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Q62447

- CCNC_MOUSE

UniProt

Q62447 - CCNC_MOUSE

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Protein

Cyclin-C

Gene

Ccnc

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex (By similarity).By similarity

GO - Biological processi

  1. regulation of cyclin-dependent protein serine/threonine kinase activity Source: InterPro
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Cyclin, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_196464. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_198602. PPARA activates gene expression.
REACT_203903. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
REACT_206529. Generic Transcription Pathway.
REACT_252217. Transcriptional regulation of white adipocyte differentiation.
REACT_27166. Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-C
Gene namesi
Name:Ccnc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1858199. Ccnc.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. DNA-directed RNA polymerase II, holoenzyme Source: InterPro
  2. mediator complex Source: MGI
  3. nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 283283Cyclin-CPRO_0000080421Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei275 – 2751PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ62447.
PaxDbiQ62447.
PRIDEiQ62447.

PTM databases

PhosphoSiteiQ62447.

Expressioni

Gene expression databases

CleanExiMM_CCNC.
ExpressionAtlasiQ62447. baseline.
GenevestigatoriQ62447.

Interactioni

Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. The cylin/CDK pair formed by CCNC/CDK8 also associates with the large subunit of RNA polymerase II (By similarity).By similarity

Protein-protein interaction databases

BioGridi206188. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ62447.
SMRiQ62447. Positions 1-257.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 151132Cyclin N-terminalAdd
BLAST

Sequence similaritiesi

Belongs to the cyclin family. Cyclin C subfamily.Curated
Contains 1 cyclin N-terminal domain.Curated

Phylogenomic databases

eggNOGiCOG5333.
GeneTreeiENSGT00760000119191.
HOGENOMiHOG000008007.
HOVERGENiHBG050836.
InParanoidiQ62447.
KOiK15161.
OMAiCLQIACV.
OrthoDBiEOG7WX08X.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR013763. Cyclin-like.
IPR015429. Cyclin_C/H/T/L.
IPR006671. Cyclin_N.
IPR023598. CyclinC.
[Graphical view]
PANTHERiPTHR10026. PTHR10026. 1 hit.
PfamiPF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF028758. PIRSF028758. 1 hit.
SMARTiSM00385. CYCLIN. 2 hits.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.

Sequencei

Sequence statusi: Complete.

Q62447-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGNFWQSSH YLQWILDKQD LLKERQKDLK FLSEEEYWKL QIFFTNVIQA
60 70 80 90 100
LGEHLKLRQQ VIATATVYFK RFYARYSLKS IDPVLMAPTC VFLASKVEEF
110 120 130 140 150
GVVSNTRLIA ATTSVLKTRF SYAFPKEFPY RMNHILECEF YLLELMDCCL
160 170 180 190 200
IVYHPYRPLL QYVQDMGQED VLLPLAWRIV NDTYRTDLCL LYPPFMIALA
210 220 230 240 250
CLHVACVVQQ KDARQWFAEL SVDMEKILEI IRVILKLYEQ WKNFDERKEM
260 270 280
ATILSKMPKP KPPPNSEGEQ GPNGSQNSSY SQS
Length:283
Mass (Da):33,241
Last modified:October 3, 2012 - v4
Checksum:iDE2065E2E4C304FC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti73 – 731Y → D in AAB05260. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62638 mRNA. Translation: AAB05260.1.
U49050 Genomic DNA. Translation: AAD11444.1.
AL772187 Genomic DNA. Translation: CAM22879.1.
CH466538 Genomic DNA. Translation: EDL05561.1.
BC003344 mRNA. Translation: AAH03344.2.
BC120649 mRNA. Translation: AAI20650.1.
BC120677 mRNA. Translation: AAI20678.1.
AJ243075, AJ243076 Genomic DNA. Translation: CAB45390.1.
CCDSiCCDS17998.1.
RefSeqiNP_001277351.1. NM_001290422.1.
NP_058026.2. NM_016746.4.
UniGeneiMm.278584.

Genome annotation databases

EnsembliENSMUST00000102997; ENSMUSP00000100062; ENSMUSG00000028252.
GeneIDi51813.
KEGGimmu:51813.
UCSCiuc008scu.2. mouse.
uc008scw.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62638 mRNA. Translation: AAB05260.1 .
U49050 Genomic DNA. Translation: AAD11444.1 .
AL772187 Genomic DNA. Translation: CAM22879.1 .
CH466538 Genomic DNA. Translation: EDL05561.1 .
BC003344 mRNA. Translation: AAH03344.2 .
BC120649 mRNA. Translation: AAI20650.1 .
BC120677 mRNA. Translation: AAI20678.1 .
AJ243075 , AJ243076 Genomic DNA. Translation: CAB45390.1 .
CCDSi CCDS17998.1.
RefSeqi NP_001277351.1. NM_001290422.1.
NP_058026.2. NM_016746.4.
UniGenei Mm.278584.

3D structure databases

ProteinModelPortali Q62447.
SMRi Q62447. Positions 1-257.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 206188. 2 interactions.

PTM databases

PhosphoSitei Q62447.

Proteomic databases

MaxQBi Q62447.
PaxDbi Q62447.
PRIDEi Q62447.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000102997 ; ENSMUSP00000100062 ; ENSMUSG00000028252 .
GeneIDi 51813.
KEGGi mmu:51813.
UCSCi uc008scu.2. mouse.
uc008scw.2. mouse.

Organism-specific databases

CTDi 892.
MGIi MGI:1858199. Ccnc.

Phylogenomic databases

eggNOGi COG5333.
GeneTreei ENSGT00760000119191.
HOGENOMi HOG000008007.
HOVERGENi HBG050836.
InParanoidi Q62447.
KOi K15161.
OMAi CLQIACV.
OrthoDBi EOG7WX08X.

Enzyme and pathway databases

Reactomei REACT_196464. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_198602. PPARA activates gene expression.
REACT_203903. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
REACT_206529. Generic Transcription Pathway.
REACT_252217. Transcriptional regulation of white adipocyte differentiation.
REACT_27166. Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes.

Miscellaneous databases

NextBioi 308072.
PROi Q62447.
SOURCEi Search...

Gene expression databases

CleanExi MM_CCNC.
ExpressionAtlasi Q62447. baseline.
Genevestigatori Q62447.

Family and domain databases

Gene3Di 1.10.472.10. 1 hit.
InterProi IPR013763. Cyclin-like.
IPR015429. Cyclin_C/H/T/L.
IPR006671. Cyclin_N.
IPR023598. CyclinC.
[Graphical view ]
PANTHERi PTHR10026. PTHR10026. 1 hit.
Pfami PF00134. Cyclin_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF028758. PIRSF028758. 1 hit.
SMARTi SM00385. CYCLIN. 2 hits.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Chi P., Mifflin R., Thompson E.A.
    Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NMRI.
    Tissue: Brain and Mammary tumor.
  5. "Transcription of the cyclin C gene."
    Barette C., Dulic V., Piette J.
    Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-46.

Entry informationi

Entry nameiCCNC_MOUSE
AccessioniPrimary (citable) accession number: Q62447
Secondary accession number(s): Q0P542, Q5XKQ9, Q9WUZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 3, 2012
Last modified: November 26, 2014
This is version 115 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3