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Q62446

- FKBP3_MOUSE

UniProt

Q62446 - FKBP3_MOUSE

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Protein

Peptidyl-prolyl cis-trans isomerase FKBP3

Gene

Fkbp3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Inhibited preferentially by rapamycin over FK506.By similarity

GO - Molecular functioni

  1. FK506 binding Source: RefGenome
  2. peptidyl-prolyl cis-trans isomerase activity Source: RefGenome
  3. poly(A) RNA binding Source: Ensembl

GO - Biological processi

  1. chaperone-mediated protein folding Source: RefGenome
  2. protein peptidyl-prolyl isomerization Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP3 (EC:5.2.1.8)
Short name:
PPIase FKBP3
Alternative name(s):
25 kDa FK506-binding protein
Short name:
25 kDa FKBP
Short name:
FKBP-25
FK506-binding protein 3
Short name:
FKBP-3
Immunophilin FKBP25
Rapamycin-selective 25 kDa immunophilin
Rotamase
Gene namesi
Name:Fkbp3
Synonyms:Fkbp25
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1353460. Fkbp3.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: RefGenome
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 224223Peptidyl-prolyl cis-trans isomerase FKBP3PRO_0000075308Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei36 – 361PhosphoserineBy similarity
Modified residuei99 – 991N6-acetyllysine1 Publication
Modified residuei152 – 1521PhosphoserineBy similarity
Modified residuei170 – 1701N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ62446.
PaxDbiQ62446.
PRIDEiQ62446.

PTM databases

PhosphoSiteiQ62446.

Expressioni

Gene expression databases

BgeeiQ62446.
CleanExiMM_FKBP3.
ExpressionAtlasiQ62446. baseline and differential.
GenevestigatoriQ62446.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MDM2Q009874EBI-8313562,EBI-389668From a different organism.

Protein-protein interaction databases

IntActiQ62446. 5 interactions.
MINTiMINT-1870257.

Structurei

Secondary structure

1
224
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi110 – 1178
Beta strandi130 – 1389
Beta strandi144 – 1474
Beta strandi152 – 1543
Turni155 – 1584
Beta strandi162 – 1654
Beta strandi168 – 1714
Helixi173 – 1797
Beta strandi187 – 1926
Helixi194 – 1963
Helixi204 – 2063
Beta strandi214 – 22411

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3KZ7X-ray1.95A106-224[»]
ProteinModelPortaliQ62446.
SMRiQ62446. Positions 1-73, 106-224.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini128 – 22497PPIase FKBP-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the FKBP-type PPIase family.Curated
Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0545.
GeneTreeiENSGT00760000119159.
HOGENOMiHOG000007963.
HOVERGENiHBG105391.
InParanoidiQ62446.
KOiK09570.
OMAiTMSKGET.
OrthoDBiEOG7BZVT6.
PhylomeDBiQ62446.
TreeFamiTF105293.

Family and domain databases

InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62446-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAAVPQRAW TVEQLRSEQL PKKDIIKFLQ DHGSDSFLAE HKLLGNIKNV
60 70 80 90 100
AKTANKDHLV NAYNHLFESK RFKGTETISK VSEQVKNVKL SDDKPKDSKS
110 120 130 140 150
EETLDEGPPK YTKSILKKGD KTNFPKKGDV VHCWYTGTLP DGTVFDTNIQ
160 170 180 190 200
TSSKKKKNAK PLSFKVGVGK VIRGWDEALL TMSKGEKARL EIEPEWAYGK
210 220
KGQPDAKIPP NTKLIFEVEL VDID
Length:224
Mass (Da):25,148
Last modified:January 11, 2001 - v2
Checksum:iFCA2058CC4E97DAC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti219 – 2191E → G in AAB05769. (PubMed:8956998)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF135595 mRNA. Translation: AAD25097.1.
AF110812 mRNA. Translation: AAD20598.1.
BC002122 mRNA. Translation: AAH02122.1.
U62545 mRNA. Translation: AAB05769.1.
CCDSiCCDS25940.1.
RefSeqiNP_038930.1. NM_013902.4.
UniGeneiMm.28480.

Genome annotation databases

EnsembliENSMUST00000021332; ENSMUSP00000021332; ENSMUSG00000020949.
GeneIDi30795.
KEGGimmu:30795.
UCSCiuc007nrb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF135595 mRNA. Translation: AAD25097.1 .
AF110812 mRNA. Translation: AAD20598.1 .
BC002122 mRNA. Translation: AAH02122.1 .
U62545 mRNA. Translation: AAB05769.1 .
CCDSi CCDS25940.1.
RefSeqi NP_038930.1. NM_013902.4.
UniGenei Mm.28480.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3KZ7 X-ray 1.95 A 106-224 [» ]
ProteinModelPortali Q62446.
SMRi Q62446. Positions 1-73, 106-224.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q62446. 5 interactions.
MINTi MINT-1870257.

PTM databases

PhosphoSitei Q62446.

Proteomic databases

MaxQBi Q62446.
PaxDbi Q62446.
PRIDEi Q62446.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021332 ; ENSMUSP00000021332 ; ENSMUSG00000020949 .
GeneIDi 30795.
KEGGi mmu:30795.
UCSCi uc007nrb.1. mouse.

Organism-specific databases

CTDi 2287.
MGIi MGI:1353460. Fkbp3.

Phylogenomic databases

eggNOGi COG0545.
GeneTreei ENSGT00760000119159.
HOGENOMi HOG000007963.
HOVERGENi HBG105391.
InParanoidi Q62446.
KOi K09570.
OMAi TMSKGET.
OrthoDBi EOG7BZVT6.
PhylomeDBi Q62446.
TreeFami TF105293.

Miscellaneous databases

ChiTaRSi FKBP3. mouse.
NextBioi 307214.
PROi Q62446.
SOURCEi Search...

Gene expression databases

Bgeei Q62446.
CleanExi MM_FKBP3.
ExpressionAtlasi Q62446. baseline and differential.
Genevestigatori Q62446.

Family and domain databases

InterProi IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view ]
PANTHERi PTHR10516. PTHR10516. 1 hit.
Pfami PF00254. FKBP_C. 1 hit.
[Graphical view ]
PROSITEi PS50059. FKBP_PPIASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and mapping assignment of cDNAs differentially expressed in embryonic telencephalon."
    Mas C., Bourgeois F., Simonneau M.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Telencephalon.
  2. "Down-regulation of the Stathmin/Op18 and FKBP25 genes following p53 expression."
    Ahn J., Kratowicz S., Murphy M., Wang A., Levine A.J., George D.L.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.
  4. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 100-110, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.
  5. "Wild-type p53 negatively regulates the expression of a microtubule-associated protein."
    Murphy M., Hinman A., Levine A.J.
    Genes Dev. 10:2971-2980(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 168-224.
  6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-99, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiFKBP3_MOUSE
AccessioniPrimary (citable) accession number: Q62446
Secondary accession number(s): Q9WTJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 11, 2001
Last modified: October 29, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3