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Q62446

- FKBP3_MOUSE

UniProt

Q62446 - FKBP3_MOUSE

Protein

Peptidyl-prolyl cis-trans isomerase FKBP3

Gene

Fkbp3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (11 Jan 2001)
      Previous versions | rss
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    Functioni

    FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins By similarity.By similarity

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).

    Enzyme regulationi

    Inhibited preferentially by rapamycin over FK506.By similarity

    GO - Molecular functioni

    1. FK506 binding Source: RefGenome
    2. peptidyl-prolyl cis-trans isomerase activity Source: RefGenome
    3. protein binding Source: IntAct

    GO - Biological processi

    1. chaperone-mediated protein folding Source: RefGenome
    2. protein peptidyl-prolyl isomerization Source: RefGenome

    Keywords - Molecular functioni

    Isomerase, Rotamase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP3 (EC:5.2.1.8)
    Short name:
    PPIase FKBP3
    Alternative name(s):
    25 kDa FK506-binding protein
    Short name:
    25 kDa FKBP
    Short name:
    FKBP-25
    FK506-binding protein 3
    Short name:
    FKBP-3
    Immunophilin FKBP25
    Rapamycin-selective 25 kDa immunophilin
    Rotamase
    Gene namesi
    Name:Fkbp3
    Synonyms:Fkbp25
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1353460. Fkbp3.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: RefGenome
    2. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 224223Peptidyl-prolyl cis-trans isomerase FKBP3PRO_0000075308Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei36 – 361PhosphoserineBy similarity
    Modified residuei99 – 991N6-acetyllysine1 Publication
    Modified residuei152 – 1521PhosphoserineBy similarity
    Modified residuei170 – 1701N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ62446.
    PaxDbiQ62446.
    PRIDEiQ62446.

    PTM databases

    PhosphoSiteiQ62446.

    Expressioni

    Gene expression databases

    ArrayExpressiQ62446.
    BgeeiQ62446.
    CleanExiMM_FKBP3.
    GenevestigatoriQ62446.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MDM2Q009874EBI-8313562,EBI-389668From a different organism.

    Protein-protein interaction databases

    IntActiQ62446. 5 interactions.
    MINTiMINT-1870257.

    Structurei

    Secondary structure

    1
    224
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi110 – 1178
    Beta strandi130 – 1389
    Beta strandi144 – 1474
    Beta strandi152 – 1543
    Turni155 – 1584
    Beta strandi162 – 1654
    Beta strandi168 – 1714
    Helixi173 – 1797
    Beta strandi187 – 1926
    Helixi194 – 1963
    Helixi204 – 2063
    Beta strandi214 – 22411

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3KZ7X-ray1.95A106-224[»]
    ProteinModelPortaliQ62446.
    SMRiQ62446. Positions 1-73, 106-224.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini128 – 22497PPIase FKBP-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the FKBP-type PPIase family.Curated
    Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0545.
    GeneTreeiENSGT00720000108676.
    HOGENOMiHOG000007963.
    HOVERGENiHBG105391.
    InParanoidiQ62446.
    KOiK09570.
    OMAiTMSKGET.
    OrthoDBiEOG7BZVT6.
    PhylomeDBiQ62446.
    TreeFamiTF105293.

    Family and domain databases

    InterProiIPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    [Graphical view]
    PANTHERiPTHR10516. PTHR10516. 1 hit.
    PfamiPF00254. FKBP_C. 1 hit.
    [Graphical view]
    PROSITEiPS50059. FKBP_PPIASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q62446-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAAVPQRAW TVEQLRSEQL PKKDIIKFLQ DHGSDSFLAE HKLLGNIKNV    50
    AKTANKDHLV NAYNHLFESK RFKGTETISK VSEQVKNVKL SDDKPKDSKS 100
    EETLDEGPPK YTKSILKKGD KTNFPKKGDV VHCWYTGTLP DGTVFDTNIQ 150
    TSSKKKKNAK PLSFKVGVGK VIRGWDEALL TMSKGEKARL EIEPEWAYGK 200
    KGQPDAKIPP NTKLIFEVEL VDID 224
    Length:224
    Mass (Da):25,148
    Last modified:January 11, 2001 - v2
    Checksum:iFCA2058CC4E97DAC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti219 – 2191E → G in AAB05769. (PubMed:8956998)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF135595 mRNA. Translation: AAD25097.1.
    AF110812 mRNA. Translation: AAD20598.1.
    BC002122 mRNA. Translation: AAH02122.1.
    U62545 mRNA. Translation: AAB05769.1.
    CCDSiCCDS25940.1.
    RefSeqiNP_038930.1. NM_013902.4.
    UniGeneiMm.28480.

    Genome annotation databases

    EnsembliENSMUST00000021332; ENSMUSP00000021332; ENSMUSG00000020949.
    GeneIDi30795.
    KEGGimmu:30795.
    UCSCiuc007nrb.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF135595 mRNA. Translation: AAD25097.1 .
    AF110812 mRNA. Translation: AAD20598.1 .
    BC002122 mRNA. Translation: AAH02122.1 .
    U62545 mRNA. Translation: AAB05769.1 .
    CCDSi CCDS25940.1.
    RefSeqi NP_038930.1. NM_013902.4.
    UniGenei Mm.28480.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3KZ7 X-ray 1.95 A 106-224 [» ]
    ProteinModelPortali Q62446.
    SMRi Q62446. Positions 1-73, 106-224.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q62446. 5 interactions.
    MINTi MINT-1870257.

    PTM databases

    PhosphoSitei Q62446.

    Proteomic databases

    MaxQBi Q62446.
    PaxDbi Q62446.
    PRIDEi Q62446.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021332 ; ENSMUSP00000021332 ; ENSMUSG00000020949 .
    GeneIDi 30795.
    KEGGi mmu:30795.
    UCSCi uc007nrb.1. mouse.

    Organism-specific databases

    CTDi 2287.
    MGIi MGI:1353460. Fkbp3.

    Phylogenomic databases

    eggNOGi COG0545.
    GeneTreei ENSGT00720000108676.
    HOGENOMi HOG000007963.
    HOVERGENi HBG105391.
    InParanoidi Q62446.
    KOi K09570.
    OMAi TMSKGET.
    OrthoDBi EOG7BZVT6.
    PhylomeDBi Q62446.
    TreeFami TF105293.

    Miscellaneous databases

    ChiTaRSi FKBP3. mouse.
    NextBioi 307214.
    PROi Q62446.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q62446.
    Bgeei Q62446.
    CleanExi MM_FKBP3.
    Genevestigatori Q62446.

    Family and domain databases

    InterProi IPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    [Graphical view ]
    PANTHERi PTHR10516. PTHR10516. 1 hit.
    Pfami PF00254. FKBP_C. 1 hit.
    [Graphical view ]
    PROSITEi PS50059. FKBP_PPIASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and mapping assignment of cDNAs differentially expressed in embryonic telencephalon."
      Mas C., Bourgeois F., Simonneau M.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Telencephalon.
    2. "Down-regulation of the Stathmin/Op18 and FKBP25 genes following p53 expression."
      Ahn J., Kratowicz S., Murphy M., Wang A., Levine A.J., George D.L.
      Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Mammary tumor.
    4. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 100-110, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.
    5. "Wild-type p53 negatively regulates the expression of a microtubule-associated protein."
      Murphy M., Hinman A., Levine A.J.
      Genes Dev. 10:2971-2980(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 168-224.
    6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-99, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiFKBP3_MOUSE
    AccessioniPrimary (citable) accession number: Q62446
    Secondary accession number(s): Q9WTJ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 11, 2001
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3