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Q62442 (VAMP1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vesicle-associated membrane protein 1

Short name=VAMP-1
Alternative name(s):
Synaptobrevin-1
Gene names
Name:Vamp1
Synonyms:Syb1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length118 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the targeting and/or fusion of transport vesicles to their target membrane.

Subunit structure

Interacts with VAPA and VAPB By similarity.

Subcellular location

Isoform 1: Cytoplasmic vesiclesecretory vesiclesynaptic vesicle membrane; Single-pass type IV membrane protein By similarity. Cell junctionsynapsesynaptosome By similarity.

Isoform 2: Cytoplasmic vesicle membrane; Single-pass type IV membrane protein By similarity. Cell junctionsynapsesynaptosome By similarity.

Sequence similarities

Belongs to the synaptobrevin family.

Contains 1 v-SNARE coiled-coil homology domain.

Ontologies

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q62442-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q62442-2)

The sequence of this isoform differs from the canonical sequence as follows:
     114-118: IYFFT → SKYR

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 118118Vesicle-associated membrane protein 1
PRO_0000206720

Regions

Topological domain1 – 9696Cytoplasmic Potential
Transmembrane97 – 11620Helical; Anchor for type IV membrane protein; Potential
Topological domain117 – 1182Vesicular Potential
Domain33 – 9361v-SNARE coiled-coil homology

Natural variations

Alternative sequence114 – 1185IYFFT → SKYR in isoform 2.
VSP_029186

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 31CB8701446A7FB0

FASTA11812,890
        10         20         30         40         50         60 
MSAPAQPPAE GTEGAAPGGG PPGPPPNMTS NRRLQQTQAQ VEEVVDIMRV NVDKVLERDQ 

        70         80         90        100        110 
KLSELDDRAD ALQAGASQFE SSAAKLKRKY WWKNCKMMIM LGAICAIIVV VIVIYFFT 

« Hide

Isoform 2 [UniParc].

Checksum: A65589318A7FB071
Show »

FASTA11712,753

References

« Hide 'large scale' references
[1]Martin S., Tellam J.T., Livington C., Slot J.W., Gould G.W., James D.E.
Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]Olken S.K., Doerre S., Corley R.B.
Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Strain: BALB/c.
Tissue: Brain.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Cerebellum and Medulla oblongata.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6.
Tissue: Retina.
[5]Lubec G., Kang S.U., Sunyer B., Chen W.-Q.
Submitted (JAN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 34-49; 50-58 AND 62-85, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: C57BL/6 and OF1.
Tissue: Brain and Hippocampus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U61751 mRNA. Translation: AAB03491.1.
AF007167 mRNA. Translation: AAB62930.1.
AK018783 mRNA. Translation: BAB31407.1.
AK078156 mRNA. Translation: BAC37151.1.
BC049902 mRNA. Translation: AAH49902.2.
BC057587 mRNA. Translation: AAH57587.1.
CCDSCCDS20546.1. [Q62442-1]
CCDS39637.1. [Q62442-2]
RefSeqNP_001074026.1. NM_001080557.1. [Q62442-2]
NP_033522.1. NM_009496.3. [Q62442-1]
UniGeneMm.32321.

3D structure databases

ProteinModelPortalQ62442.
SMRQ62442. Positions 30-94.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ62442.

Proteomic databases

MaxQBQ62442.
PaxDbQ62442.
PRIDEQ62442.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000032487; ENSMUSP00000032487; ENSMUSG00000030337. [Q62442-1]
ENSMUST00000100942; ENSMUSP00000098503; ENSMUSG00000030337. [Q62442-2]
GeneID22317.
KEGGmmu:22317.
UCSCuc009dtx.1. mouse. [Q62442-1]
uc009dty.1. mouse. [Q62442-2]

Organism-specific databases

CTD6843.
MGIMGI:1313276. Vamp1.

Phylogenomic databases

eggNOGCOG5143.
GeneTreeENSGT00550000074449.
HOGENOMHOG000042711.
HOVERGENHBG006675.
KOK08510.
OrthoDBEOG7MSMRJ.
PhylomeDBQ62442.
TreeFamTF313666.

Gene expression databases

ArrayExpressQ62442.
BgeeQ62442.
CleanExMM_VAMP1.
GenevestigatorQ62442.

Family and domain databases

InterProIPR001388. Synaptobrevin.
IPR016444. Synaptobrevin/VAMP_met/fun.
[Graphical view]
PfamPF00957. Synaptobrevin. 1 hit.
[Graphical view]
PIRSFPIRSF005409. Synaptobrevin_euk. 1 hit.
PRINTSPR00219. SYNAPTOBREVN.
PROSITEPS00417. SYNAPTOBREVIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSVAMP1. mouse.
NextBio302523.
PROQ62442.
SOURCESearch...

Entry information

Entry nameVAMP1_MOUSE
AccessionPrimary (citable) accession number: Q62442
Secondary accession number(s): Q6PFF3, Q810K6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot