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Q62452

- UD19_MOUSE

UniProt

Q62452 - UD19_MOUSE

Protein

UDP-glucuronosyltransferase 1-9

Gene

Ugt1a9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.

    Catalytic activityi

    UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.

    GO - Molecular functioni

    1. glucuronosyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    ReactomeiREACT_198602. PPARA activates gene expression.

    Protein family/group databases

    CAZyiGT1. Glycosyltransferase Family 1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UDP-glucuronosyltransferase 1-9 (EC:2.4.1.17)
    Short name:
    UDPGT 1-9
    Short name:
    UGT1*9
    Short name:
    UGT1-09
    Short name:
    UGT1.9
    Alternative name(s):
    UDP-glucuronosyltransferase 1-7
    Short name:
    UDPGT
    UDP-glucuronosyltransferase 1A9
    UGT1A12
    UGTP4
    Gene namesi
    Name:Ugt1a9
    Synonyms:Ugt1, Ugt1a12
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:3576092. Ugt1a9.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 528505UDP-glucuronosyltransferase 1-9PRO_0000036020Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
    Modified residuei97 – 971N6-succinyllysine1 Publication
    Glycosylationi290 – 2901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi428 – 4281N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ62452.
    PRIDEiQ62452.

    PTM databases

    PhosphoSiteiQ62452.

    Expressioni

    Tissue specificityi

    Highly expressed in liver and at lower levels in stomach and kidney.1 Publication

    Gene expression databases

    BgeeiQ62452.
    GenevestigatoriQ62452.

    Interactioni

    Protein-protein interaction databases

    IntActiQ62452. 3 interactions.
    MINTiMINT-1852202.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62452.
    SMRiQ62452. Positions 279-439.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei486 – 50621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UDP-glycosyltransferase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    GeneTreeiENSGT00640000091365.
    HOGENOMiHOG000220832.
    HOVERGENiHBG004033.
    KOiK00699.
    OMAiLISHTSI.
    OrthoDBiEOG7GBFWS.
    TreeFamiTF315472.

    Family and domain databases

    InterProiIPR002213. UDP_glucos_trans.
    [Graphical view]
    PANTHERiPTHR11926. PTHR11926. 1 hit.
    PfamiPF00201. UDPGT. 1 hit.
    [Graphical view]
    PROSITEiPS00375. UDPGT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 1 isoform i produced by alternative splicing. Align

    Note: A number of isoforms may be produced. Isoforms have a different N-terminal domain and a common C-terminal domain of 245 residues.

    Isoform 1 (identifier: Q62452-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAPVAFPTSF FLCLLLASGL AQAGRLLVVP MDGSHWFTMQ MVVEKLIHRG    50
    HEVVVVIPEV SWQLGKSLNC TVKTYSISHT LEDLDREFKY LSYTQWKTPE 100
    HSIRSFLTGS ARGFFELTFS HCRSLFNDKK LVEYLKQRFF DAVFLDPFDV 150
    CGLIVAKYFS LPSVIFARGV FCDYLEEGAQ CPSLPSYVPR LFSKYTDTMT 200
    FKERVWNHLI YIEEHAFCSY FLRTAVEVAS EILQTPVTMT DLFSPVSIWL 250
    LRTDFVLEFP RPVMPNMVFI GGINCLQKKS LSKEFEAYVN ASGEHGIVVF 300
    SLGSMVSEIP EKKAMEIAEA LGRIPQTVLW RYTGTRPSNL AKNTILVKWL 350
    PQNDLLGHPK TRAFITHSGS HGIYEGICNG VPMVMMPLFG DQMDNAKRME 400
    TRGAGVTLNV LEMTADDLEN ALKTVINNKS YKENIMRLSS LHKDRPIEPL 450
    DLAVFWVEYV MRHKGAPHLR PAAHDLTWYQ YHSLDVIGFL LAIVLTVVFI 500
    VFKCCAYGCR KCFGGKGRVK KSHKSKTH 528
    Length:528
    Mass (Da):60,008
    Last modified:July 27, 2011 - v3
    Checksum:iB051E4F510EADCB4
    GO

    Sequence cautioni

    The sequence AAA40524.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti139 – 1391F → S in AAP48599. (PubMed:14672974)Curated
    Sequence conflicti139 – 1391F → S in AAI46022. (PubMed:15489334)Curated
    Sequence conflicti139 – 1391F → S in AAI38700. (PubMed:15489334)Curated
    Sequence conflicti179 – 1791A → G in AAP48599. (PubMed:14672974)Curated
    Sequence conflicti179 – 1791A → G in AAI46022. (PubMed:15489334)Curated
    Sequence conflicti179 – 1791A → G in AAI38700. (PubMed:15489334)Curated
    Sequence conflicti356 – 3561L → I in AAA40524. (PubMed:8464825)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY227200 mRNA. Translation: AAP48599.1.
    AC087780 Genomic DNA. No translation available.
    AC087801 Genomic DNA. No translation available.
    BC138699 mRNA. Translation: AAI38700.1.
    BC146021 mRNA. Translation: AAI46022.1.
    L27122 mRNA. Translation: AAA40524.1. Different initiation.
    CCDSiCCDS15138.1. [Q62452-1]
    RefSeqiNP_964006.2. NM_201644.2. [Q62452-1]
    UniGeneiMm.300095.

    Genome annotation databases

    EnsembliENSMUST00000073772; ENSMUSP00000073444; ENSMUSG00000090175. [Q62452-1]
    GeneIDi394434.
    KEGGimmu:394434.
    UCSCiuc007byb.1. mouse. [Q62452-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY227200 mRNA. Translation: AAP48599.1 .
    AC087780 Genomic DNA. No translation available.
    AC087801 Genomic DNA. No translation available.
    BC138699 mRNA. Translation: AAI38700.1 .
    BC146021 mRNA. Translation: AAI46022.1 .
    L27122 mRNA. Translation: AAA40524.1 . Different initiation.
    CCDSi CCDS15138.1. [Q62452-1 ]
    RefSeqi NP_964006.2. NM_201644.2. [Q62452-1 ]
    UniGenei Mm.300095.

    3D structure databases

    ProteinModelPortali Q62452.
    SMRi Q62452. Positions 279-439.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q62452. 3 interactions.
    MINTi MINT-1852202.

    Protein family/group databases

    CAZyi GT1. Glycosyltransferase Family 1.

    PTM databases

    PhosphoSitei Q62452.

    Proteomic databases

    MaxQBi Q62452.
    PRIDEi Q62452.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000073772 ; ENSMUSP00000073444 ; ENSMUSG00000090175 . [Q62452-1 ]
    GeneIDi 394434.
    KEGGi mmu:394434.
    UCSCi uc007byb.1. mouse. [Q62452-1 ]

    Organism-specific databases

    CTDi 54600.
    MGIi MGI:3576092. Ugt1a9.

    Phylogenomic databases

    GeneTreei ENSGT00640000091365.
    HOGENOMi HOG000220832.
    HOVERGENi HBG004033.
    KOi K00699.
    OMAi LISHTSI.
    OrthoDBi EOG7GBFWS.
    TreeFami TF315472.

    Enzyme and pathway databases

    Reactomei REACT_198602. PPARA activates gene expression.

    Miscellaneous databases

    NextBioi 405989.
    PROi Q62452.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q62452.
    Genevestigatori Q62452.

    Family and domain databases

    InterProi IPR002213. UDP_glucos_trans.
    [Graphical view ]
    PANTHERi PTHR11926. PTHR11926. 1 hit.
    Pfami PF00201. UDPGT. 1 hit.
    [Graphical view ]
    PROSITEi PS00375. UDPGT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation."
      Zhang T., Haws P., Wu Q.
      Genome Res. 14:79-89(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Stomach.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Molecular cloning of two cDNAs encoding the mouse bilirubin/phenol family of UDP-glucuronosyltransferases (mUGTBr/p)."
      Kong A.N., Ma M., Tao D., Yang L.
      Pharm. Res. 10:461-465(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-528.
      Strain: BALB/c.
      Tissue: Liver.
    5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-97, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiUD19_MOUSE
    AccessioniPrimary (citable) accession number: Q62452
    Secondary accession number(s): A6H6W3, E9QN27, Q6XL44
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 108 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3