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Protein
Submitted name:

Thiazide-sensitive Na-Cl cotransporter

Gene

Slc12a3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Thiazide-sensitive Na-Cl cotransporterImported
Gene namesi
Name:Slc12a3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:108114. Slc12a3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei166 – 191HelicalSequence analysisAdd BLAST26
Transmembranei212 – 236HelicalSequence analysisAdd BLAST25
Transmembranei256 – 275HelicalSequence analysisAdd BLAST20
Transmembranei284 – 305HelicalSequence analysisAdd BLAST22
Transmembranei337 – 359HelicalSequence analysisAdd BLAST23
Transmembranei371 – 390HelicalSequence analysisAdd BLAST20
Transmembranei449 – 471HelicalSequence analysisAdd BLAST23
Transmembranei503 – 522HelicalSequence analysisAdd BLAST20
Transmembranei528 – 549HelicalSequence analysisAdd BLAST22
Transmembranei583 – 602HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ62439.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034218.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 113AA_permease_NInterPro annotationAdd BLAST70
Domaini138 – 643AA_permeaseInterPro annotationAdd BLAST506
Domaini652 – 792SLC12InterPro annotationAdd BLAST141
Domaini797 – 1000SLC12InterPro annotationAdd BLAST204

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2083. Eukaryota.
COG0531. LUCA.
HOVERGENiHBG052851.

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR013612. AA_permease_N.
IPR018491. SLC12_C.
IPR002948. SLC12A3.
IPR004842. SLC12A_fam.
[Graphical view]
PANTHERiPTHR11827:SF9. PTHR11827:SF9. 2 hits.
PfamiPF00324. AA_permease. 1 hit.
PF08403. AA_permease_N. 1 hit.
PF03522. SLC12. 2 hits.
[Graphical view]
PRINTSiPR01230. NACLTRNSPORT.
TIGRFAMsiTIGR00930. 2a30. 1 hit.

Sequencei

Sequence statusi: Complete.

Q62439-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELPVTELP GDALCSGRFT ISTLMGGDEP PPAACDSSQP SHLTHGSTLY
60 70 80 90 100
MRTFGYNTID VVPAYEHYAN SALPGEPRKV RPTLADLHSF LKEGSHLHAL
110 120 130 140 150
AFDGRQGREL TDGLVEDETG TNSEKSPGEP VRFGWVKGVM IRCMLNIWGV
160 170 180 190 200
ILYLRLPWIT AQAGIVLTWL IILLSVMVTS ITGLSISAIS TNGKVKSGGT
210 220 230 240 250
YFLISRSLGP ELGGSIGLIF AFANAVGVAM HTVGFAETVR DLLQEYGTPI
260 270 280 290 300
VDPINDIRII GVVTVTVLLA ISLAGMEWES KAQVLFFLVI MVSFANYLVG
310 320 330 340 350
TLIPASEDKA SKGFYSYHGD IFVQNLVPDW RGIDGSFFGM FSIFFPSATG
360 370 380 390 400
ILAGANISGD LKDPAVAIPK GTLMAIFWTT ISYLAISATI GSCVVRDASG
410 420 430 440 450
DVNDTMTPGP GPCEGLACGY GWNFTECSQQ RSCRYGLINY YQTMSMVSAF
460 470 480 490 500
APLITAGIFG ATLSSALACL VSAAKVFQCL CEDQLYPLIG FFGKGYGKNR
510 520 530 540 550
EPVRGYLLAY AIAVAFIIIA ELNTIAPIIS NFFLCSYALI NFSCFHASIT
560 570 580 590 600
NSPGWRPSFR YYSKWAALFG AVISVVIMFL LTWWAALIAI GVVLFLLLYV
610 620 630 640 650
IYKKPEVNWG SSVQAGSYNL ALSYSVGLNE VEDHIKNYRP QCLVLTGPPN
660 670 680 690 700
FRPALVDFVS TFTQNLSLMI CGHVLIGPGK QRVPELRLIA SGHTKWLNKR
710 720 730 740 750
KIKAFYSDVI AEDLRSGVQI LMQASGLGRM KPNILVVGFK RNWQSAHPAT
760 770 780 790 800
VEDYIGVLHD AFDFNYGVCV MRMREGLNVS EALQTHTTPE ALIQEEQAST
810 820 830 840 850
IFQSEQGKKT IDIYWLFDDG GLTLLIPYLL HRKKRWGKCK IRVFVGGQIN
860 870 880 890 900
RMDEERKAII SLLSKFRLGF HEVHVLPDIN QKPQAEHTKR FEDMIAPFRL
910 920 930 940 950
NDGFKDEATV TEMRRDCPWK ISDEEINKNR IKSLRQVRLS EILLDYSRDA
960 970 980 990 1000
ALIILTLPIG RKGKCPSSLY MAWLETLSQD IRPPVLLIRG NQENVLTFYC

Q
Length:1,001
Mass (Da):110,566
Last modified:January 1, 1999 - v2
Checksum:i324855D07E903608
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61085 mRNA. Translation: AAC71080.1.
UniGeneiMm.25804.

Genome annotation databases

UCSCiuc009mwe.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61085 mRNA. Translation: AAC71080.1.
UniGeneiMm.25804.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034218.

Proteomic databases

PaxDbiQ62439.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc009mwe.2. mouse.

Organism-specific databases

MGIiMGI:108114. Slc12a3.

Phylogenomic databases

eggNOGiKOG2083. Eukaryota.
COG0531. LUCA.
HOVERGENiHBG052851.

Miscellaneous databases

ChiTaRSiSlc12a3. mouse.
SOURCEiSearch...

Family and domain databases

InterProiIPR004841. AA-permease/SLC12A_dom.
IPR013612. AA_permease_N.
IPR018491. SLC12_C.
IPR002948. SLC12A3.
IPR004842. SLC12A_fam.
[Graphical view]
PANTHERiPTHR11827:SF9. PTHR11827:SF9. 2 hits.
PfamiPF00324. AA_permease. 1 hit.
PF08403. AA_permease_N. 1 hit.
PF03522. SLC12. 2 hits.
[Graphical view]
PRINTSiPR01230. NACLTRNSPORT.
TIGRFAMsiTIGR00930. 2a30. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ62439_MOUSE
AccessioniPrimary (citable) accession number: Q62439
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: January 1, 1999
Last modified: March 16, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.