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Q62445

- SP4_MOUSE

UniProt

Q62445 - SP4_MOUSE

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Protein
Transcription factor Sp4
Gene
Sp4
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Binds to GT and GC boxes promoters elements. Probable transcriptional activator. Required for normal male reproductive behavior.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri645 – 66925C2H2-type 1
Add
BLAST
Zinc fingeri675 – 69925C2H2-type 2
Add
BLAST
Zinc fingeri705 – 72723C2H2-type 3
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of heart contraction Source: MGI
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor Sp4
Gene namesi
Name:Sp4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:107595. Sp4.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 782782Transcription factor Sp4
PRO_0000047145Add
BLAST

Proteomic databases

PRIDEiQ62445.

PTM databases

PhosphoSiteiQ62445.

Expressioni

Tissue specificityi

Expressed in many tissues.

Developmental stagei

Highly expressed in embryos in the developing central nervous system (CNS). Expression is seen as early as day 9 of development, where transcripts are abundant in the posterior neuropore. Expression in later embryos is detected throughout the CNS as well as in other structures.

Gene expression databases

BgeeiQ62445.
CleanExiMM_SP4.
GenevestigatoriQ62445.

Structurei

3D structure databases

ProteinModelPortaliQ62445.
SMRiQ62445. Positions 635-731.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi7 – 115Poly-Glu
Compositional biasi12 – 176Poly-Ala
Compositional biasi120 – 1289Poly-Ser
Compositional biasi285 – 2884Poly-Thr

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000234295.
HOVERGENiHBG008933.
InParanoidiQ62445.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62445-1 [UniParc]FASTAAdd to Basket

« Hide

MSDQKKEEEE EAAAAMATEG GKTSEPENNN KKPKTSGSQD SHPSPLALLA    50
ATCSKIGTPG ENQATGQQQI IIDPSQGLVQ LQNQPQQLEL VTTQLAGNAW 100
QLVASTPPAS KENNVSQPAS SSSSSSSSNN GSSSPTKTKS GNPSTPNQFQ 150
VIQVQNPSGS VQYQVIPQLQ TVEGQQIQIN PTSSSSLQDL QGQIQLISAG 200
NNQAILTAAN RTASGNILAQ NLANQTVPVQ IRPGVSIPLQ LQTLPGTQAQ 250
VVTTLPINIG GVTLALPVIN NVTAGGGTGQ VGQPTTTTDS GTSNGNQLVS 300
TPTTSTAPAS TMPESPSSST TCTTTASTTL TSSDTLVSSA DTGQYASTSA 350
SSSERTIEEP QTPAATESEA QSSSQLQSNG IQNAQDQSNS LQQVQIVGQP 400
ILQQIQIQQP QQQIIQAIPP QSFQLQSGQT IQTIQQQPLQ NVQLQAVNPT 450
QVLIRAPTLT PSGQISWQTV QVQNIQSLSN LQVQNAGLSQ QLTITPVSSS 500
GGTTLAQIAP VAVAGAPITL NTAQLASVPN LQTVSVANLG AAGVQVQGVP 550
VTITSVAGQQ QGQDGVKVQQ ATIAPVTVAV GGIANATIGA VSPDQLTQVH 600
LQQGQQTSDA EVQPGKRLRR VACSCPNCRE GEGRGSSEPG KKKQHVCHIE 650
GCGKVYGKTS HLRAHLRWHT GERPFICNWM FCGKRFTRSD ELQRHRRTHT 700
GEKRFECPEC SKRFMRSDHL SKHVKTHQNK KGGGTALAIV TSGELDSSVT 750
EVLGSPRIVT VAAISQDSNP ATPNVSTNME EF 782
Length:782
Mass (Da):81,906
Last modified:July 27, 2011 - v2
Checksum:iCAFFF89C759EA9BC
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti42 – 421H → Q in AAC52653. 1 Publication
Sequence conflicti183 – 1831S → R in AAC52653. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U62522 mRNA. Translation: AAC52653.1.
AC163032 Genomic DNA. No translation available.
AC163034 Genomic DNA. No translation available.
CCDSiCCDS36579.1.
UniGeneiMm.259312.
Mm.34699.

Genome annotation databases

UCSCiuc007pif.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U62522 mRNA. Translation: AAC52653.1 .
AC163032 Genomic DNA. No translation available.
AC163034 Genomic DNA. No translation available.
CCDSi CCDS36579.1.
UniGenei Mm.259312.
Mm.34699.

3D structure databases

ProteinModelPortali Q62445.
SMRi Q62445. Positions 635-731.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q62445.

Proteomic databases

PRIDEi Q62445.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi uc007pif.2. mouse.

Organism-specific databases

MGIi MGI:107595. Sp4.

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000234295.
HOVERGENi HBG008933.
InParanoidi Q62445.

Miscellaneous databases

NextBioi 299217.
PROi Q62445.
SOURCEi Search...

Gene expression databases

Bgeei Q62445.
CleanExi MM_SP4.
Genevestigatori Q62445.

Family and domain databases

Gene3Di 3.30.160.60. 3 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 3 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sp4, a member of the Sp1-family of zinc finger transcription factors, is required for normal murine growth, viability, and male fertility."
    Supp D.M., Witte D.P., Branford W.W., Smith E.P., Potter S.S.
    Dev. Biol. 176:284-299(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiSP4_MOUSE
AccessioniPrimary (citable) accession number: Q62445
Secondary accession number(s): E9QNI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi