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Q62442

- VAMP1_MOUSE

UniProt

Q62442 - VAMP1_MOUSE

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Protein

Vesicle-associated membrane protein 1

Gene
Vamp1, Syb1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the targeting and/or fusion of transport vesicles to their target membrane.

GO - Molecular functioni

  1. SNAP receptor activity Source: RefGenome
  2. SNARE binding Source: RefGenome

GO - Biological processi

  1. neurotransmitter secretion Source: RefGenome
  2. regulation of exocytosis Source: RefGenome
  3. SNARE complex assembly Source: BHF-UCL
  4. vesicle fusion Source: RefGenome
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle-associated membrane protein 1
Short name:
VAMP-1
Alternative name(s):
Synaptobrevin-1
Gene namesi
Name:Vamp1
Synonyms:Syb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1313276. Vamp1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9696Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei97 – 11620Helical; Anchor for type IV membrane protein; Reviewed predictionAdd
BLAST
Topological domaini117 – 1182Vesicular Reviewed prediction

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. cell surface Source: BHF-UCL
  3. integral component of membrane Source: UniProtKB-KW
  4. mitochondrion Source: MGI
  5. neuron projection Source: UniProtKB-SubCell
  6. SNARE complex Source: RefGenome
  7. synaptic vesicle Source: RefGenome
  8. synaptic vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 118118Vesicle-associated membrane protein 1PRO_0000206720Add
BLAST

Proteomic databases

MaxQBiQ62442.
PaxDbiQ62442.
PRIDEiQ62442.

PTM databases

PhosphoSiteiQ62442.

Expressioni

Gene expression databases

ArrayExpressiQ62442.
BgeeiQ62442.
CleanExiMM_VAMP1.
GenevestigatoriQ62442.

Interactioni

Subunit structurei

Interacts with VAPA and VAPB By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ62442.
SMRiQ62442. Positions 30-94.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 9361v-SNARE coiled-coil homologyAdd
BLAST

Sequence similaritiesi

Belongs to the synaptobrevin family.

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5143.
GeneTreeiENSGT00550000074449.
HOGENOMiHOG000042711.
HOVERGENiHBG006675.
KOiK08510.
OrthoDBiEOG7MSMRJ.
PhylomeDBiQ62442.
TreeFamiTF313666.

Family and domain databases

InterProiIPR001388. Synaptobrevin.
IPR016444. Synaptobrevin/VAMP_met/fun.
[Graphical view]
PfamiPF00957. Synaptobrevin. 1 hit.
[Graphical view]
PIRSFiPIRSF005409. Synaptobrevin_euk. 1 hit.
PRINTSiPR00219. SYNAPTOBREVN.
PROSITEiPS00417. SYNAPTOBREVIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q62442-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSAPAQPPAE GTEGAAPGGG PPGPPPNMTS NRRLQQTQAQ VEEVVDIMRV    50
NVDKVLERDQ KLSELDDRAD ALQAGASQFE SSAAKLKRKY WWKNCKMMIM 100
LGAICAIIVV VIVIYFFT 118
Length:118
Mass (Da):12,890
Last modified:November 1, 1996 - v1
Checksum:i31CB8701446A7FB0
GO
Isoform 2 (identifier: Q62442-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-118: IYFFT → SKYR

Show »
Length:117
Mass (Da):12,753
Checksum:iA65589318A7FB071
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei114 – 1185IYFFT → SKYR in isoform 2. VSP_029186

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U61751 mRNA. Translation: AAB03491.1.
AF007167 mRNA. Translation: AAB62930.1.
AK018783 mRNA. Translation: BAB31407.1.
AK078156 mRNA. Translation: BAC37151.1.
BC049902 mRNA. Translation: AAH49902.2.
BC057587 mRNA. Translation: AAH57587.1.
CCDSiCCDS20546.1. [Q62442-1]
CCDS39637.1. [Q62442-2]
RefSeqiNP_001074026.1. NM_001080557.1. [Q62442-2]
NP_033522.1. NM_009496.3. [Q62442-1]
UniGeneiMm.32321.

Genome annotation databases

EnsembliENSMUST00000032487; ENSMUSP00000032487; ENSMUSG00000030337. [Q62442-1]
ENSMUST00000100942; ENSMUSP00000098503; ENSMUSG00000030337. [Q62442-2]
GeneIDi22317.
KEGGimmu:22317.
UCSCiuc009dtx.1. mouse. [Q62442-1]
uc009dty.1. mouse. [Q62442-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U61751 mRNA. Translation: AAB03491.1 .
AF007167 mRNA. Translation: AAB62930.1 .
AK018783 mRNA. Translation: BAB31407.1 .
AK078156 mRNA. Translation: BAC37151.1 .
BC049902 mRNA. Translation: AAH49902.2 .
BC057587 mRNA. Translation: AAH57587.1 .
CCDSi CCDS20546.1. [Q62442-1 ]
CCDS39637.1. [Q62442-2 ]
RefSeqi NP_001074026.1. NM_001080557.1. [Q62442-2 ]
NP_033522.1. NM_009496.3. [Q62442-1 ]
UniGenei Mm.32321.

3D structure databases

ProteinModelPortali Q62442.
SMRi Q62442. Positions 30-94.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q62442.

Proteomic databases

MaxQBi Q62442.
PaxDbi Q62442.
PRIDEi Q62442.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032487 ; ENSMUSP00000032487 ; ENSMUSG00000030337 . [Q62442-1 ]
ENSMUST00000100942 ; ENSMUSP00000098503 ; ENSMUSG00000030337 . [Q62442-2 ]
GeneIDi 22317.
KEGGi mmu:22317.
UCSCi uc009dtx.1. mouse. [Q62442-1 ]
uc009dty.1. mouse. [Q62442-2 ]

Organism-specific databases

CTDi 6843.
MGIi MGI:1313276. Vamp1.

Phylogenomic databases

eggNOGi COG5143.
GeneTreei ENSGT00550000074449.
HOGENOMi HOG000042711.
HOVERGENi HBG006675.
KOi K08510.
OrthoDBi EOG7MSMRJ.
PhylomeDBi Q62442.
TreeFami TF313666.

Miscellaneous databases

ChiTaRSi VAMP1. mouse.
NextBioi 302523.
PROi Q62442.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q62442.
Bgeei Q62442.
CleanExi MM_VAMP1.
Genevestigatori Q62442.

Family and domain databases

InterProi IPR001388. Synaptobrevin.
IPR016444. Synaptobrevin/VAMP_met/fun.
[Graphical view ]
Pfami PF00957. Synaptobrevin. 1 hit.
[Graphical view ]
PIRSFi PIRSF005409. Synaptobrevin_euk. 1 hit.
PRINTSi PR00219. SYNAPTOBREVN.
PROSITEi PS00417. SYNAPTOBREVIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Martin S., Tellam J.T., Livington C., Slot J.W., Gould G.W., James D.E.
    Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. Olken S.K., Doerre S., Corley R.B.
    Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: BALB/c.
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Cerebellum and Medulla oblongata.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6.
    Tissue: Retina.
  5. Lubec G., Kang S.U., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 34-49; 50-58 AND 62-85, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6 and OF1.
    Tissue: Brain and Hippocampus.

Entry informationi

Entry nameiVAMP1_MOUSE
AccessioniPrimary (citable) accession number: Q62442
Secondary accession number(s): Q6PFF3, Q810K6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi