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Protein

Cytochrome c oxidase subunit NDUFA4

Gene

Ndufa4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cytochrome c oxidase (COX, complex IV) is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. Required for complex IV maintenance (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit NDUFA4
Gene namesi
Name:Ndufa4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:107686. Ndufa4.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • mitochondrial inner membrane Source: MGI
  • mitochondrial respiratory chain complex IV Source: UniProtKB
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8282Cytochrome c oxidase subunit NDUFA4PRO_0000118822Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei10 – 101N6-acetyllysineCombined sources
Modified residuei67 – 671PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ62425.
MaxQBiQ62425.
PaxDbiQ62425.
PeptideAtlasiQ62425.
PRIDEiQ62425.
TopDownProteomicsiQ62425.

PTM databases

iPTMnetiQ62425.
PhosphoSiteiQ62425.

Expressioni

Gene expression databases

BgeeiQ62425.
ExpressionAtlasiQ62425. baseline and differential.
GenevisibleiQ62425. MM.

Interactioni

Subunit structurei

Component of the cytochrome c oxidase complex (COX, complex IV).1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201717. 4 interactions.
IntActiQ62425. 8 interactions.
MINTiMINT-1859998.
STRINGi10090.ENSMUSP00000031637.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LEGX-ray1.75P61-68[»]
1LEKX-ray2.15P61-68[»]
1MWAX-ray2.40P/Q61-68[»]
2CKBX-ray3.00P/Q61-68[»]
ProteinModelPortaliQ62425.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ62425.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex IV NDUFA4 subunit family.Curated

Phylogenomic databases

eggNOGiENOG410J0TX. Eukaryota.
ENOG41124SW. LUCA.
GeneTreeiENSGT00390000010457.
HOGENOMiHOG000261679.
HOVERGENiHBG006548.
InParanoidiQ62425.
KOiK03948.
OMAiYKFYAVN.
OrthoDBiEOG71P2DD.
PhylomeDBiQ62425.
TreeFamiTF106383.

Family and domain databases

InterProiIPR010530. B12D.
[Graphical view]
PANTHERiPTHR14256. PTHR14256. 1 hit.
PfamiPF06522. B12D. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q62425-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRQILGQAK KHPSLIPLFV FIGAGGTGAA LYVMRLALFN PDVSWDRKNN
60 70 80
PEPWNKLGPN EQYKFYSVNV DYSKLKKEGP DF
Length:82
Mass (Da):9,327
Last modified:September 19, 2002 - v2
Checksum:i6E29865845807C7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005084 mRNA. No translation available.
AK008357 mRNA. Translation: BAB25627.1.
AK008506 mRNA. Translation: BAB25706.1.
AK076036 mRNA. Translation: BAC36137.1.
BC011114 mRNA. Translation: AAH11114.1.
U59509 mRNA. Translation: AAB03395.1.
CCDSiCCDS39427.1.
RefSeqiNP_035016.1. NM_010886.2.
UniGeneiMm.415865.

Genome annotation databases

EnsembliENSMUST00000204714; ENSMUSP00000145413; ENSMUSG00000029632.
ENSMUST00000204978; ENSMUSP00000144932; ENSMUSG00000029632.
GeneIDi17992.
KEGGimmu:17992.
UCSCiuc009ayd.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005084 mRNA. No translation available.
AK008357 mRNA. Translation: BAB25627.1.
AK008506 mRNA. Translation: BAB25706.1.
AK076036 mRNA. Translation: BAC36137.1.
BC011114 mRNA. Translation: AAH11114.1.
U59509 mRNA. Translation: AAB03395.1.
CCDSiCCDS39427.1.
RefSeqiNP_035016.1. NM_010886.2.
UniGeneiMm.415865.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1LEGX-ray1.75P61-68[»]
1LEKX-ray2.15P61-68[»]
1MWAX-ray2.40P/Q61-68[»]
2CKBX-ray3.00P/Q61-68[»]
ProteinModelPortaliQ62425.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201717. 4 interactions.
IntActiQ62425. 8 interactions.
MINTiMINT-1859998.
STRINGi10090.ENSMUSP00000031637.

PTM databases

iPTMnetiQ62425.
PhosphoSiteiQ62425.

Proteomic databases

EPDiQ62425.
MaxQBiQ62425.
PaxDbiQ62425.
PeptideAtlasiQ62425.
PRIDEiQ62425.
TopDownProteomicsiQ62425.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000204714; ENSMUSP00000145413; ENSMUSG00000029632.
ENSMUST00000204978; ENSMUSP00000144932; ENSMUSG00000029632.
GeneIDi17992.
KEGGimmu:17992.
UCSCiuc009ayd.1. mouse.

Organism-specific databases

CTDi4697.
MGIiMGI:107686. Ndufa4.

Phylogenomic databases

eggNOGiENOG410J0TX. Eukaryota.
ENOG41124SW. LUCA.
GeneTreeiENSGT00390000010457.
HOGENOMiHOG000261679.
HOVERGENiHBG006548.
InParanoidiQ62425.
KOiK03948.
OMAiYKFYAVN.
OrthoDBiEOG71P2DD.
PhylomeDBiQ62425.
TreeFamiTF106383.

Miscellaneous databases

EvolutionaryTraceiQ62425.
PROiQ62425.
SOURCEiSearch...

Gene expression databases

BgeeiQ62425.
ExpressionAtlasiQ62425. baseline and differential.
GenevisibleiQ62425. MM.

Family and domain databases

InterProiIPR010530. B12D.
[Graphical view]
PANTHERiPTHR14256. PTHR14256. 1 hit.
PfamiPF06522. B12D. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum and Small intestine.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  3. "A single T cell receptor recognizes structurally distinct MHC/peptide complexes with high specificity."
    Tallquist M.D., Yun T.J., Pease L.R.
    J. Exp. Med. 184:1017-1026(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-82, PROTEIN SEQUENCE OF 61-68.
    Strain: C57BL/6J.
  4. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 36-74, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6J.
    Tissue: Brain.
  5. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-67, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas and Testis.
  7. "NDUFA4 is a subunit of complex IV of the mammalian electron transport chain."
    Balsa E., Marco R., Perales-Clemente E., Szklarczyk R., Calvo E., Landazuri M.O., Enriquez J.A.
    Cell Metab. 16:378-386(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTFICATION AS CYTOCHROME C OXIDASE SUBUNIT.
  8. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
    Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
    Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-10, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  9. "Structural comparison of allogeneic and syngeneic T cell receptor-peptide-major histocompatibility complex complexes: a buried alloreactive mutation subtly alters peptide presentation substantially increasing V(beta) interactions."
    Luz J.G., Huang M., Garcia K.C., Rudolph M.G., Apostolopoulos V., Teyton L., Wilson I.A.
    J. Exp. Med. 195:1175-1186(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 61-68 IN COMPLEX WITH THE MAJOR HISTOCOMPATIBILITY COMPLEX.

Entry informationi

Entry nameiNDUA4_MOUSE
AccessioniPrimary (citable) accession number: Q62425
Secondary accession number(s): Q9CQP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 19, 2002
Last modified: July 6, 2016
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.