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Q62443

- NPTX1_MOUSE

UniProt

Q62443 - NPTX1_MOUSE

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Protein

Neuronal pentraxin-1

Gene

Nptx1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.By similarity

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi280 – 2801Calcium 1By similarity
Metal bindingi358 – 3581Calcium 1By similarity
Metal bindingi358 – 3581Calcium 2By similarity
Metal bindingi359 – 3591Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi360 – 3601Calcium 1By similarity
Metal bindingi360 – 3601Calcium 2By similarity
Metal bindingi370 – 3701Calcium 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. axonogenesis involved in innervation Source: MGI
  2. cellular response to glucose stimulus Source: Ensembl
  3. cellular response to potassium ion Source: Ensembl
  4. mitochondrial fragmentation involved in apoptotic process Source: Ensembl
  5. mitochondrial transport Source: Ensembl
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal pentraxin-1
Short name:
NP1
Alternative name(s):
Neuronal pentraxin I
Short name:
NP-I
Gene namesi
Name:Nptx1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:107811. Nptx1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasmic vesicle Source: UniProtKB-KW
  2. mitochondrion Source: Ensembl
  3. neuron projection Source: Ensembl
  4. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 432410Neuronal pentraxin-1PRO_0000023548Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi154 – 1541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi193 – 1931N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi256 ↔ 316By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ62443.
PaxDbiQ62443.
PRIDEiQ62443.

PTM databases

PhosphoSiteiQ62443.

Expressioni

Gene expression databases

BgeeiQ62443.
CleanExiMM_NPTX1.
ExpressionAtlasiQ62443. baseline and differential.
GenevestigatoriQ62443.

Interactioni

Subunit structurei

Homooligomer or heterooligomer (probably pentamer) with neuronal pentraxin receptor (NPTXR).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026670.

Structurei

3D structure databases

ProteinModelPortaliQ62443.
SMRiQ62443. Positions 229-411.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini230 – 432203PentaxinAdd
BLAST

Sequence similaritiesi

Contains 1 pentaxin domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG47030.
GeneTreeiENSGT00760000119128.
HOGENOMiHOG000231267.
HOVERGENiHBG003608.
InParanoidiQ62443.
OMAiGASKWTF.
OrthoDBiEOG74XS6F.
PhylomeDBiQ62443.
TreeFamiTF330208.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001759. Pentaxin.
[Graphical view]
PfamiPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00289. PENTAXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q62443-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLAGRAARTC ALLALCLLGS GAQDFGPTRF ICTSVPVDAD MCAASVAAGG
60 70 80 90 100
AEELRSNVLQ LRETVLQQKE TILSQKETIR ELTTKLGRCE SQSTLDSGPG
110 120 130 140 150
EARSGGGRKQ PGSGKNTMGD LSRTPAAETL SQLGQTLQSL KTRLENLEQY
160 170 180 190 200
SRLNSSSQTN SLKDLLQSKI DDLERQVLSR VNTLEEGKGG PKNDTEERAK
210 220 230 240 250
IESALTSLHQ RISELEKGQK DNRPGDKFQL TFPLRTNYMY AKVKKSLPEM
260 270 280 290 300
YAFTVCMWLK SSAAPGVGTP FSYAVPGQAN ELVLIEWGNN PMEILINDKV
310 320 330 340 350
AKLPFVINDG KWHHICVTWT TRDGVWEAYQ DGTQGGNGEN LAPYHPIKPQ
360 370 380 390 400
GVLVLGQEQD TLGGGFDATQ AFVGELAHFN IWDRKLTPGE VYNLATCSSK
410 420 430
ALSGNVIAWA ESQIEIFGGA TKWTFEACRQ IN
Length:432
Mass (Da):47,117
Last modified:November 1, 1997 - v1
Checksum:i0698B8BAE4948923
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62021 Genomic DNA. Translation: AAC52826.1.
CCDSiCCDS25719.1.
RefSeqiNP_032756.1. NM_008730.2.
UniGeneiMm.5142.

Genome annotation databases

EnsembliENSMUST00000026670; ENSMUSP00000026670; ENSMUSG00000025582.
GeneIDi18164.
KEGGimmu:18164.
UCSCiuc007mqv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62021 Genomic DNA. Translation: AAC52826.1 .
CCDSi CCDS25719.1.
RefSeqi NP_032756.1. NM_008730.2.
UniGenei Mm.5142.

3D structure databases

ProteinModelPortali Q62443.
SMRi Q62443. Positions 229-411.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000026670.

PTM databases

PhosphoSitei Q62443.

Proteomic databases

MaxQBi Q62443.
PaxDbi Q62443.
PRIDEi Q62443.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000026670 ; ENSMUSP00000026670 ; ENSMUSG00000025582 .
GeneIDi 18164.
KEGGi mmu:18164.
UCSCi uc007mqv.1. mouse.

Organism-specific databases

CTDi 4884.
MGIi MGI:107811. Nptx1.

Phylogenomic databases

eggNOGi NOG47030.
GeneTreei ENSGT00760000119128.
HOGENOMi HOG000231267.
HOVERGENi HBG003608.
InParanoidi Q62443.
OMAi GASKWTF.
OrthoDBi EOG74XS6F.
PhylomeDBi Q62443.
TreeFami TF330208.

Miscellaneous databases

NextBioi 293446.
PROi Q62443.
SOURCEi Search...

Gene expression databases

Bgeei Q62443.
CleanExi MM_NPTX1.
ExpressionAtlasi Q62443. baseline and differential.
Genevestigatori Q62443.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR013320. ConA-like_dom.
IPR001759. Pentaxin.
[Graphical view ]
Pfami PF00354. Pentaxin. 1 hit.
[Graphical view ]
PRINTSi PR00895. PENTAXIN.
SMARTi SM00159. PTX. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS00289. PENTAXIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Mouse and human neuronal pentraxin 1 (NPTX1): conservation, genomic structure, and chromosomal localization."
    Omeis I.A., Hsu Y.-C., Perin M.S.
    Genomics 36:543-545(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiNPTX1_MOUSE
AccessioniPrimary (citable) accession number: Q62443
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 26, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3