FLRTAVEVAS EILQTPVTMT 250 260 270 280 290 300 DLFSPVSIWL LRTDFVLEFP RPVMPNMVFI GGINCLQKKS LSKEFEAYVN ASGEHGIVVF 310 320 330 340 350 360 SLGSMVSEIP EKKAMEIAEA LGRIPQTVLW RYTGTRPSNL AKNTILVKWL PQNDLIGHPK 370 380 390 400 410 420 TRAFITHSGS HGIYEGICNG VPMVMMPLFG DQMDNAKRME TRGAGVTLNV LEMTADDLEN 430 440 450 460 470 480 ALKTVINNKS YKENIMRLSS LHKDRPIEPL DLAVFWVEYV MRHKGAPHLR PAAHDLTWYQ 490 500 510 520 YHSLDVIGFL LAIVLTVVFI VFKCCAYGCR KCFGGKGRVK KSHKSKTH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation." Zhang T., Haws P., Wu Q. Genome Res. 14:79-89(2004) [PubMed: 14672974] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Stomach.
[2]	"Molecular cloning of two cDNAs encoding the mouse bilirubin/phenol family of UDP-glucuronosyltransferases (mUGTBr/p)." Kong A.N., Ma M., Tao D., Yang L. Pharm. Res. 10:461-465(1993) [PubMed: 8464825] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-528. Strain: BALB/c. Tissue: Liver.
[3]	"Substrate and functional diversity of lysine acetylation revealed by a proteomics survey." Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T., Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y. Mol. Cell 23:607-618(2006) [PubMed: 16916647] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-348, MASS SPECTROMETRY. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY227200 mRNA. Translation: AAP48599.1. L27122 mRNA. Translation: AAA40524.1. Different initiation.
IPI	IPI00785460.
RefSeq	NP_964006.2.
UniGene	Mm.300095
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
PTM databases
PhosphoSite	Q62452.
Genome annotation databases
Ensembl	ENSMUSG00000054545. Mus musculus. [Contig view]
GeneID	394434.
KEGG	mmu:394434.
Organism-specific databases
MGI	MGI:3576092. Ugt1a9.
Phylogenomic databases
HOVERGEN	Q62452.
Enzyme and pathway databases
BRENDA	2.4.1.17. 244.
Gene expression databases
ArrayExpress	Q62452.
Bgee	Q62452.
GermOnline	ENSMUSG00000054545. Mus musculus.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	405989.
SOURCE	Search...

Entry information

Entry name

UD19_MOUSE

Accession

Primary (citable) accession number: Q62452
Secondary accession number(s): Q6XL44

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	January 9, 2007
Last modified:	June 16, 2009
This is version 68 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)