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Q62443 (NPTX1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuronal pentraxin-1

Short name=NP1
Alternative name(s):
Neuronal pentraxin I
Short name=NP-I
Gene names
Name:Nptx1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length432 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses By similarity.

Cofactor

Binds 2 calcium ions per subunit By similarity.

Subunit structure

Homooligomer or heterooligomer (probably pentamer) with neuronal pentraxin receptor (NPTXR) By similarity.

Subcellular location

Cytoplasmic vesiclesecretory vesicle Potential.

Sequence similarities

Contains 1 pentaxin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 432410Neuronal pentraxin-1
PRO_0000023548

Regions

Domain230 – 432203Pentaxin

Sites

Metal binding2801Calcium 1 By similarity
Metal binding3581Calcium 1 By similarity
Metal binding3581Calcium 2 By similarity
Metal binding3591Calcium 1; via carbonyl oxygen By similarity
Metal binding3601Calcium 1 By similarity
Metal binding3601Calcium 2 By similarity
Metal binding3701Calcium 2 By similarity

Amino acid modifications

Glycosylation1541N-linked (GlcNAc...) Potential
Glycosylation1931N-linked (GlcNAc...) Potential
Disulfide bond256 ↔ 316 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q62443 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 0698B8BAE4948923

FASTA43247,117
        10         20         30         40         50         60 
MLAGRAARTC ALLALCLLGS GAQDFGPTRF ICTSVPVDAD MCAASVAAGG AEELRSNVLQ 

        70         80         90        100        110        120 
LRETVLQQKE TILSQKETIR ELTTKLGRCE SQSTLDSGPG EARSGGGRKQ PGSGKNTMGD 

       130        140        150        160        170        180 
LSRTPAAETL SQLGQTLQSL KTRLENLEQY SRLNSSSQTN SLKDLLQSKI DDLERQVLSR 

       190        200        210        220        230        240 
VNTLEEGKGG PKNDTEERAK IESALTSLHQ RISELEKGQK DNRPGDKFQL TFPLRTNYMY 

       250        260        270        280        290        300 
AKVKKSLPEM YAFTVCMWLK SSAAPGVGTP FSYAVPGQAN ELVLIEWGNN PMEILINDKV 

       310        320        330        340        350        360 
AKLPFVINDG KWHHICVTWT TRDGVWEAYQ DGTQGGNGEN LAPYHPIKPQ GVLVLGQEQD 

       370        380        390        400        410        420 
TLGGGFDATQ AFVGELAHFN IWDRKLTPGE VYNLATCSSK ALSGNVIAWA ESQIEIFGGA 

       430 
TKWTFEACRQ IN 

« Hide

References

[1]"Mouse and human neuronal pentraxin 1 (NPTX1): conservation, genomic structure, and chromosomal localization."
Omeis I.A., Hsu Y.-C., Perin M.S.
Genomics 36:543-545(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U62021 Genomic DNA. Translation: AAC52826.1.
CCDSCCDS25719.1.
RefSeqNP_032756.1. NM_008730.2.
UniGeneMm.5142.

3D structure databases

ProteinModelPortalQ62443.
SMRQ62443. Positions 229-411.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000026670.

PTM databases

PhosphoSiteQ62443.

Proteomic databases

MaxQBQ62443.
PaxDbQ62443.
PRIDEQ62443.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000026670; ENSMUSP00000026670; ENSMUSG00000025582.
GeneID18164.
KEGGmmu:18164.
UCSCuc007mqv.1. mouse.

Organism-specific databases

CTD4884.
MGIMGI:107811. Nptx1.

Phylogenomic databases

eggNOGNOG47030.
GeneTreeENSGT00650000093153.
HOGENOMHOG000231267.
HOVERGENHBG003608.
InParanoidQ62443.
OMAGASKWTF.
OrthoDBEOG74XS6F.
PhylomeDBQ62443.
TreeFamTF330208.

Gene expression databases

ArrayExpressQ62443.
BgeeQ62443.
CleanExMM_NPTX1.
GenevestigatorQ62443.

Family and domain databases

Gene3D2.60.120.200. 1 hit.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR001759. Pentaxin.
[Graphical view]
PfamPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSPR00895. PENTAXIN.
SMARTSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
PROSITEPS00289. PENTAXIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio293446.
PROQ62443.
SOURCESearch...

Entry information

Entry nameNPTX1_MOUSE
AccessionPrimary (citable) accession number: Q62443
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot