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Q62445

- SP4_MOUSE

UniProt

Q62445 - SP4_MOUSE

Protein

Transcription factor Sp4

Gene

Sp4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    • Comment

    Functioni

    Binds to GT and GC boxes promoters elements. Probable transcriptional activator. Required for normal male reproductive behavior.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri645 – 66925C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri675 – 69925C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri705 – 72723C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of heart contraction Source: MGI
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor Sp4
    Gene namesi
    Name:Sp4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:107595. Sp4.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 782782Transcription factor Sp4PRO_0000047145Add
    BLAST

    Proteomic databases

    PRIDEiQ62445.

    PTM databases

    PhosphoSiteiQ62445.

    Expressioni

    Tissue specificityi

    Expressed in many tissues.

    Developmental stagei

    Highly expressed in embryos in the developing central nervous system (CNS). Expression is seen as early as day 9 of development, where transcripts are abundant in the posterior neuropore. Expression in later embryos is detected throughout the CNS as well as in other structures.

    Gene expression databases

    BgeeiQ62445.
    CleanExiMM_SP4.
    GenevestigatoriQ62445.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62445.
    SMRiQ62445. Positions 635-731.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi7 – 115Poly-Glu
    Compositional biasi12 – 176Poly-Ala
    Compositional biasi120 – 1289Poly-Ser
    Compositional biasi285 – 2884Poly-Thr

    Sequence similaritiesi

    Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri645 – 66925C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri675 – 69925C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri705 – 72723C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234295.
    HOVERGENiHBG008933.
    InParanoidiQ62445.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 3 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q62445-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDQKKEEEE EAAAAMATEG GKTSEPENNN KKPKTSGSQD SHPSPLALLA    50
    ATCSKIGTPG ENQATGQQQI IIDPSQGLVQ LQNQPQQLEL VTTQLAGNAW 100
    QLVASTPPAS KENNVSQPAS SSSSSSSSNN GSSSPTKTKS GNPSTPNQFQ 150
    VIQVQNPSGS VQYQVIPQLQ TVEGQQIQIN PTSSSSLQDL QGQIQLISAG 200
    NNQAILTAAN RTASGNILAQ NLANQTVPVQ IRPGVSIPLQ LQTLPGTQAQ 250
    VVTTLPINIG GVTLALPVIN NVTAGGGTGQ VGQPTTTTDS GTSNGNQLVS 300
    TPTTSTAPAS TMPESPSSST TCTTTASTTL TSSDTLVSSA DTGQYASTSA 350
    SSSERTIEEP QTPAATESEA QSSSQLQSNG IQNAQDQSNS LQQVQIVGQP 400
    ILQQIQIQQP QQQIIQAIPP QSFQLQSGQT IQTIQQQPLQ NVQLQAVNPT 450
    QVLIRAPTLT PSGQISWQTV QVQNIQSLSN LQVQNAGLSQ QLTITPVSSS 500
    GGTTLAQIAP VAVAGAPITL NTAQLASVPN LQTVSVANLG AAGVQVQGVP 550
    VTITSVAGQQ QGQDGVKVQQ ATIAPVTVAV GGIANATIGA VSPDQLTQVH 600
    LQQGQQTSDA EVQPGKRLRR VACSCPNCRE GEGRGSSEPG KKKQHVCHIE 650
    GCGKVYGKTS HLRAHLRWHT GERPFICNWM FCGKRFTRSD ELQRHRRTHT 700
    GEKRFECPEC SKRFMRSDHL SKHVKTHQNK KGGGTALAIV TSGELDSSVT 750
    EVLGSPRIVT VAAISQDSNP ATPNVSTNME EF 782
    Length:782
    Mass (Da):81,906
    Last modified:July 27, 2011 - v2
    Checksum:iCAFFF89C759EA9BC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti42 – 421H → Q in AAC52653. (PubMed:8660867)Curated
    Sequence conflicti183 – 1831S → R in AAC52653. (PubMed:8660867)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U62522 mRNA. Translation: AAC52653.1.
    AC163032 Genomic DNA. No translation available.
    AC163034 Genomic DNA. No translation available.
    CCDSiCCDS36579.1.
    UniGeneiMm.259312.
    Mm.34699.

    Genome annotation databases

    UCSCiuc007pif.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U62522 mRNA. Translation: AAC52653.1 .
    AC163032 Genomic DNA. No translation available.
    AC163034 Genomic DNA. No translation available.
    CCDSi CCDS36579.1.
    UniGenei Mm.259312.
    Mm.34699.

    3D structure databases

    ProteinModelPortali Q62445.
    SMRi Q62445. Positions 635-731.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q62445.

    Proteomic databases

    PRIDEi Q62445.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi uc007pif.2. mouse.

    Organism-specific databases

    MGIi MGI:107595. Sp4.

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234295.
    HOVERGENi HBG008933.
    InParanoidi Q62445.

    Miscellaneous databases

    NextBioi 299217.
    PROi Q62445.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q62445.
    CleanExi MM_SP4.
    Genevestigatori Q62445.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 3 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sp4, a member of the Sp1-family of zinc finger transcription factors, is required for normal murine growth, viability, and male fertility."
      Supp D.M., Witte D.P., Branford W.W., Smith E.P., Potter S.S.
      Dev. Biol. 176:284-299(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiSP4_MOUSE
    AccessioniPrimary (citable) accession number: Q62445
    Secondary accession number(s): E9QNI3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 9, 2003
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3