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Q62447 (CCNC_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cyclin-C
Gene names
Name:Ccnc
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length283 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex By similarity.

Subunit structure

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. The cylin/CDK pair formed by CCNC/CDK8 also associates with the large subunit of RNA polymerase II By similarity.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the cyclin family. Cyclin C subfamily.

Contains 1 cyclin N-terminal domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 283283Cyclin-C
PRO_0000080421

Regions

Domain20 – 151132Cyclin N-terminal

Amino acid modifications

Modified residue2751Phosphoserine By similarity

Experimental info

Sequence conflict731Y → D in AAB05260. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q62447 [UniParc].

Last modified October 3, 2012. Version 4.
Checksum: DE2065E2E4C304FC

FASTA28333,241
        10         20         30         40         50         60 
MAGNFWQSSH YLQWILDKQD LLKERQKDLK FLSEEEYWKL QIFFTNVIQA LGEHLKLRQQ 

        70         80         90        100        110        120 
VIATATVYFK RFYARYSLKS IDPVLMAPTC VFLASKVEEF GVVSNTRLIA ATTSVLKTRF 

       130        140        150        160        170        180 
SYAFPKEFPY RMNHILECEF YLLELMDCCL IVYHPYRPLL QYVQDMGQED VLLPLAWRIV 

       190        200        210        220        230        240 
NDTYRTDLCL LYPPFMIALA CLHVACVVQQ KDARQWFAEL SVDMEKILEI IRVILKLYEQ 

       250        260        270        280 
WKNFDERKEM ATILSKMPKP KPPPNSEGEQ GPNGSQNSSY SQS 

« Hide

References

« Hide 'large scale' references
[1]Chi P., Mifflin R., Thompson E.A.
Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: NMRI.
Tissue: Brain and Mammary tumor.
[5]"Transcription of the cyclin C gene."
Barette C., Dulic V., Piette J.
Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-46.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U62638 mRNA. Translation: AAB05260.1.
U49050 Genomic DNA. Translation: AAD11444.1.
AL772187 Genomic DNA. Translation: CAM22879.1.
CH466538 Genomic DNA. Translation: EDL05561.1.
BC003344 mRNA. Translation: AAH03344.2.
BC120649 mRNA. Translation: AAI20650.1.
BC120677 mRNA. Translation: AAI20678.1.
AJ243075, AJ243076 Genomic DNA. Translation: CAB45390.1.
CCDSCCDS17998.1.
RefSeqNP_001277351.1. NM_001290422.1.
NP_058026.2. NM_016746.4.
UniGeneMm.278584.

3D structure databases

ProteinModelPortalQ62447.
SMRQ62447. Positions 1-257.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid206188. 2 interactions.

PTM databases

PhosphoSiteQ62447.

Proteomic databases

MaxQBQ62447.
PaxDbQ62447.
PRIDEQ62447.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000102997; ENSMUSP00000100062; ENSMUSG00000028252.
GeneID51813.
KEGGmmu:51813.
UCSCuc008scu.2. mouse.
uc008scw.2. mouse.

Organism-specific databases

CTD892.
MGIMGI:1858199. Ccnc.

Phylogenomic databases

eggNOGCOG5333.
GeneTreeENSGT00690000101911.
HOGENOMHOG000008007.
HOVERGENHBG050836.
InParanoidQ62447.
KOK15161.
OMACLQIACV.
OrthoDBEOG7WX08X.

Enzyme and pathway databases

ReactomeREACT_188576. Developmental Biology.
REACT_200794. Mus musculus biological processes.

Gene expression databases

ArrayExpressQ62447.
CleanExMM_CCNC.
GenevestigatorQ62447.

Family and domain databases

Gene3D1.10.472.10. 1 hit.
InterProIPR013763. Cyclin-like.
IPR015429. Cyclin_C/H/T/L.
IPR006671. Cyclin_N.
IPR023598. CyclinC.
[Graphical view]
PANTHERPTHR10026. PTHR10026. 1 hit.
PfamPF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFPIRSF028758. PIRSF028758. 1 hit.
SMARTSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMSSF47954. SSF47954. 2 hits.
ProtoNetSearch...

Other

NextBio308072.
PROQ62447.
SOURCESearch...

Entry information

Entry nameCCNC_MOUSE
AccessionPrimary (citable) accession number: Q62447
Secondary accession number(s): Q0P542, Q5XKQ9, Q9WUZ4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 111 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot