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Q62442

- VAMP1_MOUSE

UniProt

Q62442 - VAMP1_MOUSE

Protein

Vesicle-associated membrane protein 1

Gene

Vamp1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Involved in the targeting and/or fusion of transport vesicles to their target membrane.

    GO - Biological processi

    1. SNARE complex assembly Source: BHF-UCL

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vesicle-associated membrane protein 1
    Short name:
    VAMP-1
    Alternative name(s):
    Synaptobrevin-1
    Gene namesi
    Name:Vamp1
    Synonyms:Syb1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1313276. Vamp1.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. cell surface Source: BHF-UCL
    3. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
    4. integral component of membrane Source: UniProtKB-KW
    5. mitochondrion Source: MGI
    6. neuron projection Source: UniProtKB-SubCell
    7. synaptic vesicle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cytoplasmic vesicle, Membrane, Synapse, Synaptosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 118118Vesicle-associated membrane protein 1PRO_0000206720Add
    BLAST

    Proteomic databases

    MaxQBiQ62442.
    PaxDbiQ62442.
    PRIDEiQ62442.

    PTM databases

    PhosphoSiteiQ62442.

    Expressioni

    Gene expression databases

    ArrayExpressiQ62442.
    BgeeiQ62442.
    CleanExiMM_VAMP1.
    GenevestigatoriQ62442.

    Interactioni

    Subunit structurei

    Interacts with VAPA and VAPB.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ62442.
    SMRiQ62442. Positions 30-94.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 9696CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini117 – 1182VesicularSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei97 – 11620Helical; Anchor for type IV membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini33 – 9361v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the synaptobrevin family.Curated
    Contains 1 v-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5143.
    GeneTreeiENSGT00550000074449.
    HOGENOMiHOG000042711.
    HOVERGENiHBG006675.
    KOiK08510.
    OrthoDBiEOG7MSMRJ.
    PhylomeDBiQ62442.
    TreeFamiTF313666.

    Family and domain databases

    InterProiIPR001388. Synaptobrevin.
    IPR016444. Synaptobrevin/VAMP_met/fun.
    [Graphical view]
    PfamiPF00957. Synaptobrevin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005409. Synaptobrevin_euk. 1 hit.
    PRINTSiPR00219. SYNAPTOBREVN.
    PROSITEiPS00417. SYNAPTOBREVIN. 1 hit.
    PS50892. V_SNARE. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q62442-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSAPAQPPAE GTEGAAPGGG PPGPPPNMTS NRRLQQTQAQ VEEVVDIMRV    50
    NVDKVLERDQ KLSELDDRAD ALQAGASQFE SSAAKLKRKY WWKNCKMMIM 100
    LGAICAIIVV VIVIYFFT 118
    Length:118
    Mass (Da):12,890
    Last modified:November 1, 1996 - v1
    Checksum:i31CB8701446A7FB0
    GO
    Isoform 2 (identifier: Q62442-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         114-118: IYFFT → SKYR

    Show »
    Length:117
    Mass (Da):12,753
    Checksum:iA65589318A7FB071
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei114 – 1185IYFFT → SKYR in isoform 2. 1 PublicationVSP_029186

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U61751 mRNA. Translation: AAB03491.1.
    AF007167 mRNA. Translation: AAB62930.1.
    AK018783 mRNA. Translation: BAB31407.1.
    AK078156 mRNA. Translation: BAC37151.1.
    BC049902 mRNA. Translation: AAH49902.2.
    BC057587 mRNA. Translation: AAH57587.1.
    CCDSiCCDS20546.1. [Q62442-1]
    CCDS39637.1. [Q62442-2]
    RefSeqiNP_001074026.1. NM_001080557.1. [Q62442-2]
    NP_033522.1. NM_009496.3. [Q62442-1]
    UniGeneiMm.32321.

    Genome annotation databases

    EnsembliENSMUST00000032487; ENSMUSP00000032487; ENSMUSG00000030337. [Q62442-1]
    ENSMUST00000100942; ENSMUSP00000098503; ENSMUSG00000030337. [Q62442-2]
    GeneIDi22317.
    KEGGimmu:22317.
    UCSCiuc009dtx.1. mouse. [Q62442-1]
    uc009dty.1. mouse. [Q62442-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U61751 mRNA. Translation: AAB03491.1 .
    AF007167 mRNA. Translation: AAB62930.1 .
    AK018783 mRNA. Translation: BAB31407.1 .
    AK078156 mRNA. Translation: BAC37151.1 .
    BC049902 mRNA. Translation: AAH49902.2 .
    BC057587 mRNA. Translation: AAH57587.1 .
    CCDSi CCDS20546.1. [Q62442-1 ]
    CCDS39637.1. [Q62442-2 ]
    RefSeqi NP_001074026.1. NM_001080557.1. [Q62442-2 ]
    NP_033522.1. NM_009496.3. [Q62442-1 ]
    UniGenei Mm.32321.

    3D structure databases

    ProteinModelPortali Q62442.
    SMRi Q62442. Positions 30-94.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q62442.

    Proteomic databases

    MaxQBi Q62442.
    PaxDbi Q62442.
    PRIDEi Q62442.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032487 ; ENSMUSP00000032487 ; ENSMUSG00000030337 . [Q62442-1 ]
    ENSMUST00000100942 ; ENSMUSP00000098503 ; ENSMUSG00000030337 . [Q62442-2 ]
    GeneIDi 22317.
    KEGGi mmu:22317.
    UCSCi uc009dtx.1. mouse. [Q62442-1 ]
    uc009dty.1. mouse. [Q62442-2 ]

    Organism-specific databases

    CTDi 6843.
    MGIi MGI:1313276. Vamp1.

    Phylogenomic databases

    eggNOGi COG5143.
    GeneTreei ENSGT00550000074449.
    HOGENOMi HOG000042711.
    HOVERGENi HBG006675.
    KOi K08510.
    OrthoDBi EOG7MSMRJ.
    PhylomeDBi Q62442.
    TreeFami TF313666.

    Miscellaneous databases

    ChiTaRSi VAMP1. mouse.
    NextBioi 302523.
    PROi Q62442.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q62442.
    Bgeei Q62442.
    CleanExi MM_VAMP1.
    Genevestigatori Q62442.

    Family and domain databases

    InterProi IPR001388. Synaptobrevin.
    IPR016444. Synaptobrevin/VAMP_met/fun.
    [Graphical view ]
    Pfami PF00957. Synaptobrevin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005409. Synaptobrevin_euk. 1 hit.
    PRINTSi PR00219. SYNAPTOBREVN.
    PROSITEi PS00417. SYNAPTOBREVIN. 1 hit.
    PS50892. V_SNARE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Martin S., Tellam J.T., Livington C., Slot J.W., Gould G.W., James D.E.
      Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. Olken S.K., Doerre S., Corley R.B.
      Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: BALB/c.
      Tissue: Brain.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Cerebellum and Medulla oblongata.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6.
      Tissue: Retina.
    5. Lubec G., Kang S.U., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 34-49; 50-58 AND 62-85, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6 and OF1.
      Tissue: Brain and Hippocampus.

    Entry informationi

    Entry nameiVAMP1_MOUSE
    AccessioniPrimary (citable) accession number: Q62442
    Secondary accession number(s): Q6PFF3, Q810K6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3