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Q62443

- NPTX1_MOUSE

UniProt

Q62443 - NPTX1_MOUSE

Protein

Neuronal pentraxin-1

Gene

Nptx1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.By similarity

    Cofactori

    Binds 2 calcium ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi280 – 2801Calcium 1By similarity
    Metal bindingi358 – 3581Calcium 1By similarity
    Metal bindingi358 – 3581Calcium 2By similarity
    Metal bindingi359 – 3591Calcium 1; via carbonyl oxygenBy similarity
    Metal bindingi360 – 3601Calcium 1By similarity
    Metal bindingi360 – 3601Calcium 2By similarity
    Metal bindingi370 – 3701Calcium 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. axonogenesis involved in innervation Source: MGI
    2. cellular response to glucose stimulus Source: Ensembl
    3. cellular response to potassium ion Source: Ensembl
    4. mitochondrial fragmentation involved in apoptotic process Source: Ensembl
    5. mitochondrial transport Source: Ensembl

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuronal pentraxin-1
    Short name:
    NP1
    Alternative name(s):
    Neuronal pentraxin I
    Short name:
    NP-I
    Gene namesi
    Name:Nptx1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:107811. Nptx1.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: Ensembl
    2. neuron projection Source: Ensembl
    3. plasma membrane Source: Ensembl
    4. transport vesicle Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasmic vesicle

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 432410Neuronal pentraxin-1PRO_0000023548Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi154 – 1541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi193 – 1931N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi256 ↔ 316By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ62443.
    PaxDbiQ62443.
    PRIDEiQ62443.

    PTM databases

    PhosphoSiteiQ62443.

    Expressioni

    Gene expression databases

    ArrayExpressiQ62443.
    BgeeiQ62443.
    CleanExiMM_NPTX1.
    GenevestigatoriQ62443.

    Interactioni

    Subunit structurei

    Homooligomer or heterooligomer (probably pentamer) with neuronal pentraxin receptor (NPTXR).By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000026670.

    Structurei

    3D structure databases

    ProteinModelPortaliQ62443.
    SMRiQ62443. Positions 229-411.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini230 – 432203PentaxinAdd
    BLAST

    Sequence similaritiesi

    Contains 1 pentaxin domain.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG47030.
    GeneTreeiENSGT00650000093153.
    HOGENOMiHOG000231267.
    HOVERGENiHBG003608.
    InParanoidiQ62443.
    OMAiGASKWTF.
    OrthoDBiEOG74XS6F.
    PhylomeDBiQ62443.
    TreeFamiTF330208.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001759. Pentaxin.
    [Graphical view]
    PfamiPF00354. Pentaxin. 1 hit.
    [Graphical view]
    PRINTSiPR00895. PENTAXIN.
    SMARTiSM00159. PTX. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS00289. PENTAXIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q62443-1 [UniParc]FASTAAdd to Basket

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    MLAGRAARTC ALLALCLLGS GAQDFGPTRF ICTSVPVDAD MCAASVAAGG    50
    AEELRSNVLQ LRETVLQQKE TILSQKETIR ELTTKLGRCE SQSTLDSGPG 100
    EARSGGGRKQ PGSGKNTMGD LSRTPAAETL SQLGQTLQSL KTRLENLEQY 150
    SRLNSSSQTN SLKDLLQSKI DDLERQVLSR VNTLEEGKGG PKNDTEERAK 200
    IESALTSLHQ RISELEKGQK DNRPGDKFQL TFPLRTNYMY AKVKKSLPEM 250
    YAFTVCMWLK SSAAPGVGTP FSYAVPGQAN ELVLIEWGNN PMEILINDKV 300
    AKLPFVINDG KWHHICVTWT TRDGVWEAYQ DGTQGGNGEN LAPYHPIKPQ 350
    GVLVLGQEQD TLGGGFDATQ AFVGELAHFN IWDRKLTPGE VYNLATCSSK 400
    ALSGNVIAWA ESQIEIFGGA TKWTFEACRQ IN 432
    Length:432
    Mass (Da):47,117
    Last modified:November 1, 1997 - v1
    Checksum:i0698B8BAE4948923
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U62021 Genomic DNA. Translation: AAC52826.1.
    CCDSiCCDS25719.1.
    RefSeqiNP_032756.1. NM_008730.2.
    UniGeneiMm.5142.

    Genome annotation databases

    EnsembliENSMUST00000026670; ENSMUSP00000026670; ENSMUSG00000025582.
    GeneIDi18164.
    KEGGimmu:18164.
    UCSCiuc007mqv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U62021 Genomic DNA. Translation: AAC52826.1 .
    CCDSi CCDS25719.1.
    RefSeqi NP_032756.1. NM_008730.2.
    UniGenei Mm.5142.

    3D structure databases

    ProteinModelPortali Q62443.
    SMRi Q62443. Positions 229-411.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000026670.

    PTM databases

    PhosphoSitei Q62443.

    Proteomic databases

    MaxQBi Q62443.
    PaxDbi Q62443.
    PRIDEi Q62443.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000026670 ; ENSMUSP00000026670 ; ENSMUSG00000025582 .
    GeneIDi 18164.
    KEGGi mmu:18164.
    UCSCi uc007mqv.1. mouse.

    Organism-specific databases

    CTDi 4884.
    MGIi MGI:107811. Nptx1.

    Phylogenomic databases

    eggNOGi NOG47030.
    GeneTreei ENSGT00650000093153.
    HOGENOMi HOG000231267.
    HOVERGENi HBG003608.
    InParanoidi Q62443.
    OMAi GASKWTF.
    OrthoDBi EOG74XS6F.
    PhylomeDBi Q62443.
    TreeFami TF330208.

    Miscellaneous databases

    NextBioi 293446.
    PROi Q62443.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q62443.
    Bgeei Q62443.
    CleanExi MM_NPTX1.
    Genevestigatori Q62443.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001759. Pentaxin.
    [Graphical view ]
    Pfami PF00354. Pentaxin. 1 hit.
    [Graphical view ]
    PRINTSi PR00895. PENTAXIN.
    SMARTi SM00159. PTX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS00289. PENTAXIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mouse and human neuronal pentraxin 1 (NPTX1): conservation, genomic structure, and chromosomal localization."
      Omeis I.A., Hsu Y.-C., Perin M.S.
      Genomics 36:543-545(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiNPTX1_MOUSE
    AccessioniPrimary (citable) accession number: Q62443
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3