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Protein

Cyclin-C

Gene

Ccnc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Cyclin, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-212436 Generic Transcription Pathway
R-MMU-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-C
Gene namesi
Name:Ccnc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1858199 Ccnc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804211 – 283Cyclin-CAdd BLAST283

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei275PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ62447
PaxDbiQ62447
PRIDEiQ62447

PTM databases

PhosphoSitePlusiQ62447

Expressioni

Gene expression databases

BgeeiENSMUSG00000028252
CleanExiMM_CCNC
ExpressionAtlasiQ62447 baseline and differential
GenevisibleiQ62447 MM

Interactioni

Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. The cylin/CDK pair formed by CCNC/CDK8 also associates with the large subunit of RNA polymerase II (By similarity).By similarity

Protein-protein interaction databases

BioGridi206188, 2 interactors
CORUMiQ62447
DIPiDIP-61081N
IntActiQ62447, 4 interactors
STRINGi10090.ENSMUSP00000100062

Structurei

3D structure databases

ProteinModelPortaliQ62447
SMRiQ62447
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 151Cyclin N-terminalAdd BLAST132

Sequence similaritiesi

Belongs to the cyclin family. Cyclin C subfamily.Curated

Phylogenomic databases

eggNOGiKOG0794 Eukaryota
COG5333 LUCA
GeneTreeiENSGT00760000119191
HOGENOMiHOG000008007
HOVERGENiHBG050836
InParanoidiQ62447
KOiK15161
OMAiSSHHQQW
OrthoDBiEOG091G0FSG

Family and domain databases

CDDicd00043 CYCLIN, 2 hits
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR031658 Cyclin_C_2
IPR006671 Cyclin_N
IPR028367 CyclinC/Ssn8
PANTHERiPTHR10026:SF7 PTHR10026:SF7, 1 hit
PfamiView protein in Pfam
PF16899 Cyclin_C_2, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SUPFAMiSSF47954 SSF47954, 2 hits

Sequencei

Sequence statusi: Complete.

Q62447-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGNFWQSSH YLQWILDKQD LLKERQKDLK FLSEEEYWKL QIFFTNVIQA
60 70 80 90 100
LGEHLKLRQQ VIATATVYFK RFYARYSLKS IDPVLMAPTC VFLASKVEEF
110 120 130 140 150
GVVSNTRLIA ATTSVLKTRF SYAFPKEFPY RMNHILECEF YLLELMDCCL
160 170 180 190 200
IVYHPYRPLL QYVQDMGQED VLLPLAWRIV NDTYRTDLCL LYPPFMIALA
210 220 230 240 250
CLHVACVVQQ KDARQWFAEL SVDMEKILEI IRVILKLYEQ WKNFDERKEM
260 270 280
ATILSKMPKP KPPPNSEGEQ GPNGSQNSSY SQS
Length:283
Mass (Da):33,241
Last modified:October 3, 2012 - v4
Checksum:iDE2065E2E4C304FC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73Y → D in AAB05260 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62638 mRNA Translation: AAB05260.1
U49050 Genomic DNA Translation: AAD11444.1
AL772187 Genomic DNA Translation: CAM22879.1
CH466538 Genomic DNA Translation: EDL05561.1
BC003344 mRNA Translation: AAH03344.2
BC120649 mRNA Translation: AAI20650.1
BC120677 mRNA Translation: AAI20678.1
AJ243075, AJ243076 Genomic DNA Translation: CAB45390.1
CCDSiCCDS17998.1
RefSeqiNP_001277351.1, NM_001290422.1
NP_058026.2, NM_016746.4
UniGeneiMm.278584

Genome annotation databases

EnsembliENSMUST00000102997; ENSMUSP00000100062; ENSMUSG00000028252
GeneIDi51813
KEGGimmu:51813
UCSCiuc008scu.3 mouse

Similar proteinsi

Entry informationi

Entry nameiCCNC_MOUSE
AccessioniPrimary (citable) accession number: Q62447
Secondary accession number(s): Q0P542, Q5XKQ9, Q9WUZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 3, 2012
Last modified: May 23, 2018
This is version 143 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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