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Protein

Cystatin-B

Gene

Cstb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This is an intracellular thiol proteinase inhibitor.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei4 – 41Reactive siteBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Thiol protease inhibitor

Protein family/group databases

MEROPSiI25.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Cystatin-B
Alternative name(s):
Stefin-B
Gene namesi
Name:Cstb
Synonyms:Cst6, Stfb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:109514. Cstb.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9898Cystatin-BPRO_0000207141Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ62426.
MaxQBiQ62426.
PaxDbiQ62426.
PeptideAtlasiQ62426.
PRIDEiQ62426.

2D gel databases

SWISS-2DPAGEQ62426.

PTM databases

iPTMnetiQ62426.
PhosphoSiteiQ62426.

Expressioni

Tissue specificityi

Widely expressed. Highest expression in heart, liver and kidney. Lower levels in brain, lung and skeletal muscle. Lowest levels in spleen and testis.

Gene expression databases

BgeeiQ62426.
CleanExiMM_CSTB.
GenevisibleiQ62426. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ62426. 5 interactions.
MINTiMINT-4092754.
STRINGi10090.ENSMUSP00000005185.

Structurei

3D structure databases

ProteinModelPortaliQ62426.
SMRiQ62426. Positions 8-98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi46 – 505Secondary area of contactBy similarity

Sequence similaritiesi

Belongs to the cystatin family.Curated

Phylogenomic databases

eggNOGiENOG410IZK7. Eukaryota.
ENOG41121QW. LUCA.
GeneTreeiENSGT00390000015607.
HOGENOMiHOG000294175.
HOVERGENiHBG002292.
InParanoidiQ62426.
KOiK13907.
OMAiTFTAKSY.
OrthoDBiEOG7FR7JX.
PhylomeDBiQ62426.
TreeFamiTF333174.

Family and domain databases

InterProiIPR000010. Cystatin_dom.
IPR018073. Prot_inh_cystat_CS.
IPR001713. Prot_inh_stefinA.
[Graphical view]
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]
PRINTSiPR00295. STEFINA.
SMARTiSM00043. CY. 1 hit.
[Graphical view]
PROSITEiPS00287. CYSTATIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62426-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMCGAPSATM PATAETQEVA DQVKSQLESK ENQKFDVFKA ISFKRQIVAG
60 70 80 90
TNLFIKVDVG GDKCVHLRVF QPLPHENKPL TLSSYQTNKE RHDELSYF
Length:98
Mass (Da):11,046
Last modified:November 1, 1997 - v1
Checksum:i87A23E6493D28AB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59807 Genomic DNA. Translation: AAC52851.1.
AK002403 mRNA. Translation: BAB22074.1.
AK151205 mRNA. Translation: BAE30202.1.
BC056170 mRNA. Translation: AAH56170.1.
CCDSiCCDS23964.1.
RefSeqiNP_031819.1. NM_007793.3.
UniGeneiMm.6095.

Genome annotation databases

EnsembliENSMUST00000005185; ENSMUSP00000005185; ENSMUSG00000005054.
GeneIDi13014.
KEGGimmu:13014.
UCSCiuc007fxt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59807 Genomic DNA. Translation: AAC52851.1.
AK002403 mRNA. Translation: BAB22074.1.
AK151205 mRNA. Translation: BAE30202.1.
BC056170 mRNA. Translation: AAH56170.1.
CCDSiCCDS23964.1.
RefSeqiNP_031819.1. NM_007793.3.
UniGeneiMm.6095.

3D structure databases

ProteinModelPortaliQ62426.
SMRiQ62426. Positions 8-98.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ62426. 5 interactions.
MINTiMINT-4092754.
STRINGi10090.ENSMUSP00000005185.

Protein family/group databases

MEROPSiI25.003.

PTM databases

iPTMnetiQ62426.
PhosphoSiteiQ62426.

2D gel databases

SWISS-2DPAGEQ62426.

Proteomic databases

EPDiQ62426.
MaxQBiQ62426.
PaxDbiQ62426.
PeptideAtlasiQ62426.
PRIDEiQ62426.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005185; ENSMUSP00000005185; ENSMUSG00000005054.
GeneIDi13014.
KEGGimmu:13014.
UCSCiuc007fxt.1. mouse.

Organism-specific databases

CTDi1476.
MGIiMGI:109514. Cstb.

Phylogenomic databases

eggNOGiENOG410IZK7. Eukaryota.
ENOG41121QW. LUCA.
GeneTreeiENSGT00390000015607.
HOGENOMiHOG000294175.
HOVERGENiHBG002292.
InParanoidiQ62426.
KOiK13907.
OMAiTFTAKSY.
OrthoDBiEOG7FR7JX.
PhylomeDBiQ62426.
TreeFamiTF333174.

Miscellaneous databases

PROiQ62426.
SOURCEiSearch...

Gene expression databases

BgeeiQ62426.
CleanExiMM_CSTB.
GenevisibleiQ62426. MM.

Family and domain databases

InterProiIPR000010. Cystatin_dom.
IPR018073. Prot_inh_cystat_CS.
IPR001713. Prot_inh_stefinA.
[Graphical view]
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]
PRINTSiPR00295. STEFINA.
SMARTiSM00043. CY. 1 hit.
[Graphical view]
PROSITEiPS00287. CYSTATIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of the mouse cystatin B gene."
    Pennacchio L.A., Myers R.M.
    Genome Res. 6:1103-1109(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow and Kidney.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiCYTB_MOUSE
AccessioniPrimary (citable) accession number: Q62426
Secondary accession number(s): Q3UAW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 6, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.