Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q62447

- CCNC_MOUSE

UniProt

Q62447 - CCNC_MOUSE

Protein

Cyclin-C

Gene

Ccnc

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 4 (03 Oct 2012)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex By similarity.By similarity

    GO - Biological processi

    1. regulation of cyclin-dependent protein serine/threonine kinase activity Source: InterPro
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Cyclin, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    ReactomeiREACT_196464. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    REACT_198602. PPARA activates gene expression.
    REACT_203903. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
    REACT_206529. Generic Transcription Pathway.
    REACT_27166. Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-C
    Gene namesi
    Name:Ccnc
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1858199. Ccnc.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. DNA-directed RNA polymerase II, holoenzyme Source: InterPro
    2. mediator complex Source: MGI
    3. nucleoplasm Source: Reactome

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 283283Cyclin-CPRO_0000080421Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei275 – 2751PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ62447.
    PaxDbiQ62447.
    PRIDEiQ62447.

    PTM databases

    PhosphoSiteiQ62447.

    Expressioni

    Gene expression databases

    ArrayExpressiQ62447.
    CleanExiMM_CCNC.
    GenevestigatoriQ62447.

    Interactioni

    Subunit structurei

    Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. The cylin/CDK pair formed by CCNC/CDK8 also associates with the large subunit of RNA polymerase II By similarity.By similarity

    Protein-protein interaction databases

    BioGridi206188. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62447.
    SMRiQ62447. Positions 1-257.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 151132Cyclin N-terminalAdd
    BLAST

    Sequence similaritiesi

    Belongs to the cyclin family. Cyclin C subfamily.Curated
    Contains 1 cyclin N-terminal domain.Curated

    Phylogenomic databases

    eggNOGiCOG5333.
    GeneTreeiENSGT00690000101911.
    HOGENOMiHOG000008007.
    HOVERGENiHBG050836.
    InParanoidiQ62447.
    KOiK15161.
    OMAiCLQIACV.
    OrthoDBiEOG7WX08X.

    Family and domain databases

    Gene3Di1.10.472.10. 1 hit.
    InterProiIPR013763. Cyclin-like.
    IPR015429. Cyclin_C/H/T/L.
    IPR006671. Cyclin_N.
    IPR023598. CyclinC.
    [Graphical view]
    PANTHERiPTHR10026. PTHR10026. 1 hit.
    PfamiPF00134. Cyclin_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF028758. PIRSF028758. 1 hit.
    SMARTiSM00385. CYCLIN. 2 hits.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q62447-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGNFWQSSH YLQWILDKQD LLKERQKDLK FLSEEEYWKL QIFFTNVIQA    50
    LGEHLKLRQQ VIATATVYFK RFYARYSLKS IDPVLMAPTC VFLASKVEEF 100
    GVVSNTRLIA ATTSVLKTRF SYAFPKEFPY RMNHILECEF YLLELMDCCL 150
    IVYHPYRPLL QYVQDMGQED VLLPLAWRIV NDTYRTDLCL LYPPFMIALA 200
    CLHVACVVQQ KDARQWFAEL SVDMEKILEI IRVILKLYEQ WKNFDERKEM 250
    ATILSKMPKP KPPPNSEGEQ GPNGSQNSSY SQS 283
    Length:283
    Mass (Da):33,241
    Last modified:October 3, 2012 - v4
    Checksum:iDE2065E2E4C304FC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti73 – 731Y → D in AAB05260. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U62638 mRNA. Translation: AAB05260.1.
    U49050 Genomic DNA. Translation: AAD11444.1.
    AL772187 Genomic DNA. Translation: CAM22879.1.
    CH466538 Genomic DNA. Translation: EDL05561.1.
    BC003344 mRNA. Translation: AAH03344.2.
    BC120649 mRNA. Translation: AAI20650.1.
    BC120677 mRNA. Translation: AAI20678.1.
    AJ243075, AJ243076 Genomic DNA. Translation: CAB45390.1.
    CCDSiCCDS17998.1.
    RefSeqiNP_001277351.1. NM_001290422.1.
    NP_058026.2. NM_016746.4.
    UniGeneiMm.278584.

    Genome annotation databases

    EnsembliENSMUST00000102997; ENSMUSP00000100062; ENSMUSG00000028252.
    GeneIDi51813.
    KEGGimmu:51813.
    UCSCiuc008scu.2. mouse.
    uc008scw.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U62638 mRNA. Translation: AAB05260.1 .
    U49050 Genomic DNA. Translation: AAD11444.1 .
    AL772187 Genomic DNA. Translation: CAM22879.1 .
    CH466538 Genomic DNA. Translation: EDL05561.1 .
    BC003344 mRNA. Translation: AAH03344.2 .
    BC120649 mRNA. Translation: AAI20650.1 .
    BC120677 mRNA. Translation: AAI20678.1 .
    AJ243075 , AJ243076 Genomic DNA. Translation: CAB45390.1 .
    CCDSi CCDS17998.1.
    RefSeqi NP_001277351.1. NM_001290422.1.
    NP_058026.2. NM_016746.4.
    UniGenei Mm.278584.

    3D structure databases

    ProteinModelPortali Q62447.
    SMRi Q62447. Positions 1-257.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 206188. 2 interactions.

    PTM databases

    PhosphoSitei Q62447.

    Proteomic databases

    MaxQBi Q62447.
    PaxDbi Q62447.
    PRIDEi Q62447.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000102997 ; ENSMUSP00000100062 ; ENSMUSG00000028252 .
    GeneIDi 51813.
    KEGGi mmu:51813.
    UCSCi uc008scu.2. mouse.
    uc008scw.2. mouse.

    Organism-specific databases

    CTDi 892.
    MGIi MGI:1858199. Ccnc.

    Phylogenomic databases

    eggNOGi COG5333.
    GeneTreei ENSGT00690000101911.
    HOGENOMi HOG000008007.
    HOVERGENi HBG050836.
    InParanoidi Q62447.
    KOi K15161.
    OMAi CLQIACV.
    OrthoDBi EOG7WX08X.

    Enzyme and pathway databases

    Reactomei REACT_196464. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
    REACT_198602. PPARA activates gene expression.
    REACT_203903. SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
    REACT_206529. Generic Transcription Pathway.
    REACT_27166. Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes.

    Miscellaneous databases

    NextBioi 308072.
    PROi Q62447.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q62447.
    CleanExi MM_CCNC.
    Genevestigatori Q62447.

    Family and domain databases

    Gene3Di 1.10.472.10. 1 hit.
    InterProi IPR013763. Cyclin-like.
    IPR015429. Cyclin_C/H/T/L.
    IPR006671. Cyclin_N.
    IPR023598. CyclinC.
    [Graphical view ]
    PANTHERi PTHR10026. PTHR10026. 1 hit.
    Pfami PF00134. Cyclin_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF028758. PIRSF028758. 1 hit.
    SMARTi SM00385. CYCLIN. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. Chi P., Mifflin R., Thompson E.A.
      Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: NMRI.
      Tissue: Brain and Mammary tumor.
    5. "Transcription of the cyclin C gene."
      Barette C., Dulic V., Piette J.
      Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-46.

    Entry informationi

    Entry nameiCCNC_MOUSE
    AccessioniPrimary (citable) accession number: Q62447
    Secondary accession number(s): Q0P542, Q5XKQ9, Q9WUZ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 113 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3