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Protein

Cystatin-B

Gene

Cstb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This is an intracellular thiol proteinase inhibitor.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei4Reactive siteBy similarity1

GO - Molecular functioni

GO - Biological processi

  • adult locomotory behavior Source: MGI
  • negative regulation of peptidase activity Source: MGI
  • negative regulation of proteolysis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Thiol protease inhibitor

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Protein family/group databases

MEROPSiI25.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Cystatin-B
Alternative name(s):
Stefin-B
Gene namesi
Name:Cstb
Synonyms:Cst6, Stfb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:109514. Cstb.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002071411 – 98Cystatin-BAdd BLAST98

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ62426.
MaxQBiQ62426.
PaxDbiQ62426.
PeptideAtlasiQ62426.
PRIDEiQ62426.

2D gel databases

SWISS-2DPAGEQ62426.

PTM databases

iPTMnetiQ62426.
PhosphoSitePlusiQ62426.

Expressioni

Tissue specificityi

Widely expressed. Highest expression in heart, liver and kidney. Lower levels in brain, lung and skeletal muscle. Lowest levels in spleen and testis.

Gene expression databases

BgeeiENSMUSG00000005054.
CleanExiMM_CSTB.
GenevisibleiQ62426. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ62426. 5 interactors.
MINTiMINT-4092754.
STRINGi10090.ENSMUSP00000005185.

Structurei

3D structure databases

ProteinModelPortaliQ62426.
SMRiQ62426.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi46 – 50Secondary area of contactBy similarity5

Sequence similaritiesi

Belongs to the cystatin family.Curated

Phylogenomic databases

eggNOGiENOG410IZK7. Eukaryota.
ENOG41121QW. LUCA.
GeneTreeiENSGT00390000015607.
HOGENOMiHOG000294175.
HOVERGENiHBG002292.
InParanoidiQ62426.
KOiK13907.
OMAiTFTAKSY.
OrthoDBiEOG091G12NK.
PhylomeDBiQ62426.
TreeFamiTF333174.

Family and domain databases

CDDicd00042. CY. 1 hit.
InterProiIPR000010. Cystatin_dom.
IPR018073. Prot_inh_cystat_CS.
IPR001713. Prot_inh_stefinA.
[Graphical view]
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]
PRINTSiPR00295. STEFINA.
SMARTiSM00043. CY. 1 hit.
[Graphical view]
PROSITEiPS00287. CYSTATIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62426-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMCGAPSATM PATAETQEVA DQVKSQLESK ENQKFDVFKA ISFKRQIVAG
60 70 80 90
TNLFIKVDVG GDKCVHLRVF QPLPHENKPL TLSSYQTNKE RHDELSYF
Length:98
Mass (Da):11,046
Last modified:November 1, 1997 - v1
Checksum:i87A23E6493D28AB8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59807 Genomic DNA. Translation: AAC52851.1.
AK002403 mRNA. Translation: BAB22074.1.
AK151205 mRNA. Translation: BAE30202.1.
BC056170 mRNA. Translation: AAH56170.1.
CCDSiCCDS23964.1.
RefSeqiNP_031819.1. NM_007793.3.
UniGeneiMm.6095.

Genome annotation databases

EnsembliENSMUST00000005185; ENSMUSP00000005185; ENSMUSG00000005054.
GeneIDi13014.
KEGGimmu:13014.
UCSCiuc007fxt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59807 Genomic DNA. Translation: AAC52851.1.
AK002403 mRNA. Translation: BAB22074.1.
AK151205 mRNA. Translation: BAE30202.1.
BC056170 mRNA. Translation: AAH56170.1.
CCDSiCCDS23964.1.
RefSeqiNP_031819.1. NM_007793.3.
UniGeneiMm.6095.

3D structure databases

ProteinModelPortaliQ62426.
SMRiQ62426.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ62426. 5 interactors.
MINTiMINT-4092754.
STRINGi10090.ENSMUSP00000005185.

Protein family/group databases

MEROPSiI25.003.

PTM databases

iPTMnetiQ62426.
PhosphoSitePlusiQ62426.

2D gel databases

SWISS-2DPAGEQ62426.

Proteomic databases

EPDiQ62426.
MaxQBiQ62426.
PaxDbiQ62426.
PeptideAtlasiQ62426.
PRIDEiQ62426.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005185; ENSMUSP00000005185; ENSMUSG00000005054.
GeneIDi13014.
KEGGimmu:13014.
UCSCiuc007fxt.1. mouse.

Organism-specific databases

CTDi1476.
MGIiMGI:109514. Cstb.

Phylogenomic databases

eggNOGiENOG410IZK7. Eukaryota.
ENOG41121QW. LUCA.
GeneTreeiENSGT00390000015607.
HOGENOMiHOG000294175.
HOVERGENiHBG002292.
InParanoidiQ62426.
KOiK13907.
OMAiTFTAKSY.
OrthoDBiEOG091G12NK.
PhylomeDBiQ62426.
TreeFamiTF333174.

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiQ62426.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005054.
CleanExiMM_CSTB.
GenevisibleiQ62426. MM.

Family and domain databases

CDDicd00042. CY. 1 hit.
InterProiIPR000010. Cystatin_dom.
IPR018073. Prot_inh_cystat_CS.
IPR001713. Prot_inh_stefinA.
[Graphical view]
PfamiPF00031. Cystatin. 1 hit.
[Graphical view]
PRINTSiPR00295. STEFINA.
SMARTiSM00043. CY. 1 hit.
[Graphical view]
PROSITEiPS00287. CYSTATIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYTB_MOUSE
AccessioniPrimary (citable) accession number: Q62426
Secondary accession number(s): Q3UAW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.