Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Peptidyl-prolyl cis-trans isomerase FKBP3

Gene

Fkbp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulationi

Inhibited preferentially by rapamycin over FK506.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP3 (EC:5.2.1.8)
Short name:
PPIase FKBP3
Alternative name(s):
25 kDa FK506-binding protein
Short name:
25 kDa FKBP
Short name:
FKBP-25
FK506-binding protein 3
Short name:
FKBP-3
Immunophilin FKBP25
Rapamycin-selective 25 kDa immunophilin
Rotamase
Gene namesi
Name:Fkbp3
Synonyms:Fkbp25
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1353460. Fkbp3.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: GO_Central
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000753082 – 224Peptidyl-prolyl cis-trans isomerase FKBP3Add BLAST223

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei36PhosphoserineBy similarity1
Modified residuei99N6-acetyllysineCombined sources1
Modified residuei152PhosphoserineBy similarity1
Modified residuei170N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ62446.
MaxQBiQ62446.
PaxDbiQ62446.
PRIDEiQ62446.

PTM databases

iPTMnetiQ62446.
PhosphoSitePlusiQ62446.

Expressioni

Gene expression databases

BgeeiENSMUSG00000020949.
CleanExiMM_FKBP3.
ExpressionAtlasiQ62446. baseline and differential.
GenevisibleiQ62446. MM.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MDM2Q009874EBI-8313562,EBI-389668From a different organism.

Protein-protein interaction databases

IntActiQ62446. 5 interactors.
MINTiMINT-1870257.
STRINGi10090.ENSMUSP00000021332.

Structurei

Secondary structure

1224
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi110 – 117Combined sources8
Beta strandi130 – 138Combined sources9
Beta strandi144 – 147Combined sources4
Beta strandi152 – 154Combined sources3
Turni155 – 158Combined sources4
Beta strandi162 – 165Combined sources4
Beta strandi168 – 171Combined sources4
Helixi173 – 179Combined sources7
Beta strandi187 – 192Combined sources6
Helixi194 – 196Combined sources3
Helixi204 – 206Combined sources3
Beta strandi214 – 224Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KZ7X-ray1.95A106-224[»]
ProteinModelPortaliQ62446.
SMRiQ62446.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini128 – 224PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST97

Sequence similaritiesi

Belongs to the FKBP-type PPIase family.Curated
Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0544. Eukaryota.
COG0545. LUCA.
GeneTreeiENSGT00760000119159.
HOGENOMiHOG000007963.
HOVERGENiHBG105391.
InParanoidiQ62446.
KOiK09570.
OMAiCWYTGSL.
OrthoDBiEOG091G02W1.
PhylomeDBiQ62446.
TreeFamiTF105293.

Family and domain databases

InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62446-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAVPQRAW TVEQLRSEQL PKKDIIKFLQ DHGSDSFLAE HKLLGNIKNV
60 70 80 90 100
AKTANKDHLV NAYNHLFESK RFKGTETISK VSEQVKNVKL SDDKPKDSKS
110 120 130 140 150
EETLDEGPPK YTKSILKKGD KTNFPKKGDV VHCWYTGTLP DGTVFDTNIQ
160 170 180 190 200
TSSKKKKNAK PLSFKVGVGK VIRGWDEALL TMSKGEKARL EIEPEWAYGK
210 220
KGQPDAKIPP NTKLIFEVEL VDID
Length:224
Mass (Da):25,148
Last modified:January 11, 2001 - v2
Checksum:iFCA2058CC4E97DAC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti219E → G in AAB05769 (PubMed:8956998).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF135595 mRNA. Translation: AAD25097.1.
AF110812 mRNA. Translation: AAD20598.1.
BC002122 mRNA. Translation: AAH02122.1.
U62545 mRNA. Translation: AAB05769.1.
CCDSiCCDS25940.1.
RefSeqiNP_038930.1. NM_013902.4.
UniGeneiMm.28480.

Genome annotation databases

EnsembliENSMUST00000021332; ENSMUSP00000021332; ENSMUSG00000020949.
GeneIDi30795.
KEGGimmu:30795.
UCSCiuc007nrb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF135595 mRNA. Translation: AAD25097.1.
AF110812 mRNA. Translation: AAD20598.1.
BC002122 mRNA. Translation: AAH02122.1.
U62545 mRNA. Translation: AAB05769.1.
CCDSiCCDS25940.1.
RefSeqiNP_038930.1. NM_013902.4.
UniGeneiMm.28480.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KZ7X-ray1.95A106-224[»]
ProteinModelPortaliQ62446.
SMRiQ62446.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ62446. 5 interactors.
MINTiMINT-1870257.
STRINGi10090.ENSMUSP00000021332.

PTM databases

iPTMnetiQ62446.
PhosphoSitePlusiQ62446.

Proteomic databases

EPDiQ62446.
MaxQBiQ62446.
PaxDbiQ62446.
PRIDEiQ62446.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021332; ENSMUSP00000021332; ENSMUSG00000020949.
GeneIDi30795.
KEGGimmu:30795.
UCSCiuc007nrb.1. mouse.

Organism-specific databases

CTDi2287.
MGIiMGI:1353460. Fkbp3.

Phylogenomic databases

eggNOGiKOG0544. Eukaryota.
COG0545. LUCA.
GeneTreeiENSGT00760000119159.
HOGENOMiHOG000007963.
HOVERGENiHBG105391.
InParanoidiQ62446.
KOiK09570.
OMAiCWYTGSL.
OrthoDBiEOG091G02W1.
PhylomeDBiQ62446.
TreeFamiTF105293.

Miscellaneous databases

ChiTaRSiFkbp3. mouse.
PROiQ62446.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020949.
CleanExiMM_FKBP3.
ExpressionAtlasiQ62446. baseline and differential.
GenevisibleiQ62446. MM.

Family and domain databases

InterProiIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 1 hit.
PfamiPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEiPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFKBP3_MOUSE
AccessioniPrimary (citable) accession number: Q62446
Secondary accession number(s): Q9WTJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 11, 2001
Last modified: November 2, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.