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Q62446 (FKBP3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peptidyl-prolyl cis-trans isomerase FKBP3

Short name=PPIase FKBP3
EC=5.2.1.8
Alternative name(s):
25 kDa FK506-binding protein
Short name=25 kDa FKBP
Short name=FKBP-25
FK506-binding protein 3
Short name=FKBP-3
Immunophilin FKBP25
Rapamycin-selective 25 kDa immunophilin
Rotamase
Gene names
Name:Fkbp3
Synonyms:Fkbp25
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length224 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins By similarity.

Catalytic activity

Peptidylproline (omega=180) = peptidylproline (omega=0).

Enzyme regulation

Inhibited preferentially by rapamycin over FK506 By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the FKBP-type PPIase family.

Contains 1 PPIase FKBP-type domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

MDM2Q009874EBI-8313562,EBI-389668From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 224223Peptidyl-prolyl cis-trans isomerase FKBP3
PRO_0000075308

Regions

Domain128 – 22497PPIase FKBP-type

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue361Phosphoserine By similarity
Modified residue991N6-acetyllysine
Modified residue1521Phosphoserine By similarity
Modified residue1701N6-acetyllysine By similarity

Experimental info

Sequence conflict2191E → G in AAB05769. Ref.5

Secondary structure

....................... 224
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q62446 [UniParc].

Last modified January 11, 2001. Version 2.
Checksum: FCA2058CC4E97DAC

FASTA22425,148
        10         20         30         40         50         60 
MAAAVPQRAW TVEQLRSEQL PKKDIIKFLQ DHGSDSFLAE HKLLGNIKNV AKTANKDHLV 

        70         80         90        100        110        120 
NAYNHLFESK RFKGTETISK VSEQVKNVKL SDDKPKDSKS EETLDEGPPK YTKSILKKGD 

       130        140        150        160        170        180 
KTNFPKKGDV VHCWYTGTLP DGTVFDTNIQ TSSKKKKNAK PLSFKVGVGK VIRGWDEALL 

       190        200        210        220 
TMSKGEKARL EIEPEWAYGK KGQPDAKIPP NTKLIFEVEL VDID 

« Hide

References

« Hide 'large scale' references
[1]"Isolation and mapping assignment of cDNAs differentially expressed in embryonic telencephalon."
Mas C., Bourgeois F., Simonneau M.
Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Telencephalon.
[2]"Down-regulation of the Stathmin/Op18 and FKBP25 genes following p53 expression."
Ahn J., Kratowicz S., Murphy M., Wang A., Levine A.J., George D.L.
Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Czech II.
Tissue: Mammary tumor.
[4]Lubec G., Kang S.U.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 100-110, MASS SPECTROMETRY.
Strain: C57BL/6.
Tissue: Brain.
[5]"Wild-type p53 negatively regulates the expression of a microtubule-associated protein."
Murphy M., Hinman A., Levine A.J.
Genes Dev. 10:2971-2980(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 168-224.
[6]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-99, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF135595 mRNA. Translation: AAD25097.1.
AF110812 mRNA. Translation: AAD20598.1.
BC002122 mRNA. Translation: AAH02122.1.
U62545 mRNA. Translation: AAB05769.1.
RefSeqNP_038930.1. NM_013902.4.
UniGeneMm.28480.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3KZ7X-ray1.95A106-224[»]
ProteinModelPortalQ62446.
SMRQ62446. Positions 1-73, 106-224.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ62446. 5 interactions.
MINTMINT-1870257.

PTM databases

PhosphoSiteQ62446.

Proteomic databases

PaxDbQ62446.
PRIDEQ62446.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000021332; ENSMUSP00000021332; ENSMUSG00000020949.
GeneID30795.
KEGGmmu:30795.
UCSCuc007nrb.1. mouse.

Organism-specific databases

CTD2287.
MGIMGI:1353460. Fkbp3.

Phylogenomic databases

eggNOGCOG0545.
GeneTreeENSGT00720000108676.
HOGENOMHOG000007963.
HOVERGENHBG105391.
InParanoidQ62446.
KOK09570.
OMATMSKGET.
OrthoDBEOG7BZVT6.
TreeFamTF105293.

Gene expression databases

ArrayExpressQ62446.
BgeeQ62446.
CleanExMM_FKBP3.
GenevestigatorQ62446.

Family and domain databases

InterProIPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERPTHR10516. PTHR10516. 1 hit.
PfamPF00254. FKBP_C. 1 hit.
[Graphical view]
PROSITEPS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFKBP3. mouse.
NextBio307214.
PROQ62446.
SOURCESearch...

Entry information

Entry nameFKBP3_MOUSE
AccessionPrimary (citable) accession number: Q62446
Secondary accession number(s): Q9WTJ7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 11, 2001
Last modified: March 19, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot