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Protein

Cytochrome c oxidase subunit NDUFA4

Gene

Ndufa4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cytochrome c oxidase (COX, complex IV) is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. Required for complex IV maintenance (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit NDUFA4
Gene namesi
Name:Ndufa4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:107686. Ndufa4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001188221 – 82Cytochrome c oxidase subunit NDUFA4Add BLAST82

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10N6-acetyllysineCombined sources1
Modified residuei67PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ62425.
MaxQBiQ62425.
PaxDbiQ62425.
PeptideAtlasiQ62425.
PRIDEiQ62425.
TopDownProteomicsiQ62425.

PTM databases

iPTMnetiQ62425.
PhosphoSitePlusiQ62425.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029632.
ExpressionAtlasiQ62425. baseline and differential.
GenevisibleiQ62425. MM.

Interactioni

Subunit structurei

Component of the cytochrome c oxidase complex (COX, complex IV).1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201717. 4 interactors.
CORUMiQ62425.
IntActiQ62425. 8 interactors.
MINTiMINT-1859998.
STRINGi10090.ENSMUSP00000031637.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LEGX-ray1.75P61-68[»]
1LEKX-ray2.15P61-68[»]
1MWAX-ray2.40P/Q61-68[»]
2CKBX-ray3.00P/Q61-68[»]
ProteinModelPortaliQ62425.
SMRiQ62425.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ62425.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex IV NDUFA4 subunit family.Curated

Phylogenomic databases

eggNOGiENOG410J0TX. Eukaryota.
ENOG41124SW. LUCA.
GeneTreeiENSGT00390000010457.
HOGENOMiHOG000261679.
HOVERGENiHBG006548.
InParanoidiQ62425.
KOiK03948.
OMAiRLAMFNP.
OrthoDBiEOG091G1352.
PhylomeDBiQ62425.
TreeFamiTF106383.

Family and domain databases

InterProiView protein in InterPro
IPR010530. B12D.
PANTHERiPTHR14256. PTHR14256. 1 hit.
PfamiView protein in Pfam
PF06522. B12D. 1 hit.

Sequencei

Sequence statusi: Complete.

Q62425-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRQILGQAK KHPSLIPLFV FIGAGGTGAA LYVMRLALFN PDVSWDRKNN
60 70 80
PEPWNKLGPN EQYKFYSVNV DYSKLKKEGP DF
Length:82
Mass (Da):9,327
Last modified:September 19, 2002 - v2
Checksum:i6E29865845807C7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005084 mRNA. No translation available.
AK008357 mRNA. Translation: BAB25627.1.
AK008506 mRNA. Translation: BAB25706.1.
AK076036 mRNA. Translation: BAC36137.1.
BC011114 mRNA. Translation: AAH11114.1.
U59509 mRNA. Translation: AAB03395.1.
CCDSiCCDS39427.1.
RefSeqiNP_035016.1. NM_010886.2.
UniGeneiMm.415865.

Genome annotation databases

EnsembliENSMUST00000204714; ENSMUSP00000145413; ENSMUSG00000029632.
ENSMUST00000204978; ENSMUSP00000144932; ENSMUSG00000029632.
GeneIDi17992.
KEGGimmu:17992.
UCSCiuc009ayd.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiNDUA4_MOUSE
AccessioniPrimary (citable) accession number: Q62425
Secondary accession number(s): Q9CQP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 19, 2002
Last modified: September 27, 2017
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families