Reviewed, UniProtKB/Swiss-Prot Q62440 (TLE1_MOUSE)

Names and origin

Protein names

Recommended name:
    Transducin-like enhancer protein 1
Alternative name(s):
    Groucho-related protein 1
      Short name=Grg-1

Gene names

Name:	Tle1
Synonyms:	Grg1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	770 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG By similarity.
Subunit structure	Homooligomer and heterooligomer with other family members. Binds RUNX1, RUNX2, FOXA2, KDM6A, UTY, histone H3, HESX1, ESRRG and the NF-kappa-B subunit RELA. Interacts with HES1 (via WRPW motif) By similarity. Binds TCF7, LEF1, TCF7L1 and TCF7L2.
Subcellular location	Nucleus. Note: Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components. Ref.4 Isoform 7: Nucleus. Cytoplasm. Ref.4 Isoform 8: Nucleus. Cytoplasm. Ref.4
Tissue specificity	Highly expressed in liver and lung. Detected at slightly lower levels in heart, brain, kidney and testis. Detected in fetal and adult stomach and small intestine, in adult ileum, duodenum and colon. In adult small intestine isoform 7 and isoform 8 are most strongly expressed at the base of the crypts of Lieberkuhn.
Post-translational modification	Phosphorylated, probably by CDC2. The degree of phosphorylation varies throughout the cell cycle, and is highest at the G2/M transition. Becomes hyperphosphorylated in response to cell differentiation and interaction with HES1 or RUNX1. Ref.4 Ref.6 Ref.7
Sequence similarities	Belongs to the WD repeat Groucho/TLE family. Contains 6 WD repeats.

Ontologies

Keywords
Biological process	Transcription Transcription regulation Wnt signaling pathway
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing
Domain	Repeat WD repeat
Molecular function	Repressor
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	Wnt receptor signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of transcription from RNA polymerase II promoter Ref.2 Inferred from direct assay. Source: MGI transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell transcription factor complex Inferred from direct assay. Source: MGI
Molecular function	chromatin binding Inferred from direct assay. Source: MGI transcription corepressor activity Inferred from direct assay. Source: MGI
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Lbx1	P52955	1	EBI-604471,EBI-604594
Lbxcor1	Q8BX46	1	EBI-604471,EBI-604451

Alternative products

This entry describes 8 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q62440-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q62440-2)

The sequence of this isoform differs from the canonical sequence as follows:
     125-198: Missing.

Isoform 3 (identifier: Q62440-3)

The sequence of this isoform differs from the canonical sequence as follows:
     79-198: Missing.

Isoform 4 (identifier: Q62440-4)

The sequence of this isoform differs from the canonical sequence as follows:
     125-198: Missing.
     477-658: Missing.

Isoform 5 (identifier: Q62440-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: MFPQSRHPTPHQAAGQPFKFTIPESLDRIKEEFQFLQAQYH → MFTLSCLFCFP

Isoform 6 (identifier: Q62440-6)

The sequence of this isoform differs from the canonical sequence as follows:
     649-653: RQLQQ → NKSYQ
     654-770: Missing.

Isoform 7 (identifier: Q62440-7)

The sequence of this isoform differs from the canonical sequence as follows:
     193-200: DRESGTSN → GERPGKPD
     201-770: Missing.

Isoform 8 (identifier: Q62440-8)

The sequence of this isoform differs from the canonical sequence as follows:
     127-127: Missing.
     193-200: DRESGTSN → GERPGKPD
     201-770: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 770	770	Transducin-like enhancer protein 1		PRO_0000051277
Regions
	Repeat	470 – 501	32	WD 1
	Repeat	528 – 558	31	WD 2
	Repeat	572 – 602	31	WD 3
	Repeat	614 – 644	31	WD 4
	Repeat	696 – 726	31	WD 5
	Repeat	737 – 767	31	WD 6
	Region	200 – 268	69	CCN domain
	Motif	225 – 228	4	Nuclear localization signal Potential
	Compositional bias	1 – 131	131	Gln-rich
	Compositional bias	132 – 199	68	Gly/Pro-rich
	Compositional bias	269 – 449	181	Pro/Ser-rich
Amino acid modifications
	Modified residue	237	1	Phosphoserine; by CK2 Potential
	Modified residue	257	1	Phosphoserine; by CDC2 Potential
	Modified residue	261	1	Phosphoserine; by CDC2 Potential
	Modified residue	265	1	Phosphoserine; by CDC2 Potential
	Modified residue	282	1	Phosphoserine Ref.7
Natural variations
	Alternative sequence	1 – 41	41	MFPQS…QAQYH → MFTLSCLFCFP in isoform 5.		VSP_006987
	Alternative sequence	79 – 198	120	Missing in isoform 3.		VSP_006988
	Alternative sequence	125 – 198	74	Missing in isoform 2 and isoform 4.		VSP_006989
	Alternative sequence	127	1	Missing in isoform 8.		VSP_006990
	Alternative sequence	193 – 200	8	DRESGTSN → GERPGKPD in isoform 7 and isoform 8.		VSP_006992
	Alternative sequence	201 – 770	570	Missing in isoform 7 and isoform 8.		VSP_006993
	Alternative sequence	477 – 658	182	Missing in isoform 4.		VSP_006991
	Alternative sequence	649 – 653	5	RQLQQ → NKSYQ in isoform 6.		VSP_006994
	Alternative sequence	654 – 770	117	Missing in isoform 6.		VSP_006995
Experimental info
	Sequence conflict	48	1	E → G in AAN77514. Ref.2
	Sequence conflict	92	1	V → D in AAB49934. Ref.1
	Sequence conflict	122	1	I → T in AAN77518. Ref.2
	Sequence conflict	163	1	S → G in AAB49934. Ref.1
	Sequence conflict	196	1	S → P Ref.1
	Sequence conflict	196	1	S → P in AAN77514. Ref.2
	Sequence conflict	196	1	S → P in AAN77518. Ref.2
	Sequence conflict	196	1	S → P in BAC35221. Ref.3
	Sequence conflict	210	1	S → G Ref.1
	Sequence conflict	210	1	S → G in AAN77519. Ref.2
	Sequence conflict	210	1	S → G in BAC35221. Ref.3
	Sequence conflict	210	1	S → G in BAC38509. Ref.3
	Sequence conflict	247	1	V → I in AAN77514. Ref.2
	Sequence conflict	258	1	P → S in AAN77514. Ref.2
	Sequence conflict	258	1	P → S in AAN77518. Ref.2
	Sequence conflict	428	1	R → S in AAN77518. Ref.2
	Sequence conflict	464 – 465	2	DA → MP in AAB49934. Ref.1
	Sequence conflict	471	1	I → F in AAB49934. Ref.1
	Sequence conflict	535	1	S → T in AAB49934. Ref.1
	Sequence conflict	542	1	G → D in AAB49934. Ref.1
	Sequence conflict	551	1	A → T in AAN77517. Ref.2
	Sequence conflict	612	1	F → Y in BAC35221. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 25, 2003. Version 2. Checksum: 65803C8F39BB0703	FASTA	770	83,097
	10 20 30 40 50 60 MFPQSRHPTP HQAAGQPFKF TIPESLDRIK EEFQFLQAQY HSLKLECEKL ASEKTEMQRH 70 80 90 100 110 120 YVMYYEMSYG LNIEMHKQTE IAKRLNTICA QVIPFLSQEH QQQVAQAVER AKQVTMAELN 130 140 150 160 170 180 AIIGQQQLQA QHLSHGHGPP VPLTPHPSGL QPPGIPPLGG SASLLALSSA LSGQSHLAIK 190 200 210 220 230 240 DDKKHHDAER HRDRESGTSN SLLVPDSLRS TDKRRNGPEF SSDIKKRKVD DKDNYDSDGD 250 260 270 280 290 300 KSDDNLVVDV SNEDPSSPHA SPTHSPRENG IDKNRLLKKD ASGSPASTAS SGSSSSLKSK 310 320 330 340 350 360 EVSLHEKANT PVLKSSTPTP RSDMPTPGTS ATPGLRPGLG KPPAMEPLVN QAAAGLRTPL 370 380 390 400 410 420 AVPGPYPAPF GMVPHAGMNG ELTSPGAAYA GLHSMSPQMS AAAAAAAAAV VAYGRSPMVG 430 440 450 460 470 480 FDPPPHMRVP SIPPNLAGIP GGKPAYSFHV TADGQMQPVP FPPDALIGPG IPRHARQINT 490 500 510 520 530 540 LNHGEVVCAV TISNPTRHVY TGGKGCVKVW DISHPGNKSP VSQLDCLNRD NYIRSCKLLP 550 560 570 580 590 600 DGCTLIVGGE ASTLSIWDLA APTPRIKAEL TSSAPACYAL AISPDSKVCF SCCSDGNIAV 610 620 630 640 650 660 WDLHNQTLVR QFQGHTDGAS CIDISNDGTK LWTGGLDNTV RSWDLREGRQ LQQHDFTSQI 670 680 690 700 710 720 FSLGYCPTGE WLAVGMESSN VEVLHVNKPD KYQLHLHESC VLSLKFAYCG KWFVSTGKDN 730 740 750 760 770 LLNAWRTPYG ASIFQSKESS SVLSCDISVD DKYIVTGSGD KKATVYEVIY
	Isoform 2. Checksum: 93CA5C16F44EEAA0	FASTA	696	75,331
	10 20 30 40 50 60 MFPQSRHPTP HQAAGQPFKF TIPESLDRIK EEFQFLQAQY HSLKLECEKL ASEKTEMQRH 70 80 90 100 110 120 YVMYYEMSYG LNIEMHKQTE IAKRLNTICA QVIPFLSQEH QQQVAQAVER AKQVTMAELN 130 140 150 160 170 180 AIIGSNSLLV PDSLRSTDKR RNGPEFSSDI KKRKVDDKDN YDSDGDKSDD NLVVDVSNED 190 200 210 220 230 240 PSSPHASPTH SPRENGIDKN RLLKKDASGS PASTASSGSS SSLKSKEVSL HEKANTPVLK 250 260 270 280 290 300 SSTPTPRSDM PTPGTSATPG LRPGLGKPPA MEPLVNQAAA GLRTPLAVPG PYPAPFGMVP 310 320 330 340 350 360 HAGMNGELTS PGAAYAGLHS MSPQMSAAAA AAAAAVVAYG RSPMVGFDPP PHMRVPSIPP 370 380 390 400 410 420 NLAGIPGGKP AYSFHVTADG QMQPVPFPPD ALIGPGIPRH ARQINTLNHG EVVCAVTISN 430 440 450 460 470 480 PTRHVYTGGK GCVKVWDISH PGNKSPVSQL DCLNRDNYIR SCKLLPDGCT LIVGGEASTL 490 500 510 520 530 540 SIWDLAAPTP RIKAELTSSA PACYALAISP DSKVCFSCCS DGNIAVWDLH NQTLVRQFQG 550 560 570 580 590 600 HTDGASCIDI SNDGTKLWTG GLDNTVRSWD LREGRQLQQH DFTSQIFSLG YCPTGEWLAV 610 620 630 640 650 660 GMESSNVEVL HVNKPDKYQL HLHESCVLSL KFAYCGKWFV STGKDNLLNA WRTPYGASIF 670 680 690 QSKESSSVLS CDISVDDKYI VTGSGDKKAT VYEVIY
	Isoform 3. Checksum: 5FCC67C8B92929C1	FASTA	650	70,258
	10 20 30 40 50 60 MFPQSRHPTP HQAAGQPFKF TIPESLDRIK EEFQFLQAQY HSLKLECEKL ASEKTEMQRH 70 80 90 100 110 120 YVMYYEMSYG LNIEMHKQSN SLLVPDSLRS TDKRRNGPEF SSDIKKRKVD DKDNYDSDGD 130 140 150 160 170 180 KSDDNLVVDV SNEDPSSPHA SPTHSPRENG IDKNRLLKKD ASGSPASTAS SGSSSSLKSK 190 200 210 220 230 240 EVSLHEKANT PVLKSSTPTP RSDMPTPGTS ATPGLRPGLG KPPAMEPLVN QAAAGLRTPL 250 260 270 280 290 300 AVPGPYPAPF GMVPHAGMNG ELTSPGAAYA GLHSMSPQMS AAAAAAAAAV VAYGRSPMVG 310 320 330 340 350 360 FDPPPHMRVP SIPPNLAGIP GGKPAYSFHV TADGQMQPVP FPPDALIGPG IPRHARQINT 370 380 390 400 410 420 LNHGEVVCAV TISNPTRHVY TGGKGCVKVW DISHPGNKSP VSQLDCLNRD NYIRSCKLLP 430 440 450 460 470 480 DGCTLIVGGE ASTLSIWDLA APTPRIKAEL TSSAPACYAL AISPDSKVCF SCCSDGNIAV 490 500 510 520 530 540 WDLHNQTLVR QFQGHTDGAS CIDISNDGTK LWTGGLDNTV RSWDLREGRQ LQQHDFTSQI 550 560 570 580 590 600 FSLGYCPTGE WLAVGMESSN VEVLHVNKPD KYQLHLHESC VLSLKFAYCG KWFVSTGKDN 610 620 630 640 650 LLNAWRTPYG ASIFQSKESS SVLSCDISVD DKYIVTGSGD KKATVYEVIY
	Isoform 4. Checksum: 7C36084BE935D848	FASTA	514	55,619
	10 20 30 40 50 60 MFPQSRHPTP HQAAGQPFKF TIPESLDRIK EEFQFLQAQY HSLKLECEKL ASEKTEMQRH 70 80 90 100 110 120 YVMYYEMSYG LNIEMHKQTE IAKRLNTICA QVIPFLSQEH QQQVAQAVER AKQVTMAELN 130 140 150 160 170 180 AIIGSNSLLV PDSLRSTDKR RNGPEFSSDI KKRKVDDKDN YDSDGDKSDD NLVVDVSNED 190 200 210 220 230 240 PSSPHASPTH SPRENGIDKN RLLKKDASGS PASTASSGSS SSLKSKEVSL HEKANTPVLK 250 260 270 280 290 300 SSTPTPRSDM PTPGTSATPG LRPGLGKPPA MEPLVNQAAA GLRTPLAVPG PYPAPFGMVP 310 320 330 340 350 360 HAGMNGELTS PGAAYAGLHS MSPQMSAAAA AAAAAVVAYG RSPMVGFDPP PHMRVPSIPP 370 380 390 400 410 420 NLAGIPGGKP AYSFHVTADG QMQPVPFPPD ALIGPGIPRH ARQIFSLGYC PTGEWLAVGM 430 440 450 460 470 480 ESSNVEVLHV NKPDKYQLHL HESCVLSLKF AYCGKWFVST GKDNLLNAWR TPYGASIFQS 490 500 510 KESSSVLSCD ISVDDKYIVT GSGDKKATVY EVIY
	Isoform 5. Checksum: E18B2A843F1F8FE9	FASTA	740	79,521
	10 20 30 40 50 60 MFTLSCLFCF PSLKLECEKL ASEKTEMQRH YVMYYEMSYG LNIEMHKQTE IAKRLNTICA 70 80 90 100 110 120 QVIPFLSQEH QQQVAQAVER AKQVTMAELN AIIGQQQLQA QHLSHGHGPP VPLTPHPSGL 130 140 150 160 170 180 QPPGIPPLGG SASLLALSSA LSGQSHLAIK DDKKHHDAER HRDRESGTSN SLLVPDSLRS 190 200 210 220 230 240 TDKRRNGPEF SSDIKKRKVD DKDNYDSDGD KSDDNLVVDV SNEDPSSPHA SPTHSPRENG 250 260 270 280 290 300 IDKNRLLKKD ASGSPASTAS SGSSSSLKSK EVSLHEKANT PVLKSSTPTP RSDMPTPGTS 310 320 330 340 350 360 ATPGLRPGLG KPPAMEPLVN QAAAGLRTPL AVPGPYPAPF GMVPHAGMNG ELTSPGAAYA 370 380 390 400 410 420 GLHSMSPQMS AAAAAAAAAV VAYGRSPMVG FDPPPHMRVP SIPPNLAGIP GGKPAYSFHV 430 440 450 460 470 480 TADGQMQPVP FPPDALIGPG IPRHARQINT LNHGEVVCAV TISNPTRHVY TGGKGCVKVW 490 500 510 520 530 540 DISHPGNKSP VSQLDCLNRD NYIRSCKLLP DGCTLIVGGE ASTLSIWDLA APTPRIKAEL 550 560 570 580 590 600 TSSAPACYAL AISPDSKVCF SCCSDGNIAV WDLHNQTLVR QFQGHTDGAS CIDISNDGTK 610 620 630 640 650 660 LWTGGLDNTV RSWDLREGRQ LQQHDFTSQI FSLGYCPTGE WLAVGMESSN VEVLHVNKPD 670 680 690 700 710 720 KYQLHLHESC VLSLKFAYCG KWFVSTGKDN LLNAWRTPYG ASIFQSKESS SVLSCDISVD 730 740 DKYIVTGSGD KKATVYEVIY
	Isoform 6. Checksum: 7B72A99D3AFD5716	FASTA	653	70,000
	10 20 30 40 50 60 MFPQSRHPTP HQAAGQPFKF TIPESLDRIK EEFQFLQAQY HSLKLECEKL ASEKTEMQRH 70 80 90 100 110 120 YVMYYEMSYG LNIEMHKQTE IAKRLNTICA QVIPFLSQEH QQQVAQAVER AKQVTMAELN 130 140 150 160 170 180 AIIGQQQLQA QHLSHGHGPP VPLTPHPSGL QPPGIPPLGG SASLLALSSA LSGQSHLAIK 190 200 210 220 230 240 DDKKHHDAER HRDRESGTSN SLLVPDSLRS TDKRRNGPEF SSDIKKRKVD DKDNYDSDGD 250 260 270 280 290 300 KSDDNLVVDV SNEDPSSPHA SPTHSPRENG IDKNRLLKKD ASGSPASTAS SGSSSSLKSK 310 320 330 340 350 360 EVSLHEKANT PVLKSSTPTP RSDMPTPGTS ATPGLRPGLG KPPAMEPLVN QAAAGLRTPL 370 380 390 400 410 420 AVPGPYPAPF GMVPHAGMNG ELTSPGAAYA GLHSMSPQMS AAAAAAAAAV VAYGRSPMVG 430 440 450 460 470 480 FDPPPHMRVP SIPPNLAGIP GGKPAYSFHV TADGQMQPVP FPPDALIGPG IPRHARQINT 490 500 510 520 530 540 LNHGEVVCAV TISNPTRHVY TGGKGCVKVW DISHPGNKSP VSQLDCLNRD NYIRSCKLLP 550 560 570 580 590 600 DGCTLIVGGE ASTLSIWDLA APTPRIKAEL TSSAPACYAL AISPDSKVCF SCCSDGNIAV 610 620 630 640 650 WDLHNQTLVR QFQGHTDGAS CIDISNDGTK LWTGGLDNTV RSWDLREGNK SYQ
	Isoform 7. Checksum: 5DAC9D0AF949D0D7	FASTA	200	22,439
	10 20 30 40 50 60 MFPQSRHPTP HQAAGQPFKF TIPESLDRIK EEFQFLQAQY HSLKLECEKL ASEKTEMQRH 70 80 90 100 110 120 YVMYYEMSYG LNIEMHKQTE IAKRLNTICA QVIPFLSQEH QQQVAQAVER AKQVTMAELN 130 140 150 160 170 180 AIIGQQQLQA QHLSHGHGPP VPLTPHPSGL QPPGIPPLGG SASLLALSSA LSGQSHLAIK 190 200 DDKKHHDAER HRGERPGKPD
	Isoform 8. Checksum: E5F799939675DE4C	FASTA	199	22,310
	10 20 30 40 50 60 MFPQSRHPTP HQAAGQPFKF TIPESLDRIK EEFQFLQAQY HSLKLECEKL ASEKTEMQRH 70 80 90 100 110 120 YVMYYEMSYG LNIEMHKQTE IAKRLNTICA QVIPFLSQEH QQQVAQAVER AKQVTMAELN 130 140 150 160 170 180 AIIGQQLQAQ HLSHGHGPPV PLTPHPSGLQ PPGIPPLGGS ASLLALSSAL SGQSHLAIKD 190 DKKHHDAERH RGERPGKPD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Transcripts of Grg4, a murine groucho-related gene, are detected in adjacent tissues to other murine neurogenic gene homologues during embryonic development." Koop K.E., Macdonald L.M., Lobe C.G. Mech. Dev. 59:73-87(1996) [PubMed: 8892234] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Characterization of a novel mammalian groucho isoform and its role in transcriptional regulation." Lepourcelet M., Shivdasani R.A. J. Biol. Chem. 277:47732-47740(2002) [PubMed: 12359720] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 6 AND 8), PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4). Strain: C57BL/6J and ICR. Tissue: Fetal intestine.
[3]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 5 AND 7). Strain: C57BL/6J. Tissue: Cerebellum.
[4]	"Affinity for the nuclear compartment and expression during cell differentiation implicate phosphorylated Groucho/TLE1 forms of higher molecular mass in nuclear functions." Husain J., Lo R., Grbavec D., Stifani S. Biochem. J. 317:523-531(1996) [PubMed: 8713081] [Abstract] Cited for: SUBCELLULAR LOCATION, PHOSPHORYLATION.
[5]	"All Tcf HMG box transcription factors interact with Groucho-related co-repressors." Brantjes H., Roose J., van De Wetering M., Clevers H. Nucleic Acids Res. 29:1410-1419(2001) [PubMed: 11266540] [Abstract] Cited for: INTERACTION WITH TCF7; LEF1; TCF7L1 AND TCF7L2.
[6]	"Role for Hes1-induced phosphorylation in Groucho-mediated transcriptional repression." Nuthall H.N., Husain J., McLarren K.W., Stifani S. Mol. Cell. Biol. 22:389-399(2002) [PubMed: 11756536] [Abstract] Cited for: PHOSPHORYLATION DURING NEURAL CELL DIFFERENTIATION.
[7]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed: 17242355] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-282, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U61362 mRNA. Translation: AAB49934.1. AY155195 mRNA. Translation: AAN77514.1. AY155196 mRNA. Translation: AAN77515.1. AY155197 mRNA. Translation: AAN77516.1. AY155198 mRNA. Translation: AAN77517.1. AY155199 mRNA. Translation: AAN77518.1. AY155200 mRNA. Translation: AAN77519.1. AK046402 mRNA. Translation: BAC32708.1. AK052961 mRNA. Translation: BAC35221.1. AK076750 mRNA. Translation: BAC36464.1. AK082499 mRNA. Translation: BAC38509.1.
IPI	IPI00230248. IPI00230249. IPI00230250. IPI00230252. IPI00230253. IPI00230254. IPI00321347. IPI00623322.
RefSeq	NP_035729.3.
UniGene	Mm.278444 Mm.388819 Mm.399716
3D structure databases
HSSP	HSSP built from PDB template 1GXR based on UniProtKB Q04724.
SMR	Q62440. Positions 438-770.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q62440. 2 interactions.
PTM databases
PhosphoSite	Q62440.
Genome annotation databases
Ensembl	ENSMUSG00000008305. Mus musculus. [Contig view]
GeneID	21885.
KEGG	mmu:21885.
Organism-specific databases
MGI	MGI:104636. Tle1.
Phylogenomic databases
HOVERGEN	Q62440.
Gene expression databases
ArrayExpress	Q62440.
Bgee	Q62440.
GermOnline	ENSMUSG00000008305. Mus musculus.
Family and domain databases
InterPro	IPR009146. Groucho_enhance. IPR005617. TLE_N. IPR015943. WD40/YVTN_repeat-like. IPR001680. WD40_repeat. IPR019782. WD40_repeat_2. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_region. IPR019781. WD40_repeat_sg. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
Pfam	PF03920. TLE_N. 1 hit. PF00400. WD40. 6 hits. [Graphical view]
PRINTS	PR01850. GROUCHOFAMLY.
ProDom	PD000018. WD40. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00320. WD40. 7 hits. [Graphical view]
PROSITE	PS00678. WD_REPEATS_1. 2 hits. PS50082. WD_REPEATS_2. 2 hits. PS50294. WD_REPEATS_REGION. 2 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	301400.
SOURCE	Search...

Entry information

Entry name

TLE1_MOUSE

Accession

Primary (citable) accession number: Q62440

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	March 25, 2003
Last modified:	June 16, 2009
This is version 90 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)