ID   CCNC_MOUSE              Reviewed;         283 AA.
AC   Q62447; Q0P542; Q5XKQ9; Q9WUZ4;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 4.
DT   27-MAR-2024, entry version 174.
DE   RecName: Full=Cyclin-C;
GN   Name=Ccnc;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RA   Chi P., Mifflin R., Thompson E.A.;
RL   Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=NMRI; TISSUE=Brain, and Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-46.
RA   Barette C., Dulic V., Piette J.;
RT   "Transcription of the cyclin C gene.";
RL   Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC       regulated gene transcription of nearly all RNA polymerase II-dependent
CC       genes. Mediator functions as a bridge to convey information from gene-
CC       specific regulatory proteins to the basal RNA polymerase II
CC       transcription machinery. Mediator is recruited to promoters by direct
CC       interactions with regulatory proteins and serves as a scaffold for the
CC       assembly of a functional preinitiation complex with RNA polymerase II
CC       and the general transcription factors. Binds to and activates cyclin-
CC       dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain)
CC       of the large subunit of RNA polymerase II (RNAp II), which may inhibit
CC       the formation of a transcription initiation complex (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Mediator complex, which is composed of MED1,
CC       MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L,
CC       MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23,
CC       MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and
CC       CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct
CC       module termed the CDK8 module. Mediator containing the CDK8 module is
CC       less active than Mediator lacking this module in supporting
CC       transcriptional activation. Individual preparations of the Mediator
CC       complex lacking one or more distinct subunits have been variously
CC       termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. The cylin/CDK pair formed
CC       by CCNC/CDK8 also associates with the large subunit of RNA polymerase
CC       II (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cyclin family. Cyclin C subfamily.
CC       {ECO:0000305}.
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DR   EMBL; U62638; AAB05260.1; -; mRNA.
DR   EMBL; U49050; AAD11444.1; -; Genomic_DNA.
DR   EMBL; AL772187; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH466538; EDL05561.1; -; Genomic_DNA.
DR   EMBL; BC003344; AAH03344.2; -; mRNA.
DR   EMBL; BC120649; AAI20650.1; -; mRNA.
DR   EMBL; BC120677; AAI20678.1; -; mRNA.
DR   EMBL; AJ243075; CAB45390.1; -; Genomic_DNA.
DR   EMBL; AJ243076; CAB45390.1; JOINED; Genomic_DNA.
DR   CCDS; CCDS17998.1; -.
DR   RefSeq; NP_001277351.1; NM_001290422.1.
DR   RefSeq; NP_058026.2; NM_016746.4.
DR   AlphaFoldDB; Q62447; -.
DR   SMR; Q62447; -.
DR   BioGRID; 206188; 3.
DR   ComplexPortal; CPX-3266; CKM complex variant 1.
DR   ComplexPortal; CPX-3267; CKM complex variant 2.
DR   ComplexPortal; CPX-331; Cyclin C-CDK3 complex.
DR   CORUM; Q62447; -.
DR   DIP; DIP-61081N; -.
DR   IntAct; Q62447; 4.
DR   STRING; 10090.ENSMUSP00000100062; -.
DR   BindingDB; Q62447; -.
DR   ChEMBL; CHEMBL4296068; -.
DR   PhosphoSitePlus; Q62447; -.
DR   EPD; Q62447; -.
DR   MaxQB; Q62447; -.
DR   PaxDb; 10090-ENSMUSP00000100062; -.
DR   ProteomicsDB; 281127; -.
DR   Pumba; Q62447; -.
DR   Antibodypedia; 4188; 407 antibodies from 32 providers.
DR   DNASU; 51813; -.
DR   Ensembl; ENSMUST00000102997.8; ENSMUSP00000100062.2; ENSMUSG00000028252.21.
DR   GeneID; 51813; -.
DR   KEGG; mmu:51813; -.
DR   UCSC; uc008scu.3; mouse.
DR   AGR; MGI:1858199; -.
DR   CTD; 892; -.
DR   MGI; MGI:1858199; Ccnc.
DR   VEuPathDB; HostDB:ENSMUSG00000028252; -.
DR   eggNOG; KOG0794; Eukaryota.
DR   GeneTree; ENSGT00940000155625; -.
DR   InParanoid; Q62447; -.
DR   OMA; KVAHSQF; -.
DR   OrthoDB; 102875at2759; -.
DR   PhylomeDB; Q62447; -.
DR   Reactome; R-MMU-2173796; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
DR   BioGRID-ORCS; 51813; 23 hits in 81 CRISPR screens.
DR   ChiTaRS; Ccnc; mouse.
DR   PRO; PR:Q62447; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   RNAct; Q62447; Protein.
DR   Bgee; ENSMUSG00000028252; Expressed in ectoplacental cone and 256 other cell types or tissues.
DR   ExpressionAtlas; Q62447; baseline and differential.
DR   GO; GO:1990508; C:CKM complex; ISO:MGI.
DR   GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; ISO:MGI.
DR   GO; GO:0016592; C:mediator complex; IDA:MGI.
DR   GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000151; C:ubiquitin ligase complex; ISO:MGI.
DR   GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR   GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR   GO; GO:0045023; P:G0 to G1 transition; ISO:MGI.
DR   GO; GO:0045746; P:negative regulation of Notch signaling pathway; ISO:MGI.
DR   GO; GO:0090209; P:negative regulation of triglyceride metabolic process; ISO:MGI.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0016567; P:protein ubiquitination; ISO:MGI.
DR   CDD; cd20513; CYCLIN_CCNC_rpt1; 1.
DR   CDD; cd20514; CYCLIN_CCNC_rpt2; 1.
DR   Gene3D; 1.10.472.10; Cyclin-like; 2.
DR   InterPro; IPR013763; Cyclin-like_dom.
DR   InterPro; IPR036915; Cyclin-like_sf.
DR   InterPro; IPR043198; Cyclin/Ssn8.
DR   InterPro; IPR031658; Cyclin_C_2.
DR   InterPro; IPR006671; Cyclin_N.
DR   PANTHER; PTHR10026; CYCLIN; 1.
DR   PANTHER; PTHR10026:SF7; CYCLIN-C; 1.
DR   Pfam; PF16899; Cyclin_C_2; 1.
DR   Pfam; PF00134; Cyclin_N; 1.
DR   PIRSF; PIRSF028758; Cyclin, C/H/G types; 1.
DR   SMART; SM00385; CYCLIN; 2.
DR   SUPFAM; SSF47954; Cyclin-like; 2.
DR   Genevisible; Q62447; MM.
PE   2: Evidence at transcript level;
KW   Activator; Cyclin; Nucleus; Phosphoprotein; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..283
FT                   /note="Cyclin-C"
FT                   /id="PRO_0000080421"
FT   DOMAIN          20..151
FT                   /note="Cyclin N-terminal"
FT   REGION          252..283
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        268..283
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         275
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P24863"
FT   CONFLICT        73
FT                   /note="Y -> D (in Ref. 1; AAB05260)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   283 AA;  33241 MW;  DE2065E2E4C304FC CRC64;
     MAGNFWQSSH YLQWILDKQD LLKERQKDLK FLSEEEYWKL QIFFTNVIQA LGEHLKLRQQ
     VIATATVYFK RFYARYSLKS IDPVLMAPTC VFLASKVEEF GVVSNTRLIA ATTSVLKTRF
     SYAFPKEFPY RMNHILECEF YLLELMDCCL IVYHPYRPLL QYVQDMGQED VLLPLAWRIV
     NDTYRTDLCL LYPPFMIALA CLHVACVVQQ KDARQWFAEL SVDMEKILEI IRVILKLYEQ
     WKNFDERKEM ATILSKMPKP KPPPNSEGEQ GPNGSQNSSY SQS
//