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Q62445

- SP4_MOUSE

UniProt

Q62445 - SP4_MOUSE

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Protein

Transcription factor Sp4

Gene

Sp4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Binds to GT and GC boxes promoters elements. Probable transcriptional activator. Required for normal male reproductive behavior.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri645 – 66925C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri675 – 69925C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri705 – 72723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of heart contraction Source: MGI
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor Sp4
Gene namesi
Name:Sp4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:107595. Sp4.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 782782Transcription factor Sp4PRO_0000047145Add
BLAST

Proteomic databases

PRIDEiQ62445.

PTM databases

PhosphoSiteiQ62445.

Expressioni

Tissue specificityi

Expressed in many tissues.

Developmental stagei

Highly expressed in embryos in the developing central nervous system (CNS). Expression is seen as early as day 9 of development, where transcripts are abundant in the posterior neuropore. Expression in later embryos is detected throughout the CNS as well as in other structures.

Gene expression databases

BgeeiQ62445.
CleanExiMM_SP4.
GenevestigatoriQ62445.

Structurei

3D structure databases

ProteinModelPortaliQ62445.
SMRiQ62445. Positions 625-731.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi7 – 115Poly-Glu
Compositional biasi12 – 176Poly-Ala
Compositional biasi120 – 1289Poly-Ser
Compositional biasi285 – 2884Poly-Thr

Sequence similaritiesi

Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri645 – 66925C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri675 – 69925C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri705 – 72723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000234295.
HOVERGENiHBG008933.
InParanoidiQ62445.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62445-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDQKKEEEE EAAAAMATEG GKTSEPENNN KKPKTSGSQD SHPSPLALLA
60 70 80 90 100
ATCSKIGTPG ENQATGQQQI IIDPSQGLVQ LQNQPQQLEL VTTQLAGNAW
110 120 130 140 150
QLVASTPPAS KENNVSQPAS SSSSSSSSNN GSSSPTKTKS GNPSTPNQFQ
160 170 180 190 200
VIQVQNPSGS VQYQVIPQLQ TVEGQQIQIN PTSSSSLQDL QGQIQLISAG
210 220 230 240 250
NNQAILTAAN RTASGNILAQ NLANQTVPVQ IRPGVSIPLQ LQTLPGTQAQ
260 270 280 290 300
VVTTLPINIG GVTLALPVIN NVTAGGGTGQ VGQPTTTTDS GTSNGNQLVS
310 320 330 340 350
TPTTSTAPAS TMPESPSSST TCTTTASTTL TSSDTLVSSA DTGQYASTSA
360 370 380 390 400
SSSERTIEEP QTPAATESEA QSSSQLQSNG IQNAQDQSNS LQQVQIVGQP
410 420 430 440 450
ILQQIQIQQP QQQIIQAIPP QSFQLQSGQT IQTIQQQPLQ NVQLQAVNPT
460 470 480 490 500
QVLIRAPTLT PSGQISWQTV QVQNIQSLSN LQVQNAGLSQ QLTITPVSSS
510 520 530 540 550
GGTTLAQIAP VAVAGAPITL NTAQLASVPN LQTVSVANLG AAGVQVQGVP
560 570 580 590 600
VTITSVAGQQ QGQDGVKVQQ ATIAPVTVAV GGIANATIGA VSPDQLTQVH
610 620 630 640 650
LQQGQQTSDA EVQPGKRLRR VACSCPNCRE GEGRGSSEPG KKKQHVCHIE
660 670 680 690 700
GCGKVYGKTS HLRAHLRWHT GERPFICNWM FCGKRFTRSD ELQRHRRTHT
710 720 730 740 750
GEKRFECPEC SKRFMRSDHL SKHVKTHQNK KGGGTALAIV TSGELDSSVT
760 770 780
EVLGSPRIVT VAAISQDSNP ATPNVSTNME EF
Length:782
Mass (Da):81,906
Last modified:July 27, 2011 - v2
Checksum:iCAFFF89C759EA9BC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti42 – 421H → Q in AAC52653. (PubMed:8660867)Curated
Sequence conflicti183 – 1831S → R in AAC52653. (PubMed:8660867)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U62522 mRNA. Translation: AAC52653.1.
AC163032 Genomic DNA. No translation available.
AC163034 Genomic DNA. No translation available.
CCDSiCCDS36579.1.
UniGeneiMm.259312.
Mm.34699.

Genome annotation databases

UCSCiuc007pif.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U62522 mRNA. Translation: AAC52653.1 .
AC163032 Genomic DNA. No translation available.
AC163034 Genomic DNA. No translation available.
CCDSi CCDS36579.1.
UniGenei Mm.259312.
Mm.34699.

3D structure databases

ProteinModelPortali Q62445.
SMRi Q62445. Positions 625-731.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q62445.

Proteomic databases

PRIDEi Q62445.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi uc007pif.2. mouse.

Organism-specific databases

MGIi MGI:107595. Sp4.

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000234295.
HOVERGENi HBG008933.
InParanoidi Q62445.

Miscellaneous databases

NextBioi 299217.
PROi Q62445.
SOURCEi Search...

Gene expression databases

Bgeei Q62445.
CleanExi MM_SP4.
Genevestigatori Q62445.

Family and domain databases

Gene3Di 3.30.160.60. 3 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 3 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sp4, a member of the Sp1-family of zinc finger transcription factors, is required for normal murine growth, viability, and male fertility."
    Supp D.M., Witte D.P., Branford W.W., Smith E.P., Potter S.S.
    Dev. Biol. 176:284-299(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiSP4_MOUSE
AccessioniPrimary (citable) accession number: Q62445
Secondary accession number(s): E9QNI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3