Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neuronal pentraxin-1

Gene

Nptx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.By similarity

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi280Calcium 1By similarity1
Metal bindingi358Calcium 1By similarity1
Metal bindingi358Calcium 2PROSITE-ProRule annotation1
Metal bindingi359Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi360Calcium 1By similarity1
Metal bindingi360Calcium 2PROSITE-ProRule annotation1
Metal bindingi370Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • axonogenesis involved in innervation Source: MGI

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal pentraxin-1
Short name:
NP1
Alternative name(s):
Neuronal pentraxin I
Short name:
NP-I
Gene namesi
Name:Nptx1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:107811. Nptx1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000002354823 – 432Neuronal pentraxin-1Add BLAST410

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi154N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi193N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi256 ↔ 316PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ62443.
PaxDbiQ62443.
PRIDEiQ62443.

PTM databases

iPTMnetiQ62443.
PhosphoSitePlusiQ62443.

Expressioni

Gene expression databases

BgeeiENSMUSG00000025582.
CleanExiMM_NPTX1.
ExpressionAtlasiQ62443. baseline and differential.
GenevisibleiQ62443. MM.

Interactioni

Subunit structurei

Homooligomer or heterooligomer (probably pentamer) with neuronal pentraxin receptor (NPTXR).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026670.

Structurei

3D structure databases

ProteinModelPortaliQ62443.
SMRiQ62443.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini226 – 428Pentraxin (PTX)PROSITE-ProRule annotationAdd BLAST203

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFFF. Eukaryota.
ENOG410XR4W. LUCA.
GeneTreeiENSGT00760000119128.
HOGENOMiHOG000231267.
HOVERGENiHBG003608.
InParanoidiQ62443.
OMAiTKLGRCE.
OrthoDBiEOG091G0AHP.
PhylomeDBiQ62443.
TreeFamiTF330208.

Family and domain databases

CDDicd00152. PTX. 1 hit.
InterProiView protein in InterPro
IPR013320. ConA-like_dom.
IPR030476. Pentaxin_CS.
IPR001759. Pentraxin-related.
PfamiView protein in Pfam
PF00354. Pentaxin. 1 hit.
PRINTSiPR00895. PENTAXIN.
SMARTiView protein in SMART
SM00159. PTX. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiView protein in PROSITE
PS00289. PTX_1. 1 hit.
PS51828. PTX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62443-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAGRAARTC ALLALCLLGS GAQDFGPTRF ICTSVPVDAD MCAASVAAGG
60 70 80 90 100
AEELRSNVLQ LRETVLQQKE TILSQKETIR ELTTKLGRCE SQSTLDSGPG
110 120 130 140 150
EARSGGGRKQ PGSGKNTMGD LSRTPAAETL SQLGQTLQSL KTRLENLEQY
160 170 180 190 200
SRLNSSSQTN SLKDLLQSKI DDLERQVLSR VNTLEEGKGG PKNDTEERAK
210 220 230 240 250
IESALTSLHQ RISELEKGQK DNRPGDKFQL TFPLRTNYMY AKVKKSLPEM
260 270 280 290 300
YAFTVCMWLK SSAAPGVGTP FSYAVPGQAN ELVLIEWGNN PMEILINDKV
310 320 330 340 350
AKLPFVINDG KWHHICVTWT TRDGVWEAYQ DGTQGGNGEN LAPYHPIKPQ
360 370 380 390 400
GVLVLGQEQD TLGGGFDATQ AFVGELAHFN IWDRKLTPGE VYNLATCSSK
410 420 430
ALSGNVIAWA ESQIEIFGGA TKWTFEACRQ IN
Length:432
Mass (Da):47,117
Last modified:November 1, 1997 - v1
Checksum:i0698B8BAE4948923
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62021 Genomic DNA. Translation: AAC52826.1.
CCDSiCCDS25719.1.
RefSeqiNP_032756.1. NM_008730.2.
UniGeneiMm.5142.

Genome annotation databases

EnsembliENSMUST00000026670; ENSMUSP00000026670; ENSMUSG00000025582.
GeneIDi18164.
KEGGimmu:18164.
UCSCiuc007mqv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62021 Genomic DNA. Translation: AAC52826.1.
CCDSiCCDS25719.1.
RefSeqiNP_032756.1. NM_008730.2.
UniGeneiMm.5142.

3D structure databases

ProteinModelPortaliQ62443.
SMRiQ62443.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026670.

PTM databases

iPTMnetiQ62443.
PhosphoSitePlusiQ62443.

Proteomic databases

MaxQBiQ62443.
PaxDbiQ62443.
PRIDEiQ62443.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026670; ENSMUSP00000026670; ENSMUSG00000025582.
GeneIDi18164.
KEGGimmu:18164.
UCSCiuc007mqv.1. mouse.

Organism-specific databases

CTDi4884.
MGIiMGI:107811. Nptx1.

Phylogenomic databases

eggNOGiENOG410IFFF. Eukaryota.
ENOG410XR4W. LUCA.
GeneTreeiENSGT00760000119128.
HOGENOMiHOG000231267.
HOVERGENiHBG003608.
InParanoidiQ62443.
OMAiTKLGRCE.
OrthoDBiEOG091G0AHP.
PhylomeDBiQ62443.
TreeFamiTF330208.

Miscellaneous databases

PROiPR:Q62443.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025582.
CleanExiMM_NPTX1.
ExpressionAtlasiQ62443. baseline and differential.
GenevisibleiQ62443. MM.

Family and domain databases

CDDicd00152. PTX. 1 hit.
InterProiView protein in InterPro
IPR013320. ConA-like_dom.
IPR030476. Pentaxin_CS.
IPR001759. Pentraxin-related.
PfamiView protein in Pfam
PF00354. Pentaxin. 1 hit.
PRINTSiPR00895. PENTAXIN.
SMARTiView protein in SMART
SM00159. PTX. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiView protein in PROSITE
PS00289. PTX_1. 1 hit.
PS51828. PTX_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNPTX1_MOUSE
AccessioniPrimary (citable) accession number: Q62443
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 7, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.